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Article: Analysis of postoperative ocular surface changes and intervention effect after pars plana vitrectomy in meibomian gland dysfunction dry eye patients.

Liu, Bo-Shi / Wei, Jiao-Ting / Nie, Ze-Tong / Yang, Meng / Pang, Shao-Fang / Li, Wen-Bo / Li, Xiao-Rong / Hu, Bo-Jie

2023 Volume 16, Issue 5, Page(s) 721–729

Abstract: Aim: To observe ocular surface changes after phacovitrectomy in patients with mild to moderate meibomian gland dysfunction (MGD)-type dry eye and track clinical treatment response using a Keratograph 5M and a LipiView interferometer.: Methods: Forty ... ...

Abstract	Aim: To observe ocular surface changes after phacovitrectomy in patients with mild to moderate meibomian gland dysfunction (MGD)-type dry eye and track clinical treatment response using a Keratograph 5M and a LipiView interferometer. Methods: Forty cases were randomized into control group A and treatment group B; the latter received meibomian gland treatment 3d before phacovitrectomy and sodium hyaluronate before and after surgery. The average non-invasive tear film break-up time (NITBUTav), first non-invasive tear film break-up time (NITBUTf), non-invasive measured tear meniscus height (NTMH), meibomian gland loss (MGL), lipid layer thickness (LLT) and partial blink rate (PBR) were measured preoperatively and 1wk, 1 and 3mo postoperatively. Results: The NITBUTav values of group A at 1wk (4.38±0.47), 1mo (6.76±0.70), and 3mo (7.25±0.68) were significantly lower than those of group B (7.45±0.78, 10.46±0.97, and 11.31±0.89; Conclusion: Mild to moderate MGD dry eye worsens in the short term after phacovitrectomy. Preoperative cleaning, hot compresses, and meibomian gland massage as well as preoperative and postoperative sodium hyaluronate promote the rapid recovery of tear film stability.
Language	English
Publishing date	2023-05-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2023.05.08
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: T lymphocyte characteristics and immune repertoires in the epicardial adipose tissue of heart failure patients.

Zhang, Xu-Zhe / Chen, Xian-Li / Tang, Ting-Ting / Zhang, Si / Li, Qin-Lin / Xia, Ni / Nie, Shao-Fang / Zhang, Min / Zhu, Zheng-Feng / Zhou, Zi-Hua / Dong, Nian-Guo / Cheng, Xiang

Frontiers in immunology

2023 Volume 14, Page(s) 1126997

Abstract: Background: Epicardial adipose tissue (EAT) acts as an active immune organ and plays a critical role in the pathogenesis of heart failure (HF). However, the characteristics of immune cells in EAT of HF patients have rarely been elucidated.: Methods: ... ...

Abstract	Background: Epicardial adipose tissue (EAT) acts as an active immune organ and plays a critical role in the pathogenesis of heart failure (HF). However, the characteristics of immune cells in EAT of HF patients have rarely been elucidated. Methods: To identify key immune cells in EAT, an integrated bioinformatics analysis was performed on public datasets. EAT samples with paired subcutaneous adipose tissue (SAT), heart, and peripheral blood samples from HF patients were collected in validation experiments. T cell receptor (TCR) repertoire was assessed by high-throughput sequencing. The phenotypic characteristics and key effector molecules of T lymphocytes in EAT were assessed by flow cytometry and histological staining. Results: Compared with SAT, EAT was enriched for immune activation-related genes and T lymphocytes. Compared with EAT from the controls, activation of T lymphocytes was more pronounced in EAT from HF patients. T lymphocytes in EAT of HF patients were enriched by highly expanded clonotypes and had greater TCR clonotype sharing with cardiac tissue relative to SAT. Experiments confirmed the abundance of IFN-γ Conclusion: EAT of HF patients was characterized by pronounced immune activation of clonally expanded IFN-γ
MeSH term(s)	Humans ; Adipose Tissue ; Heart Failure/pathology ; Subcutaneous Fat ; Pericardium/pathology ; Receptors, Antigen, T-Cell
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1126997
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Article ; Online: Effects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization.

Zha, Ling-Feng / Dong, Jiang-Tao / Wang, Jing-Lin / Chen, Qian-Wen / Wu, Jian-Fei / Zhou, Ying-Chao / Nie, Shao-Fang / Tu, Xin

Oxidative medicine and cellular longevity

2021 Volume 2021, Page(s) 2216314

Abstract: Objectives: Observational studies indicate that insomnia may increase risk of peptic ulcer disease (PUD). Our purpose is to clarify the possible causal relationship between insomnia and PUD by Mendelian randomization analyses.: Methods: We carried ... ...

Abstract	Objectives: Observational studies indicate that insomnia may increase risk of peptic ulcer disease (PUD). Our purpose is to clarify the possible causal relationship between insomnia and PUD by Mendelian randomization analyses. Methods: We carried out analyses using summary statistics data for genetic variants reported from a GWAS of insomnia ( Results: Conventional Mendelian randomization analysis showed clear causality between insomnia and PUD; 1 SD increased insomnia incident was related to a 19% higher risk of PUD ( Conclusions: This Mendelian randomization study suggests insomnia as a causal risk factor for PUD. The potential mechanisms included may be immune and oxidative stress. These findings indicate that improving sleep quality could have substantial health benefits.
MeSH term(s)	Causality ; Chromosome Mapping/methods ; Databases, Genetic ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Incidence ; Mendelian Randomization Analysis/methods ; Multigene Family ; Peptic Ulcer/epidemiology ; Peptic Ulcer/genetics ; Polymorphism, Single Nucleotide ; Risk Factors ; Sleep Initiation and Maintenance Disorders/complications ; Sleep Initiation and Maintenance Disorders/genetics ; Sleep Quality
Language	English
Publishing date	2021-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2021/2216314
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Article ; Online: Negative effects of enlarging internal limiting membrane peeling for idiopathic macular hole surgery

Ze-Tong Nie / Bo-Shi Liu / Yong Wang / Qiong Chen / Jiao-Ting Wei / Meng Yang / Shao-Fang Pang / Xiao-Rong Li / Bo-Jie Hu

International Journal of Ophthalmology, Vol 15, Iss 11, Pp 1806-

2022 Volume 1813

Abstract: AIM: To observe the effects of the different extents of internal limiting membrane (ILM) peeling on the surgical success and anatomical and functional outcomes of idiopathic macular hole (IMH). METHODS: In this retrospective cohort study, 36 patients ... ...

Abstract	AIM: To observe the effects of the different extents of internal limiting membrane (ILM) peeling on the surgical success and anatomical and functional outcomes of idiopathic macular hole (IMH). METHODS: In this retrospective cohort study, 36 patients were reviewed and divided into two groups according to the extent of ILM peeling: group A (18 patients), with the peeling area within one-half of the optic disc macular distance as the radius; group B (18 patients), with the peeling area larger than that of group A but did not exceed the optic disc macular distance as the radius. The main outcomes included the best corrected visual acuity (BCVA), light-adaptive electroretinography, macular hole (MH) closure rate, central macular thickness (CMT), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness [nine regions based on the Early Treatment of Diabetic Retinopathy Study (ETDRS) ring] before and 1, 3, and 6mo after surgery. RESULTS: The closure rate was 94.4% (17/18) both in groups A and B. The BCVA in both groups improved significantly compared with the preoperative values, but there was no difference between the two groups. The b-wave amplitude of the electroretinogram analysis was significantly improved in both groups compared to that of the preoperative period, with a greater increase in group A than in group B at 6mo (P=0.017). The CMT in both groups gradually decreased after surgery, and there was no difference between the two groups. The RNFL thickness of the temporal outer ring region in group B was significantly lower than that in group A at 3 and 6mo after surgery (P=0.010, 0.032). The GCC thickness of the temporal outer ring region in group B was significantly lower than that in group A at 6mo after surgery (P=0.038). CONCLUSION: Enlarging the extent of ILM peeling doesn't affect the IMH closure rate and visual acuity recovery, but the greater the extent of peeling, the greater the damage to the inner retinal structures.
Keywords	idiopathic macular hole ; internal limiting membrane ; light-adapted electroretinography ; retinal nerve fiber layer ; ganglion cell complex ; Ophthalmology ; RE1-994
Subject code	796
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Press of International Journal of Ophthalmology (IJO PRESS)
Document type	Article ; Online
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Article: Negative effects of enlarging internal limiting membrane peeling for idiopathic macular hole surgery.

Nie, Ze-Tong / Liu, Bo-Shi / Wang, Yong / Chen, Qiong / Wei, Jiao-Ting / Yang, Meng / Pang, Shao-Fang / Li, Xiao-Rong / Hu, Bo-Jie

International journal of ophthalmology

2022 Volume 15, Issue 11, Page(s) 1806–1813

Abstract: Aim: To observe the effects of the different extents of internal limiting membrane (ILM) peeling on the surgical success and anatomical and functional outcomes of idiopathic macular hole (IMH).: Methods: In this retrospective cohort study, 36 ... ...

Abstract	Aim: To observe the effects of the different extents of internal limiting membrane (ILM) peeling on the surgical success and anatomical and functional outcomes of idiopathic macular hole (IMH). Methods: In this retrospective cohort study, 36 patients were reviewed and divided into two groups according to the extent of ILM peeling: group A (18 patients), with the peeling area within one-half of the optic disc macular distance as the radius; group B (18 patients), with the peeling area larger than that of group A but did not exceed the optic disc macular distance as the radius. The main outcomes included the best corrected visual acuity (BCVA), light-adaptive electroretinography, macular hole (MH) closure rate, central macular thickness (CMT), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness [nine regions based on the Early Treatment of Diabetic Retinopathy Study (ETDRS) ring] before and 1, 3, and 6mo after surgery. Results: The closure rate was 94.4% (17/18) both in groups A and B. The BCVA in both groups improved significantly compared with the preoperative values, but there was no difference between the two groups. The b-wave amplitude of the electroretinogram analysis was significantly improved in both groups compared to that of the preoperative period, with a greater increase in group A than in group B at 6mo ( Conclusion: Enlarging the extent of ILM peeling doesn't affect the IMH closure rate and visual acuity recovery, but the greater the extent of peeling, the greater the damage to the inner retinal structures.
Language	English
Publishing date	2022-11-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2022.11.11
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Article: Nanomaterial-Based Antivascular Therapy in the Multimodal Treatment of Cancer.

Ma, Xiaocong / Fang, Weimin / Wang, Duo / Shao, Ni / Chen, Jifeng / Nie, Tianqi / Huang, Cuiqing / Huang, Yanyu / Luo, Liangping / Xiao, Zeyu

Pharmaceutics

2023 Volume 15, Issue 4

Abstract: Abnormal tumor vasculature and a hypoxic tumor microenvironment (TME) limit the effectiveness of conventional cancer treatment. Recent studies have shown that antivascular strategies that focus on antagonizing the hypoxic TME and promoting vessel ... ...

Abstract	Abnormal tumor vasculature and a hypoxic tumor microenvironment (TME) limit the effectiveness of conventional cancer treatment. Recent studies have shown that antivascular strategies that focus on antagonizing the hypoxic TME and promoting vessel normalization effectively synergize to increase the antitumor efficacy of conventional therapeutic regimens. By integrating multiple therapeutic agents, well-designed nanomaterials exhibit great advantages in achieving higher drug delivery efficiency and can be used as multimodal therapy with reduced systemic toxicity. In this review, strategies for the nanomaterial-based administration of antivascular therapy combined with other common tumor treatments, including immunotherapy, chemotherapy, phototherapy, radiotherapy, and interventional therapy, are summarized. In particular, the administration of intravascular therapy and other therapies with the use of versatile nanodrugs is also described. This review provides a reference for the development of multifunctional nanotheranostic platforms for effective antivascular therapy in combined anticancer treatments.
Language	English
Publishing date	2023-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15041207
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Article ; Online: Active disturbance rejection control for non-minimum phase systems under plant reconstruction.

Liu, Ruijuan / Nie, Zhuo-Yun / Shao, Hui / Fang, Huijuan / Luo, Ji-Liang

ISA transactions

2022 Volume 134, Page(s) 497–510

Abstract: Active disturbance rejection control (ADRC) for non-minimum phase (NMP) systems is a challenging problem due to the conflict between stability and feedback tuning. The key point on this issue is to avoid heavy feedback tuning for robustness enhancement. ... ...

Abstract	Active disturbance rejection control (ADRC) for non-minimum phase (NMP) systems is a challenging problem due to the conflict between stability and feedback tuning. The key point on this issue is to avoid heavy feedback tuning for robustness enhancement. We perform plant reconstruction to obtain an explicit expression of internal disturbance, such that it can be reduced by cascade compensation. Then, a new ADRC scheme is developed based on plant reconstruction and the internal stability criterion for ADRC system is derived. The stability conditions provide guidelines on the design of the cascade compensator and disturbance observer. It also indicates that the cascade compensation contributes to the robust stability of NMP systems. Simulation results of two typical NMP systems are provided to show the efficacy of the proposed ADRC scheme. Physical realizability is also demonstrated through experiments on a motion NMP system.
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012746-7
ISSN	1879-2022 ; 0019-0578
ISSN (online)	1879-2022
ISSN	0019-0578
DOI	10.1016/j.isatra.2022.08.017
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Article ; Online: Neutrophil-derived oxidative stress contributes to skin inflammation and scratching in a mouse model of allergic contact dermatitis via triggering pro-inflammatory cytokine and pruritogen production in skin.

Yang, Yunqin / Pan, Yushuang / Liu, Boyu / Zhang, Yunwen / Yin, Chengyu / Wang, Jie / Nie, Huimin / Xu, Ruoyao / Tai, Yan / He, Xiaofen / Shao, Xiaomei / Liang, Yi / Fang, Jianqiao / Liu, Boyi

Biochemical pharmacology

2024 Volume 223, Page(s) 116163

Abstract: Allergic contact dermatitis (ACD) is a common skin disease featured with skin inflammation and a mixed itch/pain sensation. The itch/pain causes the desire to scratch, affecting both physical and psychological aspects of patients. Nevertheless, the ... ...

Abstract	Allergic contact dermatitis (ACD) is a common skin disease featured with skin inflammation and a mixed itch/pain sensation. The itch/pain causes the desire to scratch, affecting both physical and psychological aspects of patients. Nevertheless, the mechanisms underlying itch/pain sensation of ACD still remain elusive. Here, we found that oxidative stress and oxidation-related injury were remarkably increased in the inflamed skin of a mouse model of ACD. Reducing oxidative stress significantly attenuated itch/pain-related scratching, allokonesis and skin inflammation. RNA-Sequencing reveals oxidative stress contributes to a series of skin biological processes, including inflammation and immune response. Attenuating oxidative stress reduces overproduction of IL-1β and IL-33, two critical cytokines involved in inflammation and pain/itch, in the inflamed skin of model mice. Exogenously injecting H
MeSH term(s)	Humans ; Animals ; Mice ; Interleukin-33/genetics ; Cytokines ; Hydrogen Peroxide/pharmacology ; Neutrophils ; Skin ; Dermatitis, Allergic Contact/psychology ; Pruritus/chemically induced ; Disease Models, Animal ; Inflammation ; Pain
Chemical Substances	Interleukin-33 ; Cytokines ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2024.116163
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Article ; Online: CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.

Yin, Chengyu / Liu, Boyu / Dong, Zishan / Shi, Sai / Peng, Chenxing / Pan, Yushuang / Bi, Xiaochen / Nie, Huimin / Zhang, Yunwen / Tai, Yan / Hu, Qimiao / Wang, Xuan / Shao, Xiaomei / An, Hailong / Fang, Jianqiao / Wang, Chuan / Liu, Boyi

Nature communications

2024 Volume 15, Issue 1, Page(s) 3263

Abstract: Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 ... ...

Abstract	Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons.
MeSH term(s)	Animals ; Humans ; Male ; Mice ; Arthralgia ; Arthritis, Gouty ; Chemokine CXCL5/genetics ; Chemokine CXCL5/metabolism ; Inflammation ; Nociception ; Nociceptors/metabolism ; Pain
Chemical Substances	Chemokine CXCL5 ; CXCL5 protein, human ; CXCR2 protein, human ; Cxcr2 protein, mouse ; Cxcl5 protein, mouse
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47640-7
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Article ; Online: Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19.

Nie, Shao-Fang / Yu, Miao / Xie, Tian / Yang, Fen / Wang, Hong-Bo / Wang, Zhao-Hui / Li, Ming / Gao, Xing-Li / Lv, Bing-Jie / Wang, Shi-Jia / Zhang, Xiao-Bo / He, Shao-Lin / Qiu, Zhi-Hua / Liao, Yu-Hua / Zhou, Zi-Hua / Cheng, Xiang

Circulation

2020 Volume 142, Issue 6, Page(s) 608–610

MeSH term(s)	Aged ; Betacoronavirus ; Biomarkers/blood ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/mortality ; Female ; Follow-Up Studies ; Hospitalization/trends ; Humans ; Male ; Middle Aged ; Mortality/trends ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/mortality ; Predictive Value of Tests ; SARS-CoV-2 ; Troponin I/blood
Chemical Substances	Biomarkers ; Troponin I
Keywords	covid19
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Letter
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.120.048789
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