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  1. Article: Pyridine-Based 1,2,4-Triazolo-Tethered Indole Conjugates Potentially Affecting TNKS and PI3K in Colorectal Cancer.

    Yakkala, Prasanna A / Panda, Samir R / Naidu, Vegi G M / Shafi, Syed / Kamal, Ahmed

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 3, Page(s) 260–269

    Abstract: A library of pyridine-based 1,2,4-triazolo-tethered indole conjugates were designed, synthesized, and evaluated for anti-proliferative activity against a panel of six human cancer cell lines. All the synthesized conjugates ( ...

    Abstract A library of pyridine-based 1,2,4-triazolo-tethered indole conjugates were designed, synthesized, and evaluated for anti-proliferative activity against a panel of six human cancer cell lines. All the synthesized conjugates (
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Consenting in cardiac surgery during COVID-19: Are the risks quantifiable?

    Shafi, Ahmed M A / Harky, Amer

    Journal of cardiac surgery

    2020  Volume 35, Issue 11, Page(s) 2883–2886

    MeSH term(s) COVID-19/epidemiology ; Cardiac Surgical Procedures ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/virology ; Delivery of Health Care/organization & administration ; Elective Surgical Procedures ; Humans ; Infection Control ; Informed Consent ; Pandemics ; Risk Assessment ; Safety Management
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14993
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2221: Show issues Location:
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  3. Article ; Online: Mechanism of Oxygen Quenching of the Excited States of Heteroleptic Chromium(III) Phenanthroline Derivatives.

    Alazaly, Ahmed M M / Clarkson, Guy J / Ward, Michael D / Abdel-Shafi, Ayman A

    Inorganic chemistry

    2023  Volume 62, Issue 39, Page(s) 16101–16113

    Abstract: In this study, we report the synthesis and characterization of some heteroleptic Cr(III) complexes of the form [Cr(Phen) ...

    Abstract In this study, we report the synthesis and characterization of some heteroleptic Cr(III) complexes of the form [Cr(Phen)
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c02343
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  4. Article ; Online: Response to Letter to the Editor.

    Shafi, Ahmed M A / Magni, Francesco / Olatigbe, Temitope A T / Harky, Amer

    Journal of cardiac surgery

    2021  Volume 36, Issue 7, Page(s) 2605–2606

    MeSH term(s) Humans ; Postoperative Complications ; Sternotomy ; Sternum ; Wound Closure Techniques
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.15528
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  6. Article: Corrigendum to "A comprehensive review on modelling the adsorption process for heavy metal removal from waste water using artificial neural network technique" [Heliyon 9(4) (April 2023) e15455].

    Fiyadh, Seef Saadi / Alardhi, Saja Mohsen / Al Omar, Mohamed / Aljumaily, Mustafa M / Al Saadi, Mohammed Abdulhakim / Fayaed, Sabah Saadi / Ahmed, Sulaiman Nayef / Salman, Ali Dawood / Abdalsalm, Alyaa H / Jabbar, Noor Mohsen / El-Shafi, Ahmed

    Heliyon

    2023  Volume 9, Issue 7, Page(s) e17675

    Abstract: This corrects the article DOI: 10.1016/j.heliyon.2023.e15455.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.heliyon.2023.e15455.].
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e17675
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  7. Article ; Online: Consenting in cardiac surgery during COVID‐19

    Shafi, Ahmed M. A. / Harky, Amer

    Journal of Cardiac Surgery

    Are the risks quantifiable?

    2020  Volume 35, Issue 11, Page(s) 2883–2886

    Keywords Surgery ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14993
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Assessment of therapeutic potential of

    Eissa, Fatma M A / Abdel-Shafi, Iman R / El-Sayed, Shaimaa H / Negm, Mohamed S / Ahmed, Jumana A

    Journal of parasitic diseases : official organ of the Indian Society for Parasitology

    2022  Volume 46, Issue 3, Page(s) 704–713

    Abstract: ... Giardia ... ...

    Abstract Giardia lamblia
    Language English
    Publishing date 2022-04-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2548456-4
    ISSN 0975-0703 ; 0971-7196
    ISSN (online) 0975-0703
    ISSN 0971-7196
    DOI 10.1007/s12639-022-01489-z
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  9. Article ; Online: Novel approaches for the development of direct KRAS inhibitors: structural insights and drug design.

    Haider, Kashif / Sharma, Anku / Yar, M Shahar / Yakkala, Prasanna Anjaneyulu / Shafi, Syed / Kamal, Ahmed

    Expert opinion on drug discovery

    2022  Volume 17, Issue 3, Page(s) 247–257

    Abstract: Introduction: Hyperactivated RAS signaling is reported in 13% of all human cancers, in which ~80% resulted due to KRAS mutations alone. Direct inhibition of KRAS is an important aspect in treating KRAS-related tumors. Despite the efforts of more than ... ...

    Abstract Introduction: Hyperactivated RAS signaling is reported in 13% of all human cancers, in which ~80% resulted due to KRAS mutations alone. Direct inhibition of KRAS is an important aspect in treating KRAS-related tumors. Despite the efforts of more than four decades, not many KRAS inhibitors have been successful in obtaining clinical approval, except the very recent FDA approval for sotorasib. In recent years, the understanding of structural insights and allosteric pocket identification at catalytic sites of KRAS are likely to provide an excellent opportunity for the development of much more effective clinical candidates.
    Area covered: The presented review article mainly summarizes the developments of small molecule KRAS inhibitors as drug candidates and rational approaches that are being utilized for the selective targeting of
    Expert opinion: After the initial success in targeting the mutant KRAS G12C variants, the search has been shifted to address the challenges concerning the resistance and efficacy of small molecule KRAS inhibitors. However, the contribution of other KRAS mutations at G12V, G13C, and G13D variants causing cancers is much higher than the mutations at G12C. In view of this aspect, specific attention is required to target all other mutations as well. Accordingly, for the development of KRAS targeted therapies, the design of small molecule inhibitors that can inhibit KRAS signaling and as well as target inhibition of other signaling pathways like RAS-SOS and RAS-PI3K has to be explored extensively.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Drug Design ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemical Substances Antineoplastic Agents ; KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2022.2029842
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  10. Article: Retraction: Abdominal Pseudocyst: A Rare Complication of Ventriculoperitoneal Shunts.

    Bin Saqyan, Turki M / Basunbul, Lama I / Badahdah, Ahmed A / Saleh, Yasir A / Filimban, Suhail S / Alwabari, Ali A / Almutairi, Ahmad A / Alanazi, Sultanah R / Alghamdi, Abdulrazaq S / Aldadi, Bader O / Alghamdi, Bakheet A / Alzahrani, Shafi A / Alzahrani, Ahmed R / Alghamdi, Osama H / Alshammari, Malak

    Cureus

    2024  Volume 16, Issue 1, Page(s) r90

    Abstract: This retracts the article DOI: 10.7759/cureus.18956.]. ...

    Abstract [This retracts the article DOI: 10.7759/cureus.18956.].
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.r90
    Database MEDical Literature Analysis and Retrieval System OnLINE

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