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  1. Book ; Conference proceedings: Familial amyloid polyneuropathy

    Ikeda, Shu-Ichi

    papers presented at the 5th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders and the 4th International Workshop on Liver Transplantation in Familial Amyloid Polyneuropathy, Matsumoto, Japan, September 24 - 27, 2002

    (Amyloid ; 10, Suppl. 1)

    2003  

    Institution International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders
    International Workshop on Liver Transplantation in Familial Amyloid Polyneuropathy
    Author's details guest ed.: Shu-ichi Ikeda
    Series title Amyloid ; 10, Suppl. 1
    Collection
    Language English
    Size 87 S. : Ill., graph. Darst.
    Publisher Parthenon Publ
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013853936
    Database Catalogue ZB MED Medicine, Health

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    Zs A 4114 -10,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination

    Akiyo Hineno / Shu-Ichi Ikeda

    Vaccines, Vol 9, Iss 856, p

    2021  Volume 856

    Abstract: In Japan, a significant number of adolescent females noted unusual symptoms after receiving the human papillomavirus (HPV) vaccination, of which the vast majority of them were initially diagnosed with psychiatric illnesses because of the absence of ... ...

    Abstract In Japan, a significant number of adolescent females noted unusual symptoms after receiving the human papillomavirus (HPV) vaccination, of which the vast majority of them were initially diagnosed with psychiatric illnesses because of the absence of pathologic radiological images and specific abnormalities in laboratory test results. Later these symptoms were thought to be adverse effects of HPV vaccination. However, a causal link between HPV vaccination and the development of these symptoms has not been demonstrated. Between June 2013 and March 2021, we examined 200 patients who noted various symptoms after HPV vaccination. In total, 87 were diagnosed with HPV vaccination-related symptoms based on our proposed diagnostic criteria. The clinical histories of these 87 patients were analyzed. The age at initial vaccination ranged from 11 to 19 years old (mean ± SD: 13.5 ± 1.5 years old), and the age at the first appearance of symptoms ranged from 12 to 20 years old (mean ± SD: 14.3 ± 1.6 years old). The patients received an initial HPV vaccine injection between May 2010 and May 2013, but the first affected patient developed symptoms in October 2010, and the last affected developed symptoms in October 2015. A cluster of patients with a post-HPV vaccination disorder has not appeared in Japan during the last five years. Our study shows that, in Japan, the period of HPV vaccination considerably overlapped with that of a unique post-HPV vaccination disorder development. This disorder appears as a combination of orthostatic intolerance, chronic regional pain syndrome, and cognitive dysfunction, but its exact pathogenesis remains unclear.
    Keywords human papillomavirus vaccination ; adverse effects ; orthostatic dysregulation ; chronic regional pain syndrome ; cognitive dysfunction ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: A Long-Term Observation on the Possible Adverse Effects in Japanese Adolescent Girls after Human Papillomavirus Vaccination.

    Hineno, Akiyo / Ikeda, Shu-Ichi

    Vaccines

    2021  Volume 9, Issue 8

    Abstract: In Japan, a significant number of adolescent females noted unusual symptoms after receiving the human papillomavirus (HPV) vaccination, of which the vast majority of them were initially diagnosed with psychiatric illnesses because of the absence of ... ...

    Abstract In Japan, a significant number of adolescent females noted unusual symptoms after receiving the human papillomavirus (HPV) vaccination, of which the vast majority of them were initially diagnosed with psychiatric illnesses because of the absence of pathologic radiological images and specific abnormalities in laboratory test results. Later these symptoms were thought to be adverse effects of HPV vaccination. However, a causal link between HPV vaccination and the development of these symptoms has not been demonstrated. Between June 2013 and March 2021, we examined 200 patients who noted various symptoms after HPV vaccination. In total, 87 were diagnosed with HPV vaccination-related symptoms based on our proposed diagnostic criteria. The clinical histories of these 87 patients were analyzed. The age at initial vaccination ranged from 11 to 19 years old (mean ± SD: 13.5 ± 1.5 years old), and the age at the first appearance of symptoms ranged from 12 to 20 years old (mean ± SD: 14.3 ± 1.6 years old). The patients received an initial HPV vaccine injection between May 2010 and May 2013, but the first affected patient developed symptoms in October 2010, and the last affected developed symptoms in October 2015. A cluster of patients with a post-HPV vaccination disorder has not appeared in Japan during the last five years. Our study shows that, in Japan, the period of HPV vaccination considerably overlapped with that of a unique post-HPV vaccination disorder development. This disorder appears as a combination of orthostatic intolerance, chronic regional pain syndrome, and cognitive dysfunction, but its exact pathogenesis remains unclear.
    Language English
    Publishing date 2021-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9080856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Localized amyloidogenic immunoglobulin light chain-derived amyloidosis in a young boy and an adolescent girl.

    Ikeda, Shu-Ichi

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

    2017  Volume 24, Issue 2, Page(s) 138–140

    MeSH term(s) Adolescent ; Amyloid/genetics ; Child ; Female ; Humans ; Immunoglobulin Light Chains/genetics ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/diagnostic imaging ; Immunoglobulin Light-chain Amyloidosis/genetics ; Immunoglobulin Light-chain Amyloidosis/physiopathology ; Male
    Chemical Substances Amyloid ; Immunoglobulin Light Chains
    Language English
    Publishing date 2017-06-20
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1205246-2
    ISSN 1744-2818 ; 1350-6129
    ISSN (online) 1744-2818
    ISSN 1350-6129
    DOI 10.1080/13506129.2017.1339686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4114: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [Neurologic Complications in HPV Vaccination].

    Ikeda, Shu-ichi

    Brain and nerve = Shinkei kenkyu no shinpo

    2015  Volume 67, Issue 7, Page(s) 835–843

    Abstract: A relatively high incidence of chronic limb pain, frequently complicated by violent, tremulous involuntary movements, has been noted in Japanese girls following human papillomavirus vaccination. The average incubation period after the first dose of the ... ...

    Abstract A relatively high incidence of chronic limb pain, frequently complicated by violent, tremulous involuntary movements, has been noted in Japanese girls following human papillomavirus vaccination. The average incubation period after the first dose of the vaccine was 5.47 ± 5.00 months. Frequent manifestations included headaches, general fatigue, coldness of the feet, limb pain, and weakness. The skin temperature of the girls with limb symptoms was slightly lower in the fingers and moderately lower in the toes. Digital plethysmograms revealed a reduced peak of the waves, especially in the toes. Limb symptoms of the affected girls were compatible with the diagnostic criteria for complex regional pain syndrome. The Schellong test identified a significant number of patients with orthostatic hypotension and a few with postural orthostatic tachycardia syndrome. Electron-microscopic examinations of the intradermal nerves showed an abnormal pathology in the unmyelinated fibers in two of the three girls examined. The symptoms observed in this study can be explained by abnormal peripheral sympathetic responses. The most common previous diagnosis in the patients was psychosomatic disease. Recently, delayed manifestation of cognitive dysfunction in the post-vaccinated girls has attracted attention. The symptoms include memory loss and difficulty in reading textbooks and/or calculation.
    MeSH term(s) Adolescent ; Female ; Humans ; Incidence ; Nervous System Diseases/epidemiology ; Nervous System Diseases/etiology ; Nervous System Diseases/therapy ; Pain/chemically induced ; Papillomavirus Vaccines/adverse effects ; Young Adult
    Chemical Substances Papillomavirus Vaccines
    Language Japanese
    Publishing date 2015-07
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416200222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 398: Show issues Location:
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  6. Article: [The 40th scientific meeting: perspectives of internal medicine; present situation and future extension of organ transplantation in Japan 9. Summary].

    Ikeda, Shu-ichi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2013  Volume 102, Issue 3, Page(s) 592–593

    MeSH term(s) Brain Death ; Humans ; Internal Medicine/trends ; Japan ; Organ Transplantation
    Language Japanese
    Publishing date 2013-05-21
    Publishing country Japan
    Document type Editorial
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.102.592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 594: Show issues Location:
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  7. Article: [The 40th scientific meeting: perspectives of internal medicine; present situation and future extension of organ transplantation in Japan; 7. Liver transplanation for hereditary diseases].

    Ikeda, Shu-ichi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2013  Volume 102, Issue 3, Page(s) 582–584

    MeSH term(s) Genetic Diseases, Inborn/therapy ; Genetic Predisposition to Disease ; Humans ; Internal Medicine/trends ; Japan ; Liver Transplantation/methods ; Treatment Outcome
    Language Japanese
    Publishing date 2013-05-21
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.102.582
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    Zs.B 594: Show issues Location:
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  8. Article ; Online: Transthyretin Val30Met familial amyloid polyneuropathy: a considerably different clinical picture and natural course in endemic and non-endemic areas.

    Ikeda, Shu-ichi

    Journal of neurology, neurosurgery, and psychiatry

    2012  Volume 83, Issue 2, Page(s) 121

    MeSH term(s) Amyloid Neuropathies, Familial/genetics ; Female ; Humans ; Male ; Prealbumin/genetics
    Chemical Substances Prealbumin
    Language English
    Publishing date 2012-02
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2011-301582
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    Ui II Zs.93: Show issues Location:
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  9. Article ; Online: [Pathogenesis and treatment of brachial plexus neuritis].

    Ikeda, Shu-Ichi

    Rinsho shinkeigaku = Clinical neurology

    2013  Volume 53, Issue 11, Page(s) 969–973

    Abstract: Neuralgic amyotrophy (NA, also known as Parsonage-Turner syndrome) is a distinct peripheral nervous system (PNS) disorder, characterized by sudden attacks of severe neuropathic pain usually in the shoulder and/or arm. The neuralgia commonly disappears ... ...

    Abstract Neuralgic amyotrophy (NA, also known as Parsonage-Turner syndrome) is a distinct peripheral nervous system (PNS) disorder, characterized by sudden attacks of severe neuropathic pain usually in the shoulder and/or arm. The neuralgia commonly disappears after a few days to weeks, and consequently patchy paresis with amyotrophy appears. The available evidence suggests that NA is essentially idiopathic immune-mediated neuritis of the brachial plexus, and also has a complex pathogenesis that includes an underlying predisposition, susceptibility to dysfunction of some PNS structure, and a trigger for the attacks, such as viral infection, vaccination, trauma, surgery, and strenuous exercise. Genetic factors also contribute to the pathogenesis of NA, and thus, this disorder occurs in both idiopathic and hereditary forms, but hereditary one is considered to be 10 times less common than idiopathic one. NA has been considered to be self-limiting, benign disorder showing good recovery without specific treatments. However, recent studies have indicated that the long-term prognosis of NA is less favorable than has been assumed. In 2009, a Cochrane review identified one open label, retrospective series, the results of which suggested that administration of corticosteroids in the acute phase of NA could shorten the duration of painful symptoms and also accelerate recovery in some patients. We recently have reported that intravenous immunoglobulin (IVIg) with methylpredonisolone pulse therapy is effective for motor impairment of NA.
    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Brachial Plexus Neuritis/diagnosis ; Brachial Plexus Neuritis/etiology ; Brachial Plexus Neuritis/therapy ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Immunomodulation ; Methylprednisolone/administration & dosage ; Prognosis ; Pulse Therapy, Drug ; Time Factors
    Chemical Substances Adrenal Cortex Hormones ; Immunoglobulins, Intravenous ; Methylprednisolone (X4W7ZR7023)
    Language Japanese
    Publishing date 2013-09-05
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.53.969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Human Papillomavirus (HPV) Vaccination Safety Assessment: The Methods Matter.

    Kinoshita, Tomomi / Ikeda, Shu-ichi

    Internal medicine (Tokyo, Japan)

    2015  Volume 54, Issue 19, Page(s) 2533

    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Comment ; Letter
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.54.4876
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    Zs.A 240: Show issues Location:
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