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  1. Article ; Online: Innovation Lessons From the COVID-19 Pandemic.

    Farrugia, Gianrico / Plutowski, Roshelle W

    Mayo Clinic proceedings

    2020  Volume 95, Issue 8, Page(s) 1574–1577

    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Global Health ; Humans ; Intersectoral Collaboration ; Pandemics/economics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Telemedicine/methods ; Telemedicine/organization & administration ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-06-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.05.024
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  2. Article ; Online: Histologic changes in diabetic gastroparesis.

    Farrugia, Gianrico

    Gastroenterology clinics of North America

    2015  Volume 44, Issue 1, Page(s) 31–38

    Abstract: The cellular abnormalities that lead to diabetic gastroparesis are increasingly being understood. Several key cell types are affected by diabetes, leading to gastroparesis. These changes include abnormalities in the extrinsic innervation to the stomach, ... ...

    Abstract The cellular abnormalities that lead to diabetic gastroparesis are increasingly being understood. Several key cell types are affected by diabetes, leading to gastroparesis. These changes include abnormalities in the extrinsic innervation to the stomach, loss of key neurotransmitters at the level of the enteric nervous system, smooth muscle abnormalities, loss of interstitial cells of Cajal, and changes in the macrophage population resident in the muscle wall. This article reviews the current understanding with a focus on data from human studies when available.
    MeSH term(s) Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/pathology ; Diabetes Mellitus, Type 1/physiopathology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/pathology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Neuropathies/complications ; Diabetic Neuropathies/pathology ; Diabetic Neuropathies/physiopathology ; Gastric Emptying/physiology ; Gastroparesis/etiology ; Gastroparesis/pathology ; Gastroparesis/physiopathology ; Humans ; Interstitial Cells of Cajal/pathology ; Macrophages/pathology ; Muscle, Smooth/pathology ; Muscle, Smooth/physiopathology ; Stomach/innervation ; Stomach/pathology ; Stomach/physiopathology
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 92114-2
    ISSN 1558-1942 ; 0889-8553
    ISSN (online) 1558-1942
    ISSN 0889-8553
    DOI 10.1016/j.gtc.2014.11.004
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  3. Article ; Online: Stretch response of the mechano-gated channel TMEM63A in membrane patches and single cells.

    Niloy, Sayeman Islam / Strege, Peter R / Hannan, Elizabeth C / Cowan, Luke M / Linsenmeier, Fabian / Friedrich, Oliver / Farrugia, Gianrico / Beyder, Arthur

    American journal of physiology. Cell physiology

    2024  Volume 326, Issue 2, Page(s) C622–C631

    Abstract: The recently discovered ion channel TMEM63A has biophysical features distinctive for mechano-gated cation channels, activating at high pressures with slow kinetics while not inactivating. However, some biophysical properties are less clear, including no ... ...

    Abstract The recently discovered ion channel TMEM63A has biophysical features distinctive for mechano-gated cation channels, activating at high pressures with slow kinetics while not inactivating. However, some biophysical properties are less clear, including no information on its function in whole cells. The aim of this study is to expand the TMEM63A biophysical characterization and examine the function in whole cells. Piezo1-knockout HEK293T cells were cotransfected with human TMEM63A and green fluorescent protein (GFP), and macroscopic currents in cell-attached patches were recorded by high-speed pressure clamp at holding voltages from -120 to -20 mV with 0-100 mmHg patch suction for 1 s. HEK293 cells cotransfected with TMEM63A and GCaMP5 were seeded onto polydimethylsiloxane (PDMS) membrane, and the response to 3-12 s of 1%-15% whole cell isotropic (equi-biaxial) stretch induced by an IsoStretcher was measured by the change in intracellular calcium ([Ca
    MeSH term(s) Humans ; Cations/metabolism ; Cell Membrane/metabolism ; HEK293 Cells ; Ion Channels/metabolism ; Kinetics ; Membrane Potentials/physiology
    Chemical Substances Cations ; Ion Channels ; TMEM63A protein, human
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00583.2023
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  5. Article ; Online: Innovation Lessons From the COVID-19 Pandemic

    Farrugia, Gianrico / Plutowski, Roshelle W.

    Mayo Clinic Proceedings

    2020  Volume 95, Issue 8, Page(s) 1574–1577

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.05.024
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Capsaicin as an amphipathic modulator of Na

    Cowan, Luke M / Strege, Peter R / Rusinova, Radda / Andersen, Olaf S / Farrugia, Gianrico / Beyder, Arthur

    Channels (Austin, Tex.)

    2022  Volume 16, Issue 1, Page(s) 9–26

    Abstract: ... ...

    Abstract SCN5A
    MeSH term(s) Capsaicin/pharmacology ; Channelopathies ; Humans ; Myocytes, Cardiac/metabolism ; NAV1.5 Voltage-Gated Sodium Channel ; Sodium/metabolism
    Chemical Substances NAV1.5 Voltage-Gated Sodium Channel ; Sodium (9NEZ333N27) ; Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2262854-X
    ISSN 1933-6969 ; 1933-6969
    ISSN (online) 1933-6969
    ISSN 1933-6969
    DOI 10.1080/19336950.2022.2026015
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  7. Article ; Online: Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel.

    Strege, Peter R / Cowan, Luke M / Alcaino, Constanza / Mazzone, Amelia / Ahern, Christopher A / Milescu, Lorin S / Farrugia, Gianrico / Beyder, Arthur

    eLife

    2023  Volume 12

    Abstract: Voltage-gated ion channels (VGICs) orchestrate electrical activities that drive mechanical functions in contractile tissues such as the heart and gut. In turn, contractions change membrane tension and impact ion channels. VGICs are mechanosensitive, but ... ...

    Abstract Voltage-gated ion channels (VGICs) orchestrate electrical activities that drive mechanical functions in contractile tissues such as the heart and gut. In turn, contractions change membrane tension and impact ion channels. VGICs are mechanosensitive, but the mechanisms of mechanosensitivity remain poorly understood. Here, we leverage the relative simplicity of NaChBac, a prokaryotic voltage-gated sodium channel from
    MeSH term(s) Humans ; Ion Channel Gating/physiology ; HEK293 Cells ; Voltage-Gated Sodium Channels ; Mutagenesis
    Chemical Substances Voltage-Gated Sodium Channels
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.79271
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  8. Article ; Online: Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease.

    Mischopoulou, Magdalini / D'Ambrosio, Mario / Bigagli, Elisabetta / Luceri, Cristina / Farrugia, Gianrico / Cipriani, Gianluca

    Cellular and molecular gastroenterology and hepatology

    2022  Volume 13, Issue 6, Page(s) 1849–1862

    Abstract: The gut contains the largest macrophage pool in the body, with populations of macrophages residing in the mucosa and muscularis propria of the gastrointestinal (GI) tract. Muscularis macrophages (MMs), which are located within the muscularis propria, ... ...

    Abstract The gut contains the largest macrophage pool in the body, with populations of macrophages residing in the mucosa and muscularis propria of the gastrointestinal (GI) tract. Muscularis macrophages (MMs), which are located within the muscularis propria, interact with cells essential for GI function, such as interstitial cells of Cajal, enteric neurons, smooth muscle cells, enteric glia, and fibroblast-like cells, suggesting that these immune cells contribute to several aspects of GI function. This review focuses on the latest insights on the factors contributing to MM heterogeneity and the functional interaction of MMs with other cell types essential for GI function. This review integrates the latest findings on macrophages in other organs with increasing knowledge of MMs to better understand their role in a healthy and diseased gut. We describe the factors that contribute to (muscularis macrophage) MM heterogeneity, and the nature of MM interactions with cells regulating GI function. Finally, we also describe the increasing evidence suggesting a critical role of another immune cell type, the mast cell, in normal and diseased GI physiology.
    MeSH term(s) Gastrointestinal Tract/physiology ; Homeostasis ; Macrophages/metabolism ; Mast Cells ; Muscle, Smooth
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.02.017
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  9. Article ; Online: Preliminary study on the dynamic positron emission tomography imaging with

    Maalouf, Elisia / Khasawneh, Hala / Karbhari, Aashna / AlAsfoor, Shefaa / Breen-Lyles, Margaret / Bernard, Cheryl / Rajan, Elizabeth / Farrugia, Gianrico / Lowe, Val / Goenka, Ajit / Grover, Madhusudan

    Neurogastroenterology and motility

    2024  Volume 36, Issue 5, Page(s) e14762

    Abstract: Background: Animal models and human data have suggested macrophage-driven immune dysregulation in diabetic gastroparesis (DG). Translocator protein (TSPO) upregulation has been suggested to indicate activated state of macrophages and ER176 is a high ... ...

    Abstract Background: Animal models and human data have suggested macrophage-driven immune dysregulation in diabetic gastroparesis (DG). Translocator protein (TSPO) upregulation has been suggested to indicate activated state of macrophages and ER176 is a high affinity third generation TSPO-specific radioligand. The aim of this study was to determine feasibility of dynamic
    Methods: Twelve patients, all females, were recruited (4 DG, 4 diabetics, and 4 healthy volunteers) for
    Key results: Age was comparable among the three groups with a median of 53 years. The uptake was higher in pylorus in diabetics compared to DG and healthy (SUV
    Conclusions and inferences: Female diabetic gastroparesis patients did not demonstrate increased TSPO ligand
    MeSH term(s) Humans ; Female ; Gastroparesis/diagnostic imaging ; Middle Aged ; Adult ; Macrophage Activation ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Aged ; Carbon Radioisotopes ; Diabetes Complications/diagnostic imaging
    Chemical Substances Carbon Radioisotopes
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.14762
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  10. Article ; Online: Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels.

    Joshi, Vikram / Strege, Peter R / Farrugia, Gianrico / Beyder, Arthur

    American journal of physiology. Gastrointestinal and liver physiology

    2021  Volume 320, Issue 5, Page(s) G897–G906

    Abstract: Mechanosensation, the ability to properly sense mechanical stimuli and transduce them into physiologic responses, is an essential determinant of gastrointestinal (GI) function. Abnormalities in this process result in highly prevalent GI functional and ... ...

    Abstract Mechanosensation, the ability to properly sense mechanical stimuli and transduce them into physiologic responses, is an essential determinant of gastrointestinal (GI) function. Abnormalities in this process result in highly prevalent GI functional and motility disorders. In the GI tract, several cell types sense mechanical forces and transduce them into electrical signals, which elicit specific cellular responses. Some mechanosensitive cells like sensory neurons act as specialized mechanosensitive cells that detect forces and transduce signals into tissue-level physiological reactions. Nonspecialized mechanosensitive cells like smooth muscle cells (SMCs) adjust their function in response to forces. Mechanosensitive cells use various mechanoreceptors and mechanotransducers. Mechanoreceptors detect and convert force into electrical and biochemical signals, and mechanotransducers amplify and direct mechanoreceptor responses. Mechanoreceptors and mechanotransducers include ion channels, specialized cytoskeletal proteins, cell junction molecules, and G protein-coupled receptors. SMCs are particularly important due to their role as final effectors for motor function. Myogenic reflex-the ability of smooth muscle to contract in response to stretch rapidly-is a critical smooth muscle function. Such rapid mechanotransduction responses rely on mechano-gated and mechanosensitive ion channels, which alter their ion pores' opening in response to force, allowing fast electrical and Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Gastrointestinal Motility/physiology ; Humans ; Ion Channels/metabolism ; Mechanotransduction, Cellular/physiology ; Myocytes, Smooth Muscle/metabolism
    Chemical Substances Ion Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00481.2020
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