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Article ; Online: Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane.

Chen, Xi / Yang, Jia-Bin / Cao, Hui-Hui / Fang, Xiao-Chuan / Liu, Shan-Hong / Zou, Li-Fang / Yu, Jian-Hai / Zuo, Jian-Ping / Zhao, Wei / Lu, Zi-Bin / Liu, Jun-Shan / Yu, Lin-Zhong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 119, Page(s) 154977

Abstract: ... therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently ...

Abstract	Background: Dengue virus (DENV) is a major public health threat. However, there are no specific therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently used in the virus-induced diseases. The antiviral effect of LGS has not been reported yet. Purpose: In this study, the effect of LGS on the inhibition of dengue virus serotype 2 (DENV-2) was investigated and the relevant mechanism was explored. Methods: High-performance liquid chromatography was applied to analyze the chemical characterization of LGS. The in vitro antiviral activities of LGS against DENV-2 were evaluated by time-of-drug-addition assay. The binding of heat shock protein 70 (Hsp70) and envelope (E) protein or caveolin1 (Cav1) were analyzed by immunofluorescence and immunoprecipitation assays. Then the role of Cav1 in the anti-DENV-2 effects of LGS was further examined. DENV-2 infected Institute of Cancer Research suckling mice (n = 10) and AG129 mice (n = 8) were used to examine the protective effects of LGS. Results: It was found that geniposide, liquiritin, forsythenside A, forsythin, baicalin, baicalein, rhein, and emodin maybe the characteristic components of LGS. LGS inhibited the early stage of DENV-2 infection, decreased the expression levels of viral E and non-structural protein 1 (NS1) proteins. LGS also reduced E protein and Hsp70 binding and attenuated the translocation of Hsp70 from cytoplasm to the cell membrane. Moreover, LGS decreased the binding of Hsp70 to Cav1. Further study showed that the overexpression of Cav1 reversed LGS-mediated E protein and Hsp70 inhibition in the plasma membrane. In the in vivo study, LGS was highly effective in prolonging the survival time, reducing viral loads. Conclusion: This work demonstrates for the first time that LGS exerts anti-DENV-2 activity in vitro and in vivo. LGS decreases DENV-2-stimulated cytoplasmic Hsp70 translocation into the plasma membrane by Cav1 inhibition, thereby inhibiting the early stage of virus infection. These findings indicate that LGS may be a candidate for the treatment of DENV.
MeSH term(s)	Animals ; Mice ; Dengue Virus ; Dengue/drug therapy ; HSP70 Heat-Shock Proteins ; Serogroup ; Cell Membrane ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cytoplasm/metabolism
Chemical Substances	HSP70 Heat-Shock Proteins ; Antiviral Agents
Language	English
Publishing date	2023-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154977
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Article ; Online: Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing Caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane

Chen, Xi / Yang, Jia-bin / Cao, Hui-hui / Fang, Xiao-chuan / Liu, Shan-hong / Zou, Li-fang / Yu, Jian-hai / Zuo, Jian-ping / Zhao, Wei / Lu, Zi-bin / Liu, Jun-shan / Yu, Lin-zhong

Phytomedicine. 2023 July 18, p.154977-

2023 , Page(s) 154977–

Abstract: ... therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently ...

Abstract	Dengue virus (DENV) is a major public health threat. However, there are no specific therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently used in the virus-induced diseases. The antiviral effect of LGS has not been reported yet. In this study, the effect of LGS on the inhibition of dengue virus serotype 2 (DENV-2) was investigated and the relevant mechanism was explored. High-performance liquid chromatography was applied to analyze the chemical characterization of LGS. The in vitro antiviral activities of LGS against DENV-2 were evaluated by time-of-drug-addition assay. The binding of heat shock protein 70 (Hsp70) and envelope (E) protein or caveolin1 (Cav1) were analyzed by immunofluorescence and immunoprecipitation assays. Then the role of Cav1 in the anti-DENV-2 effects of LGS was further examined. DENV-2 infected Institute of Cancer Research suckling mice (n=10) and AG129 mice (n=8) were used to examine the protective effects of LGS. It was found that geniposide, liquiritin, forsythenside A, forsythin, baicalin, baicalein, rhein, and emodin maybe the characteristic components of LGS. LGS inhibited the early stage of DENV-2 infection, decreased the expression levels of viral E and non-structural protein 1 (NS1) proteins. LGS also reduced E protein and Hsp70 binding and attenuated the translocation of Hsp70 from cytoplasm to the cell membrane. Moreover, LGS decreased the binding of Hsp70 to Cav1. Further study showed that the overexpression of Cav1 reversed LGS-mediated E protein and Hsp70 inhibition in the plasma membrane. In the in vivo study, LGS was highly effective in prolonging the survival time, reducing viral loads. This work demonstrates for the first time that LGS exerts anti-DENV-2 activity in vitro and in vivo. LGS decreases DENV-2-stimulated cytoplasmic Hsp70 translocation into the plasma membrane by Cav1 inhibition, thereby inhibiting the early stage of virus infection. These findings indicate that LGS may be a candidate for the treatment of DENV.
Keywords	Dengue virus ; antiviral properties ; baicalin ; cytoplasm ; emodin ; fluorescent antibody technique ; heat-shock protein 70 ; high performance liquid chromatography ; plasma membrane ; precipitin tests ; public health ; therapeutics ; viral nonstructural proteins ; viruses ; Liang-Ge-San ; Dengue virus serotype 2 ; Heat shock protein 70 ; Caveolin1 ; Envelope protein ; :ALT ; Cav1 ; CCK8 ; CPE ; DENV ; DENV-2 ; DHF ; DSS ; DAPI ; dpi ; E ; ECL ; FBS ; Hsp70 ; HPLC ; ICR ; LGS ; MTT ; MβCD ; NS1 ; PBS ; PFU ; PFA ; PVDF ; PLT ; Q-PCR ; WTO
Language	English
Dates of publication	2023-0718
Publishing place	Elsevier GmbH
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154977
Database	NAL-Catalogue (AGRICOLA)

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Article: Comment on “Masking and unmasking fishing down effects: The Bohai Sea (China) as a case study” (https://doi.org/10.1016/j.ocecoaman.2019.105033) by Cui Liang and Daniel Pauly

Guan, Lisha / Shan, Xiujuan / Jin, Xianshi

Ocean & coastal management. 2020 Oct. 01, v. 196

2020

Abstract: ... Liang and Pauly 2020) concluded that the mean trophic level of fishable biomass (MTL_b) declined more ... a long time series like decades of years. Additionally, we illustrate that Liang and Pauly attributing ...

Abstract	The article “Masking and unmasking fishing down effects: The Bohai Sea (China) as a case study” (Liang and Pauly 2020) concluded that the mean trophic level of fishable biomass (MTL_b) declined more rapidly than the mean trophic level of catches (MTL_c) in the Bohai Sea since the 1950s. We have no doubt on the occurrence of a fishing down phenomenon or trophic cascades in the Bohai Sea, but argue that their comparative conclusion above is an artifact based on a flawed analysis of the relative biomass and catch data. First, they claimed a sharp decline in estimated MTL_b in the Bohai Sea based on bottom trawl survey data in only five years (i.e., 1959, 1982, 1992, 1998 and 2010) over half a century (1959–2010). We propose that changes in fishing vessels and gear types in those surveys after 1959 could make the estimated MTL_b in 1959 not comparable to those in the other years later. We also demonstrate that the declines in MTL_b from 1992 to 1998 and then to 2010 mainly resulted from the abrupt blooms of C. punctatus (a species with the lowest trophic level at 2.4 among all common or dominant fish and invertebrate species in the ecosystem) in 1998 and 2010. These two occasional declines based on three data points should be explained by large interannual variability in C. punctatus population dynamics, instead of trophic cascades or a fishing down effect which are ecological processes at system scale that usually only become apparent over a long time series like decades of years. Additionally, we illustrate that Liang and Pauly attributing the artifact of a much steeper decline in MTL_b than that in MTL_c to a masking effect for fishing down is unsupported by the data and literatures. Furthermore, we explain in details for our concerns on the accuracy of estimated marine fisheries catches data by taxa/species from China Fishery Statistical Yearbooks for any specific fishing area like the Bohai Sea, and suggest such data should be used with caution in future studies.
Keywords	biomass ; case studies ; coastal zone management ; ecosystems ; fish ; fishing boats ; invertebrates ; marine fisheries ; population dynamics ; surveys ; time series analysis ; trophic levels ; China ; Yellow Sea
Language	English
Dates of publication	2020-1001
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0964-5691
DOI	10.1016/j.ocecoaman.2020.105282
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Article ; Online: Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway.

Liu, Jun-Shan / Wei, Xi-Duan / Lu, Zi-Bin / Xie, Pei / Zhou, Hong-Ling / Chen, Yu-Yao / Ma, Jia-Mei / Yu, Lin-Zhong

Oncotarget

2016 Volume 7, Issue 16, Page(s) 21222–21234

Abstract: Liang-Ge-San (LGS) is a classic formula in traditional Chinese medicine, which is widely used ...

Abstract	Liang-Ge-San (LGS) is a classic formula in traditional Chinese medicine, which is widely used to treat acute lung injury (ALI), pharyngitis and amygdalitis in clinic. However, the underlying mechanisms remain poorly defined. In this study, we discovered that LGS exerted potent anti-inflammatory effects in lipopolysaccharide (LPS)-induced inflammation. We found that LGS significantly depressed the production of IL-6 and TNF-α in LPS-stimulated RAW 264.7 macrophage cells. The degradation and phosphorylation of IκBα and the nuclear translocation of NF-κB p65 were also inhibited. Moreover, LGS activated α7 nicotinic cholinergic receptor (α7nAchR). The blockage of α7nAchR by selective inhibitor methyllycaconitine (MLA) or α7nAchR siRNA attenuated the inhibitory effects of LGS on IκBα, NF-κB p65, IL-6 and TNF-α. Critically, LGS significantly inhibited inflammation in LPS-induced ALI rats through the activation of NF-κB signaling pathway. However, these protective effects could be counteracted by the treatment of MLA. Taken together, we first demonstrated anti-inflammatory effects of LGS both in vitro and in vivo through cholinergic anti-inflammatory pathway. The study provides a rationale for the clinical application of LGS as an anti-inflammatory agent and supports the critical role of cholinergic anti-inflammatory pathway in inflammation.
Language	English
Publishing date	2016-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.8452
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Article ; Online: Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis.

Chen, Da-Peng / Wong, Chun-Kwok / Leung, Ping-Chung / Fung, Kwok-Pui / Lau, Clara Bik-San / Lau, Ching-Po / Li, Edmund Kwok-Ming / Tam, Lai-Shan / Lam, Christopher Wai-Kei

Journal of ethnopharmacology

2011 Volume 137, Issue 1, Page(s) 457–468

Abstract: ... used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs ...

Abstract	Aim of the study: Sinomenine, an alkaloid isolated from the root of Sinomenium acutum, has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs Rhizoma Atractylodis (Cangzhu) and Cotex Phellodendri (Huangbai), is another traditional Chinese medicine formula for rheumatoid arthritis (RA) treatment. Although numerous studies have demonstrated the potential anti-inflammatory activities of sinomenine and LMS, the underlying intracellular mechanisms regulating the anti-inflammatory activities of sinomenine and LMS on human primary fibroblast-like synoviocytes (FLS) from RA patients and normal control subjects have not been elucidated. Materials and methods: We investigated the in vitro anti-inflammatory activity of sinomenine and LMS on inflammatory cytokine tumor necrosis factor (TNF)-α-mediated activation of human normal and RA-FLS. The underlying intracellular signaling molecules were analyzed quantitatively using flow cytometry. Results: Sinomenine was found to significantly inhibit TNF-α induced cell surface expression of vascular cell adhesion molecule (VCAM)-1 and release of inflammatory cytokine and chemokine IL-6, CCL2 and CXCL8 from both normal and RA-FLS (all p<0.05). Moreover, the suppression of sinomenine on TNF-α induced VCAM-1 expression and IL-6 release of RA-FLS was significantly higher than that of normal FLS (p<0.05). LMS significantly inhibited TNF-α-induced inflammatory chemokines CXCL10 and CCL5 release from both normal and RA-FLS, with significantly higher suppression on CXCL10 secretion in RA-FLS than that of normal FLS (all p<0.05). Further investigations showed that sinomenine and LMS could significantly suppress TNF-α-induced phosphorylation of inhibitor κBα and extracellular signal-regulated protein kinase, the central signaling molecules mediating TNF-α-induced VCAM-1 expression and chemokine production. Conclusion: Our results therefore provide a new insight into the differential anti-inflammatory activities of sinomenine and LMS through the suppression of TNF-α-activated FLS by modulating distinct intracellular signaling pathways in RA.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/toxicity ; Antirheumatic Agents/pharmacology ; Antirheumatic Agents/toxicity ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Case-Control Studies ; Cells, Cultured ; Chemokine CCL2/metabolism ; Chemokine CCL5/metabolism ; Chemokine CXCL10/metabolism ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibroblasts/drug effects ; Fibroblasts/immunology ; Flow Cytometry ; Humans ; I-kappa B Proteins/metabolism ; Inflammation Mediators/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Medicine, Chinese Traditional ; Morphinans/pharmacology ; NF-KappaB Inhibitor alpha ; NF-kappa B/metabolism ; Phosphorylation ; Signal Transduction/drug effects ; Synovial Membrane/drug effects ; Synovial Membrane/immunology ; Tumor Necrosis Factor-alpha/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Antirheumatic Agents ; CCL2 protein, human ; CCL5 protein, human ; CXCL10 protein, human ; CXCL8 protein, human ; Chemokine CCL2 ; Chemokine CCL5 ; Chemokine CXCL10 ; Drugs, Chinese Herbal ; I-kappa B Proteins ; IL6 protein, human ; Inflammation Mediators ; Interleukin-6 ; Interleukin-8 ; Morphinans ; NF-kappa B ; NFKBIA protein, human ; Tumor Necrosis Factor-alpha ; Vascular Cell Adhesion Molecule-1 ; liang miao san ; NF-KappaB Inhibitor alpha (139874-52-5) ; sinomenine (63LT81K70N) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2011-06-06
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2011.05.048
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Article: Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis

Chen, Da-Peng / Wong, Chun-Kwok / Leung, Ping-Chung / Fung, Kwok-Pui / Lau, Clara Bik-San / Lau, Ching-Po / Li, Edmund Kwok-Ming / Tam, Lai-Shan / Lam, Christopher Wai-Kei

Journal of ethnopharmacology. 2011 Sept. 1, v. 137, no. 1

2011

Abstract: ... used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs ...

Abstract	AIM OF THE STUDY: Sinomenine, an alkaloid isolated from the root of Sinomenium acutum, has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs Rhizoma Atractylodis (Cangzhu) and Cotex Phellodendri (Huangbai), is another traditional Chinese medicine formula for rheumatoid arthritis (RA) treatment. Although numerous studies have demonstrated the potential anti-inflammatory activities of sinomenine and LMS, the underlying intracellular mechanisms regulating the anti-inflammatory activities of sinomenine and LMS on human primary fibroblast-like synoviocytes (FLS) from RA patients and normal control subjects have not been elucidated. MATERIALS AND METHODS: We investigated the in vitro anti-inflammatory activity of sinomenine and LMS on inflammatory cytokine tumor necrosis factor (TNF)-α-mediated activation of human normal and RA-FLS. The underlying intracellular signaling molecules were analyzed quantitatively using flow cytometry. RESULTS: Sinomenine was found to significantly inhibit TNF-α induced cell surface expression of vascular cell adhesion molecule (VCAM)-1 and release of inflammatory cytokine and chemokine IL-6, CCL2 and CXCL8 from both normal and RA-FLS (all p<0.05). Moreover, the suppression of sinomenine on TNF-α induced VCAM-1 expression and IL-6 release of RA-FLS was significantly higher than that of normal FLS (p<0.05). LMS significantly inhibited TNF-α-induced inflammatory chemokines CXCL10 and CCL5 release from both normal and RA-FLS, with significantly higher suppression on CXCL10 secretion in RA-FLS than that of normal FLS (all p<0.05). Further investigations showed that sinomenine and LMS could significantly suppress TNF-α-induced phosphorylation of inhibitor κBα and extracellular signal-regulated protein kinase, the central signaling molecules mediating TNF-α-induced VCAM-1 expression and chemokine production. CONCLUSION: Our results therefore provide a new insight into the differential anti-inflammatory activities of sinomenine and LMS through the suppression of TNF-α-activated FLS by modulating distinct intracellular signaling pathways in RA.
Keywords	alkaloids ; anti-inflammatory activity ; cell adhesion ; chemokines ; flow cytometry ; herbal medicines ; herbs ; humans ; mitogen-activated protein kinase ; patients ; phosphorylation ; quantitative analysis ; rheumatoid arthritis ; roots ; secretion ; traditional medicine ; tumor necrosis factors
Language	English
Dates of publication	2011-0901
Size	p. 457-468.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2011.05.048
Database	NAL-Catalogue (AGRICOLA)

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Book: Tso wu liang chung fan yü

Chi, Chia-lu / Yu, Chan-shan / Li, Fu-mei

1984

Title translation	Breeding of fine field crops.
Institution	Chi-lin sheng nung yeh hsüeh hsiao
Author's details	Chi-lin sheng nung yeh hsüeh hsiao pien ; [pien hsieh Chi Chia-lu, Yu Chan-shan, Li Fu-mei]
Keywords	Field crops/Genetics. ; Field crops/Breeding.
Language	Chinese
Size	2, 4, 232 p. :, ill. ;, 19 cm.
Edition	Chu chi pen, Ti 1 pen.
Publisher	Nung yeh ch'u pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
Publishing place	Pei-ching
Document type	Book
Note	"Ch'üan kuo t'ung pien nung min chih yeh chi shu chiao yü chiao ts'ai."
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Article: Spatiotemporal differences and influencing factors of urban vitality and urban expansion coupling coordination in the Pearl River Delta.

Liao, Zhenjie / Liang, Shan

Heliyon

2024 Volume 10, Issue 4, Page(s) e25682

Abstract: In the contemporary state of accelerated urbanization in China, urban expansion has become the mainstream trend of urban development. However, in the context of urban expansion, whether coordinated development between urban expansion and urban vitality ... ...

Abstract	In the contemporary state of accelerated urbanization in China, urban expansion has become the mainstream trend of urban development. However, in the context of urban expansion, whether coordinated development between urban expansion and urban vitality is achieved is an important concern facing the current urban expansion process. The Pearl River Delta (PRD) urban agglomeration is a hotspot of rapid economic development in China, and it is essential to examine the coupling relationship between the region's urban dynamics and urban expansion to promote rational urban development. This study analyzes the dynamics and evolutionary characteristics of urban expansion based on multisource nighttime light data, employing an UERI and other methods. We apply the entropy method and coupling coordination model to evaluate urban vitality and conduct a coupling analysis of urban expansion and urban vitality from 1992 to 2021. The results show that during the study period, the urban built-up area of the PRD urban agglomeration increased by 61,131.59 km
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25682
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Article: Construction and evolutionary factors of spatial correlation network of China's provincial tourism resource conversion efficiency.

Liao, Zhenjie / Liang, Shan

Heliyon

2024 Volume 10, Issue 8, Page(s) e28740

Abstract: Research objective: To explore the spatial correlation network characteristics and formation mechanisms of tourism resource conversion efficiency, and provide reference for the collaborative improvement of tourism resource conversion efficiency at the ... ...

Abstract	Research objective: To explore the spatial correlation network characteristics and formation mechanisms of tourism resource conversion efficiency, and provide reference for the collaborative improvement of tourism resource conversion efficiency at the provincial level in China. Research methods: Non parametric SBM efficiency measurement method and social network analysis method. Research hypothesis: The spatial network correlation characteristics of tourism resource conversion efficiency are obvious, and regional connections are close. Research findings: (i) during the research period, the spatial connection strength of China's tourism resource conversion efficiency continued to increase and the spatial network structure of tourism resource conversion efficiency tended to become more complex and significantly more stable. (ii) A spatially linked network with a stable tourism resource conversion efficiency structure formed in China. The number of network relations and density of the network fluctuated and increased, while the network efficiency continued to decrease; however, a strong small-world nature was observed. (iii) The economic development level difference matrix, tourism industry agglomeration difference matrix, human capital difference matrix, and marketization degree difference matrix significantly and positively affected spatial association relationship establishment, while the provincial adjacency matrix significantly and negatively affected such relationships.
Language	English
Publishing date	2024-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28740
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Article ; Online: Mesenchymal Stem Cell-Derived Extracellular Vesicles in Cancer Therapy Resistance: from Biology to Clinical Opportunity.

Shan, Chan / Liang, Yan / Wang, Kun / Li, Peifeng

International journal of biological sciences

2024 Volume 20, Issue 1, Page(s) 347–366

Abstract: Mesenchymal stem cells (MSCs) are a type of stromal cells characterized by their properties of self-renewal and multi-lineage differentiation, which make them prominent in regenerative medicine. MSCs have shown significant potential for the treatment of ... ...

Abstract	Mesenchymal stem cells (MSCs) are a type of stromal cells characterized by their properties of self-renewal and multi-lineage differentiation, which make them prominent in regenerative medicine. MSCs have shown significant potential for the treatment of various diseases, primarily through the paracrine effects mediated by soluble factors, specifically extracellular vesicles (EVs). MSC-EVs play a crucial role in intercellular communication by transferring various bioactive substances, including proteins, RNA, DNA, and lipids, highlighting the contribution of MSC-EVs in regulating cancer development and progression. Remarkably, increasing evidence indicates the association between MSC-EVs and resistance to various types of cancer treatments, including radiotherapy, chemotherapy, targeted therapy, immunotherapy, and endocrinotherapy. In this review, we provide an overview of the recent advancements in the biogenesis, isolation, and characterization of MSC-EVs, with an emphasis on their functions in cancer therapy resistance. The clinical applications and future prospects of MSC-EVs for mitigating cancer therapy resistance and enhancing drug delivery are also discussed. Elucidating the role and mechanism of MSC-EVs in the development of treatment resistance in cancer, as well as evaluating the clinical significance of MSC-EVs, is crucial for advancing our understanding of tumor biology. Meanwhile, inform the development of effective treatment strategies for cancer patients in the future.
MeSH term(s)	Humans ; Extracellular Vesicles/metabolism ; Cell Differentiation/physiology ; Regenerative Medicine ; Mesenchymal Stem Cells/metabolism ; Biology ; Neoplasms/therapy ; Neoplasms/metabolism
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.88500
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