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  1. Article ; Online: A Novel Approach to Improve Accuracy of CYP2D6 Enzyme Activity and Drug Response Predictions.

    Moyer, Ann M / Langman, Loralie J / Black, John L

    Clinical chemistry

    2022  Volume 68, Issue 5, Page(s) 616–618

    MeSH term(s) Cytochrome P-450 CYP2D6/genetics ; Humans
    Chemical Substances Cytochrome P-450 CYP2D6 (EC 1.14.14.1)
    Language English
    Publishing date 2022-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvab269
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  2. Article: Determination of the Duplicated

    Atiq, Mazen A / Peterson, Sandra E / Langman, Loralie J / Baudhuin, Linnea M / Black, John L / Moyer, Ann M

    Journal of personalized medicine

    2023  Volume 13, Issue 6

    Abstract: ... ...

    Abstract CYP2D6
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13060883
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  3. Article: Severe acute pancreatitis following biopsy of the minor papilla of the duodenum.

    Langman, Yael / Lambert, Antoine / Arvanitakis, Marianna / Devière, Jacques / Degrez, Thierry / Gokburun, Yeter / Blero, Daniel

    Endoscopy international open

    2022  Volume 10, Issue 6, Page(s) E731–E732

    Language English
    Publishing date 2022-06-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-1811-5708
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  4. Article ; Online: Drug testing in support of the diagnosis of neonatal abstinence syndrome: The current situation.

    Langman, Loralie J / Rushton, Alysha M / Thomas, Dylan / Colbourne, Penny / Seiden-Long, Isolde / Brun, Miranda M / Colantonio, David / Jannetto, Paul J

    Clinical biochemistry

    2022  

    Abstract: Illicit drug use during pregnancy is a concern worldwide, with many international studies describing attempted strategies to mitigate this problem. Drug misuse during pregnancy is associated with significant maternal as well as perinatal complications, ... ...

    Abstract Illicit drug use during pregnancy is a concern worldwide, with many international studies describing attempted strategies to mitigate this problem. Drug misuse during pregnancy is associated with significant maternal as well as perinatal complications, which include a high incidence of stillbirths, fetal distress, neonatal abstinence syndrome (NAS) and increased neonatal mortality. Unfortunately, the identification of a drug-exposed mother or neonate is challenging. Maternal disclosure of drug use is often inaccurate, principally due to psychosocial factors including behavioral denial or the fear of the consequences resulting from such admissions. Likewise, many infants who have been exposed to drugs in utero may appear normal at birth and initially show no overt manifestations of drug effects. Thus, the identification of the drug-exposed infant requires a high index of clinical suspicion. Conversely, analytical testing is an objective means of determining drug exposure when it may be necessary to document proof of the infant's exposure to illicit drugs. The review will discuss the different matrices that are most commonly used for testing (e.g., maternal urine, neonatal urine, meconium, and umbilical cord), the strengths and limitations for each matrix, which drugs and metabolites are appropriate for testing, the various testing methods, and the advantages and disadvantages of each method.
    Language English
    Publishing date 2022-11-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2022.11.002
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  5. Article: Epidemiology of cancer of the large intestine.

    Langman, M J

    Proceedings of the Royal Society of Medicine

    2010  Volume 59, Issue 2, Page(s) 132–134

    Language English
    Publishing date 2010-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 209243-8
    ISSN 0035-9157
    ISSN 0035-9157
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  6. Article ; Online: Now or Later? Patient Satisfaction and Anxiety Among Women Undergoing Breast Biopsies Performed the Same Day as Recommended Versus a Later Day.

    Grimm, Lars J / Shelby, Rebecca A / Destounis, Stamatia V / Knippa, Emily E / Langman, Eun L / Nedrud, Marybeth A / Musick, Alexis / Yoon, Sora / Johnson, Karen / Baker, Jay / Taylor-Cho, Michael / Soo, Mary Scott

    Journal of the American College of Radiology : JACR

    2024  Volume 21, Issue 3, Page(s) 415–424

    Abstract: Purpose: The aim of this study was to determine differences in patient satisfaction and anxiety among women undergoing core-needle breast biopsies performed the same day as recommended versus a future date.: Methods: After institutional review board ... ...

    Abstract Purpose: The aim of this study was to determine differences in patient satisfaction and anxiety among women undergoing core-needle breast biopsies performed the same day as recommended versus a future date.
    Methods: After institutional review board exemption was granted, a survey was administered to patients at four sites on the day of imaging-guided core-needle breast biopsy. The survey was available from November 2020 through January 2022. Questions pertained to biopsy timing (same day versus later day), pre- and postbiopsy satisfaction with overall breast-care experience, biopsy wait-time satisfaction, pre- and postbiopsy anxiety, radiologist-patient communication, demographics, life stressors, breast cancer history, and risk factors. Comparisons were made between same-day and later-day biopsies by multivariable analysis.
    Results: Of 974 respondents (response rate 65.6%), almost half were scheduled for same-day biopsies (47.8% [466 of 974]). In multivariate analyses, same-day biopsies were associated with higher prebiopsy overall breast-care satisfaction (P < .001), higher wait-time satisfaction (P < .001), and higher prebiopsy (P = .001) and postbiopsy anxiety (P = .001). Better radiologist-patient communication was associated with lower prebiopsy anxiety (P < .001) and greater prebiopsy overall (P < .001) and wait-time (P < .001) satisfaction. Compared with White women, Black women reported lower postbiopsy anxiety (P < .001) but also lower prebiopsy satisfaction (P = .03) and wait-time satisfaction (P < .001).
    Conclusions: Same-day versus later-day biopsies resulted in better prebiopsy overall breast-care and wait-time patient satisfaction scores; however, no satisfaction differences were noted after biopsy. Clinically significant anxiety was associated with both same- and later-day biopsies but was higher for same-day biopsies. Higher anxiety levels correlated with lower overall satisfaction, suggesting that interventions to reduce anxiety and improve communication could improve patient experiences during same-day biopsies.
    MeSH term(s) Humans ; Female ; Patient Satisfaction ; Breast ; Anxiety/epidemiology ; Anxiety Disorders ; Biopsy/adverse effects
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2023.07.028
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    Zs.A 6636: Show issues Location:
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  7. Article ; Online: Determination of the Duplicated CYP2D6 Allele Using Real-Time PCR Signal

    Mazen A. Atiq / Sandra E. Peterson / Loralie J. Langman / Linnea M. Baudhuin / John L. Black / Ann M. Moyer

    Journal of Personalized Medicine, Vol 13, Iss 883, p

    An Alternative Approach

    2023  Volume 883

    Abstract: CYP2D6 duplication has important pharmacogenomic implications. Reflex testing with long-range PCR (LR-PCR) can resolve the genotype when a duplication and alleles with differing activity scores are detected. We evaluated whether visual inspection of ... ...

    Abstract CYP2D6 duplication has important pharmacogenomic implications. Reflex testing with long-range PCR (LR-PCR) can resolve the genotype when a duplication and alleles with differing activity scores are detected. We evaluated whether visual inspection of plots from real-time-PCR-based targeted genotyping with copy number variation (CNV) detection could reliably determine the duplicated CYP2D6 allele. Six reviewers evaluated QuantStudio OpenArray CYP2D6 genotyping results and the TaqMan Genotyper plots for seventy-three well-characterized cases with three copies of CYP2D6 and two different alleles. Reviewers blinded to the final genotype visually assessed the plots to determine the duplicated allele or opt for reflex sequencing. Reviewers achieved 100% accuracy for cases with three CYP2D6 copies that they opted to report. Reviewers did not request reflex sequencing in 49–67 (67–92%) cases (and correctly identified the duplicated allele in each case); all remaining cases (6–24) were marked by at least one reviewer for reflex sequencing. In most cases with three copies of CYP2D6 , the duplicated allele can be determined using a combination of targeted genotyping using real-time PCR with CNV detection without need for reflex sequencing. In ambiguous cases and those with >3 copies, LR-PCR and Sanger sequencing may still be necessary for determination of the duplicated allele.
    Keywords CYP2D6 ; real-time PCR ; Sanger sequencing ; pharmacogenomics ; duplications ; copy number variation ; Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Conference proceedings: A review of the developments in H2-receptor antagonist therapy: focus on famotidine

    Langman, M. J.

    proceedings of an official satellite symposium to the 8th Asian-Pacific Congress of Gastroenterology ... in Seoul, Korea, 10 October 1988

    (The journal of international medical research ; 17, Suppl. 1)

    1989  

    Event/congress Asian Pacific Congress of Gastroenterology (8, 1988, Sǒul)
    Author's details meeting chairman M. J. S. Langman
    Series title The journal of international medical research ; 17, Suppl. 1
    Collection
    Keywords Thiazoles / congresses ; Histamine H2 Antagonists / congresses ; Antiulcer Agents / congresses
    Size 53A S. : Ill., graph. Darst.
    Publisher Cambridge Medical Publ
    Publishing place Northampton
    Publishing country Japan
    Document type Book ; Conference proceedings
    HBZ-ID HT003472850
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 925 -17,Suppl.1- verfügbar in Königswinter Königswinter

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  9. Article ; Online: The psychological journey of weight gain in psychosis.

    Waite, Felicity / Langman, Amy / Mulhall, Sophie / Glogowska, Margaret / Hartmann-Boyce, Jamie / Aveyard, Paul / Lennox, Belinda / Kabir, Thomas / Freeman, Daniel

    Psychology and psychotherapy

    2022  Volume 95, Issue 2, Page(s) 525–540

    Abstract: Background: Rapid weight gain is common with antipsychotic medication. Lost confidence, low mood and medication non-adherence often follow. Yet, the dynamic interactions between the physical and psychological consequences of weight gain, and ... ...

    Abstract Background: Rapid weight gain is common with antipsychotic medication. Lost confidence, low mood and medication non-adherence often follow. Yet, the dynamic interactions between the physical and psychological consequences of weight gain, and implications for intervention, are unknown.
    Objectives: We examined first-person accounts of weight gain to identify preferences for weight change interventions.
    Design: A qualitative design was used to explore patients' experiences of weight change in the context of psychosis.
    Method: Semi-structured interviews, analysed using grounded theory, were conducted with 10 patients with psychosis. Sample validation was conducted with peer researchers with lived experience of psychosis.
    Results: Patients described that initially the extent and speed of weight gain was overshadowed by psychotic experiences and their treatment. This led to a shocking realisation of weight gain. The psychological impact of weight gain, most strikingly on the self-concept, was profound. Loss of self-worth and changed appearance amplified a sense of vulnerability. There were further consequences on mood, activity and psychotic experiences, such as voices commenting on appearance, that were additional obstacles in the challenging process of weight loss. Sedative effects of medication also contributed. Unsuccessful weight loss left little hope and few preferences for interventions. Early information about common weight gain trajectories and working with experts-by-experience were valued. Rebuilding self-confidence, efficacy and worth may be a necessary first step.
    Conclusions: The journey of weight gain in patients with psychosis is characterised by loss of self-worth, agency and hope. There are multiple stages in the journey, each with different psychological reactions, that may need different treatment responses.
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Humans ; Psychotic Disorders/therapy ; Self Concept ; Weight Gain ; Weight Loss
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2063873-5
    ISSN 2044-8341 ; 1476-0835
    ISSN (online) 2044-8341
    ISSN 1476-0835
    DOI 10.1111/papt.12386
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  10. Article: Mass Spectrometry Applications for Toxicology.

    Mbughuni, Michael M / Jannetto, Paul J / Langman, Loralie J

    EJIFCC

    2016  Volume 27, Issue 4, Page(s) 272–287

    Abstract: Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation ... ...

    Abstract Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both. To date, MS applications have permeated all fields of toxicology which include; environmental, clinical, and forensic toxicology. While many different analytical applications are used in these fields, MS and its hyphenated applications such as; gas chromatography MS (GC-MS), liquid chromatography MS (LC-MS), inductively coupled plasma ionization MS (ICP-MS), tandem mass spectrometry (MS/MS and MS
    Language English
    Publishing date 2016-12-01
    Publishing country Italy
    Document type Journal Article
    ISSN 1650-3414
    ISSN 1650-3414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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