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Article ; Online: Pre-dinner walks may be superior to post-dinner walks for glucose time in range in adults with type 1 diabetes on hybrid closed-loop insulin delivery systems.

Turner, Lauren V / Riddell, Michael C

2024

Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Letter
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15532
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Article ; Online: Arterial thrombosis in a replanted thumb due to factor V mutation and anti-phospholipid antibodies.

Amjadi, Mahyar / Zoumaris, Jack / Marshall, Nick / Riddell, Peter

The Journal of hand surgery, European volume

2009 Volume 34, Issue 4, Page(s) 545–546

MeSH term(s)	Adult ; Amputation, Traumatic/surgery ; Antibodies, Antiphospholipid/blood ; Factor V/genetics ; Graft Survival/physiology ; Humans ; Ischemia/etiology ; Male ; Microsurgery ; Point Mutation ; Postoperative Complications/etiology ; Replantation ; Thrombosis/etiology ; Thumb/blood supply ; Thumb/injuries ; Thumb/surgery ; Treatment Failure
Chemical Substances	Antibodies, Antiphospholipid ; factor V Leiden ; Factor V (9001-24-5)
Language	English
Publishing date	2009-08
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	2272801-6
ISSN	2043-6289 ; 1753-1934
ISSN (online)	2043-6289
ISSN	1753-1934
DOI	10.1177/1753193409102474
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Zs.A 1940: Show issues

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Article ; Online: Pushing the limits of insulin delivery 100 years later: A case study of a race across Canada.

Turner, Lauren V / Riddell, Michael C

Diabetes, obesity & metabolism

2022 Volume 24 Suppl 1, Page(s) 58–62

MeSH term(s)	Blood Glucose ; Blood Glucose Self-Monitoring ; Canada ; Diabetes Mellitus, Type 1/drug therapy ; Humans ; Hypoglycemia ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Insulin Infusion Systems
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2022-01-04
Publishing country	England
Document type	Letter
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.14629
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Article: Is There an Optimal Time of Day for Exercise? A Commentary on When to Exercise for People Living With Type 1 or Type 2 Diabetes.

Riddell, Michael C / Turner, Lauren V / Patton, Susana R

Diabetes spectrum : a publication of the American Diabetes Association

2023 Volume 36, Issue 2, Page(s) 146–150

Abstract: Exercise is a cornerstone of diabetes self-care because of its association with many health benefits. Several studies that have explored the best time of day to exercise to inform clinical recommendations have yielded mixed results. For example, for ... ...

Abstract	Exercise is a cornerstone of diabetes self-care because of its association with many health benefits. Several studies that have explored the best time of day to exercise to inform clinical recommendations have yielded mixed results. For example, for people with prediabetes or type 2 diabetes, there may be benefits to timing exercise to occur after meals, whereas people with type 1 diabetes may benefit from performing exercise earlier in the day. One common thread is the health benefits of consistent exercise, suggesting that the issue of exercise timing may be secondary to the goal of helping people with diabetes establish an exercise routine that best fits their life.
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211544-4
ISSN	1040-9165
ISSN	1040-9165
DOI	10.2337/dsi22-0017
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Zs.A 6232: Show issues

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Article ; Online: Hydric effects on thermal tolerances influence climate vulnerability in a high‐latitude beetle

Riddell, Eric A. / Mutanen, Marko / Ghalambor, Cameron K.

Global Change Biology. 2023 Sept., v. 29, no. 18 p.5184-5198

2023

Abstract: Species' thermal tolerances are used to estimate climate vulnerability, but few studies consider the role of the hydric environment in shaping thermal tolerances. As environments become hotter and drier, organisms often respond by limiting water loss to ... ...

Abstract	Species' thermal tolerances are used to estimate climate vulnerability, but few studies consider the role of the hydric environment in shaping thermal tolerances. As environments become hotter and drier, organisms often respond by limiting water loss to lower the risk of desiccation; however, reducing water loss may produce trade‐offs that lower thermal tolerances if respiration becomes inhibited. Here, we measured the sensitivity of water loss rate and critical thermal maximum (CTₘₐₓ) to precipitation in nature and laboratory experiments that exposed click beetles (Coleoptera: Elateridae) to acute‐ and long‐term humidity treatments. We also took advantage of their unique clicking behavior to characterize subcritical thermal tolerances. We found higher water loss rates in the dry acclimation treatment compared to the humid, and water loss rates were 3.2‐fold higher for individuals that had experienced a recent precipitation event compared to individuals that had not. Acute humidity treatments did not affect CTₘₐₓ, but precipitation indirectly affected CTₘₐₓ through its effect on water loss rates. Contrary to our prediction, we found that CTₘₐₓ was negatively associated with water loss rate, such that individuals with high water loss rate exhibited a lower CTₘₐₓ. We then incorporated the observed variation of CTₘₐₓ into a mechanistic niche model that coupled leaf and click beetle temperatures to predict climate vulnerability. The simulations indicated that indices of climate vulnerability can be sensitive to the effects of water loss physiology on thermal tolerances; moreover, exposure to temperatures above subcritical thermal thresholds is expected to increase by as much as 3.3‐fold under future warming scenarios. The correlation between water loss rate and CTₘₐₓ identifies the need to study thermal tolerances from a “whole‐organism” perspective that considers relationships between physiological traits, and the population‐level variation in CTₘₐₓ driven by water loss rate complicates using this metric as a straightforward proxy of climate vulnerability.
Keywords	Elateridae ; acclimation ; climate ; global change ; heat tolerance ; humidity ; latitude ; leaves ; models ; physiology ; prediction ; risk
Language	English
Dates of publication	2023-09
Size	p. 5184-5198.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.16830
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Introduction of a Registered Undergraduate Student of Nursing workforce: A qualitative study of student and registered nurses.

Mcbrearty, Katherine / Zordan, Rachel / Mcinnes, Elizabeth / Murphy, Jade / Riddell, Kathryn / Walker, Virginia / Jacob, Elisabeth

Journal of advanced nursing

2024

Abstract: Aim: To explore the benefits and challenges of a recently introduced Registered Undergraduate Student of Nursing workforce from the perspective of Nurses and Registered Undergraduate Students of Nursing, in a major metropolitan hospital in Australia in ... ...

Abstract	Aim: To explore the benefits and challenges of a recently introduced Registered Undergraduate Student of Nursing workforce from the perspective of Nurses and Registered Undergraduate Students of Nursing, in a major metropolitan hospital in Australia in 2020. Design: A qualitative descriptive study was undertaken using individual interviews and focus groups. Methods: Purposively selected employed Registered Undergraduate Students of Nursing and nurses who worked with them were interviewed, using a semi-structured format. Recordings were transcribed and coded using NVivo software. Reflexive thematic analysis using an inductive approach was undertaken. Results: Four major themes were revealed: (i) Navigating the programme, (ii) Belonging and integration; (iii) Patient care; and (iv) Continuing Development. Initial challenges were common, often related to clarifying the scope of practice for the new role. Ongoing issues were associated with gaps in understanding the role and lack of integration into the team. Mostly, nurses and Registered Undergraduate Students of Nursing built positive, professional relationships. Nurses valued the Registered Undergraduate Student of Nursing knowledge and skill level, reporting improved workload and work experiences when the Registered Undergraduate Student of Nursing was on shift. Nurses believed that the Registered Undergraduate Students of Nursing enhanced patient care. Registered Undergraduate Students of Nursing described positive, therapeutic relationships with patients. Registered Undergraduate Student of Nursing employment provided opportunities for new learning, leading to increased efficiency and confidence on clinical placement. Conclusions: This employment model benefited the Registered Undergraduate Students of Nursing and nurses who worked with them. In the absence of adequate training and support, challenges remained unresolved and negatively impacted the experience for nurses. In addition to university-level education and clinical placement, the employment model can create a third space for student learning via on-the-job training. The study supports the ongoing employment of student nurses through the Registered Undergraduate Student of Nursing model. Implications for the profession and/or patient care: Impact This study contributes to the very small body of literature investigating Registered Undergraduate Student of Nursing workforces in Australian hospitals. It is the first to explore the experiences of both nurses and students working together in a major metropolitan setting and also the first in the context of the COVID-19 pandemic. This study reflected a mostly positive experience for Registered Undergraduate Student of Nursing and the nurses who worked with them and highlighted the importance of adequate oversight and support in the implementation and maintenance of a Registered Undergraduate Student of Nursing workforce. Employed Registered Undergraduate Students of Nursing reported improved confidence, skills, and felt like they started clinical placement at an advantage, ready to step up and learn the Registered Nurse scope of practice. In addition to university-level education and clinical placement, this employment model creates a third space for learning via on-the-job training. Reporting method: COREQ guidelines were followed in the reporting of this study. Patient or public contribution: No patient or public contribution.
Language	English
Publishing date	2024-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	197634-5
ISSN	1365-2648 ; 0309-2402
ISSN (online)	1365-2648
ISSN	0309-2402
DOI	10.1111/jan.16046
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Article ; Online: Benchmarking informatics approaches for virus discovery: caution is needed when combining

Hegarty, Bridget / Riddell V, James / Bastien, Eric / Langenfeld, Kathryn / Lindback, Morgan / Saini, Jaspreet S / Wing, Anthony / Zhang, Jessica / Duhaime, Melissa

mSystems

2024 Volume 9, Issue 3, Page(s) e0110523

Abstract: Understanding the ecological impacts of viruses on natural and engineered ecosystems relies on the accurate identification of viral sequences from community sequencing data. To maximize viral recovery from metagenomes, researchers frequently combine ... ...

Abstract	Understanding the ecological impacts of viruses on natural and engineered ecosystems relies on the accurate identification of viral sequences from community sequencing data. To maximize viral recovery from metagenomes, researchers frequently combine viral identification tools. However, the effectiveness of this strategy is unknown. Here, we benchmarked combinations of six widely used informatics tools for viral identification and analysis (VirSorter, VirSorter2, VIBRANT, DeepVirFinder, CheckV, and Kaiju), called "rulesets." Rulesets were tested against mock metagenomes composed of taxonomically diverse sequence types and diverse aquatic metagenomes to assess the effects of the degree of viral enrichment and habitat on tool performance. We found that six rulesets achieved equivalent accuracy [Matthews Correlation Coefficient (MCC) = 0.77, Importance: The identification of viruses from environmental metagenomes using informatics tools has offered critical insights in microbial ecology. However, it remains difficult for researchers to know which tools optimize viral recovery for their specific study. In an attempt to recover more viruses, studies are increasingly combining the outputs from multiple tools without validating this approach. After benchmarking combinations of six viral identification tools against mock metagenomes and environmental samples, we found that these tools should only be combined cautiously. Two to four tool combinations maximized viral recovery and minimized non-viral contamination compared with either the single-tool or the five- to six-tool ones. By providing a rigorous overview of the behavior of
MeSH term(s)	Benchmarking ; Ecosystem ; Viruses ; Metagenomics/methods ; Databases, Nucleic Acid
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.01105-23
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Article ; Online: Effect of Mini-Dose Ready-to-Use Liquid Glucagon on Preventing Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes.

Aronson, Ronnie / Riddell, Michael C / Conoscenti, Valentina / Junaidi, M Khaled

Diabetes care

2023 Volume 46, Issue 4, Page(s) 765–772

Abstract: Objective: To determine effect of mini-dose, ready-to-use glucagon on incidence of exercise-associated hypoglycemia (EAH) in adults with type 1 diabetes.: Research design and methods: Individuals initially participated in the in-clinic training phase ...

Abstract	Objective: To determine effect of mini-dose, ready-to-use glucagon on incidence of exercise-associated hypoglycemia (EAH) in adults with type 1 diabetes. Research design and methods: Individuals initially participated in the in-clinic training phase for which they were randomly assigned to a crossover design: 150 µg glucagon (treatment arm A) or placebo (arm B) subcutaneously, immediately before exercise, plus 50% reduction in continuous subcutaneous insulin infusion (CSII) basal delivery rate. Completers were then rerandomly assigned in the 12-week outpatient investigational phase: arm A, B, or open-label C, 150 µg glucagon alone. Participants were to undertake their usual aerobic exercise at moderate to high intensity for 30 to 75 min in real-world settings. Data were analyzed for incidence of level 1 hypoglycemia based on self-monitoring blood glucose and for various secondary and exploratory end points. Results: Of 48 participants who completed the training phase, 45 continued to the outpatient phase. For all exercise sessions in the outpatient phase (n = 795), incidence of level 1 hypoglycemia was lower in both glucagon arms (A, 12% [P < 0.0001]; C, 16% [P = 0.0032]) than in the placebo arm (B, 39%). Times below range, in range, and above range from 0 to 300 min did not significantly differ among treatment arms. Consumed grams of exercise carbohydrates were lower with glucagon use than with placebo use but did not reach statistical significance (P = 0.12). Adverse events were similar among treatment arms. Conclusions: Mini-dose glucagon with or without 50% reduction in CSII basal delivery rate may help to decrease EAH incidence in adults with type 1 diabetes.
MeSH term(s)	Adult ; Humans ; Blood Glucose ; Cross-Over Studies ; Diabetes Mellitus, Type 1 ; Exercise ; Glucagon/therapeutic use ; Hypoglycemia ; Hypoglycemic Agents/therapeutic use ; Insulin ; Insulin Infusion Systems/adverse effects
Chemical Substances	Blood Glucose ; Glucagon (9007-92-5) ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc22-1145
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Article: Response to desmopressin of factors XI, X and V in patients with factor VIII deficiency and von Willebrand disease.

White, B / Lawler, P / Riddell, A / Nitu-Whalley, I C / Hermans, C / Lee, C A / Brown, S A

British journal of haematology

2004 Volume 126, Issue 1, Page(s) 100–104

Abstract: ... We assessed the DDAVP response of FXI coagulant activity (FXI:C), FXI antigen (FXI:Ag), factor V coagulant ...

Abstract	Desmopressin [1-deamino-8-d-arginine vasopressin (DDAVP)] has been successfully used in the treatment of type 1 von Willebrand disease (VWD) and mild haemophilia A (MHA). Data suggest that DDAVP can increase factor XI (FXI) plasma levels and may represent an effective treatment for mild FXI deficiency. We assessed the DDAVP response of FXI coagulant activity (FXI:C), FXI antigen (FXI:Ag), factor V coagulant activity (FV:C), and factor X coagulant activity (FX:C) in 33 individuals with VWD or MHA. DDAVP did not produce a clinically significant increase in FXI:C, FXI:Ag, FX:C or FV:C in any patient. The mean +/- SD FXI:C pre-DDAVP (time 0) and at 1 h post-DDAVP was 90.7 (+/-22.9) U/dl and 92.1 (+/-20.9) U/dl, respectively. The mean (+/-SD) FXI:Ag at time 0 and 1 h was 92.2 (+/-20.1) U/dl and 89.9 (+/-21.3) U/dl, respectively. There was a small reduction at 1 h post-DDAVP in both FV:C, from 101.8 (+/-20.9) U/dl to 97.2 (+/-21.4) U/dl (P < 0.001), and FX:C from 103 (+/-19.5) U/dl to 98.8 (+/-18.7) U/dl (P < 0.001). No significant increase in FXI:C, FXI:Ag, FV:C or FX:C levels was seen at 4 h post-DDAVP. This study failed to demonstrate a clinically significant increase in the levels of FXI, FX or FV following administration of DDAVP.
MeSH term(s)	Adolescent ; Adult ; Blood Coagulation Factors/analysis ; Child ; Deamino Arginine Vasopressin/therapeutic use ; Factor V/analysis ; Factor X/analysis ; Factor XI/analysis ; Female ; Hemophilia A/blood ; Hemophilia A/drug therapy ; Hemostatics/therapeutic use ; Humans ; Male ; Middle Aged ; Statistics, Nonparametric ; Treatment Failure ; von Willebrand Diseases/blood ; von Willebrand Diseases/drug therapy
Chemical Substances	Blood Coagulation Factors ; Hemostatics ; Factor V (9001-24-5) ; Factor X (9001-29-0) ; Factor XI (9013-55-2) ; Deamino Arginine Vasopressin (ENR1LLB0FP)
Language	English
Publishing date	2004-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/j.1365-2141.2004.04988.x
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Article ; Online: The effect of SARS-Co-V2 infection on prothrombotic and anticoagulant factors in dialysis patients.

Riddell, Anne / Chowdary, Pratima / Davenport, Andrew

Artificial organs

2022 Volume 46, Issue 7, Page(s) 1328–1333

Abstract: ... were Lupus anticoagulant positive, and two Factor V: Conclusion: COVID-19 dialysis patients have ...

Abstract	Background: Patients with COVID-19 infection are at increased risk of thrombosis. We wished to determine whether this was is due to an increase in prothrombotic or reduction in anticoagulant factors and whether heparin would be an appropriate anticoagulant. Methods: We measured routine coagulation and prothrombotic factors in dialysis patients after a positive COVID-19 test between March 2020 -April 2021. Results: Routine coagulation tests were measured in 227 dialysis patients, 148 males (65.2%), median age 67.5 (53.8-77.0) years. The international normalized ratio was prolonged in 11.5%, activated partial thromboplastin time in 48.5%, thrombin time in 57%. Factor VIII was increased in 59.1%, fibrinogen 73.8%, and D-dimer 95.5%. Protein C was reduced in 15.3%, protein S 28%, and antithrombin (AT) in 12.1%. Two patients were Lupus anticoagulant positive, and two Factor V Conclusion: COVID-19 dialysis patients have increased levels of fibrinogen and D-Dimers, but only factor VIII levels in the clotting profile increased with clinical disease severity increasing systemic hypercoagulability. AT concentrations are maintained and as such should not compromise anticoagulation with heparins.
MeSH term(s)	Aged ; Anticoagulants/therapeutic use ; COVID-19/complications ; Factor VIII ; Heparin/adverse effects ; Humans ; Male ; Protein S ; Renal Dialysis/adverse effects
Chemical Substances	Anticoagulants ; Protein S ; Factor VIII (9001-27-8) ; Heparin (9005-49-6)
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14206
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