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Article ; Online: Staphylococcus lugdunensis

Silvis, M J M / van den Heuvel, F M A / van Garsse, L / Nijveldt, R

European heart journal. Case reports

2023 Volume 7, Issue 4, Page(s) ytad164

Abstract: Background: Staphylococcus lugdunensis: Case summary: A 74-year-old female with a history of asymptomatic severe aortic valve stenosis and permanent atrial fibrillation presented with acute onset of fever (39.0°C). Electrocardiogram showed diffuse ST- ...

Abstract	Background: Staphylococcus lugdunensis Case summary: A 74-year-old female with a history of asymptomatic severe aortic valve stenosis and permanent atrial fibrillation presented with acute onset of fever (39.0°C). Electrocardiogram showed diffuse ST-segment elevation. She was hospitalized for further analysis. All blood cultures were positive for Conclusion: Staphylococcus lugdunensis
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad164
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Article ; Online: A qualitative evaluation of the oncologists', neurologists', and pain specialists' views on the management and care of chemotherapy-induced peripheral neuropathy in The Netherlands.

van Haren, F G A M / Steegers, M A H / Vissers, K C P / van den Heuvel, S A S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2024 Volume 32, Issue 5, Page(s) 301

Abstract: Purpose: In treating cancer, different chemotherapy regimens cause chemotherapy-induced peripheral neuropathy (CIPN). Despite recent international guidelines, a gold standard for diagnosis, treatment, and care is lacking. To identify the current ... ...

Abstract	Purpose: In treating cancer, different chemotherapy regimens cause chemotherapy-induced peripheral neuropathy (CIPN). Despite recent international guidelines, a gold standard for diagnosis, treatment, and care is lacking. To identify the current clinical practice and the physicians' point of view and ideas for improvement, we evaluated CIPN care by interviewing different specialists involved. Methods: We performed semi-structured, audio-recorded, transcribed, and coded interviews with a purposive sample of oncologists, pain specialists, and neurologists involved in CIPN patients' care. Data is analyzed by a constant comparative method for content analysis, using ATLAS.ti software. Codes, categories, and themes are extracted, generating common denominators and conclusions. Results: With oncologists, pain specialists, and neurologists, nine, nine, and eight interviews were taken respectively (including three, two, and two interviews after thematic saturation occurred). While useful preventive measures and predictors are lacking, patient education (e.g., on symptoms and timely reporting) is deemed pivotal, as is low-threshold screening (e.g., anamnesis and questionnaires). Diagnosis focusses on a temporal relationship to chemotherapy, with adjuvant testing (e.g., EMG) used in severe or atypical cases. Symptomatic antineuropathic and topical medication are often prescribed, but personalized and multidimensional care based on individual symptoms and preferences is highly valued. The limited efficacy of existing treatments, and the lack of standardized protocols, interdisciplinary coordination, and awareness among healthcare providers pose significant challenges. Conclusion: Besides the obvious need for better therapeutic options, and multidisciplinary exploration of patients' perspectives, a structured and collaborative approach towards diagnosis, treatment, referral, and follow-up, nurtured by improving knowledge and use of existing CIPN guidelines, could enhance care.
MeSH term(s)	Humans ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/therapy ; Netherlands ; Oncologists ; Antineoplastic Agents/adverse effects ; Neurologists ; Attitude of Health Personnel ; Qualitative Research ; Male ; Female ; Interviews as Topic ; Neoplasms/drug therapy ; Middle Aged ; Pain Management/methods
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-04-22
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-024-08493-4
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Zs.A 3697: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Influence of stressful life events and personality traits on PLN cardiomyopathy severity: an exploratory study.

van Drie, E / Taal, S E L / Schmidt, A F / Verstraelen, T E / de Brouwer, R / Schoormans, D / Mommersteeg, P M C / de Boer, R A / Wilde, A A M / Asselbergs, F W / Baas, A F / van Tintelen, J P / van den Heuvel, L M

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2024 Volume 26, Issue 1

MeSH term(s)	Humans ; Personality ; Stress, Psychological/complications ; Cardiomyopathies/complications
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Letter
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euad368
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Zs.A 5434: Show issues

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Article ; Online: Ex Vivo Test of Complement Dysregulation in Atypical Hemolytic Uremic Syndrome Kidney Transplant patients: A Pilot Study.

Duineveld, Caroline / Bouwmeester, Romy N / van den Heuvel, Lambertus P W J / van de Kar, Nicole C A J / Wetzels, Jack F M

Kidney international reports

2023 Volume 9, Issue 1, Page(s) 145–151

Abstract: Introduction: In 2014, a complement assay, which evaluates C5b-9 deposition on endothelial cells, was proposed as a biomarker for atypical hemolytic uremic syndrome (aHUS). Early diagnosis and/or prediction of aHUS (relapse) is pivotal in aHUS kidney ... ...

Abstract	Introduction: In 2014, a complement assay, which evaluates C5b-9 deposition on endothelial cells, was proposed as a biomarker for atypical hemolytic uremic syndrome (aHUS). Early diagnosis and/or prediction of aHUS (relapse) is pivotal in aHUS kidney transplant recipients who do not receive eculizumab prophylaxis. Methods: In this pilot study, serum samples of transplanted patients with aHUS in remission without eculizumab and patients with other primary kidney diseases (controls) were blinded and evaluated in the complement assay. Results: We included 13 patients with aHUS (4 males, 9 females) of median age of 54 years (range: 35-69) and median of 5.9 years (range: 0.25-14.1) after transplantation; and 13 controls (7 males, 6 females) of median age of 42 years (range: 27-60) and median of 5.8 years (range: 1.6-11.7) after transplantation. There were no significant differences in C5b-9 deposits between patients with aHUS and controls on resting cells (median of 136% [range: 93%-382%] and 121% [range: 75%-200%], respectively) and activated cells (median of 196% [range: 99%-388%] and 170% [range: 113%-260%], respectively). Three patients with aHUS and 4 controls showed elevated C5b-9 deposits on resting cells, which should correspond to active aHUS. None of these patients had laboratory signs of thrombotic microangiopathy (TMA). During follow-up (15.8 months, range: 6-21), estimated glomerular filtration rate remained stable in all. In 5 patients with aHUS with a genetic variant, no increase in C5b-9 deposits was found on activated endothelial cells, which contrasts with the literature suggesting that the test should identify carriers of a genetic variant. Conclusion: Our data question the routine use of the
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2023.10.003
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Article ; Online: Corrigendum to "Comparative Analysis of Radiotherapy Linear Accelerator Downtime and Failure Modes in the UK, Nigeria and Botswana" [Clinical Oncology 32 (2020) e111-e118].

Wroe, L M / Ige, T A / Asogwa, O C / Aruah, S C / Grover, S / Makufa, R / Fitz-Gibbon, M / Coleman, N / Dosanjh, M / Van den Heuvel, F / Sheehy, S L

Clinical oncology (Royal College of Radiologists (Great Britain))

2023 Volume 35, Issue 5, Page(s) e347

Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Published Erratum
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2023.02.004
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Zs.A 2774: Show issues

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Article ; Online: Experiences with Family Planning amongst Persons with Mental Health Problems: A Nationwide Patient Survey.

Schonewille, Noralie N / van den Eijnden, Monique J M / Jonkman, Nini H / van Kempen, Anne A M W / van Pampus, Maria G / Goedhart, Francisca G / van den Heuvel, Odile A / Broekman, Birit F P

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: High rates of unintended pregnancies in patients with mental health problems reflect the unmet need for tailored family planning. This study aims to explore aspects of family planning that are especially challenging for patients experiencing health ... ...

Abstract	High rates of unintended pregnancies in patients with mental health problems reflect the unmet need for tailored family planning. This study aims to explore aspects of family planning that are especially challenging for patients experiencing health problems by obtaining the perspective of (former) patients and those with close relationships with the (former) patients. In August 2021, members of a Dutch national mental health panel, consisting of (former) patients and close ones, were invited to respond to a 34-question online survey that included questions on four domains: reproductive history, decision making, parenting, and sexuality. This study has revealed the severe and adverse impact of mental health problems across all of the four domains of reproductive health and family planning, which the questions specifically targeted. Based on these results, we recommend discussing family planning with all patients experiencing or at risk for mental health problems and their partners. These discussions should address a desire to have children, (involuntary) childlessness, uncertainties about parenting and sexuality, while remaining considerate of experienced taboos.
MeSH term(s)	Pregnancy ; Female ; Child ; Humans ; Family Planning Services ; Mental Health ; Sexual Behavior ; Pregnancy, Unplanned ; Parenting/psychology
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043070
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Conference proceedings ; Online: Sea salt aerosol in snow on sea ice as a potential source of Ice Nucleating Particles in the Arctic

Kirchgaessner, A. / Frey, M. / van den Heuvel, F. / Yang, X. / Lachlan-Cope, T.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: ... of a few tens [particle m-3], that were often associated with high wind speeds. Initial offline analyses of snow ...

Abstract	Our lack of understanding with respect to the sources and nucleating capabilities of natural aerosol in the high Arctic is one reason why Arctic clouds are still poorly represented in climate models. Recent field campaigns provide evidence of a source of sea salt aerosol (SSA) from blowing snow above sea ice, which can account for the SSA winter/spring maxima observed in the Polar Regions. This SSA has the potential to influence the regional climate through the indirect radiative effect, but the relative magnitude of its contribution to cloud forming particles, especially ice nucleating particles (INP), are still largely unknown. For this presentation we use online and offline measurements of airborne aerosol for its ice nucleating properties that were carried out in the Central Arctic during MOSAiC. We combine these with INP measurements from snow samples, observations of snow particle fluxes, and aerosol measurements from the comprehensive MOSAiC data set. Online observations of INP in spring show concentrations in the order of a few tens [particle m-3], that were often associated with high wind speeds. Initial offline analyses of snow samples from the sea ice taken during the same period indicate the presence of INPs. This is evidence that snow on sea ice represents a viable source of INPs, which may release these particles via blowing snow into the atmosphere.
Subject code	551
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Physical frailty deteriorates after a 5-day dexamethasone course in children with acute lymphoblastic leukemia, results of a national prospective study.

Verwaaijen, Emma J / van Hulst, Annelienke M / Hartman, Annelies / Pieters, Rob / Fiocco, Marta / Pluijm, Saskia M F / van Litsenburg, Raphaële R L / Grootenhuis, Martha A / van den Akker, Erica L T / van den Heuvel-Eibrink, Marry M

Cancer medicine

2023 Volume 12, Issue 24, Page(s) 22304–22315

Abstract: Background: Dexamethasone is important in the treatment for pediatric acute lymphoblastic leukemia (ALL) but induces muscle atrophy with negative consequences for muscle mass, muscle strength, and functional abilities. The aim of this study was to ... ...

Abstract	Background: Dexamethasone is important in the treatment for pediatric acute lymphoblastic leukemia (ALL) but induces muscle atrophy with negative consequences for muscle mass, muscle strength, and functional abilities. The aim of this study was to establish the effect of a dexamethasone course on sarcopenia and physical frailty in children with ALL, and to explore prognostic factors. Methods: Patients with ALL aged 3-18 years were included during maintenance therapy. Patients had a sarcopenia/frailty assessment on the first day of (T1) and on the day after (T2) a 5-day dexamethasone course. Sarcopenia was defined as low muscle strength in combination with low muscle mass. Prefrailty and frailty were defined as having two or ≥three of the following components, respectively: low muscle mass, low muscle strength, fatigue, slow walking speed, and low physical activity. Chi-squared and paired t-tests were used to assess differences between T1 and T2. Logistic regression models were estimated to explore patient- and therapy-related prognostic factors for frailty on T2. Results: We included 105 patients, 61% were boys. Median age was 5.3 years (range: 3-18.8). At T1, sarcopenia, prefrailty, and frailty were observed in respectively 2.8%, 23.5%, and 4.2% of patients. At T2, the amount of patients with frailty had increased to 17.7% (p = 0.002), whereas the number of patients with sarcopenia and prefrailty remained similar. Higher ASMM (odds ratio [OR]: 0.49, 95% CI: 0.28-0.83), stronger handgrip strength (OR: 0.41, 95% CI: 0.22-0.77) and more physical activity minutes per day (OR: 0.98, 95% CI: 0.96-0.99) decreased the risk of frailty at T2. Slower walking performance (OR: 2, 95% CI: 1.2-3.39) increased the risk. Fatigue levels at T1 were not associated with frailty at T2. Conclusion: Physical frailty increased strikingly after a 5-days dexamethasone course in children with ALL. Children with poor physical state at start of the dexamethasone course were more likely to be frail after the course.
MeSH term(s)	Child ; Child, Preschool ; Female ; Humans ; Male ; Dexamethasone/adverse effects ; Fatigue/chemically induced ; Frailty/epidemiology ; Geriatric Assessment/methods ; Hand Strength/physiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Prospective Studies ; Sarcopenia/chemically induced
Chemical Substances	Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6779
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Article: Mitral regurgitation: when to intervene? : A historical perspective.

Bergstra, A / Simsek, C / van den Heuvel, A F M

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2020 Volume 28, Issue 5, Page(s) 266–271

Abstract: Although mitral regurgitation (MR) is the most common valvular heart disease, it should be regarded as a complex multifactorial disease that involves multiple entities. Optimal medical therapy alone does not hinder the progression of the disease, and in ... ...

Abstract	Although mitral regurgitation (MR) is the most common valvular heart disease, it should be regarded as a complex multifactorial disease that involves multiple entities. Optimal medical therapy alone does not hinder the progression of the disease, and in the 1980s it was already recognised that corrective surgery is indicated if MR is severe and patients are symptomatic (except for those with the most severe left ventricle dysfunction). Later on, asymptomatic patients with deterioration of the left ventricular ejection fraction were also operated on to avoid irreversible left ventricular dysfunction, heart failure and eventually death. However, a major drawback remains the fact that a significant group of patients is considered to have a high perioperative risk due to their advanced age or severe comorbidities. Since less invasive, percutaneous interventions have been developed and recently thoroughly investigated in the MITRA-FR and the COAPT studies, the type of intervention and also the timing have become more crucial. In this critical review of the literature, we describe what we should have learned from the past and which (haemodynamic) parameters can best predict the outcome in patients with MR.
Language	English
Publishing date	2020-04-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-020-01417-x
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Zs.A 6216: Show issues

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Article ; Online: Changes in depression symptom profile with gender-affirming hormone use in transgender persons.

Morssinkhof, Margot W L / Wiepjes, Chantal M / van den Heuvel, Odile A / Kreukels, Baudewijntje P C / van der Tuuk, Karin / T'Sjoen, Guy / den Heijer, Martin / Broekman, Birit F P

Journal of affective disorders

2023 Volume 348, Page(s) 323–332

Abstract: Background: Women show higher prevalence of depression and different symptomatology than men, possibly influenced by sex hormones. Many transgender persons, who face a high risk of depression, use Gender-Affirming Hormone Therapy (GAHT), but the impact ... ...

Abstract	Background: Women show higher prevalence of depression and different symptomatology than men, possibly influenced by sex hormones. Many transgender persons, who face a high risk of depression, use Gender-Affirming Hormone Therapy (GAHT), but the impact of GAHT on depressive symptom profiles is unknown. Methods: This study examined depressive symptoms in transgender persons before GAHT and after 3- and 12 months of GAHT. We used the Inventory of Depressive Symptomatology-Self Report to assess depressive symptoms, exploratory factor analysis (EFA) to assess symptom clusters, and linear mixed models to assess changes in symptom clusters. Results: This study included 110 transmasculine (TM) and 89 transfeminine (TF) participants. EFA revealed four symptom clusters: mood, anxiety, lethargy, and somatic symptoms. Changes in total depressive symptoms significantly differed between TM and TF groups. After 3 months of GAHT, TM participants reported improvement in lethargy (-16 %; 95%CI: -29 %; -2 %), and after 12 months TF participants reported worsening in low mood (24 %; 95%CI: 3 %; 51 %), but absolute score changes were modest. Neither group showed changes in anxiety or somatic symptoms. Limitations: This study had limited sample sizes at 12 months follow-up and did not include relevant biological or psychosocial covariates. Discussion: Changes in depressive symptoms after GAHT use differ in TM and TF persons: TM persons report slight improvements in lethargy, whereas TF persons report a slight increase in low mood. Starting GAHT represents a significant life event with profound social and physical effects, and further research should assess social and biological effects of GAHT on mood-related symptoms.
MeSH term(s)	Male ; Female ; Humans ; Transgender Persons ; Depression/drug therapy ; Depression/epidemiology ; Lethargy ; Medically Unexplained Symptoms ; Syndrome ; Hormones
Chemical Substances	Hormones
Language	English
Publishing date	2023-12-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.12.056
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