LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 32

Search options

  1. Article ; Online: The American Heart Association at 100: A Century of Scientific Progress and the Future of Cardiovascular Science: A Presidential Advisory From the American Heart Association.

    Elkind, Mitchell S V / Arnett, Donna K / Benjamin, Ivor J / Eckel, Robert H / Grant, Augustus O / Houser, Steven R / Jacobs, Alice K / Jones, Daniel W / Robertson, Rose Marie / Sacco, Ralph L / Smith, Sidney C / Weisfeldt, Myron L / Wu, Joseph C / Jessup, Mariell

    Circulation

    2024  Volume 149, Issue 12, Page(s) e964–e985

    Abstract: In 1924, the founders of the American Heart Association (AHA) envisioned an international society focused on the heart and aimed at facilitating research, disseminating information, increasing public awareness, and developing public health policy related ...

    Abstract In 1924, the founders of the American Heart Association (AHA) envisioned an international society focused on the heart and aimed at facilitating research, disseminating information, increasing public awareness, and developing public health policy related to heart disease. This presidential advisory provides a comprehensive review of the past century of cardiovascular and stroke science, with a focus on the AHA's contributions, as well as informed speculation about the future of cardiovascular science into the next century of the organization's history. The AHA is a leader in fundamental, translational, clinical, and population science, and it promotes the concept of the "learning health system," in which a continuous cycle of evidence-based practice leads to practice-based evidence, permitting an iterative refinement in clinical evidence and care. This advisory presents the AHA's journey over the past century from instituting professional membership to establishing extraordinary research funding programs; translating evidence to practice through clinical practice guidelines; affecting systems of care through quality programs, certification, and implementation; leading important advocacy efforts at the federal, state and local levels; and building global coalitions around cardiovascular and stroke science and public health. Recognizing an exciting potential future for science and medicine, the advisory offers a vision for even greater impact for the AHA's second century in its continued mission to be a relentless force for longer, healthier lives.
    MeSH term(s) United States ; Humans ; American Heart Association ; Heart Diseases ; Stroke/therapy ; Stroke/epidemiology ; Evidence-Based Practice ; Mediastinum ; Cardiovascular Diseases/therapy ; Cardiovascular Diseases/epidemiology
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIR.0000000000001213
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Basic Electrophysiology.

    Grant, Augustus O

    Cardiac electrophysiology clinics

    2010  Volume 2, Issue 3, Page(s) 325–340

    Abstract: Available evidence suggests that the ion channels that generate the normal action potential are also the basis for the arrhythmias that occur in disease states. Therefore, a thorough understanding of the function of the ion channels that generate the ... ...

    Abstract Available evidence suggests that the ion channels that generate the normal action potential are also the basis for the arrhythmias that occur in disease states. Therefore, a thorough understanding of the function of the ion channels that generate the action potential is an important foundation for understanding the bases of arrhythmias and their treatment. This need is made all the more pressing by the discoveries in molecular genetics and membrane biophysics that have elucidated the fundamental mechanisms of a broad range of cardiac arrhythmias.
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Journal Article
    ISSN 1877-9190
    ISSN (online) 1877-9190
    DOI 10.1016/j.ccep.2010.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Cardiac ion channels.

    Grant, Augustus O

    Circulation. Arrhythmia and electrophysiology

    2009  Volume 2, Issue 2, Page(s) 185–194

    MeSH term(s) Action Potentials/physiology ; Animals ; Arrhythmias, Cardiac/physiopathology ; Electrocardiography ; Heart Conduction System/physiology ; Humans ; Ion Channels/physiology
    Chemical Substances Ion Channels
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.108.789081
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: The variability of the electrical properties of the pulmonary veins.

    Grant, Augustus O

    Journal of cardiovascular electrophysiology

    2009  Volume 20, Issue 9, Page(s) 1046–1047

    MeSH term(s) Action Potentials ; Animals ; Arrhythmias, Cardiac/physiopathology ; Biological Clocks ; Cells, Cultured ; Heart Conduction System/physiopathology ; Ion Channel Gating ; Membrane Potentials ; Myocytes, Cardiac/metabolism ; Potassium/metabolism ; Potassium Channels/metabolism ; Pulmonary Veins/physiopathology ; Rabbits
    Chemical Substances Potassium Channels ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2009-09
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2009.01541.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Critical reviews in basic electrophysiology: realizing the synergy between the basic and clinical sciences.

    Grant, Augustus O

    Journal of cardiovascular electrophysiology

    2006  Volume 17, Issue 2, Page(s) 219

    MeSH term(s) Action Potentials ; Arrhythmias, Cardiac/physiopathology ; Heart Conduction System/physiology ; Humans ; Long QT Syndrome/physiopathology
    Language English
    Publishing date 2006-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2006.00430.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Electrophysiological basis and genetics of Brugada syndrome.

    Grant, Augustus O

    Journal of cardiovascular electrophysiology

    2005  Volume 16 Suppl 1, Page(s) S3–7

    Abstract: Brugada syndrome is a primary arrhythmic syndrome arising in the structurally normal heart. Any proposed mechanism should account for the major features of the syndrome: localization of the ST segment and T-wave changes to the right precordial leads, ... ...

    Abstract Brugada syndrome is a primary arrhythmic syndrome arising in the structurally normal heart. Any proposed mechanism should account for the major features of the syndrome: localization of the ST segment and T-wave changes to the right precordial leads, association of conduction slowing at several levels, precipitation or aggravation of the major ECG changes by sodium channel-blocking drugs and the occurrence of ventricular fibrillation. Heterogeneity of repolarization across the ventricle wall plays a major role. Any agency that shifts the net current gradient during phase I outward would exaggerate the normal heterogeneity of repolarization and result in the ST segment and T-wave changes characteristic of the syndrome. When the outward current shift is marked, premature repolarization may occur in epicardial zone and the resulting gradient may precipitate reentry. The syndrome is inherited as an autosomal dominant. However, 75% of clinically affected individuals are males. In 20% of cases, the syndrome is associated with mutations of the cardiac sodium channel gene SCN5A. The mutations result in a loss-of-function as a result of the synthesis of a non-functional protein, altered protein trafficking, or change in gating. Agencies that reduce the sodium current may precipitate the characteristic ECG changes, for example, sodium channel blockers and membrane depolarization by hyperkalemia. Sympathetic stimulation may reverse the ECG changes and reduce arrhythmia recurrence. By its nonspecific potassium channel blocking action, quinidine may also reduce arrhythmia recurrence. We still do not know the basis for defect in the majority of patients with Brugada syndrome.
    MeSH term(s) Bundle-Branch Block/diagnosis ; Bundle-Branch Block/epidemiology ; Bundle-Branch Block/genetics ; Bundle-Branch Block/physiopathology ; Electrocardiography/methods ; Genetic Predisposition to Disease/genetics ; Heart Conduction System/physiopathology ; Humans ; Ion Channel Gating/genetics ; Muscle Proteins/genetics ; NAV1.5 Voltage-Gated Sodium Channel ; Polymorphism, Genetic ; Sodium Channels/genetics ; Syndrome
    Chemical Substances Muscle Proteins ; NAV1.5 Voltage-Gated Sodium Channel ; SCN5A protein, human ; Sodium Channels
    Language English
    Publishing date 2005-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2005.50104.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Ethnicity and arrhythmia susceptibility.

    Thomas, Kevin / Grant, Augustus O

    Journal of cardiovascular electrophysiology

    2008  Volume 19, Issue 4, Page(s) 427–429

    MeSH term(s) Brugada Syndrome/diagnosis ; Brugada Syndrome/ethnology ; Brugada Syndrome/genetics ; Electrocardiography/statistics & numerical data ; Genetic Predisposition to Disease/ethnology ; Genetic Predisposition to Disease/genetics ; Humans
    Language English
    Publishing date 2008-04
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2008.01106.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Novel insights into beta-blocker therapy for long QT syndromes.

    Daubert, James P / Grant, Augustus O / Nilsson, Kent R

    Journal of the American College of Cardiology

    2012  Volume 60, Issue 20, Page(s) 2100–2102

    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Female ; Humans ; Long QT Syndrome/drug therapy ; Male ; Metoprolol/therapeutic use ; Nadolol/therapeutic use ; Propranolol/therapeutic use
    Chemical Substances Adrenergic beta-Antagonists ; Nadolol (42200-33-9) ; Propranolol (9Y8NXQ24VQ) ; Metoprolol (GEB06NHM23)
    Language English
    Publishing date 2012-11-13
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2012.08.965
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Recent advances in the treatment of arrhythmias.

    Grant, Augustus O

    Circulation journal : official journal of the Japanese Circulation Society

    2003  Volume 67, Issue 8, Page(s) 651–655

    Abstract: Advances in endocardial mapping techniques and ablation have greatly increased the indications for catheter-ablation of supraventricular arrhythmias. Rate or rhythm control is a valid treatment option for patients with atrial fibrillation; however, all ... ...

    Abstract Advances in endocardial mapping techniques and ablation have greatly increased the indications for catheter-ablation of supraventricular arrhythmias. Rate or rhythm control is a valid treatment option for patients with atrial fibrillation; however, all patients with one or more risk factors should be treated with oral anticoagulants. The early success rate and long-term cure of atrial fibrillation by radiofrequency catheter ablation continues to increase. The number of centers offering this treatment option has increased substantially. Implantable defibrillator-cardioverters are the primary treatment modality for patients with ventricular tachycardia and their role in primary prevention is also being defined. Future advances in arrhythmia management will include improvements in catheter design and energy sources for ablation, and greater monitoring capacity of implantable devices.
    MeSH term(s) Arrhythmias, Cardiac/therapy ; Cardiology/trends ; Death, Sudden, Cardiac/prevention & control ; Humans ; Tachycardia, Supraventricular/therapy ; Tachycardia, Ventricular/therapy ; Ventricular Fibrillation/therapy
    Language English
    Publishing date 2003-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.67.651
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation.

    Grant, Augustus O / Tranquillo, Joseph

    Journal of cardiovascular electrophysiology

    2007  Volume 18, Issue 2, Page(s) 204–205

    MeSH term(s) Action Potentials/drug effects ; Animals ; Anti-Arrhythmia Agents/pharmacology ; Arrhythmias, Cardiac/physiopathology ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/drug effects ; Guinea Pigs ; Hydantoins ; Imidazolidines/pharmacology ; Myocytes, Cardiac/drug effects ; Nicardipine/pharmacology ; Patch-Clamp Techniques ; Phenethylamines/pharmacology ; Piperazines/pharmacology ; Rabbits ; Sulfonamides/pharmacology ; Torsades de Pointes/physiopathology
    Chemical Substances Anti-Arrhythmia Agents ; Calcium Channel Blockers ; Calcium Channels, L-Type ; Hydantoins ; Imidazolidines ; Phenethylamines ; Piperazines ; Sulfonamides ; azimilide (74QU6P2934) ; Nicardipine (CZ5312222S) ; dofetilide (R4Z9X1N2ND)
    Language English
    Publishing date 2007-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/j.1540-8167.2007.00726.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top