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Article ; Online: Letter: Predictive Value of Systemic Immune-Inflammatory Index in No-Reflow in Patients with ST-Segment Elevation Myocardial Infarction.

Liu, Jia-Hui / Zeng, Min / Zhang, Yue / Mo, De-Gang

2022 Volume 74, Issue 4, Page(s) 395–396

MeSH term(s)	Humans ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; No-Reflow Phenomenon ; Percutaneous Coronary Intervention ; Predictive Value of Tests ; Coronary Angiography
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/00033197221125024
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Article: Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis.

Li, Yi-Nan / Wei, Shao-Ming / Fu, Yang-Kai / Zeng, Zhen-Xin / Huang, Li-Ming / Lv, Jia-Hui / Chen, Wei-Zhao / Wei, Yong-Gang / Zhang, Zhi-Bo / Zhou, Jian-Yin / Wu, Jia-Yi / Yan, Mao-Lin

Frontiers in oncology

2024 Volume 14, Page(s) 1372123

Abstract: Background: Portal vein tumor thrombus (PVTT) seriously affects the prognosis of hepatocellular carcinoma (HCC). However, whether bile duct tumor thrombus (BDTT) significantly affects the prognosis of HCC as much as PVTT remains unclear. We aimed to ... ...

Abstract	Background: Portal vein tumor thrombus (PVTT) seriously affects the prognosis of hepatocellular carcinoma (HCC). However, whether bile duct tumor thrombus (BDTT) significantly affects the prognosis of HCC as much as PVTT remains unclear. We aimed to compare the long-term surgical outcomes of HCC with macroscopic PVTT (macro-PVTT) and macroscopic BDTT (macro-BDTT). Methods: The data of HCC patients with macro-BDTT or macro-PVTT who underwent hemihepatectomy were retrospectively reviewed. A propensity score matching (PSM) analysis was performed to reduce the baseline imbalance. The recurrence-free survival (RFS) and overall survival (OS) rates were compared between the cohorts. Results: Before PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.043 and P = 0.008, respectively). Multivariate analyses identified PVTT (hazard ratio [HR] = 1.835, P = 0.016) and large HCC (HR = 1.553, P = 0.039) as independent risk factors for poor OS and RFS, respectively. After PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.037 and P = 0.004, respectively). The 3- and 5-year OS rates were significantly higher in the BDTT group (59.5% and 52.1%, respectively) than in the PVTT group (33.3% and 20.2%, respectively). Conclusion: Aggressive hemihepatectomy provides an acceptable prognosis for HCC patients with macro-BDTT. Furthermore, the long-term surgical outcomes of HCC patients with macro-BDTT were significantly better than those of HCC patients with macro-PVTT.
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1372123
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Article ; Online: Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans

Jing-Yi Peng / Xuqing Liu / Xian-Ting Zeng / Yue Hao / Jia-Hui Zhang / Qian Li / Xia-Jing Tong

Cell Reports, Vol 42, Iss 6, Pp 112598- (2023)

2023

Abstract: Summary: Age-associated neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues ... ...

Abstract	Summary: Age-associated neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues modulate neurodegeneration remains unclear. Here, we found that in Caenorhabditis elegans, exposure to pheromones in the L1 stage accelerates neurodegeneration in adults. Perception of pheromones ascr#3 and ascr#10 is mediated by chemosensory neurons ASK and ASI. ascr#3 perceived by G protein-coupled receptor (GPCR) DAF-38 in ASK activates glutamatergic transmission into AIA interneurons. ascr#10 perceived by GPCR STR-2 in ASI activates the secretion of neuropeptide NLP-1, which binds to the NPR-11 receptor in AIA. Activation of both ASI and ASK is required and sufficient to remodel neurodevelopment via AIA, which triggers insulin-like signaling and inhibits autophagy in adult neurons non-cell-autonomously. Our work reveals how pheromone perception at the early developmental stage modulates neurodegeneration in adults and provides insights into how the external environment impacts neurodegenerative diseases.
Keywords	CP: Neuroscience ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inhibition of α-glucosidase by Cyclocarya paliurus based on HPLC fingerprinting integrated with molecular docking and molecular dynamics.

Chai, Shan-Shan / Cai, Jia-Han / Luo, Jia-Hui / Zhao, Bi-Xin / Wu, Zhi-Min / Liu, Xiao-Tong / Tian, Hui / Zeng, Yu

Biomedical chromatography : BMC

2022 Volume 36, Issue 9, Page(s) e5429

Abstract: Cyclocarya paliurus (CP) extracts have been shown to lower sugar and lipid levels in blood, but the material basis is not clear. We analyzed CP aqueous extracts using high-performance liquid chromatography "fingerprinting", checked their pharmacological ... ...

Abstract	Cyclocarya paliurus (CP) extracts have been shown to lower sugar and lipid levels in blood, but the material basis is not clear. We analyzed CP aqueous extracts using high-performance liquid chromatography "fingerprinting", checked their pharmacological parameters using virtual screening, and undertook molecular docking and molecular dynamics simulations. Also, the inhibitory effects of CP components upon α-glucosidase in vitro were evaluated. Fingerprinting and virtual screening showed that the aqueous extract of CP contained the active components protocatechuic acid, chlorogenic acid, caffeic acid and rutin, which were safe and had no side effects in vivo. Molecular docking and molecular dynamics simulations showed that chlorogenic acid and rutin might have a potent inhibitory effect on α-glucosidase. An enzyme-activity assay in vitro showed that the half-maximal inhibitory values of chlorogenic acid and rutin were 398.9 and 351.8 μg/ml, respectively. Chlorogenic acid and rutin had an inhibitory effect on α-glucosidase. Cyclocarya paliurus could be developed as a natural α-glucosidase inhibitor.
MeSH term(s)	Chlorogenic Acid/pharmacology ; Chromatography, High Pressure Liquid ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Juglandaceae/chemistry ; Juglandaceae/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rutin ; alpha-Glucosidases/metabolism
Chemical Substances	Glycoside Hydrolase Inhibitors ; Plant Extracts ; Chlorogenic Acid (318ADP12RI) ; Rutin (5G06TVY3R7) ; alpha-Glucosidases (EC 3.2.1.20)
Language	English
Publishing date	2022-06-26
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5429
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Zs.A 2166: Show issues

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Article ; Online: Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans.

Peng, Jing-Yi / Liu, Xuqing / Zeng, Xian-Ting / Hao, Yue / Zhang, Jia-Hui / Li, Qian / Tong, Xia-Jing

Cell reports

2023 Volume 42, Issue 6, Page(s) 112598

Abstract: Age-associated neurodegenerative disorders such as Parkinson's and Alzheimer's diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues modulate ... ...

Abstract	Age-associated neurodegenerative disorders such as Parkinson's and Alzheimer's diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues modulate neurodegeneration remains unclear. Here, we found that in Caenorhabditis elegans, exposure to pheromones in the L1 stage accelerates neurodegeneration in adults. Perception of pheromones ascr#3 and ascr#10 is mediated by chemosensory neurons ASK and ASI. ascr#3 perceived by G protein-coupled receptor (GPCR) DAF-38 in ASK activates glutamatergic transmission into AIA interneurons. ascr#10 perceived by GPCR STR-2 in ASI activates the secretion of neuropeptide NLP-1, which binds to the NPR-11 receptor in AIA. Activation of both ASI and ASK is required and sufficient to remodel neurodevelopment via AIA, which triggers insulin-like signaling and inhibits autophagy in adult neurons non-cell-autonomously. Our work reveals how pheromone perception at the early developmental stage modulates neurodegeneration in adults and provides insights into how the external environment impacts neurodegenerative diseases.
MeSH term(s)	Animals ; Caenorhabditis elegans/metabolism ; Signal Transduction ; Pheromones/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Insulin/metabolism ; Perception
Chemical Substances	Pheromones ; Caenorhabditis elegans Proteins ; Insulin
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112598
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Article ; Online: Efficacy and Safety of Endoscopic Submucosal Dissection for Rectal Tumors Extending Versus Not to the Dentate Line: A Systematic Review and Meta-Analysis.

Zeng, Qi-Shan / Zou, Min / Nie, Jiao / Yang, Jia-Hui / Luo, Zhen-Yi / Gan, Hua-Tian

Journal of clinical gastroenterology

2022 Volume 56, Issue 6, Page(s) 518–528

Abstract: Goals: To evaluate the outcomes of endoscopic submucosal dissection (ESD) for rectal tumors extending to the dentate line (RTDLs) compared with rectal tumors not extending to the dentate line (non-RTDLs).: Background: There is limited composite data ... ...

Abstract	Goals: To evaluate the outcomes of endoscopic submucosal dissection (ESD) for rectal tumors extending to the dentate line (RTDLs) compared with rectal tumors not extending to the dentate line (non-RTDLs). Background: There is limited composite data on the outcomes of ESD for RTDLs versus non-RTDLs. Study: We performed a systematic review and meta-analysis of studies that reported the clinical outcomes of ESD for RTDLs and non-RTDLs. Main outcomes were pooled estimated rates of en bloc/complete/curative resection, local recurrence, and incidence of bleeding, perforation, stricture, anal pain, and fever. Results: Six studies were enrolled, including 265 cases of RTDLs and 788 cases of non-RTDLs. The en bloc resection rate was comparable for RTDLs and non-RTDLs [odds ratio (OR), 1.04; 95% confidence interval (CI), 0.55-1.95; P=0.90]. The complete resection rate was significantly lower for RTDLs (OR, 0.59; 95% CI, 0.41-0.83; P=0.003), as well as the curative resection rate (OR, 0.57; 95% CI, 0.38-0.87; P=0.010). The rates of stricture, postoperative anal pain and local recurrence were significantly higher for RTDLs than non-RTDLs (OR, 3.07; 95% CI, 1.01-9.31; P=0.05) (OR, 42.10; 95% CI, 4.73-374.97; P=0.0008) (OR, 3.00; 95% CI, 1.13-7.96; P=0.03), but the higher rates of postoperative bleeding and fever for RTDLs were not significantly (OR, 1.33; 95% CI, 0.53-3.30; P=0.54) (OR, 2.23; 95% CI, 0.55-9.07; P=0.26), as well as its lower perforation rate (OR, 0.85; 95% CI, 0.27-2.63; P=0.78). Conclusions: Despite its inferior outcomes than non-RTDLs, ESD is still a feasible and safe treatment for RTDLs if appropriate lesions are treated by experienced operators.
MeSH term(s)	Constriction, Pathologic ; Endoscopic Mucosal Resection/adverse effects ; Humans ; Neoplasm Recurrence, Local/epidemiology ; Pain ; Postoperative Hemorrhage ; Rectal Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001692
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Zs.A 1523: Show issues

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Article: Comparative Analyses of Rhizosphere Bacteria Along an Elevational Gradient of

Zuo, You-Wei / Zhang, Jia-Hui / Ning, Deng-Hao / Zeng, Yu-Lian / Li, Wen-Qiao / Xia, Chang-Ying / Zhang, Huan / Deng, Hong-Ping

Frontiers in microbiology

2022 Volume 13, Page(s) 881921

Abstract: ... Thuja ... ...

Abstract	Thuja sutchuenensis
Language	English
Publishing date	2022-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.881921
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Article ; Online: HbBIN2 Functions in Plant Cold Stress Resistance through Modulation of HbICE1 Transcriptional Activity and ROS Homeostasis in

Qiu, Yi-Min / Guo, Jing / Jiang, Wei-Zeng / Ding, Jia-Hui / Song, Ru-Feng / Zhang, Jian-Long / Huang, Xi / Yuan, Hong-Mei

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: Cold stress poses significant limitations on the growth, latex yield, and ecological distribution of rubber trees ( ...

Abstract	Cold stress poses significant limitations on the growth, latex yield, and ecological distribution of rubber trees (
MeSH term(s)	Hevea/genetics ; Hevea/metabolism ; Cold-Shock Response/genetics ; Reactive Oxygen Species/metabolism ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Homeostasis ; Protein Kinases/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism
Chemical Substances	Reactive Oxygen Species ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; BIN2 protein, Arabidopsis (EC 2.7.1.-) ; Protein Kinases (EC 2.7.-) ; Arabidopsis Proteins
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115778
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Article: Assessment of land use change of ecological green wedge and cooling island effect: A case study of Wuhan, China.

Liu, Hui-Min / Qian, Wen-Qi / Tang, Lu-Jia / Wu, Yi-Han / Zeng, Jia-Ying

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 35, Issue 2, Page(s) 480–488

Abstract: The construction of urban ecological green wedges, which can mitigate the heat island effect through cooling and ventilation effects, is an important way to enhance the adaptation of cities to climate change. Dynamic monitoring and periodic assessment of ...

Title translation	城市生态绿楔土地利用变化及冷岛效应评估——以武汉市为例.
Abstract	The construction of urban ecological green wedges, which can mitigate the heat island effect through cooling and ventilation effects, is an important way to enhance the adaptation of cities to climate change. Dynamic monitoring and periodic assessment of both the conservation status and cooling effect of ecological green wedges is a key to ensure the heat mitigation benefits. Based on multi-source remote sensing data, we systematically analyzed the land use changes of six ecological green wedges in Wuhan in 2013 and 2020 using the methods of Markov transfer matrix, land use dynamics, and comprehensive index of land use degree, and evaluated the changes in surface temperature of the ecological green wedges and their cooling island effect. Results showed that the ecological green wedges in Wuhan generally had a large amount of construction land encroaching on ecological land from 2013 to 2020, with the water decreased the most. With the continuous deterioration of ecological green wedges, their land surface temperatures showed rising trends, together with significant weakening trends in cooling island effects. Among all the six wedges, the Dadonghu, Tangxun, and Wuhu exhibited relatively better ecological conservation, slighter land use change and lower overall development degree. Qinglinghu and Houguanhu demonstrated average levels of conservation. Fuhe experienced the most severe change under the significant influence of the westward policy of Wuhan City, with the proportion of water decreasing by 7.1%, warming up by 3.00 ℃, and the largest reduction in cooling distance for the cooling island effect, amounting to about 210 m. The results provided scientific evidence for the urban heat island mitigation-oriented planning and management of ecological green wedges for Wuhan City.
MeSH term(s)	Cities ; Hot Temperature ; Temperature ; China ; Water ; Environmental Monitoring/methods
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-03-24
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202402.019
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Article ; Online: ILC2s: Unraveling the innate immune orchestrators in allergic inflammation.

Lu, Hui-Fei / Zhou, Yi-Chi / Luo, Dan-Dan / Yang, Dun-Hui / Wang, Xi-Jia / Cheng, Bao-Hui / Zeng, Xian-Hai

International immunopharmacology

2024 Volume 131, Page(s) 111899

Abstract: The prevalence rate of allergic diseases including asthma, atopic rhinitis (AR) and atopic dermatitis (AD) has been significantly increasing in recent decades due to environmental changes and social developments. With the study of innate lymphoid cells, ... ...

Abstract	The prevalence rate of allergic diseases including asthma, atopic rhinitis (AR) and atopic dermatitis (AD) has been significantly increasing in recent decades due to environmental changes and social developments. With the study of innate lymphoid cells, the crucial role played by type 2 innate lymphoid cells (ILC2s) have been progressively unveiled in allergic diseases. ILC2s, which are a subset of innate lymphocytes initiate allergic responses. They respond swiftly during the onset of allergic reactions and produce type 2 cytokines, working in conjunction with T helper type 2 (Th2) cells to induce and sustain type 2 immune responses. The role of ILC2s represents an intriguing frontier in immunology; however, the intricate immune mechanisms of ILC2s in allergic responses remain relatively poorly understood. To gain a comphrehensive understanding of the research progress of ILC2, we summarize recent advances in ILC2s biology in pathologic allergic inflammation to inspire novel approaches for managing allergic diseases.
MeSH term(s)	Humans ; Immunity, Innate ; Lymphocytes ; Cytokines ; Inflammation ; Rhinitis, Allergic
Chemical Substances	Cytokines
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111899
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