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  1. Article ; Online: Caracterización patogénica, clínica y diagnóstica de la pandemia por SARS-CoV-2.

    Abarca Rozas, Bastian / Vargas Urra, Jocelyn / García Garzón, Javier

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2021  Volume 37, Issue 3, Page(s) 265–275

    Abstract: SARS-CoV-2 is the pathogen responsible for COVID-19, an infectious disease that can evolve from a mild viral illness to multiple organ failure and death. This disease is characterized by a high transmissibility rate, which has lead to its spread ... ...

    Title translation Pathogenic, clinical and diagnostic characteristics of the SARS-CoV-2 pandemic.
    Abstract SARS-CoV-2 is the pathogen responsible for COVID-19, an infectious disease that can evolve from a mild viral illness to multiple organ failure and death. This disease is characterized by a high transmissibility rate, which has lead to its spread throughout the world. There are no clear prognostic markers to guide the severity of the condition; however, some clinical elements could be considered possible predictors of severity. Knowing its viral structure and pathogenesis has allowed to recognize specific molecular pathways candidates as therapeutic targets for various drugs, which are still under investigation and will set the guidelines for future protocols.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language Spanish
    Publishing date 2021-02-04
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/s0716-10182020000300265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Caracterización patogénica, clínica y diagnóstica de la pandemia por SARS-CoV-2/ Pathogenic, clinical and diagnostic characteristics of the SARS-CoV-2 pandemic

    Abarca Rozas, Bastian / Vargas Urra, Jocelyn / García Garzón, Javier

    Rev. chil. infectol

    Abstract: Resumen El SARS-CoV-2 es el agente patógeno responsable del COVID-19, enfermedad infecciosa que puede evolucionar desde un cuadro viral leve hasta la falla multiorgánica y muerte. Esta enfermedad se caracteriza por tener una tasa de transmisibilidad ... ...

    Abstract Resumen El SARS-CoV-2 es el agente patógeno responsable del COVID-19, enfermedad infecciosa que puede evolucionar desde un cuadro viral leve hasta la falla multiorgánica y muerte. Esta enfermedad se caracteriza por tener una tasa de transmisibilidad elevada, lo que ha permitido su diseminación por el mundo. No existen marcadores pronósticos claros que guíen la gravedad del cuadro; no obstante, hay elementos clínicos que podrían considerarse posibles predictores de gravedad. Conocer su estructura viral y patogenia ha posibilitado objetivar los pasos moleculares específicos que pueden ser blancos terapéuticos de variados fármacos, los cuales se mantienen en investigación y marcarán las directrices de futuros protocolos.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #734319
    Database COVID19

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  3. Article ; Online: Características de la ventilación mecánica invasiva en COVID-19 para médicos no especialistas

    Jocelyn Vargas Urra E.U. / Bastian Abarca Rozas / Javier García Garzón

    Revista Chilena de Anestesia, Vol 49, Iss 4, Pp 504-

    2020  Volume 513

    Keywords sars-cov-2 ; covid-19 ; insuficiencia respiratoria aguda ; ventilación mecánica ; Medicine ; R ; Anesthesiology ; RD78.3-87.3 ; covid19
    Language Spanish
    Publishing date 2020-07-01T00:00:00Z
    Publisher Editorial Iku
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A current view on the early diagnosis and treatment of acute kidney failure.

    Abarca Rozas, Bastian / Mestas Rodríguez, Manuel / Widerström Isea, Jorge / Lobos Pareja, Beatriz / Vargas Urra, Jocelyn

    Medwave

    2020  Volume 20, Issue 5, Page(s) e7928

    Abstract: Acute kidney injury is a syndrome characterized by a sudden, sustained, and potentially reversible decrease in glomerular filtration rate and tubular function, which globally impacts renal function. It comprises of a series of events starting with the ... ...

    Title translation Un enfoque actual para el diagnóstico precoz y tratamiento de la insuficiencia renal aguda.
    Abstract Acute kidney injury is a syndrome characterized by a sudden, sustained, and potentially reversible decrease in glomerular filtration rate and tubular function, which globally impacts renal function. It comprises of a series of events starting with the presence of risk factors, then evolving towards acute kidney injury progression, characterized by stress, injury, and renal failure, culminating with either the use of renal replacement therapy or death. Currently, the use of biomarkers that differentiate between the initial functional deterioration and late-onset structural damage of the kidney enables the clinician to perform an early diagnosis and indicate treatment before the stages of acute kidney injury progression are established, thus increasing survival rates.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Biomarkers/metabolism ; Disease Progression ; Early Diagnosis ; Humans ; Renal Replacement Therapy ; Survival Rate
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-06-09
    Publishing country Chile
    Document type Journal Article ; Review
    ZDB-ID 2818022-7
    ISSN 0717-6384 ; 0717-6384
    ISSN (online) 0717-6384
    ISSN 0717-6384
    DOI 10.5867/medwave.2020.05.7928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Aspectos esenciales sobre el uso de hemocomponentes en el paciente hospitalizado: revisión narrativa de literatura.

    Abarca Rozas, Bastian / Vargas Urra, Jocelyn / Dadlani Mahtani, Pavan / Widerström Isea, Jorge / Mestas Rodríguez, Manuel

    Medwave

    2020  Volume 20, Issue 10, Page(s) e8060

    Abstract: Introduction: Transfusion medicine develops and disseminates guidelines that govern the optimal conditions for transfusion. The purpose of this article is to review the current evidence on the use of blood components.: Methods: We searched PubMed, ... ...

    Title translation Essential aspects for the administration of blood components in hospitalized patients: A narrative literature review.
    Abstract Introduction: Transfusion medicine develops and disseminates guidelines that govern the optimal conditions for transfusion. The purpose of this article is to review the current evidence on the use of blood components.
    Methods: We searched PubMed, Scholar Google, ScienceDirect, SciELO and Cochrane web portals, as well as official documents published in the Chilean Society of Hematology. Articles from the last ten years were included, of which 42 were appropriate for this narrative literature review.
    Conclusion: First of all, there is a controversy between two types of strategies regarding the practice of red blood cell transfusion: a liberal strategy and a restrictive strategy. Second, for the management of coagulopathies, clotting times do not reflect the true ability of patients to clot. Third, to reverse the effect of coumadin, the administration of vitamin K would suffice over the use of fresh frozen plasma. Fourth, the use of physiological triggers could help define the best time for a transfusion.
    MeSH term(s) Chile ; Erythrocyte Transfusion ; Humans
    Language Spanish
    Publishing date 2020-11-12
    Publishing country Chile
    Document type Journal Article ; Review
    ZDB-ID 2818022-7
    ISSN 0717-6384 ; 0717-6384
    ISSN (online) 0717-6384
    ISSN 0717-6384
    DOI 10.5867/medwave.2020.10.8060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A current view on the early diagnosis and treatment of acute kidney failure

    Bastian Abarca Rozas / Manuel Mestas Rodríguez / Jorge Widerström Isea / Beatriz Lobos Pareja / Jocelyn Vargas Urra

    Medwave, Vol 20, Iss 25, Pp e7928-e

    2020  Volume 7928

    Abstract: Acute kidney injury is a syndrome characterized by a sudden, sustained, and potentially reversible decrease in glomerular filtration rate and tubular function, which globally impacts renal function. It comprises of a series of events starting with the ... ...

    Abstract Acute kidney injury is a syndrome characterized by a sudden, sustained, and potentially reversible decrease in glomerular filtration rate and tubular function, which globally impacts renal function. It comprises of a series of events starting with the presence of risk factors, then evolving towards acute kidney injury progression, characterized by stress, injury, and renal failure, culminating with either the use of renal replacement therapy or death. Currently, the use of biomarkers that differentiate between the initial functional deterioration and late-onset structural damage of the kidney enables the clinician to perform an early diagnosis and indicate treatment before the stages of acute kidney injury progression are established, thus increasing survival rates.
    Keywords kdigo ; acute kidney injury ; biomarkers ; therapy ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Medwave Estudios Limitada
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Essential aspects for the administration of blood components in hospitalized patients

    Bastian Abarca Rozas / Jocelyn Vargas Urra / Pavan Dadlani Mahtani / Jorge Widerström Isea / Manuel Mestas Rodríguez

    Medwave, Vol 20, Iss 10, Pp e8060-e

    A narrative literature review

    2020  Volume 8060

    Abstract: Introduction Transfusion medicine develops and disseminates guidelines that govern the optimal conditions for transfusion. The purpose of this article is to review the current evidence on the use of blood components. Methods We searched PubMed, Scholar ... ...

    Abstract Introduction Transfusion medicine develops and disseminates guidelines that govern the optimal conditions for transfusion. The purpose of this article is to review the current evidence on the use of blood components. Methods We searched PubMed, Scholar Google, ScienceDirect, SciELO and Cochrane web portals, as well as official documents published in the Chilean Society of Hematology. Articles from the last ten years were included, of which 42 were appropriate for this narrative literature review. Conclusion First of all, there is a controversy between two types of strategies regarding the practice of red blood cell transfusion: a liberal strategy and a restrictive strategy. Second, for the management of coagulopathies, clotting times do not reflect the true ability of patients to clot. Third, to reverse the effect of coumadin, the administration of vitamin K would suffice over the use of fresh frozen plasma. Fourth, the use of physiological triggers could help define the best time for a transfusion.
    Keywords blood component transfusions ; erythrocyte transfusion ; platelet transfusion ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Medwave Estudios Limitada
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Atypical presentation and late diagnosis of acute aortic dissection without timely surgical treatment: case report and literature review.

    Abarca Rozas, Bastián Aaron / Schwarze Fieldhouse, Mathias Wilhelm / Contreras Bertolo, Rodrigo Ignacio / Rodríguez Hernández, Pablo Andrés / Roa Aravena, Iván Osvaldo / Schwarze Grossi, Hermann Antonio

    Medwave

    2018  Volume 18, Issue 5, Page(s) e7249

    Abstract: Acute aortic syndrome includes a group of diseases that have clinical similarity in their natural history, the most important characteristic being their association with a high vital risk. The diagnosis and management of aortic dissection depends on the ... ...

    Title translation Presentación atípica y diagnóstico tardío de disección aórtica aguda sin tratamiento quirúrgico oportuno: reporte de un caso y revisión de la literatura.
    Abstract Acute aortic syndrome includes a group of diseases that have clinical similarity in their natural history, the most important characteristic being their association with a high vital risk. The diagnosis and management of aortic dissection depends on the degree of aortic involvement according to the location of the lesion, as defined by the Stanford classification. In this syndrome, chest pain is considered the cardinal symptom; however, there are situations where clinical feedback is difficult. We present the case of a patient who debuted with a Stanford A aortic dissection, with an indication for surgical resolution in the acute phase, but who unexpectedly presented unspecific clinical manifestations. An opportune diagnosis was not obtained. After repeated consultations for changes in his symptoms, the definitive diagnosis was determined through imaging study, evolving favorably with ambulatory therapy.
    MeSH term(s) Aneurysm, Dissecting/diagnosis ; Aneurysm, Dissecting/physiopathology ; Chest Pain/etiology ; Delayed Diagnosis ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2018-09-14
    Publishing country Chile
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2818022-7
    ISSN 0717-6384 ; 0717-6384
    ISSN (online) 0717-6384
    ISSN 0717-6384
    DOI 10.5867/medwave.2018.05.7249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Atypical presentation and late diagnosis of acute aortic dissection without timely surgical treatment

    Bastián Aaron Abarca Rozas / Mathias Wilhelm Schwarze Fieldhouse / Rodrigo Ignacio Contreras Bertolo / Pablo Andrés Rodríguez Hernández / Iván Osvaldo Roa Aravena / Hermann Antonio Schwarze Grossi

    Medwave, Vol 18, Iss 05, Pp e7249-e

    case report and literature review

    2018  Volume 7249

    Abstract: Resumen El síndrome aórtico agudo incluye un grupo de enfermedades que poseen similitud clínica en su historia natural, siendo la característica más importante su asociación a un alto riesgo vital. Entre estas patologías, el diagnóstico y manejo de la ... ...

    Abstract Resumen El síndrome aórtico agudo incluye un grupo de enfermedades que poseen similitud clínica en su historia natural, siendo la característica más importante su asociación a un alto riesgo vital. Entre estas patologías, el diagnóstico y manejo de la disección aórtica depende del grado de compromiso aórtico según la ubicación de la lesión definida bajo la clasificación de Stanford. Dentro de las manifestaciones clave se considera al dolor torácico como el síntoma cardinal. Sin embargo, existen situaciones que por ambigüedad clínica retrasan el diagnóstico. Se presenta el caso de un paciente que debutó con una disección aórtica Stanford A, con indicación de resolución quirúrgica en fase aguda pero que dado lo inespecífico de su cuadro clínico, no se logró un diagnóstico oportuno. Posterior a reiteradas consultas por cambios en su sintomatología, se determinó el cuadro definitivo a través de estudio imagenológico, evolucionando de forma favorable con terapia ambulatoria.
    Keywords aortic dissection ; chest pain ; acute aortic syndrome ; case report ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher Medwave Estudios Limitada
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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