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  1. Article ; Online: Does the small conductance Ca

    Giommi, Alessandro / Gurgel, Aline R B / Smith, Godfrey L / Workman, Antony J

    Journal of molecular and cellular cardiology

    2023  Volume 183, Page(s) 70–80

    Abstract: Background: The small conductance Ca: Aim: To clarify, in rabbit and human atrial cardiomyocytes, the intracellular [Ca: Methods: Whole-cell-patch clamp, fluorescence microscopy: to record ion currents, APs and [Ca: Results: In rabbit atrial ... ...

    Abstract Background: The small conductance Ca
    Aim: To clarify, in rabbit and human atrial cardiomyocytes, the intracellular [Ca
    Methods: Whole-cell-patch clamp, fluorescence microscopy: to record ion currents, APs and [Ca
    Results: In rabbit atrial myocytes, 0.5 mM Ba
    Conclusion: I
    MeSH term(s) Animals ; Humans ; Rabbits ; Myocytes, Cardiac/drug effects ; Apamin/pharmacology ; Small-Conductance Calcium-Activated Potassium Channels ; Heart Atria/drug effects ; Atrial Fibrillation ; Action Potentials/drug effects
    Chemical Substances Apamin (24345-16-2) ; Small-Conductance Calcium-Activated Potassium Channels
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2023.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adrenoceptor sub-type involvement in Ca

    Saxena, Priyanka / Myles, Rachel C / Smith, Godfrey L / Workman, Antony J

    Pflugers Archiv : European journal of physiology

    2022  Volume 474, Issue 12, Page(s) 1311–1321

    Abstract: Atrial fibrillation (AF) from elevated adrenergic activity may involve increased atrial L-type ... ...

    Abstract Atrial fibrillation (AF) from elevated adrenergic activity may involve increased atrial L-type Ca
    MeSH term(s) Animals ; Humans ; Rabbits ; Atrial Fibrillation/physiopathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; Norepinephrine/pharmacology ; Norepinephrine/physiology ; Prazosin/pharmacology ; Receptors, Adrenergic, alpha-2 ; Heart Atria/cytology ; Receptors, Adrenergic, beta/physiology ; Receptors, Adrenergic, alpha/physiology ; Adrenergic alpha-Antagonists/pharmacology ; Adrenergic beta-Antagonists/pharmacology ; Calcium Channels, L-Type/physiology
    Chemical Substances Norepinephrine (X4W3ENH1CV) ; Prazosin (XM03YJ541D) ; Receptors, Adrenergic, alpha-2 ; Receptors, Adrenergic, beta ; Receptors, Adrenergic, alpha ; Adrenergic alpha-Antagonists ; Adrenergic beta-Antagonists ; Calcium Channels, L-Type
    Language English
    Publishing date 2022-09-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-022-02746-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Atrial Electrophysiological Remodeling and Fibrillation in Heart Failure.

    Pandit, Sandeep V / Workman, Antony J

    Clinical Medicine Insights. Cardiology

    2016  Volume 10, Issue Suppl 1, Page(s) 41–46

    Abstract: Heart failure (HF) causes complex, chronic changes in atrial structure and function, which can cause substantial electrophysiological remodeling and predispose the individual to atrial fibrillation (AF). Pharmacological treatments for preventing AF in ... ...

    Abstract Heart failure (HF) causes complex, chronic changes in atrial structure and function, which can cause substantial electrophysiological remodeling and predispose the individual to atrial fibrillation (AF). Pharmacological treatments for preventing AF in patients with HF are limited. Improved understanding of the atrial electrical and ionic/molecular mechanisms that promote AF in these patients could lead to the identification of novel therapeutic targets. Animal models of HF have identified numerous changes in atrial ion currents, intracellular calcium handling, action potential waveform and conduction, as well as expression and signaling of associated proteins. These studies have shown that the pattern of electrophysiological remodeling likely depends on the duration of HF, the underlying cardiac pathology, and the species studied. In atrial myocytes and tissues obtained from patients with HF or left ventricular systolic dysfunction, the data on changes in ion currents and action potentials are largely equivocal, probably owing mainly to difficulties in controlling for the confounding influences of multiple variables, such as patient's age, sex, disease history, and drug treatments, as well as the technical challenges in obtaining such data. In this review, we provide a summary and comparison of the main animal and human electrophysiological studies to date, with the aim of highlighting the consistencies in some of the remodeling patterns, as well as identifying areas of contention and gaps in the knowledge, which warrant further investigation.
    Language English
    Publishing date 2016-10-31
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2575256-X
    ISSN 1179-5468
    ISSN 1179-5468
    DOI 10.4137/CMC.S39713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Description of the Human Atrial Action Potential Derived From a Single, Congruent Data Source: Novel Computational Models for Integrated Experimental-Numerical Study of Atrial Arrhythmia Mechanisms.

    Colman, Michael A / Saxena, Priyanka / Kettlewell, Sarah / Workman, Antony J

    Frontiers in physiology

    2018  Volume 9, Page(s) 1211

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2018-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.01211
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  5. Article ; Online: Mechanisms of postcardiac surgery atrial fibrillation: more pieces in a difficult puzzle.

    Workman, Antony J

    Heart rhythm

    2009  Volume 6, Issue 10, Page(s) 1423–1424

    MeSH term(s) Animals ; Atrial Fibrillation/physiopathology ; Cardiac Surgical Procedures ; Fibrosis ; Heart Atria/pathology ; Heart Atria/physiopathology ; Humans ; Postoperative Complications ; Sheep
    Language English
    Publishing date 2009-07-17
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2009.07.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cardiac adrenergic control and atrial fibrillation.

    Workman, Antony J

    Naunyn-Schmiedeberg's archives of pharmacology

    2009  Volume 381, Issue 3, Page(s) 235–249

    Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it causes substantial mortality. The autonomic nervous system, and particularly the adrenergic/cholinergic balance, has a profound influence on the occurrence of AF. Adrenergic ... ...

    Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it causes substantial mortality. The autonomic nervous system, and particularly the adrenergic/cholinergic balance, has a profound influence on the occurrence of AF. Adrenergic stimulation from catecholamines can cause AF in patients. In human atrium, catecholamines can affect each of the electrophysiological mechanisms of AF initiation and/or maintenance. Catecholamines may produce membrane potential oscillations characteristic of afterdepolarisations, by increasing Ca(2+) current, [Ca(2+)](i) and consequent Na(+)-Ca(2+) exchange, and may also enhance automaticity. Catecholamines might affect reentry, by altering excitability or conduction, rather than action potential terminal repolarisation or refractory period. However, which arrhythmia mechanisms predominate is unclear, and likely depends on cardiac pathology and adrenergic tone. Heart failure (HF), a major cause of AF, causes adrenergic activation and adaptational changes, remodelling, of atrial electrophysiology, Ca(2+) homeostasis, and adrenergic responses. Chronic AF also remodels these, but differently to HF. Myocardial infarction and AF cause neural remodelling that also may promote AF. beta-Adrenoceptor antagonists (beta-blockers) are used in the treatment of AF, mainly to control the ventricular rate, by slowing atrioventricular conduction. beta-Blockers also reduce the incidence of AF, particularly in HF or after cardiac surgery, when adrenergic tone is high. Furthermore, the chronic treatment of patients with beta-blockers remodels the atria, with a potentially antiarrhythmic increase in the refractory period. Therefore, the suppression of AF by beta-blocker treatment may involve an attenuation of arrhythmic activity that is caused by increased [Ca(2+)](i), coupled with effects of adaptation to the treatment. An improved understanding of the involvement of the adrenergic system and its control in basic mechanisms of AF under differing cardiac pathologies might lead to better treatments.
    MeSH term(s) Action Potentials/drug effects ; Adrenergic beta-Antagonists/administration & dosage ; Adrenergic beta-Antagonists/pharmacology ; Adrenergic beta-Antagonists/therapeutic use ; Animals ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/metabolism ; Atrial Fibrillation/physiopathology ; Calcium Signaling/drug effects ; Catecholamines/metabolism ; Humans ; Receptors, Adrenergic/metabolism ; Species Specificity
    Chemical Substances Adrenergic beta-Antagonists ; Catecholamines ; Receptors, Adrenergic
    Language English
    Publishing date 2009-12-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-009-0474-0
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  7. Article ; Online: Dynamic clamping human and rabbit atrial calcium current: narrowing I

    Kettlewell, Sarah / Saxena, Priyanka / Dempster, John / Colman, Michael A / Myles, Rachel C / Smith, Godfrey L / Workman, Antony J

    The Journal of physiology

    2019  Volume 597, Issue 14, Page(s) 3619–3638

    Abstract: Key points: Early-afterdepolarizations (EADs) are abnormal action potential oscillations and a known cause of cardiac arrhythmias. Ventricular EADs involve reactivation of a Ca: Abstract: Atrial early-afterdepolarizations (EADs) may contribute to ... ...

    Abstract Key points: Early-afterdepolarizations (EADs) are abnormal action potential oscillations and a known cause of cardiac arrhythmias. Ventricular EADs involve reactivation of a Ca
    Abstract: Atrial early-afterdepolarizations (EADs) may contribute to atrial fibrillation (AF), perhaps involving reactivation of L-type Ca
    MeSH term(s) Action Potentials/physiology ; Aged ; Animals ; Atrial Fibrillation/metabolism ; Calcium/metabolism ; Calcium Channels, L-Type/metabolism ; Cells, Cultured ; Female ; Heart Atria/metabolism ; Humans ; Male ; Myocytes, Cardiac/metabolism ; Patch-Clamp Techniques/methods ; Rabbits
    Chemical Substances Calcium Channels, L-Type ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-06-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP277827
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  8. Article ; Online: Do hypoxemia or hypercapnia predispose to atrial fibrillation in breathing disorders, and, if so, how?

    Workman, Antony J / Rankin, Andrew C

    Heart rhythm

    2010  Volume 7, Issue 9, Page(s) 1271–1272

    MeSH term(s) Acute Disease ; Animals ; Atrial Fibrillation/complications ; Atrial Fibrillation/physiopathology ; Electrophysiologic Techniques, Cardiac/methods ; Heart Atria/physiopathology ; Humans ; Hypercapnia/etiology ; Hypercapnia/physiopathology ; Hypoxia ; Lung Diseases/complications ; Lung Diseases/physiopathology ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/physiopathology
    Language English
    Publishing date 2010-04-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2010.04.004
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  9. Article ; Online: Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times?

    Rankin, Andrew C / Workman, Antony J

    Cardiovascular research

    2009  Volume 84, Issue 2, Page(s) 180–181

    MeSH term(s) Action Potentials ; Animals ; Atrial Fibrillation/etiology ; Atrial Fibrillation/metabolism ; Atrial Fibrillation/physiopathology ; Atrial Function, Left ; Calcium Channels, L-Type/metabolism ; Calcium Signaling ; Chronic Disease ; Heart Conduction System/drug effects ; Heart Conduction System/metabolism ; Heart Conduction System/physiopathology ; Heart Failure/complications ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Myocardial Contraction ; Myocardium/metabolism ; Myocardium/pathology ; Potassium Channels/metabolism ; Refractory Period, Electrophysiological ; Risk Factors ; Time Factors ; Ventricular Function, Left
    Chemical Substances Calcium Channels, L-Type ; Potassium Channels
    Language English
    Publishing date 2009-08-27
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvp299
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  10. Article: Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation.

    Grandi, Eleonora / Workman, Antony J / Pandit, Sandeep V

    Journal of atrial fibrillation

    2012  Volume 4, Issue 6, Page(s) 495

    Abstract: This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ... ...

    Abstract This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca
    Language English
    Publishing date 2012-04-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2451936-4
    ISSN 1941-6911
    ISSN 1941-6911
    DOI 10.4022/jafib.495
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