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Article ; Online: Effect of ultrasound geometry on the production efficiency of damaged starch: Determining rheology parameters, and non-isothermal reaction kinetics.

Roohi, Reza / Abedi, Elahe / Hashemi, Seyed Mohammad Bagher / Akbari, Masoud

2024 Volume 106, Page(s) 106882

Abstract: ... dissipated power decreases from 8.43 to 0.655 mW/m ...

Abstract	Present study investigates the effects of probe size geometry on thermodynamic kinetics, rheology, and microstructure of wheat and tapioca starch. Ultrasound treatment using different probe diameters (20 mm and 100 mm) significantly influenced the gelatinization process. Results showed reduced enthalpy (ΔH) and Gibbs energy (ΔG), indicating enhanced gelatinization efficiency. According to the results, using a 20 mm and 100 mm probe leads to a reduction of 52.7 % and 68.6 % in reaction enthalpy for wheat starch compared to native starch, respectively. Microstructure analysis revealed structural changes, with ultrasound treatment leading to granular fractures and a sheet-like structure with air bubbles. The rheological behavior of the starches is found to exhibit shear thinning behavior, with the Casson model providing the best fit for the experimental data. Moreover, rheology modeling using Herschel-Bulkley and power law models showed increased viscosity and shear stress in larger probes. Numerical simulation data demonstrated that probe size influenced ultrasonic pressure, sound pressure level, and thermal power dissipation density, affecting fluid motion and velocity field components. Moreover, the maximum dissipated power decreases from 8.43 to 0.655 mW/m
Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2024.106882
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Article: Clear aligner therapy versus conventional brackets: Oral impacts over time.

Hashemi, Sara / Hashemi, Seyed Saman / Tafti, Kioumars Tavakoli / Khademi, Seyed Sobhan / Ariana, Niyosha / Ghasemi, Shohreh / Dashti, Mahmood / Ghanati, Hamed / Mansourian, Marjan

Dental research journal

2024 Volume 21, Page(s) 6

Abstract: Background: The objective is to compare the impact of clear aligner treatment (CAT) versus conventional fixed appliance treatment (FAT) on oral health-related quality of life (OHRQoL) among adults at five-time points: pretreatment (T0), 1 week (T1), 1 ... ...

Abstract	Background: The objective is to compare the impact of clear aligner treatment (CAT) versus conventional fixed appliance treatment (FAT) on oral health-related quality of life (OHRQoL) among adults at five-time points: pretreatment (T0), 1 week (T1), 1 month after (T2), and 6 months after (T3) treatment initiation, and in the long-term follow-up (T4). Materials and methods: Search terms were based on Medical Subject Headings (MeSH) and non-MeSH. Potentially eligible studies compared OHRQoL in clear aligner (CA) and fixed appliance (FA) patients. In February 2023, Scopus, Web of Science, Cochrane, and PubMed were searched for published studies. Nine out of 94 shortlisted papers were eligible for a systematic review. Of these nine papers, five studies were considered for a meta-analysis. Results: At T0, CA and FA patients had similar oral health impact profile (OHIP)-14 questionnaire scores with a standard mean difference (SMD) of 0.105 (confidence interval [CI]: -1.029-1.48). The SMD of the OHRQoL related to T1, T2, and T3 was -3.119 (CI: -0.145, 0.355), -1.527 (CI: -5.597, -0.64), and - 2.331 (CI: -1.906, -1.148). T4 showed no difference between groups (SMD = 0.007, CI: CI: -4.286, -0.376). Regarding the OHIP-14 domains, functional limitations remained consistent in both groups across all time intervals. Psychological discomfort exhibited a notable difference only at T2. Throughout the treatment, CAT showed significantly lower levels of physical, psychological, and social disability, as well as handicap, though these differences did not persist beyond T4. Notably, physical pain was the sole domain that remained elevated in the FAT group up to T4. Conclusion: During the 1
Language	English
Publishing date	2024-01-25
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2418290-4
ISSN	2008-0255 ; 1735-3327
ISSN (online)	2008-0255
ISSN	1735-3327
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Article ; Online: Report of an Iranian child with chronic abdominal pain and constipation diagnosed as glycogen storage disease type IX: a case report.

Zamanfar, Daniel / Hashemi-Soteh, Seyed MohammadBagher / Ghazaiean, Mobin / Keyhanian, Elham

Journal of medical case reports

2024 Volume 18, Issue 1, Page(s) 14

Abstract: Background: Glycogen storage disease type IX is a rare disorder that can cause a wide variety of symptoms depending on the specific deficiency of the phosphorylase kinase enzyme and the organs it affects.: Case presentation: A 4-and-a-half-year-old ... ...

Abstract	Background: Glycogen storage disease type IX is a rare disorder that can cause a wide variety of symptoms depending on the specific deficiency of the phosphorylase kinase enzyme and the organs it affects. Case presentation: A 4-and-a-half-year-old Caucasian girl was referred to our clinic with a liver biopsy report indicating a diagnosis of glycogen storage disease. Prior to being referred to our clinic, the patient had been under the care of pediatric gastroenterologists. The patient's initial symptoms included chronic abdominal pain, constipation, and elevated liver transaminase. With the help of the pediatric gastroenterologists, cholestasis, Wilson disease, and autoimmune hepatitis were ruled out. Given that glycogen storage diseases type I and type III are the most common, we initially managed the patient with frequent feedings and a diet that included complex carbohydrates such as a corn starch supplement and a lactose restriction. Following an unfavorable growth velocity and hepatomegaly during the follow-up period, genetic analysis was conducted, which revealed a novel mutation of the phosphorylase kinase regulatory subunit beta gene- a c.C412T (P.Q138x) mutation. As the diagnosis of glycogen storage disease type IX was confirmed, the treatment regimen was altered to a high protein diet (more than 2 g/kg/day) and a low fat diet. Conclusion: Given the mild and varied clinical manifestations of glycogen storage disease type IX, it is possible for the diagnosis to be overlooked. It is important to consider glycogen storage disease type IX in children who present with unexplained hepatomegaly and elevated transaminase levels. Furthermore, due to the distinct management of glycogen storage disease type IX compared with glycogen storage disease type I and glycogen storage disease type III, genetic analysis is essential for an accurate diagnosis.
MeSH term(s)	Child, Preschool ; Female ; Humans ; Abdominal Pain/etiology ; Constipation ; Glycogen Storage Disease/diagnosis ; Glycogen Storage Disease/genetics ; Glycogen Storage Disease/pathology ; Glycogen Storage Disease Type I/complications ; Glycogen Storage Disease Type I/diagnosis ; Glycogen Storage Disease Type I/genetics ; Hepatomegaly/pathology ; Iran ; Liver/pathology ; Mutation ; Phosphorylase Kinase/genetics ; Phosphorylase Kinase/metabolism ; Transaminases
Chemical Substances	Phosphorylase Kinase (EC 2.7.1.19) ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04295-0
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Article: Frequency of PAH Mutations Among Classic Phenylketon Urea Patients in Mazandaran and Golestan Provinces, North of Iran.

Hosseini, Elaheh / Mousavi, Seyed S / Zamanfar, Daniel / Hashemi-Soteh, S M Bagher

Clinical laboratory

2022 Volume 68, Issue 1

Abstract: Background: Phenylketonuria (PKU) is the most common aminoacidopathy with an autosomal recessive inheritance pattern. A global PKU prevalence is estimated about 6.002 in 100,000 newborns. In Iran, the prevalence of PKU is estimated at about 1 in 4,698, ... ...

Abstract	Background: Phenylketonuria (PKU) is the most common aminoacidopathy with an autosomal recessive inheritance pattern. A global PKU prevalence is estimated about 6.002 in 100,000 newborns. In Iran, the prevalence of PKU is estimated at about 1 in 4,698, and it shows an increasing trend from north (0.0015%) to south (0.02%) of the country. Untreated PKU causes mental retardation, microcephaly, and seizure. PAH gene mutations located at chromosome 12q23 are responsible for the classical type of this disease. The spectrum of PAH mutations is varied in different ethnicities and different parts of the world. The aim of this study was to investigate the frequency of PAH mutation in the Mazandaran province, which could be useful for genetic counseling and prenatal diagnosis. Methods: A total of 66 individuals from 33 families from two provinces (9 families from Golestan and 24 families from Mazandaran) from north of Iran participated in this study. After genomic DNA extraction, PAH gene analysis was carried out using DNA sequencing of both coding and non-coding regions by ABI 3130XL genetic analyzer. Results: Twenty-six different mutations were identified in the PAH gene in this study. Four mutations including IVS10-11 (c.1066-11G>A), c.727C>T (p.Arg243X), c.898G>T (p.Ala300Ser), and c.601C>T (p.His201Tyr) were the most common mutations with 37.48% frequency in Mazandaran province. Most frequent mutations in Golestan province were IVSI0-11 (c.1066-11G>A), c.722delG (p.Arg241fs), c.842C>T (p.Pro281Leu), and IVSII+5 (G>A) with frequency 58.57%. Conclusions: The results from the present study verify heterogeneity of the PAH gene and may help to diagnose tests for carrier detection and prenatal diagnosis of the PKU disease in Iranian population.
MeSH term(s)	Gene Frequency ; Genetics, Population ; Humans ; Infant, Newborn ; Iran/epidemiology ; Mutation ; Phenylalanine Hydroxylase/genetics ; Phenylketonurias/diagnosis ; Phenylketonurias/epidemiology ; Phenylketonurias/genetics ; Urea
Chemical Substances	Urea (8W8T17847W) ; Phenylalanine Hydroxylase (EC 1.14.16.1)
Language	English
Publishing date	2022-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2021.210512
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Ud II Zs.170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Transport and accumulation of microplastics through wastewater treatment sludge processes.

Alavian Petroody, Somayye Sadat / Hashemi, Seyed Hossein / van Gestel, Cornelis A M

Chemosphere

2021 Volume 278, Page(s) 130471

Abstract: Wastewater treatment plants (WWTPs) are important routes for releasing microplastics into the environment, with the produced sludge acting as a recipient of microplastics from wastewater. There is little information on the impact of sludge processes on ... ...

Abstract	Wastewater treatment plants (WWTPs) are important routes for releasing microplastics into the environment, with the produced sludge acting as a recipient of microplastics from wastewater. There is little information on the impact of sludge processes on the number of microplastics in sludge. In this study, the presence of microplastics in sludge produced by the Sari WWTP in northern Iran was investigated. Samples were taken in 3 replications and microplastics larger than 37 μm were extracted. The sludge from primary settling tank, clarifier, after sludge thickener and after aerobic digester, and after dewatering contained 214, 206, 200, 238, and 129 microplastics/g dry weight, respectively. According to the amount of sludge produced for each unit, this equals 280, 362, 599, 601, and 276 million microplastics/day, respectively, of which more than 85% were fibers. The numbers of microplastics in the sludge from the output of the sludge thickener and the aerobic digester did not significantly differ. However, their numbers decreased by more than 50% after dewatering, probably due to the destruction of flocs in the digestive process and the release of attached microplastics, which are returned into the wastewater treatment process with the rejected water. Polyester and polyethylene were the predominant types of fibers and particles, respectively. Given the annual amount of sludge produced, more than 100 billion microplastics enter the environment per year. Wastewater sludge, therefore, is an important source for the emission of microplastics, especially fibers, to the environment, warranting further evaluation of the associated environmental hazards.
MeSH term(s)	Environmental Monitoring ; Iran ; Microplastics ; Plastics ; Sewage ; Waste Disposal, Fluid ; Waste Water ; Water Pollutants, Chemical/analysis ; Water Purification
Chemical Substances	Microplastics ; Plastics ; Sewage ; Waste Water ; Water Pollutants, Chemical
Language	English
Publishing date	2021-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.130471
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Zs.A 2540: Show issues

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Article ; Online: UV Light Causes Structural Changes in Microplastics Exposed in Bio-Solids.

Alavian Petroody, Somayye Sadat / Hashemi, Seyed Hossein / Škrlep, Luka / Mušič, Branka / van Gestel, Cornelis A M / Sever Škapin, Andrijana

Polymers

2023 Volume 15, Issue 21

Abstract: Bio-solids (biological sludge) from wastewater treatment plants are a significant source of the emission of microplastics (MPs) into the environment. Weakening the structure of MPs before they enter the environment may accelerate their degradation and ... ...

Abstract	Bio-solids (biological sludge) from wastewater treatment plants are a significant source of the emission of microplastics (MPs) into the environment. Weakening the structure of MPs before they enter the environment may accelerate their degradation and reduce the environmental exposure time. Therefore, we studied the effect of UV-A and UV-C, applied at 70 °C, on three types of MPs, polypropylene (PP), polyethylene (PE), and polyethylene terephthalate (PET), that are commonly found in sewage sludge, using three shapes (fibers, lines, granules). The MPs were exposed to UV radiation in bio-solid suspensions, and to air and water as control. The structural changes in and degradation of the MPs were investigated using Attenuated Total Reflectance-Fourier Transform Infrared Spectrometry (ATR-FTIR) and surface morphology was performed with SEM analysis. UV exposure led to the emergence of carbonyl and hydroxyl groups in all of the PP samples. In PE and PET, these groups were formed only in the bio-solid suspensions. The presence of carbonyl and hydroxyl groups increased with an increasing exposure time. Overall, UV radiation had the greatest impact on the MPs in the bio-solids suspension. Due to the surface-to-volume ratio of the tested samples, which influences the degradation rate, the fibers were more degraded than the other two plastic shapes. UV-A was slightly more effective at degrading the MPs than UV-C. These findings show that ultraviolet radiation in combination with an elevated temperature affects the structure of polymers in wastewater bio-solids, which can accelerate their degradation.
Language	English
Publishing date	2023-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15214322
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Article ; Online: Determinants of Self-monitoring of Blood Glucose in Iranian Children and Adolescents with Type 1 Diabetes.

Fayyaz, Farimah / Khosravi, Sepehr / Mosallanejad, Asieh / Tabatabaei-Malazy, Ozra / Hashemi Nazari, Seyed Saeed / Shaghaghi, Maede

International journal of endocrinology and metabolism

2023 Volume 21, Issue 4, Page(s) e138377

Abstract: ... 37.45 ± 15.51 kg, and 18.31 ± 3.55 kg/m: Conclusions: This study underscores the significance ...

Abstract	Background: Type 1 diabetes mellitus (T1DM) is a prevalent chronic disease among children and adolescents, necessitating effective self-monitoring of blood glucose (SMBG) levels. Understanding the determinants and factors influencing SMBG behavior is crucial for optimizing diabetes management in this population. Objectives: This study aimed to investigate the frequency of SMBG and identify the determinants influencing factors in children and adolescents with T1DM. Methods: This cross-sectional study was conducted in Tehran, Iran, and included 275 participants selected through simple random sampling from the Gabric Diabetes Education Association. The inclusion criteria comprised children and adolescents aged 3 - 18 years diagnosed with T1DM for at least 6 months who were using analog or neutral protamine Hagedorn (NPH) and regular insulin subcutaneously. Patients using insulin pumps were excluded. Data collection involved an online questionnaire covering demographic information (e.g., age, gender, educational status, and parental occupations) as well as clinical information (number of hypoglycemic episodes, hemoglobin A1C (HbA1C) levels, diabetes duration, insulin regimen, diabetes complications, glucose monitoring practices, hospitalizations, and behavioral characteristics). Statistical analyses, including descriptive statistics, correlation tests, and Poisson regressions, were performed using SPSS software (version 21). A significance level of P-value < 0.05 was considered statistically significant. Results: The participants had a mean age of 10.00 ± 3.77 years, with 54.2% being males. Most of the participants (87.3%) were schoolchildren, and the mean age of diagnosis was 6.56 ± 3.73 years, with a mean duration of 44.72 ± 36.32 months. Anthropometric investigations revealed mean height, weight, and body mass index (BMI) values of 136.69 ± 21.11 cm, 37.45 ± 15.51 kg, and 18.31 ± 3.55 kg/m Conclusions: This study underscores the significance of SMBG in children and adolescents with T1DM. The findings emphasize the critical role of price and availability of glucometers and strips in achieving standard care for T1DM patients.
Language	English
Publishing date	2023-11-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2744447-8
ISSN	1726-9148 ; 1726-9148
ISSN (online)	1726-9148
ISSN	1726-9148
DOI	10.5812/ijem-138377
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Article: The effectiveness of neurodynamic techniques in patients with diabetic peripheral neuropathy: Study protocol for a randomized sham-controlled trial.

Ashoori, Mahdi / Pourahmadi, Mohammadreza / Hashemi, Seyed Ebrahim / Dadgoo, Mehdi / Hosseini, Mahboobeh Sadat

Advanced biomedical research

2024 Volume 13, Page(s) 6

Abstract: Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus (DM). DPN is the primary risk factor for diabetic foot ulcers that can cause amputation. Although several observational studies have ... ...

Abstract	Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus (DM). DPN is the primary risk factor for diabetic foot ulcers that can cause amputation. Although several observational studies have investigated the morphological and biomechanical characteristics of peripheral nerves in DPN, interventional studies regarding the effectiveness of neurodynamic techniques (NDT) in DPN patients are confined to a handful. The effects of NDT on neuropathy severity, nerve conduction parameters, quality of life (QoL), and mechanosensitivity have not been explored yet in this population. Materials and methods: Forty type 2 DPN (T2DPN) patients, diagnosed based on an electrodiagnosis study, will be recruited into two groups. The experimental group will receive the tibial nerve's real proximal and distal slider techniques in addition to DPN standard treatment as a basic treatment, and the control group will receive the tibial nerve's sham proximal and distal slider techniques along with the basic treatment for eight sessions twice a week. Baseline and post-intervention assessments will be based on the Michigan diabetic neuropathy score (MDNS) (primary outcome), tibial nerve conduction parameters, neuropathy-specific quality of life (Neuro QoL) questionnaire, and straight leg raising range of motion (SLR ROM) (secondary outcomes). Results: This study is expected to last approximately seven months, depending on recruitment. The results of the study will be published in a peer-reviewed journal. Conclusions: The present study will evaluate the efficacy of NDT on the primary and secondary outcome measurements in DPN patients.
Language	English
Publishing date	2024-01-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_180_23
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Article ; Online: A Systematic Review of the Impact of Resveratrol on Viral Hepatitis and Chronic Viral Hepatitis-related Hepatocellular Carcinoma.

Darvishi, Mohammad / Nouri, Majid / Rahimi, Rasoul / Heidari-Soureshjani, Saeid / Hashemi Rafsanjani, Seyed Mahmood Reza

Current molecular medicine

2024

Abstract: Background: Resveratrol (RSV) is used for the treatment of various diseases due to their anti-inflammatory and antioxidant activities. However, its beneficial aspects on viral hepatitis have been less investigated.: Objective: This report reviews the ...

Abstract	Background: Resveratrol (RSV) is used for the treatment of various diseases due to their anti-inflammatory and antioxidant activities. However, its beneficial aspects on viral hepatitis have been less investigated. Objective: This report reviews the impact of resveratrol on viral hepatitis and chronic viral hepatitis-related hepatocellular carcinoma (HCC). Methods: The systematic review was performed and reported according to the PRISMA 2020 statement. Several core databases, such as Cochrane Library, PubMed, Web of Science, EMBASE, and Scopus, were used for search on September 6, 2023. After extraction of the data, the desired information of the full text of the studies was recorded in Excel, and the outcomes and mechanisms were reviewed. Results: RSV inhibits viral replication through anti-HCV NS3 helicase activity, maintains redox homeostasis via glutathione (GSH) synthesis, improves T and B cell activity, and suppresses miR-155 expression. It also enhances viral replication by enhancing hepatitis C virus (HCV) RNA transcription, activating sirtuin-1 (SIRT1), which can increase peroxisome proliferator-activated receptor (PPAR), and SIRT1 activates the HBV X protein (HBx). Moreover, RSV is responsible for hepatitis-related HCC proliferation via suppression of mammalian target of rapamycin (mTOR), SIRT1 up-regulation, inhibiting expression of HBx, and reducing expression of cyclin D1. Conclusion: Despite the promising properties of RSV in inhibiting hepatitis-related HCC cell proliferation, its antiviral effects in viral hepatitis are controversial. The antihepatitis behaviors of RSV are mainly dose-dependent, and in some studies, activating some hepatoprotective pathways increases the transcription and replication of chronic HBV and HCV. Therefore, healthcare providers should be aware of viral hepatitis before using RSV supplements.
Language	English
Publishing date	2024-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064873-X
ISSN	1875-5666 ; 1566-5240
ISSN (online)	1875-5666
ISSN	1566-5240
DOI	10.2174/0115665240284347240125072555
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Article: Applications of SMILE-extracted lenticules in ophthalmology.

Aghamollaei, Hossein / Hashemi, Hassan / Fallahtafti, Mahsa / Daryabari, Seyed-Hashem / Khabazkhoob, Mehdi / Jadidi, Khosrow

International journal of ophthalmology

2024 Volume 17, Issue 1, Page(s) 173–187

Abstract: Aim: To review recent innovations, challenges, and applications of small incision lenticule extraction (SMILE) extracted lenticule for treating ocular disorders.: Methods: A literature review was performed in the PubMed database, which was last ... ...

Abstract	Aim: To review recent innovations, challenges, and applications of small incision lenticule extraction (SMILE) extracted lenticule for treating ocular disorders. Methods: A literature review was performed in the PubMed database, which was last updated on 30 December 2021. There was no limit regarding language. The authors evaluated the reference lists of the collected papers to find any relevant research. Results: Due to the simplicity and accuracy of modern femtosecond lasers and the extensive development of SMILE surgery, many healthy human corneal stromal lenticules were extracted during surgery, motivating some professionals to investigate the SMILE lenticule reusability in different ocular disorders. In addition, new approaches had been developed to preserve, modify, and bioengineer the corneal stroma, leading to the optimal use of discarded byproducts such as lenticules from SMILE surgery. The lenticules can be effectively re-implanted into the autologous or allogenic corneas of human subjects to treat refractive errors, corneal ectasia, and corneal perforation and serve as a patch graft for glaucoma drainage devices with better cosmetic outcomes. Conclusion: SMILE-extracted lenticules could be a viable alternative to human donor corneal tissue.
Language	English
Publishing date	2024-01-18
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2024.01.23
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