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  1. Article: Type 2 diabetes and in-hospital sudden cardiac arrest in ST-elevation myocardial infarction in the US.

    Mhaimeed, Omar / Pillai, Krishnadev / Dargham, Soha / Al Suwaidi, Jassim / Jneid, Hani / Abi Khalil, Charbel

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1175731

    Abstract: Aims: We aimed to assess the impact of diabetes on sudden cardiac arrest (SCA) in US patients hospitalized for ST-elevation myocardial infarction (STEMI).: Methods: We used the National Inpatient Sample (2005-2017) data to identify adult patients ... ...

    Abstract Aims: We aimed to assess the impact of diabetes on sudden cardiac arrest (SCA) in US patients hospitalized for ST-elevation myocardial infarction (STEMI).
    Methods: We used the National Inpatient Sample (2005-2017) data to identify adult patients with STEMI. The primary outcome was in-hospital SCA. Secondary outcomes included in-hospital mortality, ventricular tachycardia (VT), ventricular fibrillation (VF), cardiogenic shock (CS), acute renal failure (ARF), and the revascularization strategy in SCA patients.
    Results: SCA significantly increased from 4% in 2005 to 7.6% in 2018 in diabetes patients and from 3% in 2005 to 4.6% in 2018 in non-diabetes ones (
    Conclusion: Diabetes is associated with an increased risk of sudden cardiac arrest in ST-elevation myocardial infarction. It is also associated with a higher mortality risk in SCA patients. However, the recent temporal mortality trend in SCA patients shows a steady decline, irrespective of diabetes.
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1175731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Primary hyperaldosteronism is associated with increased mortality and morbidity in patients with hypertension and diabetes.

    Pillai, Krishnadev / Fares, Ahmed / Dargham, Soha / Al Suwaidi, Jassim / Jayyousi, Amin / Abi Khalil, Charbel

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1147225

    Abstract: Aims: Primary hyperaldosteronism (PA) is a common cause of hypertension. It is more prevalent in patients with diabetes. We assessed the cardiovascular impact of PA in patients with established hypertension and diabetes.: Methods: Data from the ... ...

    Abstract Aims: Primary hyperaldosteronism (PA) is a common cause of hypertension. It is more prevalent in patients with diabetes. We assessed the cardiovascular impact of PA in patients with established hypertension and diabetes.
    Methods: Data from the National Inpatient Sample (2008-2016) was used to identify adults with PA with hypertension and diabetes comorbidities and then compared to non-PA patients. The primary outcome was in-hospital death. Secondary outcomes included ischemic stroke, hemorrhagic stroke, acute renal failure, atrial fibrillation, and acute heart failure.
    Results: A total of 48,434,503 patients with hypertension and diabetes were included in the analysis, of whom 12,850 (0.03%) were diagnosed with primary hyperaldosteronism (PA). Compared to patients with hypertension and diabetes but no PA, those with PA were more likely to be younger [63(13) vs. 67 (14), male (57.1% vs. 48.3%), and African-Americans (32% vs. 18.5%) (p<0.001 for all). PA was associated with a higher risk of mortality (adjusted OR 1.076 [1.076-1.077]), ischemic stroke [adjusted OR 1.049 (1.049-1.05)], hemorrhagic stroke [adjusted OR 1.05 (1.05-1.051)], acute renal failure [adjusted OR 1.058 (1.058-1.058)], acute heart failure [OR 1.104 (1.104-1.104)], and atrial fibrillation [adjusted OR 1.034 (1.033-1.034)]. As expected, older age and underlying cardiovascular disease were the strongest predictors of mortality. However, the female gender conferred protection [OR 0.889 (0.886-0.892].
    Conclusion: Primary hyperaldosteronism in patients with hypertension and diabetes is associated with increased mortality and morbidity.
    MeSH term(s) Adult ; Humans ; Female ; Male ; Atrial Fibrillation ; Hemorrhagic Stroke ; Hospital Mortality ; Hypertension/complications ; Hypertension/epidemiology ; Morbidity ; Diabetes Mellitus/epidemiology ; Heart Failure ; Ischemic Stroke ; Hyperaldosteronism/complications ; Hyperaldosteronism/epidemiology
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1147225
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  3. Article: Diabetes outcomes in heart failure patients with hypertrophic cardiomyopathy.

    Mekhaimar, Menatalla / Al Mohannadi, Moza / Dargham, Soha / Al Suwaidi, Jassim / Jneid, Hani / Abi Khalil, Charbel

    Frontiers in physiology

    2022  Volume 13, Page(s) 976315

    Abstract: Aims: ...

    Abstract Aims:
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.976315
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  4. Article: Temporal Trends in Outcomes of ST-Elevation Myocardial Infarction Patients With Heart Failure and Diabetes.

    Ali, Bassem / Dargham, Soha / Al Suwaidi, Jassim / Jneid, Hani / Abi Khalil, Charbel

    Frontiers in physiology

    2022  Volume 13, Page(s) 803092

    Abstract: Aims: We aimed to assess temporal trends in outcomes of ST-elevation myocardial infarction (STEMI) patients with diabetes and heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) and compared ... ...

    Abstract Aims: We aimed to assess temporal trends in outcomes of ST-elevation myocardial infarction (STEMI) patients with diabetes and heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) and compared both groups.
    Methods: Data from the National Inpatient Sample was analyzed between 2005 and 2017. We assessed hospitalizations rate and in-hospital mortality, ventricular tachycardia (VT), ventricular fibrillation (VF), atrial fibrillation (AF), cardiogenic shock (CS), ischemic stroke, acute renal failure (ARF), and revascularization strategy. Socio-economic outcomes consisted of the length of stay (LoS) and total charges/stay.
    Results: Hospitalization rate steadily decreased with time in STEMI patients with diabetes and HFrEF. Mean age (SD) decreased from 71 ± 12 to 67 ± 12 (
    Conclusion: While hospitalizations for STEMI in patients with diabetes and HFpEF followed an upward trend, we observed a temporal decrease in those with HFrEF. Mortality was unchanged in both HF groups despite the temporal increase in risk factors. Nevertheless, HFpEF patients had lower in-hospital mortality and cardiovascular events, except for AF.
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.803092
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  5. Article: Trends and Outcomes of Aortic Valve Replacement in Patients With Diabetes in the US.

    Khan, Sarah / Dargham, Soha / Al Suwaidi, Jassim / Jneid, Hani / Abi Khalil, Charbel

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 844068

    Abstract: Aims: We aimed to assess the trend and outcome of aortic valve replacement in patients with diabetes.: Background: Diabetes is associated with higher cardiovascular events.: Methods: Data from the National Inpatient Sample was analyzed between ... ...

    Abstract Aims: We aimed to assess the trend and outcome of aortic valve replacement in patients with diabetes.
    Background: Diabetes is associated with higher cardiovascular events.
    Methods: Data from the National Inpatient Sample was analyzed between 2012 and 2017. We compared hospitalizations and in-hospital cardiovascular outcomes in patients with diabetes to those without diabetes, hospitalized for aortic valve replacement.
    Results: In diabetes patients undergoing TAVR, the mean age of participants decreased from 79.6 ± 8 to 67.8 ± 8, hospitalizations increased from 0.97 to 7.68/100,000 US adults (
    Conclusion: The recent temporal trend of aortic valve replacement in patients with diabetes shows a significant increase in TAVR coupled with a decrease in sAVR. Mortality and other cardiovascular outcomes decreased in both techniques. sAVR, but not TAVR, was associated with higher in-hospital mortality risk.
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.844068
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  6. Article: Hypoglycemia is associated with a higher risk of mortality and arrhythmias in ST-elevation myocardial infarction, irrespective of diabetes.

    Humos, Basel / Mahfoud, Ziyad / Dargham, Soha / Al Suwaidi, Jassim / Jneid, Hani / Abi Khalil, Charbel

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 940035

    Abstract: Aims: We aimed to assess the impact of hypoglycemia in ST-elevation myocardial infarction (STEMI).: Background: Hypoglycemia increases the risk of mortality in patients with diabetes and high cardiovascular risk.: Methods: We used the National ... ...

    Abstract Aims: We aimed to assess the impact of hypoglycemia in ST-elevation myocardial infarction (STEMI).
    Background: Hypoglycemia increases the risk of mortality in patients with diabetes and high cardiovascular risk.
    Methods: We used the National Inpatient Sample (2005-2017) database to identify adult patients with STEMI as the primary diagnosis. The secondary diagnosis was hypoglycemia. We compared cardiovascular and socio-economic outcomes between STEMI patients with and without hypoglycemia and assessed temporal trends.
    Results: Hypoglycemia tends to complicate 0.17% of all cases hospitalized for STEMI. The mean age (±SD) of STEMI patients hospitalized with hypoglycemia decreased from 67 ± 15 in 2005 to 63 ± 12 in 2017 (
    Conclusion: Hypoglycemia is a rare event in patients hospitalized with STEMI. However, it was found to have higher odds of mortality, arrhythmias, and other comorbidities, irrespective of diabetes.
    Language English
    Publishing date 2022-10-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.940035
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  7. Article ; Online: Overweight and obesity are associated with better survival in STEMI patients with diabetes.

    Chaudhry, Hamza / Bodair, Ramez / Mahfoud, Ziyad / Dargham, Soha / Al Suwaidi, Jassim / Jneid, Hani / Abi Khalil, Charbel

    Obesity (Silver Spring, Md.)

    2023  Volume 31, Issue 11, Page(s) 2834–2844

    Abstract: Objective: The relationship between obesity and in-hospital outcomes in individuals with type 2 diabetes mellitus (T2DM) who develop an ST-elevation myocardial infarction (STEMI) was assessed.: Methods: Data from the National Inpatient Sample (NIS) ... ...

    Abstract Objective: The relationship between obesity and in-hospital outcomes in individuals with type 2 diabetes mellitus (T2DM) who develop an ST-elevation myocardial infarction (STEMI) was assessed.
    Methods: Data from the National Inpatient Sample (NIS) from 2008 to 2017 were analyzed. Patients with STEMI and T2DM were classified as being underweight or having normal weight, overweight, obesity, and severe obesity. The temporal trend of those BMI ranges and in-hospital outcomes among different obesity groups were assessed.
    Results: A total of 74,099 patients with T2DM and STEMI were included in this analysis. In 2008, 35.8% of patients had obesity, and 37.3% had severe obesity. However, patients with obesity accounted for most of the study population in 2017 (57.8%). During the observation period, mortality decreased in underweight patients from 18.1% to 13.2% (p < 0.001). Still, it gradually increased in all other BMI ranges, along with cardiogenic shock, atrial fibrillation, and ventricular fibrillation (p < 0.001 for all). After the combination of all patients during the observation period, mortality was lower in patients with overweight and obesity (adjusted odds ratio = 0.625 [95% CI 0.499-0.784]; 0.606 [95% CI 0.502-0.733], respectively).
    Conclusions: A U-shaped association governs the relationship between BMI and mortality in STEMI patients with diabetes, with those having overweight and obesity experiencing better survival.
    MeSH term(s) Humans ; ST Elevation Myocardial Infarction/complications ; ST Elevation Myocardial Infarction/epidemiology ; Obesity, Morbid ; Overweight/complications ; Diabetes Mellitus, Type 2/complications ; Thinness/complications ; Thinness/epidemiology ; Obesity/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23863
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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 87: Show issues

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  8. Article ; Online: Investigating palpitations: the role of Holter monitoring and loop recorders.

    Abi Khalil, Charbel / Haddad, Fadi / Al Suwaidi, Jassim

    BMJ (Clinical research ed.)

    2017  Volume 358, Page(s) j3123

    Language English
    Publishing date 2017--27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.j3123
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  9. Article ; Online: Pure Laparoscopic Donor Nephrectomy: A Single Institution Experience From a Middle Eastern Country.

    Abi Tayeh, Georges / Chebel, Josselin Abi / Semaan, Albert / Sarkis, Julien / Alkassis, Marwan / Khalil, Nour / Chalouhy, Charbel / Moukarzel, Maroun

    Transplantation proceedings

    2022  Volume 54, Issue 8, Page(s) 2109–2111

    Abstract: Background: Laparoscopic live donor nephrectomy (LLDN) is the most adopted technique for kidney transplantation. Several obstacles preclude brain-dead organ transplantation in the Middle East, going from social and cultural barriers to economical and ... ...

    Abstract Background: Laparoscopic live donor nephrectomy (LLDN) is the most adopted technique for kidney transplantation. Several obstacles preclude brain-dead organ transplantation in the Middle East, going from social and cultural barriers to economical and structural difficulties. To our knowledge, this is the first study to report Lebanese experience with pure LLDN, and kidney transplantation.
    Methods: We included 120 cases of pure LLDN performed at our center. Demographic, perioperative, and immediate postoperative data were analyzed. Surgical particularities of the technique are described.
    Results: The reported laparoscopic technique allowed for minimal perioperative morbidity, with an overall complication rate of 3%. Operative time averaged 146 minutes and warm ischemia time averaged 4 minutes. Mean hospital stay was 3 ± 1 days. Postoperative hemoglobin and creatinine showed a mean absolute variation of 0.09 ± 0.06 g/dL for hemoglobin and 0.51 ± 015 μmoles/L increase for creatinine. No Clavien-Dindo III-V complications were recorded.
    Conclusions: Strict adherence to the reproducible pure LLDN technique allowed for the performance of almost 45 cases per year with minimal morbidity and results comparable to similar series.
    MeSH term(s) Humans ; Living Donors ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Creatinine ; Tissue and Organ Harvesting/adverse effects ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Retrospective Studies
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.07.013
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    Zs.A 835: Show issues Location:
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  10. Article: The emerging role of epigenetics in cardiovascular disease.

    Abi Khalil, Charbel

    Therapeutic advances in chronic disease

    2014  Volume 5, Issue 4, Page(s) 178–187

    Abstract: There is a worldwide epidemic of cardiovascular diseases causing not only a public health issue but also accounting for trillions of dollars of healthcare expenditure. Studies pertaining to epidemiology, pathophysiology, molecular biology, gene ... ...

    Abstract There is a worldwide epidemic of cardiovascular diseases causing not only a public health issue but also accounting for trillions of dollars of healthcare expenditure. Studies pertaining to epidemiology, pathophysiology, molecular biology, gene identification and genetic linkage maps have been able to lay a strong foundation for both the diagnosis and treatment of cardiovascular medicine. Although the concept of 'epigenetics' is not recent, the term in current usage is extended from the initial concept of 'controlling developmental gene expression and signaling pathways in undifferentiated zygotes' to include heritable changes to gene expression that are not from differences in the genetic code. The impact of epigenetics in cardiovascular disease is now emerging as an important regulatory key player at different levels from pathophysiology to therapeutics. This review focuses on the emerging role of epigenetics in major cardiovascular medicine specialties such as coronary artery disease, heart failure, cardiac hypertrophy and diabetes.
    Language English
    Publishing date 2014-05-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622314529325
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