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Article ; Online: Akute und chronische kardiale Beteiligung bei COVID-19.

Beitzke, Dietrich

2021 Volume 61, Issue 10, Page(s) 896–901

Abstract: Background: Infections with coronavirus disease 2019 (COVID-19) most frequently affect the lungs but may also result in cardiovascular involvement and cardiovascular complications. The heart can either be involved as part of a systemic infection or ... ...

Title translation	Acute and chronic cardiac involvement in COVID-19.
Abstract	Background: Infections with coronavirus disease 2019 (COVID-19) most frequently affect the lungs but may also result in cardiovascular involvement and cardiovascular complications. The heart can either be involved as part of a systemic infection or directly involved due to myocarditis or pericarditis as well as in hypoxia, volume overload, fever or thromboembolic complications. Moreover, pre-existing underlying cardiovascular diseases have a substantial influence on the prognosis of patients with COVID-19 infections. Method: This review article is based on a comprehensive literature search in the PubMed database on cardiac involvement and cardiac complications of COVID 19 infections, enriched by experiences in dealing with this disorder. Results and conclusion: Depending on the severity of the infection, cardiac involvement in a COVID 19 infection is observed in up to 50% of the patients. Besides echocardiography as the first-line examination method, cardiac magnetic resonance imaging (MRI) for assessment of the myocardial structure and cardiac computed tomography (CT) for assessment of coronary arteries and to rule out intracardiac thrombus formation represent important imaging modalities. The most important cardiac manifestations in COVID 19 infections are ischemic and inflammatory diseases. The imaging diagnostics play an important role in the acute as well as in the postinfectious phases.
MeSH term(s)	COVID-19 ; Heart Diseases/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Myocarditis/diagnostic imaging ; SARS-CoV-2
Language	German
Publishing date	2021-09-16
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	505520-9
ISSN	1432-2102 ; 0033-832X
ISSN (online)	1432-2102
ISSN	0033-832X
DOI	10.1007/s00117-021-00913-4
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Article ; Online: Reply to Letter to the Editor: "How to set up a 24/7 cardiac computed tomography service in an emergency department".

Loewe, Christian / Beitzke, Dietrich / Francone, Marco

European radiology

2023

Language	English
Publishing date	2023-12-08
Publishing country	Germany
Document type	Editorial
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10477-7
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Zs.A 3300: Show issues

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Article ; Online: Hybrid PET/MRI of large vessel vasculitis : Radiation dose compared to PET/CT with view on cumulative effective dose.

Brauner, Johanna-Felicia / Rasul, Sazan / Berzaczy, Dominik / Beitzke, Daniela / Wollenweber, Tim / Beitzke, Dietrich

Wiener klinische Wochenschrift

2024

Abstract: Background: The diagnosis of large vessel vasculitis (LVV) is often challenging due to the various clinical appearances and the low prevalence. Hybrid imaging by positron emission tomography and computed tomography (PET/CT) is a highly relevant imaging ... ...

Abstract	Background: The diagnosis of large vessel vasculitis (LVV) is often challenging due to the various clinical appearances and the low prevalence. Hybrid imaging by positron emission tomography and computed tomography (PET/CT) is a highly relevant imaging modality for diagnostics and disease surveillance but may be associated with a significant amount of radiation dose especially in patients with complications. Objective: The aim of this retrospective analysis was to compare the image quality and impact of hybrid imaging methods PET/CT and PET/MRI on the potential for dose reduction. Methods: This retrospective single-center study included a cohort of 32 patients who were referred to PET/MRI for the evaluation of LVV, including graft infections and fever of unknown origin. This cohort was compared to a similar cohort of 37 patients who were examined with PET/CT in the same period. Mean radiation dose as well as image quality to establish a diagnosis were compared between the groups. Results: The mean radiation dose applied in PET/MRI was significantly lower when compared to PET/CT (mean 6.6 mSV vs. 31.7 mSV; p < 0.001). This effect was based on the partially multiphasic CT protocols. At the same time, diagnostic image quality using a 4-point scale showed similar results for both imaging modalities in the work-up of LVV. Conclusion: With PET/MRI, the radiation exposure can be significantly reduced with similar image quality and diagnostic impact. Patients with LVV have a higher risk of receiving a clinically relevant cumulative effective dose (CED) and PET/MRI should be made available to them.
Language	English
Publishing date	2024-03-08
Publishing country	Austria
Document type	Journal Article
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
DOI	10.1007/s00508-024-02336-2
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Article ; Online: How to set up a 24/7 cardiac computed tomography service in an emergency department.

Loewe, Christian / Beitzke, Dietrich / Francone, Marco

European radiology

2023 Volume 33, Issue 11, Page(s) 8177–8179

MeSH term(s)	Humans ; Coronary Artery Disease ; Heart ; Emergency Service, Hospital ; Tomography ; Chest Pain
Language	English
Publishing date	2023-05-09
Publishing country	Germany
Document type	Editorial
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09721-x
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Article: [No title information]

Schuck, Linus / Beitzke, Dietrich

Radiopraxis

2023 Volume 16, Issue 02, Page(s) 71–82

Abstract: Among other imaging modalities, cardiac MRI is an established modality for the detection of myocardial ischemia and viability. With updated guidelines, the demand for this modality will increase in the coming years. ...

Abstract	Among other imaging modalities, cardiac MRI is an established modality for the detection of myocardial ischemia and viability. With updated guidelines, the demand for this modality will increase in the coming years. The aim of noninvasive functional testing is to prove or rule out myocardial ischemia and viability using stress perfusion and late gadolinium enhancement.
Keywords	Ischämie ; Vitalität ; koronare Herzerkrankung ; kardiale MRT ; ischemia ; viability ; coronary heart disease ; cardiac MRI
Language	German
Publishing date	2023-06-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2422980-5
ISSN	1866-1041 ; 1866-1033 ; 1866-1033
ISSN (online)	1866-1041 ; 1866-1033
ISSN	1866-1033
DOI	10.1055/a-1843-1398
Database	Thieme publisher's database

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Article ; Online: Etelcalcetide Inhibits the Progression of Left Atrial Volume Index Compared to Alfacalcidol in Hemodialysis Patients.

Dörr, Katharina / Reindl-Schwaighofer, Roman / Lorenz, Matthias / Marculescu, Rodrig / Beitzke, Dietrich / Hödlmoser, Sebastian

Cardiorenal medicine

2023 Volume 13, Issue 1, Page(s) 332–341

Abstract: Introduction: Increased left atrial (LA) size is a risk factor for cardiovascular events and all-cause mortality. It is closely related to left ventricular hypertrophy and chronic volume overload, both of which are common in hemodialysis. Calcimimetic ... ...

Abstract	Introduction: Increased left atrial (LA) size is a risk factor for cardiovascular events and all-cause mortality. It is closely related to left ventricular hypertrophy and chronic volume overload, both of which are common in hemodialysis. Calcimimetic treatment with etelcalcetide (ETL) previously showed an inhibitory effect on left ventricular mass index (LVMI) progression in this population. Methods: This is a post hoc analysis of the EtECAR-HD trial, where 62 patients were randomized to ETL or alfacalcidol (ALFA) for 1 year. LA volume index (LAVI) was measured using cardiac magnetic resonance imaging. The aim of the study was to investigate whether ETL was associated with a change of LAVI. Results: Median baseline levels of LAVI were 40 mL/m2 (31, 54 IQR) in the ETL group and 36 mL/m2 (26, 46 IQR) in the ALFA group. In the ITT population, the change of LAVI was 5.0 mL/m2 [95% CI: -0.04, 10] lower under ETL, compared to ALFA (p = 0.052, R2adj = 0.259). In the PP population, the difference in LAVI changes widened to 5.8 [95% CI: 0.36, 11], p = 0.037, R2adj = 0.302). Secondary analysis showed that the study delta of LVMI was correlated with the LAVI delta (r = 0.387) and that an inclusion of LVMI delta in the ANCOVA model mediated the effect on LAVI delta to β = 3.3 [95% CI: -0.04, 10] (p = 0.2, R2adj = 0.323). The same could not be observed for parameters assessing the volume status. Conclusions: The analysis indicates that ETL could inhibit LAVI progression compared with ALFA. This effect was mediated by the change of LVMI.
MeSH term(s)	Humans ; Heart Atria/diagnostic imaging ; Heart Atria/pathology ; Peptides ; Renal Dialysis
Chemical Substances	etelcalcetide hydrochloride (72PT5993DU) ; alfacalcidol (URQ2517572) ; Peptides
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2595659-0
ISSN	1664-5502 ; 1664-3828
ISSN (online)	1664-5502
ISSN	1664-3828
DOI	10.1159/000533899
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Article ; Online: Effect of etelcalcetide versus alfacalcidol on left ventricular function and feature-tracking cardiac magnetic resonance imaging in hemodialysis-a post-hoc analysis of a randomized, controlled trial.

Dörr, Katharina / Kammerlander, Andreas / Lauriero, Francesco / Lorenz, Matthias / Marculescu, Rodrig / Beitzke, Dietrich

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2023 Volume 25, Issue 1, Page(s) 62

Abstract: Background: Calcimimetic therapy with etelcalcetide (ETEL) has been shown to attenuate the advancement of left ventricular (LV) hypertrophy in hemodialysis patients measured by cardiac magnetic resonance (CMR). The aim of the study was to evaluate ... ...

Abstract	Background: Calcimimetic therapy with etelcalcetide (ETEL) has been shown to attenuate the advancement of left ventricular (LV) hypertrophy in hemodialysis patients measured by cardiac magnetic resonance (CMR). The aim of the study was to evaluate whether this effect is accompanied by alterations in LV function and myocardial composition. Methods: This was a post-hoc analysis of a randomized-controlled trial of ETEL versus Alfacalcidol (ALFA) in 62 hemodialysis patients. LV function was assessed using LV ejection fraction (LVEF) and LV global longitudinal strain (GLS) on feature-tracking (FT) CMR. Myocardial tissue characteristics were analyzed using parametric T1 and T2 mapping. Results: Of the total study cohort (n = 62), 48 subjects completed both CMR scans with sufficient quality for FT analysis. In the one-year follow-up, LV GLS deteriorated in the ALFA group, whereas the ETEL group remained stable (LV GLS change: + 2.6 ± 4.6 versus + 0.3 ± 3.8; p = 0.045 when adjusting for randomization factors and baseline LV GLS). We did not observe a difference in the change of LVEF between the two groups (p = 0.513). The impact of ETEL treatment on LV GLS over time remained significant after additional adjustment for the change in LV mass during the study period. ETEL treatment did not significantly affect other CMR parameters. There were no changes in myocardial composition between treatment groups (T1 time change: + 15 ± 42 versus + 10 ± 50; p = 0.411; T2 time change: - 0.13 ± 2.45 versus - 0.70 ± 2.43; p = 0.652). Conclusions: In patients undergoing hemodialysis, treatment with ETEL was protective against deterioration of LV longitudinal function, as evaluated through FT CMR, when compared to the control therapy of ALFA. This effect was not mediated by the change in LV mass. Trial registration URL: https://clinicaltrials.gov/ct2/show/NCT03182699 . Unique identifier: NCT03182699.
MeSH term(s)	Humans ; Hypertrophy, Left Ventricular ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine ; Predictive Value of Tests ; Renal Dialysis ; Stroke Volume ; Ventricular Function, Left ; Randomized Controlled Trials as Topic
Chemical Substances	alfacalcidol (URQ2517572) ; etelcalcetide hydrochloride (72PT5993DU)
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-023-00975-4
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Article: Autosomal recessive cutis laxa type Ib-Successful redo aortic root and arch replacement.

Pees, Christiane / Zimpfer, Daniel / Radakovic, Sonja / Beitzke, Dietrich / Michel-Behnke, Ina / Laccone, Franco A

Clinical case reports

2022 Volume 10, Issue 12, Page(s) e6573

Abstract: We present an adolescent girl with a highly stenotic ascending aortic conduit of her former during infancy corrected giant aneurysm. Genetic testing ... ...

Abstract	We present an adolescent girl with a highly stenotic ascending aortic conduit of her former during infancy corrected giant aneurysm. Genetic testing determined
Language	English
Publishing date	2022-12-12
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.6573
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Article ; Online: Tacrolimus-induced left ventricular hypertrophy: insights with cardiac magnetic resonance mapping techniques.

Muršić, Miroslav / Andreas, Zuckermann / Christian, Loewe / Sabine, Greil / Dietrich, Beitzke

European heart journal. Cardiovascular Imaging

2021 Volume 22, Issue 6, Page(s) e78

MeSH term(s)	Heart ; Humans ; Hypertrophy, Left Ventricular/chemically induced ; Hypertrophy, Left Ventricular/diagnostic imaging ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Tacrolimus ; Ventricular Function, Left ; Ventricular Remodeling
Chemical Substances	Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2021-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeaa294
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Article ; Online: Preprocedural imaging modalities in patients undergoing iliocaval venous recanalization and stent placement.

Müller, Markus / Wolf, Florian / Loewe, Christian / Beitzke, Dietrich / Zehetmayer, Sonja / Gschwandtner, Michael E / Willfort-Ehringer, Andrea / Koppensteiner, Renate / Schlager, Oliver

Vascular medicine (London, England)

2023 Volume 28, Issue 4, Page(s) 315–323

Abstract: Purpose: To determine the diagnostic accuracy of preinterventional imaging modalities in patients being evaluated for iliocaval venous recanalization and stent placement.: Methods: Consecutive patients with iliocaval postthrombotic obstructions or ... ...

Abstract	Purpose: To determine the diagnostic accuracy of preinterventional imaging modalities in patients being evaluated for iliocaval venous recanalization and stent placement. Methods: Consecutive patients with iliocaval postthrombotic obstructions or nonthrombotic iliac vein lesions (NIVL), who were scheduled for recanalization, underwent duplex ultrasound (DUS), magnetic resonance venography (MRV), multiplanar venography (MPV), and intravascular ultrasound (IVUS). The diagnostic accuracies of DUS, MRV, and MPV were analyzed using IVUS as reference. Results: A total of 216 limbs in 108 patients (80 patients with postthrombotic obstructions, 28 patients with NIVL) were examined. In patients with postthrombotic obstructions, the diagnostic sensitivities for the detection of lesions of the common femoral vein were 81% (95% CI 71-89%) for DUS, 76% (95% CI 65-85%) for MRV, and 86% (95% CI 76-93%) for MPV. The sensitivities for detecting lesions of the iliac veins were 96% (95% CI 89-99%) for DUS, 99% (95% CI 92-100%) for MRV, and 100% (95% CI 94-100%) for MPV. Regarding the inferior vena cava, the sensitivities were 44% (95% CI 24-65%) for DUS, 52% (95% CI 31-73%) for MRV, and 70% (95% CI 47-86%) for MPV. The sensitivities for detecting NIVL were 58% (95% CI 34-79%) for DUS, 90% (95% CI 68-97%) for MRV, and 95% (95% CI 73-99%) for MPV. Conclusion: In patients scheduled for recanalization of iliocaval postthrombotic obstructions, the sensitivities of DUS, MRV, and MPV were similar. In patients with suspected inferior vena cava involvement and in patients with NIVL, additional imaging with MR or conventional venography is required.
MeSH term(s)	Humans ; Vena Cava, Inferior/diagnostic imaging ; Iliac Vein/diagnostic imaging ; Phlebography ; Ultrasonography, Doppler, Duplex ; Stents ; Retrospective Studies ; Treatment Outcome ; Vascular Patency
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X231161938
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