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Article ; Online: D

Yamada, Michio / Tanabe, Yukiko / Dang, Jing-Shuang / Sato, Satoru / Mizorogi, Naomi / Hachiya, Makoto / Suzuki, Mitsuaki / Abe, Tsuneyuki / Kurihara, Hiroki / Maeda, Yutaka / Zhao, Xiang / Lian, Yongfu / Nagase, Shigeru / Akasaka, Takeshi

Journal of the American Chemical Society

2016 Volume 138, Issue 50, Page(s) 16523–16532

Abstract: We compared the chemical reactivity of D ...

Abstract	We compared the chemical reactivity of D
Language	English
Publishing date	2016-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.6b10751
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Article ; Online: Interaction of Vitamin D Supplements and Marine

Fukuzato, Soichiro / Ohdaira, Hironori / Suzuki, Yutaka / Urashima, Mitsuyoshi

Nutrients

2024 Volume 16, Issue 7

Abstract: A meta-analysis suggested that ... ...

Abstract	A meta-analysis suggested that marine
MeSH term(s)	Humans ; Fatty Acids ; Dietary Supplements ; Vitamins ; Prognosis ; Vitamin D ; Docosahexaenoic Acids ; Eicosapentaenoic Acid ; Gastrointestinal Neoplasms ; Randomized Controlled Trials as Topic
Chemical Substances	Fatty Acids ; Vitamins ; Vitamin D (1406-16-2) ; Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA)
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16070921
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Article ; Online: Decision tree classification of cognitive functions with D

Kusudo, Keisuke / Ochi, Ryo / Nakajima, Shinichiro / Suzuki, Takefumi / Mamo, David / Caravaggio, Fernando / Mar, Wanna / Gerretsen, Philip / Mimura, Masaru / Pollock, Bruce G / Mulsant, Benoit H / Graff-Guerrero, Ariel / Rajji, Tarek K / Uchida, Hiroyuki

Schizophrenia research

2022 Volume 241, Page(s) 113–115

MeSH term(s)	Antipsychotic Agents/therapeutic use ; Cognition ; Decision Trees ; Humans ; Patient Acuity ; Positron-Emission Tomography ; Raclopride/therapeutic use ; Schizophrenia/complications ; Schizophrenia/drug therapy
Chemical Substances	Antipsychotic Agents ; Raclopride (430K3SOZ7G)
Language	English
Publishing date	2022-02-01
Publishing country	Netherlands
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2022.01.044
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Article ; Online: Antiproliferative effects of D-allose associated with reduced cell division frequency in glioblastoma.

Suzuki, Kenta / Ogawa, Daisuke / Kanda, Takahiro / Fujimori, Takeshi / Shibayama, Yuki / Rahman, Asadur / Ye, Juanjuan / Ohsaki, Hiroyuki / Akimitsu, Kazuya / Izumori, Ken / Tamiya, Takashi / Nishiyama, Akira / Miyake, Keisuke

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19515

Abstract: Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types ... of the head and neck. In this study, we examined the effects of D-allose on the proliferation of human ... glioblastoma (GBM) cell lines (i.e., U251MG and U87MG) in vitro and in vivo and the underlying mechanisms. D ...

Abstract	Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types of solid cancers, such as hepatocellular carcinoma, non-small-cell lung cancer, and squamous cell carcinoma of the head and neck. In this study, we examined the effects of D-allose on the proliferation of human glioblastoma (GBM) cell lines (i.e., U251MG and U87MG) in vitro and in vivo and the underlying mechanisms. D-allose treatment inhibited the proliferation of U251MG and U87MG cells in a dose-dependent manner (3-50 mM). However, D-allose treatment did not affect cell cycles or apoptosis in these cells but significantly decreased the cell division frequency in both GBM cell lines. In a subcutaneous U87MG cell xenograft model, intraperitoneal injection of D-allose (100 mg/kg/day) significantly reduced the tumor volume in 28 days. These data indicate that D-allose-induced reduction in cell proliferation is associated with a subsequent decrease in the number of cell divisions, independent of cell-cycle arrest and apoptosis. Thus, D-allose could be an attractive additive to therapeutic strategies for GBM.
MeSH term(s)	Humans ; Glioblastoma/drug therapy ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms ; Cell Proliferation ; Glucose/metabolism ; Cell Division ; Apoptosis ; Liver Neoplasms ; Cell Line, Tumor
Chemical Substances	allose (6038-51-3) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46796-4
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Article: Immunohistochemical localization of d-

Kitaya, Shiori / Ikeda, Ryoukichi / Suzuki, Jun / Oshima, Hidetoshi / Nomura, Yuri / Kusano, Yusuke / Ohta, Nobuo / Kawase, Tetsuaki / Ise, Kazue / Murakami, Kazuhiro / Nakamura, Yasuhiro / Sasano, Hironobu / Katori, Yukio

Laryngoscope investigative otolaryngology

2022 Volume 7, Issue 4, Page(s) 1155–1163

Abstract: ... of the keratinizing squamous epithelium of the temporal bone. d-: Study design: Case-control studies.: Material ... the perimatrix, matrix, and cystic contents. The patterns of immunoreactivity to d-: Results: Two patterns ... of immunoreactivity to d-: Conclusions: This study showed the expression levels of d-: Level of evidence: 4. ...

Abstract	Objective/hypothesis: Middle ear cholesteatoma is characterized by abnormal growth of the keratinizing squamous epithelium of the temporal bone. d- Study design: Case-control studies. Material and methods: Tissue samples were collected from 21 patients comprising 21 ears with congenital middle ear cholesteatoma and 26 patients comprising 29 ears with acquired type. Their clinical and histopathological features were investigated. We divided the middle ear cholesteatoma samples into three layers: the perimatrix, matrix, and cystic contents. The patterns of immunoreactivity to d- Results: Two patterns of immunoreactivity to d- Conclusions: This study showed the expression levels of d- Level of evidence: 4.
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.856
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Article ; Online: Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.

Hata, Kentaro / Tsubouchi, Kazuya / Suzuki, Kunihiro / Eto, Daisuke / Ando, Hiroyuki / Yanagihara, Toyoshi / Kan-O, Keiko / Okamoto, Isamu

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1799

Abstract: ... obstructive pulmonary disease (COPD), and exacerbates their underlying respiratory condition. Surfactant protein D (SP-D ... the inhibitory role of SP-D on mucin production in airway epithelial cells. We prepared air-liquid interface (ALI ... Then, the protective effects of SP-D against the BaP-induced mucin overproduction were examined. BaP increased MUC5AC ...

Abstract	Mucin overproduction is a common feature of chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), and exacerbates their underlying respiratory condition. Surfactant protein D (SP-D) protects against airway diseases through modulation of immune reactions, but whether it also exerts direct effects on airway epithelial cells has remained unclear. Therefore, we sought to investigate the inhibitory role of SP-D on mucin production in airway epithelial cells. We prepared air-liquid interface (ALI) cultures of human primary bronchial epithelial cells (HBECs), which recapitulated a well-differentiated human airway epithelium. Benzo(a)pyrene (BaP), a key toxicant in cigarette smoke, induced mucin 5AC (MUC5AC) production in ALI-cultured HBECs, airway secretory cell lines, and airway epithelia of mice. Then, the protective effects of SP-D against the BaP-induced mucin overproduction were examined. BaP increased MUC5AC production in ALI cultures of HBECs, and this effect was attenuated by SP-D. SP-D also suppressed the BaP-induced phosphorylation of extracellular signal-regulated kinase (ERK) and MUC5AC expression in NCI-H292 goblet-like cells, but not in NCI-H441 club-like cells. Signal regulatory protein α (SIRPα) was found to be expressed in HBECs and NCI-H292 cells but absent in NCI-H441 cells. In NCI-H292 cells, SP-D activated SH2 domain-containing tyrosine phosphatase-1 (SHP-1), downstream of SIRPα, and knockdown of SIRPα abolished the suppressive effects of SP-D on BaP-induced ERK phosphorylation and MUC5AC production. Consistent with these in vitro findings, intratracheal instillation of SP-D prevented the BaP-induced phosphorylation of ERK and Muc5ac expression in airway epithelial cells in a mouse model. SP-D acts directly on airway epithelial cells to inhibit mucin secretion through ligation of SIRPα and SHP-1-mediated dephosphorylation of ERK. Targeting of SIRPα is therefore a potential new therapeutic approach to suppression of mucin hypersecretion in chronic airway diseases such as COPD and asthma.
MeSH term(s)	Animals ; Humans ; Mice ; Asthma ; Epithelial Cells/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Goblet Cells/metabolism ; Mucin 5AC/genetics ; Mucins ; Pulmonary Disease, Chronic Obstructive ; Pulmonary Surfactant-Associated Protein D
Chemical Substances	Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Mucin 5AC ; Mucins ; Pulmonary Surfactant-Associated Protein D ; SIRPA protein, human ; Ptpns1 protein, mouse
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52328-5
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Article ; Online: Precise Measurement of the D^{0} and D^{+} Lifetimes at Belle II.

Abudinén, F / Adachi, I / Adamczyk, K / Aggarwal, L / Ahmed, H / Aihara, H / Akopov, N / Aloisio, A / Anh Ky, N / Asner, D M / Atmacan, H / Aushev, V / Babu, V / Bacher, S / Bae, H / Baehr, S / Bahinipati, S / Bambade, P / Banerjee, Sw /

Bansal, S / Barrett, M / Baudot, J / Bauer, M / Baur, A / Becker, J / Behera, P K / Bennett, J V / Bernieri, E / Bernlochner, F U / Bertemes, M / Bertholet, E / Bessner, M / Bettarini, S / Bhardwaj, V / Bianchi, F / Bilka, T / Bilokin, S / Biswas, D / Bobrov, A / Bodrov, D / Bolz, A / Bozek, A / Bračko, M / Branchini, P / Braun, N / Briere, R A / Browder, T E / Budano, A / Bussino, S / Campajola, M / Cao, L / Casarosa, G / Cecchi, C / Červenkov, D / Chang, M-C / Chang, P / Cheaib, R / Chekelian, V / Chen, C / Chen, Y-T / Cheon, B G / Chilikin, K / Chirapatpimol, K / Cho, H-E / Cho, K / Cho, S-J / Choi, S-K / Choudhury, S / Cinabro, D / Corona, L / Cremaldi, L M / Cunliffe, S / Czank, T / Dattola, F / De La Cruz-Burelo, E / de Marino, G / De Nardo, G / De Pietro, G / de Sangro, R / Destefanis, M / Dey, S / De Yta-Hernandez, A / Di Canto, A / Di Capua, F / Dingfelder, J / Doležal, Z / Domínguez Jiménez, I / Dong, T V / Dorigo, M / Dort, K / Dossett, D / Dubey, S / Duell, S / Dujany, G / Ecker, P / Epifanov, D / Ferber, T / Ferlewicz, D / Finocchiaro, G / Flood, K / Fodor, A / Forti, F / Fulsom, B G / Gabrielli, A / Gabyshev, N / Gaz, A / Gellrich, A / Giakoustidis, G / Giordano, R / Giri, A / Glazov, A / Gobbo, B / Godang, R / Goldenzweig, P / Golob, B / Gradl, W / Graziani, E / Greenwald, D / Gu, T / Guan, Y / Gudkova, K / Guilliams, J / Hadjivasiliou, C / Halder, S / Hara, K / Hara, T / Hartbrich, O / Hayasaka, K / Hayashii, H / Hazra, S / Hearty, C / Heredia de la Cruz, I / Hernández Villanueva, M / Hershenhorn, A / Higuchi, T / Hill, E C / Hirata, H / Hoek, M / Hohmann, M / Hsu, C-L / Humair, T / Iijima, T / Inami, K / Inguglia, G / Ishikawa, A / Itoh, R / Iwasaki, M / Iwasaki, Y / Jacobs, W W / Jaffe, D E / Jang, E-J / Jia, S / Jin, Y / Junkerkalefeld, H / Kakuno, H / Kaliyar, A B / Kandra, J / Kang, K H / Karl, R / Karyan, G / Kato, Y / Kawasaki, T / Kiesling, C / Kim, C-H / Kim, D Y / Kim, Y-K / Kim, Y / Kimmel, T D / Kinoshita, K / Kodyš, P / Koga, T / Kohani, S / Konno, T / Korpar, S / Kovalenko, E / Kowalewski, R / Kraetzschmar, T M G / Krinner, F / Križan, P / Krokovny, P / Kuhr, T / Kumar, J / Kumar, M / Kumar, R / Kumara, K / Kurz, S / Kuzmin, A / Kwon, Y-J / Lacaprara, S / Lalwani, K / Lam, T / Lanceri, L / Lange, J S / Laurenza, M / Lautenbach, K / Le Diberder, F R / Lee, S C / Leitl, P / Levit, D / Li, C / Li, L K / Libby, J / Lieret, K / Liptak, Z / Liu, Q Y / Liventsev, D / Longo, S / Lueck, T / Lyu, C / Manfredi, R / Manoni, E / Marinas, C / Martini, A / Matsuda, T / Matsuoka, K / Matvienko, D / McKenna, J A / Meier, F / Merola, M / Metzner, F / Miller, C / Miyabayashi, K / Mizuk, R / Mohanty, G B / Molina-Gonzalez, N / Moon, H / Moser, H-G / Mrvar, M / Murphy, C / Mussa, R / Nakamura, I / Nakamura, K R / Nakao, M / Nakazawa, H / Natkaniec, Z / Natochii, A / Nazaryan, G / Niebuhr, C / Niiyama, M / Nisar, N K / Nishida, S / Nishimura, K / Ogawa, S / Onishchuk, Y / Ono, H / Onuki, Y / Oskin, P / Oxford, E R / Ozaki, H / Pakhlov, P / Paladino, A / Pang, T / Panta, A / Paoloni, E / Pardi, S / Park, H / Park, S-H / Paschen, B / Passeri, A / Pathak, A / Patra, S / Paul, S / Pedlar, T K / Peruzzi, I / Peschke, R / Pestotnik, R / Pham, F / Piccolo, M / Piilonen, L E / Pinna Angioni, G / Podesta-Lerma, P L M / Podobnik, T / Pokharel, S / Polat, G / Popov, V / Praz, C / Prell, S / Prencipe, E / Prim, M T / Purohit, M V / Purwar, H / Rad, N / Rados, P / Raiz, S / Reiter, S / Remnev, M / Ripp-Baudot, I / Rizzo, G / Rizzuto, L B / Robertson, S H / Roney, J M / Rostomyan, A / Rout, N / Rozanska, M / Sahoo, D / Sanders, D A / Sandilya, S / Sangal, A / Santelj, L / Sato, Y / Savinov, V / Scavino, B / Schueler, J / Schwanda, C / Schwartz, A J / Seino, Y / Selce, A / Senyo, K / Serrano, J / Sfienti, C / Shiu, J-G / Shwartz, B / Sibidanov, A / Simon, F / Sobie, R J / Soffer, A / Sokolov, A / Solovieva, E / Spataro, S / Spruck, B / Starič, M / Stefkova, S / Stottler, Z S / Stroili, R / Strube, J / Sumihama, M / Sutcliffe, W / Suzuki, S Y / Svidras, H / Tabata, M / Takizawa, M / Tamponi, U / Tanaka, S / Tanida, K / Tanigawa, H / Taniguchi, N / Tenchini, F / Tiwary, R / Tonelli, D / Torassa, E / Toutounji, N / Trabelsi, K / Tsuboyama, T / Ueda, I / Uehara, S / Uematsu, Y / Uglov, T / Unger, K / Unno, Y / Uno, K / Uno, S / Urquijo, P / Ushiroda, Y / Usov, Y V / Vahsen, S E / van Tonder, R / Varner, G S / Vinokurova, A / Vitale, L / Vossen, A / Waheed, E / Wakeling, H M / Wang, E / Wang, M-Z / Wang, X L / Warburton, A / Watanabe, M / Welsch, M / Wessel, C / Wiechczynski, J / Won, E / Xu, X P / Yabsley, B D / Yamada, S / Yan, W / Yang, S B / Ye, H / Yelton, J / Yin, J H / Yoshihara, K / Yusa, Y / Zani, L / Zhilich, V / Zhou, Q D / Zhou, X Y / Zhukova, V I / Žlebčík, R

Physical review letters

2021 Volume 127, Issue 21, Page(s) 211801

Abstract: We report a measurement of the D^{0} and D^{+} lifetimes using D^{0}→K^{-}π^{+} and D^{+}→K^{-}π^ ... the ϒ(4S) resonance, correspond to an integrated luminosity of 72 fb^{-1}. The results, τ(D^{0})=410 ... 5±1.1(stat)±0.8(syst) fs and τ(D^{+})=1030.4±4.7(stat)±3.1(syst) fs, are the most precise to date ...

Abstract	We report a measurement of the D^{0} and D^{+} lifetimes using D^{0}→K^{-}π^{+} and D^{+}→K^{-}π^{+}π^{+} decays reconstructed in e^{+}e^{-}→cc[over ¯] data recorded by the Belle II experiment at the SuperKEKB asymmetric-energy e^{+}e^{-} collider. The data, collected at center-of-mass energies at or near the ϒ(4S) resonance, correspond to an integrated luminosity of 72 fb^{-1}. The results, τ(D^{0})=410.5±1.1(stat)±0.8(syst) fs and τ(D^{+})=1030.4±4.7(stat)±3.1(syst) fs, are the most precise to date and are consistent with previous determinations.
Language	English
Publishing date	2021-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.211801
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Article ; Online: The Interaction of Vitamin D and Corticosteroids

Jimmy T. Efird / Ethan J. Anderson / Charulata Jindal / Thomas S. Redding / Andrew D. Thompson / Ashlyn M. Press / Julie Upchurch / Christina D. Williams / Yuk Ming Choi / Ayako Suzuki

International Journal of Environmental Research and Public Health, Vol 19, Iss 447, p

A Mortality Analysis of 26,508 Veterans Who Tested Positive for SARS-CoV-2

2022 Volume 447

Abstract: ... of post-index vitamin D (Vit D) and corticosteroid (CRT) use on 30-day mortality among hospitalized and ... non-hospitalized patients with coronavirus disease 2019 (COVID-19). Combination Vit D and CRT drug use ... a significantly decreased aRR was observed for the use of Vit D in the absence of CRTs relative to patients ...

Abstract	This data-based cohort consisted of 26,508 (7%) United States veterans out of the 399,290 who tested positive for SARS-CoV-2 from 1 March to 10 September 2020. We aimed to assess the interaction of post-index vitamin D (Vit D) and corticosteroid (CRT) use on 30-day mortality among hospitalized and non-hospitalized patients with coronavirus disease 2019 (COVID-19). Combination Vit D and CRT drug use was assessed according to four multinomial pairs (−\|+, −\|−, +\|+, +\|−). Respective categorical effects were computed on a log-binomial scale as adjusted relative risk (aRR). Approximately 6% of veterans who tested positive for SARS-CoV-2 died within 30 days of their index date. Among hospitalized patients, a significantly decreased aRR was observed for the use of Vit D in the absence of CRTs relative to patients who received CRTs but not Vit D (aRR = 0.30; multiplicity corrected, p = 0.0004). Among patients receiving systemically administered CRTs (e.g., dexamethasone), the use of Vit D was associated with fewer deaths in hospitalized patients (aRR = 0.51) compared with non-hospitalized patients (aRR = 2.5) ( P -for-Interaction = 0.0071). Evaluating the effect of modification of these compounds in the context of hospitalization may aid in the management of COVID-19 and provide a better understanding of the pathophysiological mechanisms underlying this and future infectious disease outbreaks.
Keywords	anti-inflammatory ; corticosteroids ; COVID-19 ; cytokine storm ; SARS-CoV-2 ; vitamin D ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Discovery research and development history of the dopamine D

Kikuchi, Tetsuro / Maeda, Kenji / Suzuki, Mikio / Hirose, Tsuyoshi / Futamura, Takashi / McQuade, Robert D

Neuropsychopharmacology reports

2021 Volume 41, Issue 2, Page(s) 134–143

Abstract: Otsuka Pharmaceutical Co., Ltd. successfully developed the first dopamine D ...

Abstract	Otsuka Pharmaceutical Co., Ltd. successfully developed the first dopamine D
MeSH term(s)	Aripiprazole/therapeutic use ; Depressive Disorder, Major/drug therapy ; Dopamine ; Dopamine Agonists/therapeutic use ; Humans ; Quinolones ; Research ; Thiophenes ; United States
Chemical Substances	Dopamine Agonists ; Quinolones ; Thiophenes ; brexpiprazole (2J3YBM1K8C) ; Aripiprazole (82VFR53I78) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2021-05-07
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2574-173X
ISSN (online)	2574-173X
DOI	10.1002/npr2.12180
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Article ; Online: Noradrenaline activation of hippocampal dopamine D

Kobayashi, Katsunori / Shikano, Kisako / Kuroiwa, Mahomi / Horikawa, Mio / Ito, Wakana / Nishi, Akinori / Segi-Nishida, Eri / Suzuki, Hidenori

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 33, Page(s) e2117903119

Abstract: Dopamine D ...

Abstract	Dopamine D
MeSH term(s)	Animals ; Antidepressive Agents/pharmacology ; Dentate Gyrus/metabolism ; Depressive Disorder/metabolism ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Mice ; Norepinephrine/metabolism ; Norepinephrine/pharmacology ; Receptors, Dopamine D1/metabolism
Chemical Substances	Antidepressive Agents ; Receptors, Dopamine D1 ; Dopamine (VTD58H1Z2X) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2117903119
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