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  1. Article ; Online: Peer Mentorship for International Medical Students in the United States.

    Gallo Marin, Benjamin / Aghagoli, Ghazal

    Academic medicine : journal of the Association of American Medical Colleges

    2022  Volume 97, Issue 10, Page(s) 1431

    MeSH term(s) Humans ; Mentoring ; Mentors/education ; Peer Group ; Students, Medical ; United States
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical uses of epigenetics in cardiology and cardiothoracic surgery: an update.

    Heinl, James F / Aghagoli, Ghazal / Sellke, Frank W

    Epigenomics

    2023  Volume 15, Issue 8, Page(s) 475–478

    Abstract: Tweetable abstract Epigenetics is a promising field in the prevention, diagnosis and intervention of cardiovascular diseases. Here, we highlight recent advances in epigenetics in the fields of cardiology and cardiothoracic surgery. ...

    Abstract Tweetable abstract Epigenetics is a promising field in the prevention, diagnosis and intervention of cardiovascular diseases. Here, we highlight recent advances in epigenetics in the fields of cardiology and cardiothoracic surgery.
    MeSH term(s) Humans ; Thoracic Surgery ; Cardiology ; Cardiovascular Diseases/genetics
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Editorial
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2023-0120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epigenetics and recurrent urinary tract infections: an update on current research and potential clinical application.

    Aghagoli, Ghazal / Fedulov, Alexey V / Shinnick, Julia K

    Epigenomics

    2023  Volume 15, Issue 19, Page(s) 961–964

    Abstract: Tweetable abstract Exploring ... ...

    Abstract Tweetable abstract Exploring uropathogenic
    MeSH term(s) Humans ; Escherichia coli Infections/drug therapy ; Urinary Tract Infections/genetics ; Urinary Tract Infections/drug therapy ; Epigenesis, Genetic ; Epigenomics ; Uropathogenic Escherichia coli/genetics
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2023-0311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Abortion Policy Positions of Federal Legislators Who Received Support From the American College of Obstetricians and Gynecologists, 2012-2022.

    Chhabria, Karisma / Raman, Vineet / Aghagoli, Ghazal / Brown, Benjamin P

    JAMA network open

    2023  Volume 6, Issue 4, Page(s) e2310405

    MeSH term(s) Pregnancy ; Female ; Humans ; United States ; Gynecologists ; Obstetricians ; Abortion, Induced ; Obstetrics ; Abortion, Spontaneous ; Policy
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Research Support, N.I.H., Extramural ; Letter
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.10405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prevalence of non-communicable disease among displaced Rohingya in southern Bangladesh: a first look at a persecuted ethnic minority from Myanmar.

    Tsichlis, Jason T / Trisha, Ipsita Hamid / Aghagoli, Ghazal / Flora, Meerjady Sabrina / Abid, M Ruhul

    International health

    2023  

    Abstract: Background: In Cox's Bazar, Bangladesh, 860 356 Rohingya living in refugee camps have experienced decades of persecution. Little is known about disease burden in this population.: Methods: A retrospective review of deidentified electronic health ... ...

    Abstract Background: In Cox's Bazar, Bangladesh, 860 356 Rohingya living in refugee camps have experienced decades of persecution. Little is known about disease burden in this population.
    Methods: A retrospective review of deidentified electronic health records (EHR) of 51 270 Rohingya attending two primary health clinics in Kutupalong and Balukahli from October 2017 to October 2019 was performed. A novel EHR system named NIROG was used for patients' medical records'.
    Results: Females comprised 53.8% of patients. The median age of females was 25 y and for males it was 19 y. Prevalence of adult hypertension and diabetes was 14.1% and 11.0%, respectively. Also, 16.6% of children aged <5 y had moderate or severe acute malnutrition, while 36.6% were at risk of malnutrition. Body mass index (BMI) analysis showed that 34.4% of adults were underweight. Females were more likely to be hypertensive, diabetic, overweight/obese and malnourished. BMI had a statistically significant positive correlation with fasting blood glucose levels and systolic blood pressure.
    Conclusions: The use of a portable EHR system was highly effective at providing longitudinal care in a humanitarian setting. Significant proportions of the adult population appear to have hypertension or diabetes, pointing to a critical need for management of chronic non-communicable diseases (NCDs). The findings of the current study will help stakeholders to plan effective prevention and management of NCDs among displaced Rohingya and other displaced populations.
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2526175-7
    ISSN 1876-3405 ; 1876-3413
    ISSN (online) 1876-3405
    ISSN 1876-3413
    DOI 10.1093/inthealth/ihad106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bilateral thalamic responsive neurostimulation for multifocal, bilateral frontotemporal epilepsy: illustrative case.

    Phillips, Ronald K / Aghagoli, Ghazal / Blum, Andrew S / Asaad, Wael F

    Journal of neurosurgery. Case lessons

    2022  Volume 3, Issue 12

    Abstract: Background: Patients with refractory, bilateral, multifocal epilepsy have few treatment options that typically include a combination of antiseizure medications (ASMs) and vagus nerve stimulation (VNS). A man in his 40s presented with epilepsy refractory ...

    Abstract Background: Patients with refractory, bilateral, multifocal epilepsy have few treatment options that typically include a combination of antiseizure medications (ASMs) and vagus nerve stimulation (VNS). A man in his 40s presented with epilepsy refractory to a combination of five ASMs plus VNS; he was still experiencing 7-10 seizures per week. His seizure network involved multiple foci in both frontal and temporal lobes. Bilateral depth electrodes were implanted into the centromedian/parafascicular (CM/PF) complex of the thalamus and connected to the responsive neurostimulation (RNS) system for closed-loop stimulation and neurophysiological monitoring.
    Observations: The patient reported clear improvement in his seizures since the procedure, with a markedly reduced number of seizures and decreased seizure intensity. He also reported stretches of seizure freedom not typical of his preoperative baseline, and his remaining seizures were milder, more often with preserved awareness. Generalized seizures with loss of consciousness have decreased to about one per month. RNS data confirmed a right-sided predominance of the bilateral seizure onsets.
    Lessons: In this patient with multifocal, bilateral frontotemporal epilepsy, RNS of the CM/PF thalamic complex combined with VNS was found to be beneficial. The RNS device was able to detect seizures propagating through the thalamus, and stimulation produced a decrease in seizure burden and intensity.
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE21672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Calciphylaxis and Kidney Disease: A Review.

    Gallo Marin, Benjamin / Aghagoli, Ghazal / Hu, Susie L / Massoud, Cathy M / Robinson-Bostom, Leslie

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2022  Volume 81, Issue 2, Page(s) 232–239

    Abstract: Calciphylaxis is a life-threatening complication most often associated with chronic kidney disease that occurs as a result of the deposition of calcium in dermal and adipose microvasculature. However, this condition may also be seen in patients with ... ...

    Abstract Calciphylaxis is a life-threatening complication most often associated with chronic kidney disease that occurs as a result of the deposition of calcium in dermal and adipose microvasculature. However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortality rates associated with calciphylaxis highlight the importance to correctly diagnose and treat this condition. However, calciphylaxis remains a diagnosis that may be clinically challenging to make. Here, we review the literature on uremic calciphylaxis with a focus on its pathophysiology, clinical presentation, advances in diagnostic tools, and treatment strategies. We also discuss the unique histopathological features of calciphylaxis and contrast it with those of other forms of general vessel calcification. This review emphasizes the need for multidisciplinary collaboration including nephrology, dermatology, and palliative care to ultimately provide the best possible care to patients with calciphylaxis.
    MeSH term(s) Humans ; Calciphylaxis/diagnosis ; Calciphylaxis/etiology ; Calciphylaxis/therapy ; Vascular Calcification/etiology ; Renal Insufficiency, Chronic/complications ; Calcium ; Obesity/complications ; Kidney Failure, Chronic/therapy
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19: Misinformation Can Kill.

    Aghagoli, Ghazal / Siff, Emily J / Tillman, Anastasia C / Feller, Edward R

    Rhode Island medical journal (2013)

    2020  Volume 103, Issue 5, Page(s) 12–14

    MeSH term(s) COVID-19 ; Communication ; Coronavirus Infections ; Deception ; Fraud ; Humans ; Internet ; Pandemics ; Pneumonia, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419430-5
    ISSN 2327-2228 ; 0363-7913
    ISSN (online) 2327-2228
    ISSN 0363-7913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Extracellular vesicle treatment partially reverts epigenetic alterations in chronically ischemic porcine myocardium.

    Broadwin, Mark / Aghagoli, Ghazal / Sabe, Sharif A / Harris, Dwight D / Wallace, Joselynn / Lawson, Jordan / Ragayendran, Ashok / Fedulov, Alexey V / Sellke, Frank W

    Vessel plus

    2023  Volume 7

    Abstract: Introduction: Research has shown epigenetic change via alternation of the methylation profile of human skeletal muscle DNA after Cardio-Pulmonary Bypass (CPB). In this study, we investigated the change in epigenome-wide DNA methylation profiles of ... ...

    Abstract Introduction: Research has shown epigenetic change via alternation of the methylation profile of human skeletal muscle DNA after Cardio-Pulmonary Bypass (CPB). In this study, we investigated the change in epigenome-wide DNA methylation profiles of porcine myocardium after ischemic insult in the setting of treatment with extracellular vesicle (EV) therapy in normal
    Methods: Four groups of three pigs underwent ameroid constrictor placement to the left circumflex artery (LCx) and were assigned to the following groups: (1) normal diet saline injection; (2) normal diet EV injection; (3) HFD saline injection; and (4) HFD EV injection. DNA methylation was profiled via reduced-representation bisulfite sequencing (RRBS) and compared using a custom bioinformatic pipeline.
    Results: After initial analysis, 441 loci had a nominal
    Conclusions: Alterations in DNA methylation were identified in pig myocardium after ischemic insult, change in diet, and treatment with EVs. Hundreds of differentially methylated loci were detected, but the magnitude of the effects was low. These changes represent significant alterations in DNA methylation and merit further investigation.
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ISSN 2574-1209
    ISSN (online) 2574-1209
    DOI 10.20517/2574-1209.2023.103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiac involvement in COVID-19 patients: Risk factors, predictors, and complications: A review.

    Aghagoli, Ghazal / Gallo Marin, Benjamin / Soliman, Luke B / Sellke, Frank W

    Journal of cardiac surgery

    2020  Volume 35, Issue 6, Page(s) 1302–1305

    Abstract: Background: Respiratory complications have been well remarked in the novel coronavirus disease (SARS-CoV-2/COVID-19), yet an emerging body of research indicates that cardiac involvement may be implicated in poor outcomes for these patients.: Aims: ... ...

    Abstract Background: Respiratory complications have been well remarked in the novel coronavirus disease (SARS-CoV-2/COVID-19), yet an emerging body of research indicates that cardiac involvement may be implicated in poor outcomes for these patients.
    Aims: This review seeks to gather and distill the existing body of literature that describes the cardiac implications of COVID-19.
    Materials and methods: The English literature was reviewed for papers dealing with the cardiac effects of COVID-19.
    Results: Notably, COVID-19 patients with pre-existing cardiovascular disease are counted in greater frequency in intensive care unit settings, and ultimately suffer greater rates of mortality. Other studies have noted cardiac presentations for COVID-19, rather than respiratory, such as acute pericarditis and left ventricular dysfunction. In some patients there has been evidence of acute myocardial injury, with correspondingly increased serum troponin I levels. With regard to surgical interventions, there is a dearth of data describing myocardial protection during cardiac surgery for COVID-19 patients. Although some insights have been garnered in the study of cardiovascular diseases for these patients, these insights remain fragmented and have yet to cement clear guidelines for actionable clinical practice.
    Conclusion: While some information is available, further studies are imperative for a more cohesive understanding of the cardiac pathophysiology in COVID-19 patients to promote more informed treatment and, ultimately, better clinical outcomes.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cause of Death ; Comorbidity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Disease Outbreaks/statistics & numerical data ; Female ; Global Health ; Humans ; Male ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Prevalence ; Risk Assessment ; SARS-CoV-2 ; Severity of Illness Index ; Survival Analysis
    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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