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  1. Article ; Online: Cardiac effects and toxicity of chloroquine: a short update.

    Mubagwa, Kanigula

    International journal of antimicrobial agents

    2020  Volume 56, Issue 2, Page(s) 106057

    Abstract: There is currently increased interest in the use of the antimalarial drugs chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as coronavirus disease 2019 (COVID-19). However, the risk of ... ...

    Abstract There is currently increased interest in the use of the antimalarial drugs chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as coronavirus disease 2019 (COVID-19). However, the risk of cardiotoxic effects tends to limit their use. In this review, the effects of these drugs on the electrical and mechanical activities of the heart as well as on remodelling of cardiac tissue are presented and the underlying molecular and cellular mechanisms are discussed. The drugs can have proarrhythmic as well as antiarrhythmic actions resulting from their inhibition of ion channels, including voltage-dependent Na
    MeSH term(s) Betacoronavirus ; COVID-19 ; Chloroquine/adverse effects ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Chemical Substances Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2020.106057
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  2. Article: Emerging role of transient receptor potential (TRP) ion channels in cardiac fibroblast pathophysiology.

    Gwanyanya, Asfree / Mubagwa, Kanigula

    Frontiers in physiology

    2022  Volume 13, Page(s) 968393

    Abstract: Cardiac fibroblasts make up a major proportion of non-excitable cells in the heart and contribute to the cardiac structural integrity and maintenance of the extracellular matrix. During myocardial injury, fibroblasts can be activated to trans- ... ...

    Abstract Cardiac fibroblasts make up a major proportion of non-excitable cells in the heart and contribute to the cardiac structural integrity and maintenance of the extracellular matrix. During myocardial injury, fibroblasts can be activated to trans-differentiate into myofibroblasts, which secrete extracellular matrix components as part of healing, but may also induce cardiac fibrosis and pathological cardiac structural and electrical remodeling. The mechanisms regulating such cellular processes still require clarification, but the identification of transient receptor potential (TRP) channels in cardiac fibroblasts could provide further insights into the fibroblast-related pathophysiology. TRP proteins belong to a diverse superfamily, with subgroups such as the canonical (TRPC), vanilloid (TRPV), melastatin (TRPM), ankyrin (TRPA), polycystin (TRPP), and mucolipin (TRPML). Several TRP proteins form non-selective channels that are permeable to cations like Na
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.968393
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  3. Article: Cardiac effects and toxicity of chloroquine: a short update

    Mubagwa, Kanigula

    Int J Antimicrob Agents

    Abstract: There is currently increased interest in the use of the antimalarial drugs chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as coronavirus disease 2019 (COVID-19). However, the risk of ... ...

    Abstract There is currently increased interest in the use of the antimalarial drugs chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as coronavirus disease 2019 (COVID-19). However, the risk of cardiotoxic effects tends to limit their use. In this review, the effects of these drugs on the electrical and mechanical activities of the heart as well as on remodelling of cardiac tissue are presented and the underlying molecular and cellular mechanisms are discussed. The drugs can have proarrhythmic as well as antiarrhythmic actions resulting from their inhibition of ion channels, including voltage-dependent Na+ and Ca2+ channels, background and voltage-dependent K+ channels, and pacemaker channels. The drugs also exert a vagolytic effect due at least in part to a muscarinic receptor antagonist action. They also interfere with normal autophagy flux, an effect that could aggravate ischaemia/reperfusion injury or post-infarct remodelling. Most of the toxic effects occur at high concentrations, following prolonged drug administration or in the context of drug associations.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #611607
    Database COVID19

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  4. Article: Cardiac effects and toxicity of chloroquine: a short update

    Mubagwa, Kanigula

    International journal of antimicrobial agents. 2020 Aug., v. 56, no. 2

    2020  

    Abstract: There is currently increased interest in the use of the antimalarial drugs chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as coronavirus disease 2019 (COVID-19). However, the risk of ... ...

    Abstract There is currently increased interest in the use of the antimalarial drugs chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as coronavirus disease 2019 (COVID-19). However, the risk of cardiotoxic effects tends to limit their use. In this review, the effects of these drugs on the electrical and mechanical activities of the heart as well as on remodelling of cardiac tissue are presented and the underlying molecular and cellular mechanisms are discussed. The drugs can have proarrhythmic as well as antiarrhythmic actions resulting from their inhibition of ion channels, including voltage-dependent Na⁺ and Ca²⁺ channels, background and voltage-dependent K⁺ channels, and pacemaker channels. The drugs also exert a vagolytic effect due at least in part to a muscarinic receptor antagonist action. They also interfere with normal autophagy flux, an effect that could aggravate ischaemia/reperfusion injury or post-infarct remodelling. Most of the toxic effects occur at high concentrations, following prolonged drug administration or in the context of drug associations.
    Keywords Coronavirus infections ; Orthocoronavirinae ; antagonists ; autophagy ; calcium ; chloroquine ; heart ; ion channels ; ischemia ; muscarine receptors ; reperfusion injury ; risk ; toxicity
    Language English
    Dates of publication 2020-08
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2020.106057
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Matthew Amoni (March 13, 1991-October 3, 2022).

    Sipido, Karin R / Willems, Rik / Claus, Piet / Mubagwa, Kanigula / Kelly-Laubscher, Roisin / Katz, Arieh A / Gwanyanya, Asfree

    Heart rhythm

    2023  Volume 20, Issue 5, Page(s) 793–794

    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2023.03.012
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  6. Book: ACETYLCHOLINE AND THE ELECTROPHYSIOLOGICAL PROPERTIES OF RABBIT CARDIAC PURKINJE FIBRES

    MUBAGWA, KANIGULA

    1984  

    Size 175 S.
    Document type Book
    Note LEUVEN, UNIV., DISS., 1984
    HBZ-ID HT002734427
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    85 E 1243 order for loan Magazin

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  7. Article ; Online: Signalling between G-protein-coupled receptors and TASK1 channels.

    Mubagwa, Kanigula

    Cardiovascular research

    2012  Volume 97, Issue 1, Page(s) 10–12

    MeSH term(s) Animals ; Endothelin-1/pharmacology ; Ion Channel Gating ; Myocytes, Cardiac/enzymology ; Potassium Channel Blockers/pharmacology ; Potassium Channels, Tandem Pore Domain/antagonists & inhibitors ; Type C Phospholipases/metabolism
    Chemical Substances Endothelin-1 ; Potassium Channel Blockers ; Potassium Channels, Tandem Pore Domain ; potassium channel subfamily K member 3 (1HQ3YCN4GS) ; Type C Phospholipases (EC 3.1.4.-)
    Language English
    Publishing date 2012-11-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvs343
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    Zs.A 565: Show issues Location:
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  8. Article ; Online: Detection of TRPM6 and TRPM7 Proteins in Normal and Diseased Cardiac Atrial Tissue and Isolated Cardiomyocytes.

    Andriulė, Inga / Pangonytė, Dalia / Gwanyanya, Asfree / Karčiauskas, Dainius / Mubagwa, Kanigula / Mačianskienė, Regina

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Magnesium-sensitive transient receptor potential melastatin (TRPM) ion channels, TRPM6 and TRPM7, are present in several organs, but their roles in the heart remain unclear. Therefore, here, we studied the expression patterns of TRPM6 and TRPM7 in normal ...

    Abstract Magnesium-sensitive transient receptor potential melastatin (TRPM) ion channels, TRPM6 and TRPM7, are present in several organs, but their roles in the heart remain unclear. Therefore, here, we studied the expression patterns of TRPM6 and TRPM7 in normal and diseased myocardium. Cardiac atrial tissue and cardiomyocytes were obtained from healthy pigs and undiseased human hearts as well as from hearts of patients with ischemic heart disease (IHD) or atrial fibrillation (AF). Immunofluorescence and ELISA were used to detect TRP proteins. TRPM6 and TRPM7 immunofluorescence signals, localized at/near the cell surface or intracellularly, were detected in pig and human atrial tissues. The TRP channel modulators carvacrol (CAR, 100 µM) or 2-aminoethoxydiphenyl borate (2-APB, 500 µM) decreased the TRPM7 signal, but enhanced that of TRPM6. At a higher concentration (2 mM), 2-APB enhanced the signals of both proteins. TRPM6 and TRPM7 immunofluorescence signals and protein concentrations were increased in atrial cells and tissues from IHD or AF patients. TRPM6 and TRPM7 proteins were both detected in cardiac atrial tissue, with relatively similar subcellular localization, but distinctive drug sensitivity profiles. Their upregulated expression in IHD and AF suggests a possible role of the channels in cardiac atrial disease.
    Language English
    Publishing date 2022-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314860
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  9. Article ; Online: Modulation of the Cardiac Myocyte Action Potential by the Magnesium-Sensitive TRPM6 and TRPM7-like Current.

    Gwanyanya, Asfree / Andriulė, Inga / Istrate, Bogdan M / Easmin, Farjana / Mubagwa, Kanigula / Mačianskienė, Regina

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: The cardiac ... ...

    Abstract The cardiac Mg
    MeSH term(s) Action Potentials ; Animals ; Cations, Divalent ; Magnesium/metabolism ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/physiology ; Sus scrofa/metabolism ; Sus scrofa/physiology ; TRPM Cation Channels/metabolism ; TRPM Cation Channels/physiology
    Chemical Substances Cations, Divalent ; TRPM Cation Channels ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2021-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168744
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  10. Article ; Online: Detection of TRPM6 and TRPM7 Proteins in Normal and Diseased Cardiac Atrial Tissue and Isolated Cardiomyocytes

    Inga Andriulė / Dalia Pangonytė / Asfree Gwanyanya / Dainius Karčiauskas / Kanigula Mubagwa / Regina Mačianskienė

    International Journal of Molecular Sciences, Vol 23, Iss 14860, p

    2022  Volume 14860

    Abstract: Magnesium-sensitive transient receptor potential melastatin (TRPM) ion channels, TRPM6 and TRPM7, are present in several organs, but their roles in the heart remain unclear. Therefore, here, we studied the expression patterns of TRPM6 and TRPM7 in normal ...

    Abstract Magnesium-sensitive transient receptor potential melastatin (TRPM) ion channels, TRPM6 and TRPM7, are present in several organs, but their roles in the heart remain unclear. Therefore, here, we studied the expression patterns of TRPM6 and TRPM7 in normal and diseased myocardium. Cardiac atrial tissue and cardiomyocytes were obtained from healthy pigs and undiseased human hearts as well as from hearts of patients with ischemic heart disease (IHD) or atrial fibrillation (AF). Immunofluorescence and ELISA were used to detect TRP proteins. TRPM6 and TRPM7 immunofluorescence signals, localized at/near the cell surface or intracellularly, were detected in pig and human atrial tissues. The TRP channel modulators carvacrol (CAR, 100 µM) or 2-aminoethoxydiphenyl borate (2-APB, 500 µM) decreased the TRPM7 signal, but enhanced that of TRPM6. At a higher concentration (2 mM), 2-APB enhanced the signals of both proteins. TRPM6 and TRPM7 immunofluorescence signals and protein concentrations were increased in atrial cells and tissues from IHD or AF patients. TRPM6 and TRPM7 proteins were both detected in cardiac atrial tissue, with relatively similar subcellular localization, but distinctive drug sensitivity profiles. Their upregulated expression in IHD and AF suggests a possible role of the channels in cardiac atrial disease.
    Keywords TRPM6 and TRPM7 channels ; atrial myocyte and tissue ; ischemic heart disease ; atrial fibrillation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610 ; 616
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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