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Article ; Online: Cardiovascular Risks and Organ Damage in Secondary Hypertension.

Cingolani, Oscar H

Endocrinology and metabolism clinics of North America

2020 Volume 48, Issue 4, Page(s) 657–666

Abstract: Secondary hypertension is associated with increased cardiovascular risk and exaggerated target organ damage, not only due to the higher and more sustained blood pressure values often observed in these patients but also because certain forms of ... ...

Abstract	Secondary hypertension is associated with increased cardiovascular risk and exaggerated target organ damage, not only due to the higher and more sustained blood pressure values often observed in these patients but also because certain forms of hypertension can increase cardiovascular risk and organ damage by the neurohormonal and/or molecular pathways activation they exert. Early identification of secondary forms of hypertension can help mitigate organ damage and prevent cardiovascular complications. Signs and symptoms distinction among types of secondary hypertension is essential in order to prevent complications.
MeSH term(s)	Adrenal Gland Neoplasms/complications ; Aortic Coarctation/complications ; Cushing Syndrome/complications ; Humans ; Hyperaldosteronism/complications ; Hypertension/complications ; Hypertension/etiology ; Renal Artery Obstruction/complications ; Sleep Apnea, Obstructive/complications ; Thyroid Diseases/complications
Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	92116-6
ISSN	1558-4410 ; 0889-8529
ISSN (online)	1558-4410
ISSN	0889-8529
DOI	10.1016/j.ecl.2019.08.015
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Article ; Online: Thrombospondins in the transition from myocardial infarction to heart failure.

Kirk, Jonathan A / Cingolani, Oscar H

Journal of molecular and cellular cardiology

2016 Volume 90, Page(s) 102–110

Abstract: The heart's reaction to ischemic injury from a myocardial infarction involves complex cross-talk between the extra-cellular matrix (ECM) and different cell types within the myocardium. The ECM functions not only as a scaffold where myocytes beat ... ...

Abstract	The heart's reaction to ischemic injury from a myocardial infarction involves complex cross-talk between the extra-cellular matrix (ECM) and different cell types within the myocardium. The ECM functions not only as a scaffold where myocytes beat synchronously, but an active signaling environment that regulates the important post-MI responses. The thrombospondins are matricellular proteins that modulate cell--ECM interactions, functioning as "sensors" that mediate outside-in and inside-out signaling. Thrombospondins are highly expressed during embryonic stages, and although their levels decrease during adult life, can be re-expressed in high quantities in response to cardiac stress including myocardial infarction and heart failure. Like a Swiss-army knife, the thrombospondins possess many tools: numerous binding domains that allow them to interact with other elements of the ECM, cell surface receptors, and signaling molecules. It is through these that the thrombospondins function. In the present review, we provide basic as well as clinical evidence linking the thrombospondin proteins with the post myocardial infarction response, including inflammation, fibrotic matrix remodeling, angiogenesis, as well as myocyte hypertrophy, apoptosis, and contractile dysfunction in heart failure. We will describe what is known regarding the intracellular signaling pathways that are involved with these responses, paving the road for future studies identifying these proteins as therapeutic targets for cardiac disease.
MeSH term(s)	Animals ; Apoptosis ; Endomyocardial Fibrosis/genetics ; Endomyocardial Fibrosis/metabolism ; Endomyocardial Fibrosis/pathology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Gene Expression Regulation ; Heart Failure/genetics ; Heart Failure/metabolism ; Heart Failure/pathology ; Humans ; Myocardial Infarction/genetics ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Neovascularization, Physiologic ; Signal Transduction ; Thrombospondins/genetics ; Thrombospondins/metabolism
Chemical Substances	Thrombospondins
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2015.12.009
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Article ; Online: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients With Coronavirus Disease-19.

Goerlich, Erin / Gilotra, Nisha A / Minhas, Anum S / Bavaro, Nicole / Hays, Allison G / Cingolani, Oscar H

Journal of cardiac failure

2020 Volume 27, Issue 1, Page(s) 100–104

Abstract: Background: Coronavirus disease-19 (COVID-19) has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain on speckle-tracking echocardiography in ... ...

Abstract	Background: Coronavirus disease-19 (COVID-19) has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain on speckle-tracking echocardiography in hospitalized patients with COVID-19 and subsequently aimed to identify characteristics of affected patients. We hypothesized that patients with COVID-19 with reduced basal LV strain would demonstrate elevated cardiac biomarkers. Methods and result: Eighty-one consecutive patients with COVID-19 underwent speckle-tracking echocardiography. Those with poor quality speckle-tracking echocardiography (n = 2) or a known LV ejection fraction of <50% (n = 4) were excluded. Patients with an absolute value basal longitudinal strain of <13.9% (2 standard deviations below normal) were designated as cases (n = 39); those with a basal longitudinal strain of ≥13.9% were designated as controls (n = 36). Demographics and clinical variables were compared. Of 75 included patients (mean age 62 ± 14 years, 41% women), 52% had reduced basal strain. Cases had higher body mass index (median 34.1; interquartile range 26.5-37.9 kg/m Conclusions: Reduced basal LV strain is common in patients with COVID-19. Patients with hypertension, diabetes, obesity, and Black race were more likely to have reduced basal strain. Further investigation into the significance of this strain pattern is warranted.
MeSH term(s)	Aged ; COVID-19/diagnostic imaging ; COVID-19/epidemiology ; Echocardiography/methods ; Echocardiography/trends ; Female ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Hospitalization/trends ; Humans ; Male ; Middle Aged ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2020.09.469
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Article ; Online: Cardiac hypertrophy and the Wnt/Frizzled pathway.

Cingolani, Oscar H

Hypertension (Dallas, Tex. : 1979)

2007 Volume 49, Issue 3, Page(s) 427–428

MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/physiology ; Aortic Coarctation/physiopathology ; Cardiomegaly/genetics ; Cardiomegaly/physiopathology ; Dishevelled Proteins ; Frizzled Receptors/physiology ; Humans ; Phosphoproteins/genetics ; Phosphoproteins/physiology ; Signal Transduction ; Wnt Proteins/physiology ; beta Catenin/genetics ; beta Catenin/physiology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Dishevelled Proteins ; Frizzled Receptors ; Phosphoproteins ; Wnt Proteins ; beta Catenin
Language	English
Publishing date	2007-03
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/01.HYP.0000255947.79237.61
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Article ; Online: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients with COVID-19

Goerlich, Erin / Gilotra, Nisha A. / Minhas, Anum S. / Bavaro, Nicole / Hays, Allison G. / Cingolani, Oscar H.

Journal of Cardiac Failure ; ISSN 1071-9164

2020

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.cardfail.2020.09.469
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A nervous heart.

Cingolani, Oscar H / Heath, Jonathon / McDonald, Michael

Circulation

2014 Volume 129, Issue 9, Page(s) e358–9

MeSH term(s)	Adrenal Gland Diseases/complications ; Adrenal Gland Diseases/diagnosis ; Adrenal Gland Diseases/surgery ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Medulla/pathology ; Adrenalectomy ; Adult ; Diagnosis, Differential ; Humans ; Hyperplasia/complications ; Hyperplasia/diagnosis ; Hypertension/etiology ; Male ; Pheochromocytoma/diagnosis ; Tachycardia/etiology ; Treatment Outcome
Language	English
Publishing date	2014-03-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.113.007360
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Article ; Online: Prevalence and Clinical Correlates of Echo-Estimated Right and Left Heart Filling Pressures in Hospitalized Patients With Coronavirus Disease 2019.

Goerlich, Erin / Metkus, Thomas S / Gilotra, Nisha A / Wu, Katherine C / Cingolani, Oscar H / Hays, Allison G

Critical care explorations

2020 Volume 2, Issue 10, Page(s) e0227

Abstract: Objectives: The prevalence of elevated right and left heart filling pressures in coronavirus disease 2019 is not well characterized. We aimed to characterize the prevalence of pulmonary hypertension and concurrent elevated left heart filling pressure in ...

Abstract	Objectives: The prevalence of elevated right and left heart filling pressures in coronavirus disease 2019 is not well characterized. We aimed to characterize the prevalence of pulmonary hypertension and concurrent elevated left heart filling pressure in hospitalized patients with coronavirus disease 2019. We hypothesized that a significant proportion of coronavirus disease 2019 patients has evidence of pulmonary hypertension associated with elevated left heart filling pressure on transthoracic echocardiography. Design: Retrospective cohort study. Setting: Academic tertiary-care center. Patients: Hospitalized coronavirus disease 2019 patients who underwent clinical transthoracic echocardiography. Interventions: None. Measurements and main results: The exposure variable of interest was right ventricular systolic pressure, calculated using the American Society of Echocardiography guidelines. Pulmonary hypertension was defined as right ventricular systolic pressure greater than 40 mm Hg. Left heart filling pressure was estimated with Nagueh's method for pulmonary artery occlusion pressure using E/e' ratio, and normal was considered pulmonary artery occlusion pressure less than 16 mm Hg. Clinical characteristics and outcomes were compared between the patients with and without pulmonary hypertension. A total of 73 patients (median age 66 yr [57-75 yr]; 46% women) were included. Median right ventricular systolic pressure was 39 mm Hg (interquartile range, 32-50 mm Hg), and 36 patients (49.3%) had evidence of pulmonary hypertension. Patients with pulmonary hypertension were more likely to require ICU admission (86% vs 65%; Conclusions: Pulmonary hypertension is common in hospitalized patients with coronavirus disease 2019 and is associated with poor clinical outcomes. Left ventricular filling pressure is elevated in over half of those with pulmonary hypertension and may represent a target to reduce right ventricular afterload and potentially improve outcomes in coronavirus disease 2019.
Keywords	covid19
Language	English
Publishing date	2020-09-30
Publishing country	United States
Document type	Journal Article
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000227
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Sudden Change of Heart: A Case of Rapidly Reversed Stress Cardiomyopathy in a Critically Ill Patient.

Brener, Michael I / Keramati, Ali R / Mirski, Marek A / Cingolani, Oscar H

Cardiology research

2016 Volume 7, Issue 3, Page(s) 119–121

Abstract: We report the case of a 79-year-old woman who presented to our hospital for elective removal of an infratentorial meningioma and suffered a periprocedural cardiac arrest. Shortly after uncomplicated induction of anesthesia prior to the surgery, the ... ...

Abstract	We report the case of a 79-year-old woman who presented to our hospital for elective removal of an infratentorial meningioma and suffered a periprocedural cardiac arrest. Shortly after uncomplicated induction of anesthesia prior to the surgery, the patient became hypotensive and bradycardic, culminating ultimately in a cardiac arrest with pulseless electrical activity. Return of spontaneous circulation occurred within 90 seconds of arrest, but the patient remained dependent on maximal doses of epinephrine and dopamine for hemodynamic support. Echocardiography performed on the day of cardiac arrest revealed a newly depressed left ventricular ejection fraction (LVEF) of 15-20% with an apical ballooning pattern. Left heart catheterization showed no obstructive coronary lesions to explain her depressed ejection fraction. A diagnosis of stress cardiomyopathy (SCM) was made given the echocardiographic findings and absence of concomitant coronary disease. Within the next 24 hours, the patient was liberated from inotropic support, and at 6-month follow-up, her LVEF returned to 55% and she had no heart failure symptoms.
Language	English
Publishing date	2016-06-24
Publishing country	Canada
Document type	Case Reports
ZDB-ID	2598593-0
ISSN	1923-2837 ; 1923-2829
ISSN (online)	1923-2837
ISSN	1923-2829
DOI	10.14740/cr471w
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Article ; Online: Pressure-volume relation analysis of mouse ventricular function.

Cingolani, Oscar H / Kass, David A

American journal of physiology. Heart and circulatory physiology

2011 Volume 301, Issue 6, Page(s) H2198–206

Abstract: Nearly 40 years ago, the Sagawa laboratory spawned a renaissance in the use of instantaneous ventricular pressure-volume (P-V) relations to assess cardiac function. Since then, this analysis has taken hold as the most comprehensive way to quantify ... ...

Abstract	Nearly 40 years ago, the Sagawa laboratory spawned a renaissance in the use of instantaneous ventricular pressure-volume (P-V) relations to assess cardiac function. Since then, this analysis has taken hold as the most comprehensive way to quantify ventricular chamber function and energetics and cardiovascular interactions. First studied in large mammalian hearts and later in humans employing a catheter-based method, P-V analysis was translated to small rodents in the late 1990s by the Kass laboratory. Over the past decade, this approach has become a gold standard for comprehensive examination of in vivo cardiac function in mice, facilitating a new era of molecular cardiac physiology. The catheter-based method remains the most widely used approach in mice. In this brief review, we discuss this instrumentation, the theory behind its use, and how volume signals are calibrated and discuss elements of P-V analysis. The goal is to provide a convenient summary of earlier investigations and insights for users whose primary interests lie in genetic/molecular studies rather than in biomedical engineering.
MeSH term(s)	Animals ; Biomechanical Phenomena ; Cardiac Catheterization/instrumentation ; Cardiac Catheterization/methods ; Mice ; Models, Cardiovascular ; Reproducibility of Results ; Signal Processing, Computer-Assisted ; Stroke Volume ; Ventricular Function, Left ; Ventricular Pressure
Language	English
Publishing date	2011-09-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00781.2011
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Article: Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients with COVID-19

Goerlich, Erin / Gilotra, Nisha A / Minhas, Anum S / Bavaro, Nicole / Hays, Allison G / Cingolani, Oscar H

J. card. fail

Abstract: BACKGROUND: COVID-19 has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain (LS) on speckle-tracking echocardiography (STE) in hospitalized COVID- ... ...

Abstract	BACKGROUND: COVID-19 has been associated with overt and subclinical myocardial dysfunction. We observed a recurring pattern of reduced basal left ventricular (LV) longitudinal strain (LS) on speckle-tracking echocardiography (STE) in hospitalized COVID-19 patients and subsequently aimed to identify characteristics of affected patients. We hypothesized that COVID-19 patients with reduced basal LV strain would demonstrate elevated cardiac biomarkers. METHODS: 81 consecutive COVID-19 patients underwent STE. Those with poor quality STE (n=2) or known LV ejection fraction<50% (n=4) were excluded. Patients with absolute value basal LS<13.9% (2SD below normal) were designated as cases (n=39); those with basal LS≥13.9% as controls (n=36). Demographics and clinical variables were compared. RESULTS: Of 75 included patients (mean age 62±14 years, 41% women), 52% had reduced basal strain. Cases had higher BMI (median[IQR]) (34.1[26.5-37.9]kg/m2 vs. 26.9[24.8-30.0]kg/m2, p=0.009), and greater proportions of Black (74% vs. 36%, p=0.0009), hypertensive (79% vs. 56%, p=0.026) and diabetic patients (44% vs. 19%, p=0.025) compared to controls. Troponin and NT-proBNP levels trended higher in cases but were not significantly different. CONCLUSIONS AND RELEVANCE: Reduced basal LV strain is common in COVID-19 patients. Patients with hypertension, diabetes, obesity, and Black race were more likely to have reduced basal strain. Further investigation into the significance of this strain pattern is warranted.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #799270
Database	COVID19

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