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  1. Article ; Online: Breast Cancer Treatment and Diastolic Dysfunction: Should We Worry About Relaxing in Cardio-Oncology?

    Thavendiranathan, Paaladinesh / Calvillo-Argüelles, Oscar

    JACC. Cardiovascular imaging

    2019  Volume 13, Issue 1 Pt 2, Page(s) 211–214

    MeSH term(s) Anthracyclines ; Breast Neoplasms ; Humans ; Trastuzumab ; Ventricular Function, Left
    Chemical Substances Anthracyclines ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2019-09-18
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2019.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [No title information]

    Calvillo-Argüelles, Oscar / Ross, Heather J

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 46, Page(s) E1493

    Title translation Enjeux cardiaques chez les patients atteints de COVID-19.
    Keywords covid19
    Language French
    Publishing date 2020-11-16
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200562-f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Letter to the editor: Increased sensitivity to ischemic interval of donor hearts with diminished left ventricular function.

    Calvillo-Argüelles, Oscar / Foroutan, Farid / Duero Posada, Juan

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2020  Volume 39, Issue 11, Page(s) 1323

    MeSH term(s) Heart Transplantation ; Humans ; Ischemia ; Tissue Donors ; Ventricular Function, Left
    Language English
    Publishing date 2020-03-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2020.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cardiac considerations in patients with COVID-19.

    Calvillo-Argüelles, Oscar / Ross, Heather J

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 23, Page(s) E630

    MeSH term(s) Arrhythmias, Cardiac/etiology ; Betacoronavirus ; Biomarkers/blood ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Myocardial Infarction/etiology ; Myocardium/pathology ; Natriuretic Peptides/blood ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Troponin/blood ; Ventricular Dysfunction, Left/etiology
    Chemical Substances Biomarkers ; Natriuretic Peptides ; Troponin
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200562
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  5. Article ; Online: Anthracycline-induced cardiomyopathy: cellular and molecular mechanisms.

    Dadson, Keith / Calvillo-Argüelles, Oscar / Thavendiranathan, Paaladinesh / Billia, Filio

    Clinical science (London, England : 1979)

    2020  Volume 134, Issue 13, Page(s) 1859–1885

    Abstract: Despite the known risk of cardiotoxicity, anthracyclines are widely prescribed chemotherapeutic agents. They are broadly characterized as being a robust effector of cellular apoptosis in rapidly proliferating cells through its actions in the nucleus and ... ...

    Abstract Despite the known risk of cardiotoxicity, anthracyclines are widely prescribed chemotherapeutic agents. They are broadly characterized as being a robust effector of cellular apoptosis in rapidly proliferating cells through its actions in the nucleus and formation of reactive oxygen species (ROS). And, despite the early use of dexrazoxane, no effective treatment strategy has emerged to prevent the development of cardiomyopathy, despite decades of study, suggesting that much more insight into the underlying mechanism of the development of cardiomyopathy is needed. In this review, we detail the specific intracellular activities of anthracyclines, from the cell membrane to the sarcoplasmic reticulum, and highlight potential therapeutic windows that represent the forefront of research into the underlying causes of anthracycline-induced cardiomyopathy.
    MeSH term(s) Animals ; Anthracyclines/toxicity ; Antineoplastic Agents/toxicity ; Cardiomyopathies/etiology ; Cardiomyopathies/genetics ; Cardiomyopathies/metabolism ; Cell Membrane/drug effects ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Cell Nucleus/drug effects ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Humans
    Chemical Substances Anthracyclines ; Antineoplastic Agents
    Language English
    Publishing date 2020-07-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20190653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Evaluation of Risk Prediction Models to Identify Cancer Therapeutics Related Cardiac Dysfunction in Women with HER2+ Breast Cancer.

    Suntheralingam, Sivisan / Fan, Chun-Po Steve / Calvillo-Argüelles, Oscar / Abdel-Qadir, Husam / Amir, Eitan / Thavendiranathan, Paaladinesh

    Journal of clinical medicine

    2022  Volume 11, Issue 3

    Abstract: Cancer-therapeutics-related cardiac dysfunction (CTRCD) is an important concern in women receiving trastuzumab therapy for HER2+ breast cancer. However, the ability to assess CTRCD risk remains limited. In this retrospective cohort study, we apply three ... ...

    Abstract Cancer-therapeutics-related cardiac dysfunction (CTRCD) is an important concern in women receiving trastuzumab therapy for HER2+ breast cancer. However, the ability to assess CTRCD risk remains limited. In this retrospective cohort study, we apply three published risk prediction models (Ezaz et al., NSABP-31 cardiac risk scores (CRS), and HFA-ICOS trastuzumab proforma) to 629 women (mean age 52.4 ± 10.9 years) with Stage I-III HER2+ breast cancer treated with trastuzumab ± anthracyclines to assess their performance to identify CTRCD during or immediately post treatment. Using these models, patients were classified into CTRCD risk categories according to the pre-treatment characteristics. With NSABP-31 CRS and HFA-ICOS proformas, patients in the highest risk category had a 1.7-to-2.4-fold higher relative risk of CTRCD than the low-risk category (
    Language English
    Publishing date 2022-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11030847
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  8. Article ; Online: Immune checkpoint inhibitor-related myocarditis: an illustrative case series of applying the updated Cardiovascular Magnetic Resonance Lake Louise Criteria.

    Wintersperger, Bernd J / Calvillo-Argüelles, Oscar / Lheureux, Stephanie / Houbois, Christian P / Spreafico, Anna / Bedard, Philippe L / Neilan, Tomas G / Thavendiranathan, Paaladinesh

    European heart journal. Case reports

    2022  Volume 6, Issue 1, Page(s) ytab478

    Abstract: Background: Immune checkpoint inhibitors (ICIs) have improved outcomes for many types of cancer. However, ICI therapies are associated with the development of myocarditis, an immune-mediated adverse event associated with a high mortality rate. Therefore, ...

    Abstract Background: Immune checkpoint inhibitors (ICIs) have improved outcomes for many types of cancer. However, ICI therapies are associated with the development of myocarditis, an immune-mediated adverse event associated with a high mortality rate. Therefore, prompt diagnosis and early intervention are of outmost importance. There is limited data on the application of cardiovascular magnetic resonance (CMR)-based modified Lake Louise Criteria (mLLC) with the use of relaxometry techniques for the diagnosis of ICI myocarditis.
    Case summary: Four cancer patients undergoing ICI treatment presented with various clinical symptoms and troponin elevation to emergency/ambulatory clinics within 10-21 days after ICI initiation. On the suspicion of possible ICI-related myocarditis all patients underwent CMR within a few days after admission. Applying mLLC including relaxometry techniques, all patients met 'non-ischaemic injury criteria', while 3/4 patients met 'oedema criteria'. In most patients, quantitative mapping revealed substantially increased T1 values, while T2 values were only mildly increased or normal. In two patients with follow-up, CMR demonstrated improvement in findings after immunosuppressive treatment. However, there was only limited agreement between the degree of high-sensitive troponin levels and T1/T2 levels.
    Discussion: The application of mLLC with T1/T2 mapping appears useful in the CMR diagnosis of acute ICI myocarditis with non-ischaemic myocardial injury criteria being the most common finding. The sensitivity of native T1 appears higher than T2 mapping in the acute diagnosis as well as in the assessment of treatment response. As troponin elevations may persist for some time with ICI myocarditis, CMR may represent an alternate strategy to monitor treatment response.
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab478
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  9. Article ; Online: Cardiovascular Collapse in COVID-19 Infection: The Role of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).

    Chow, Justin / Alhussaini, Anhar / Calvillo-Argüelles, Oscar / Billia, Filio / Luk, Adriana

    CJC open

    2020  Volume 2, Issue 4, Page(s) 273–277

    Abstract: Coronavirus Disease 2019 (COVID-19) has been associated with cardiovascular complications, including acute cardiac injury, heart failure, and cardiogenic shock (CS). The role of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the event of ... ...

    Abstract Coronavirus Disease 2019 (COVID-19) has been associated with cardiovascular complications, including acute cardiac injury, heart failure, and cardiogenic shock (CS). The role of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the event of COVID-19-associated cardiovascular collapse has not been established. We reviewed the existing literature surrounding the role of VA-ECMO in the treatment of coronavirus-related cardiovascular collapse. COVID-19 is associated with a higher incidence of cardiovascular complications compared with previous coronavirus outbreaks (Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus). We found only 1 case report from China in which COVID-19-associated fulminant myocarditis and CS were successfully rescued using VA-ECMO as a bridge to recovery. We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state or coagulopathy, severe acute respiratory distress syndrome, multiorgan failure, or high-risk prognostic scores) specific to using VA-ECMO as a bridge to recovery in COVID-19 infection. Additional considerations and proposed recommendations specific to the COVID-19 pandemic were formulated with guidance from published data and expert consensus. A small subset of patients with cardiovascular complications from COVID-19 infection may progress to refractory CS. While accepting that resource scarcity may be the overwhelming concern for healthcare systems during this pandemic, VA-ECMO can be considered in highly selected cases of refractory CS and echocardiographic evidence of biventricular failure. The decision to initiate this therapy should take into consideration the availability of resources, perceived benefit, and risks of transmitting disease.
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2020.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Trastuzumab-Related Cardiotoxicity and Cardiac Care in Patients With HER2 Positive Metastatic Breast Cancer.

    Calvillo-Argüelles, Oscar / Abdel-Qadir, Husam / Suntheralingam, Sivisan / Michalowska, Maria / Amir, Eitan / Thavendiranathan, Paaladinesh

    The American journal of cardiology

    2020  Volume 125, Issue 8, Page(s) 1270–1275

    Abstract: Prolonged trastuzumab therapy is the standard of care for women with metastatic HER2 positive (HER2+) breast cancer. There are limited data on the incidence of cardiotoxicity, its treatment implication, and cardiac care in these patients. We ... ...

    Abstract Prolonged trastuzumab therapy is the standard of care for women with metastatic HER2 positive (HER2+) breast cancer. There are limited data on the incidence of cardiotoxicity, its treatment implication, and cardiac care in these patients. We retrospectively identified consecutive women who received >12 months of trastuzumab treatment at Princess Margaret Cancer Centre (Toronto, ON) from 2007 to 2012 for metastatic HER2 positive breast cancer and followed them until death or August 2018. Patients were included if a pretherapy multigated acquisition scan and ≥2 subsequent follow-up scans were available. The Cardiac Review and Evaluation Committee Criteria were used to identify cardiotoxicity. Baseline characteristics and outcomes (final left ventricular ejection fraction, change in LVEF, trastuzumab interruption) were compared in patients with and without cardiotoxicity. Cardiac care and treatment received were recorded. Sixty patients (mean age 52 ± 10.4 years) were included. The median trastuzumab exposure was 37 cycles (interquartile range 23 to 56) over 28 months (interquartile range 19 to 49) and 48% received previous anthracycline therapy. The cumulative incidence of cardiotoxicity was 35% (95% CI 23 to 48) at 3 years. Patients who developed cardiotoxicity were more likely to receive third-line cancer treatments and had lower final LVEF than patients without (54.9% ± 6.3% vs 64% ± 4.9%, p <0.001). Of the 23 patients with cardiotoxicity, 10 (43%) had trastuzumab interrupted for at least 1 cycle, only 7 (30%) patients were seen by a cardiologist and 4 (17%) received cardiac medications. In conclusion, patients with metastatic breast cancer receiving prolonged trastuzumab therapy appear to have high rates of cardiotoxicity. This was associated with high rates of trastuzumab interruption, but low rates of cardiology referral and cardiac treatment, reflecting a potential cardiac care gap.
    MeSH term(s) Adult ; Anthracyclines/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use ; Antineoplastic Agents, Immunological/adverse effects ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/secondary ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cardiology ; Cardiotoxicity ; Cohort Studies ; Female ; Humans ; Incidence ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/secondary ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Middle Aged ; Neoplasm Metastasis ; Receptor, ErbB-2/metabolism ; Referral and Consultation ; Retrospective Studies ; Stroke Volume ; Taxoids/therapeutic use ; Trastuzumab/adverse effects ; Ventricular Dysfunction, Left/chemically induced ; Ventricular Dysfunction, Left/epidemiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy
    Chemical Substances Anthracyclines ; Antineoplastic Agents, Hormonal ; Antineoplastic Agents, Immunological ; Taxoids ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2020.01.029
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