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Article ; Online: Correction to: Iatrogenic atrial septal defect: reassurance or inquisitiveness.

Naksuk, Niyada / Asirvatham, Samuel J

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2018 Volume 54, Issue 2, Page(s) 201

Abstract: The original version of this article unfortunately contained a mistake. The presentation of reference 1 was incorrect. The correct information is given below. ...

Abstract	The original version of this article unfortunately contained a mistake. The presentation of reference 1 was incorrect. The correct information is given below.
Language	English
Publishing date	2018-09-02
Publishing country	Netherlands
Document type	Journal Article ; Published Erratum
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-018-0442-z
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Article ; Online: Iatrogenic atrial septal defect: reassurance or inquisitiveness.

Naksuk, Niyada / Asirvatham, Samuel J

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2018 Volume 52, Issue 2, Page(s) 137–140

MeSH term(s)	Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Echocardiography, Transesophageal/methods ; Electrocardiography/methods ; Female ; Heart Septal Defects, Atrial/diagnostic imaging ; Heart Septal Defects, Atrial/etiology ; Heart Septal Defects, Atrial/mortality ; Heart Septal Defects, Atrial/surgery ; Humans ; Iatrogenic Disease ; Male ; Prognosis ; Pulmonary Veins/surgery ; Risk Assessment ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2018-04-22
Publishing country	Netherlands
Document type	Editorial ; Review
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-018-0369-4
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Article ; Online: Level of block: atrioventricular node, infra-Hisian, or intramyocardial?-Authors' reply.

Padmanabhan, Deepak / Naksuk, Niyada / Kancharla, Krishna / Mulpuru, Siva

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2019 Volume 21, Issue 4, Page(s) 682

MeSH term(s)	Atrioventricular Node ; Bundle of His ; Bundle-Branch Block ; Humans
Language	English
Publishing date	2019-02-22
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euy319
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Article ; Online: Cardiac safety of off-label COVID-19 drug therapy: a review and proposed monitoring protocol.

Naksuk, Niyada / Lazar, Sorin / Peeraphatdit, Thoetchai Bee

European heart journal. Acute cardiovascular care

2020 Volume 9, Issue 3, Page(s) 215–221

Abstract: More than 2,000,000 individuals worldwide have had coronavirus 2019 disease infection (COVID-19), yet there is no effective medical therapy. Multiple off-label and investigational drugs, such as chloroquine and hydroxychloroquine, have gained broad ... ...

Abstract	More than 2,000,000 individuals worldwide have had coronavirus 2019 disease infection (COVID-19), yet there is no effective medical therapy. Multiple off-label and investigational drugs, such as chloroquine and hydroxychloroquine, have gained broad interest due to positive pre-clinical data and are currently used for treatment of COVID-19. However, some of these medications have potential cardiac adverse effects. This is important because up to one-third of patients with COVID-19 have cardiac injury, which can further increase the risk of cardiomyopathy and arrhythmias. Adverse effects of chloroquine and hydroxychloroquine on cardiac function and conduction are broad and can be fatal. Both drugs have an anti-arrhythmic property and are proarrhythmic. The American Heart Association has listed chloroquine and hydroxychloroquine as agents which can cause direct myocardial toxicity. Similarly, other investigational drugs such as favipiravir and lopinavir/ritonavir can prolong QT interval and cause Torsade de Pointes. Many antibiotics commonly used for the treatment of patients with COVID-19, for instance azithromycin, can also prolong QT interval. This review summarizes evidenced-based data regarding potential cardiac adverse effects due to off-label and investigational drugs including chloroquine and hydroxychloroquine, antiviral therapy, monoclonal antibodies, as well as common antibiotics used for the treatment of COVID-19. The article focuses on practical points and offers a point-of-care protocol for providers who are taking care of patients with COVID-19 in an inpatient and outpatient setting. The proposed protocol is taking into consideration that resources during the pandemic are limited.
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Antibodies, Monoclonal/adverse effects ; Antimalarials/adverse effects ; Antimalarials/pharmacokinetics ; Antimalarials/toxicity ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/complications ; Betacoronavirus/drug effects ; COVID-19 ; Cardiomyopathies/chemically induced ; Cardiomyopathies/complications ; Cardiotoxicity/epidemiology ; Chloroquine/adverse effects ; Chloroquine/pharmacokinetics ; Chloroquine/toxicity ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Cytochrome P-450 CYP3A Inhibitors/adverse effects ; Drug Monitoring/methods ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/pharmacokinetics ; Hydroxychloroquine/toxicity ; Off-Label Use/statistics & numerical data ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Torsades de Pointes/chemically induced ; Torsades de Pointes/epidemiology
Chemical Substances	Anti-Bacterial Agents ; Antibodies, Monoclonal ; Antimalarials ; Cytochrome P-450 CYP3A Inhibitors ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
Keywords	covid19
Language	English
Publishing date	2020-05-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2663340-1
ISSN	2048-8734 ; 2048-8726
ISSN (online)	2048-8734
ISSN	2048-8726
DOI	10.1177/2048872620922784
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Article ; Online: Stellate ganglia stimulation counteracts vagal stimulation by significantly increasing heart rate and blood pressure.

Killu, Ammar M / Yang, Mei / Naksuk, Niyada / Tri, Jason / Li, Xuping / Asirvatham, Roshini / Asirvatham, Samuel J / Cha, Yong-Mei

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2023

Abstract: Background: Vasovagal syncope (VVS) is the leading cause of syncope. The most frequent mechanism is that of a cardioinhibitory response, vasodepressor response, or mixture of both. Neural stimulation that negates or overcomes the effects of vagal tone ... ...

Abstract	Background: Vasovagal syncope (VVS) is the leading cause of syncope. The most frequent mechanism is that of a cardioinhibitory response, vasodepressor response, or mixture of both. Neural stimulation that negates or overcomes the effects of vagal tone may be used as a treatment strategy for VVS. Methods: Six male canines were studied. Stimulation (10-Hz, 2 ms pulse duration, 2 min duration) of the cervical vagus (CV), thoracic vagus (TV), and stellate ganglia (SG) was performed using needle electrodes at 3 V, 5 V, and 10 V output. SG stimulation at an output of 10 V overlaying TV stimulation at the same output was performed. Heart rate (HR), blood pressure (BP), and cardiac output (CO) were measured before, during, and after stimulation. Results: Right cervical vagal stimulation was associated with significant hemodynamic changes. HR, SBP, and DBP were reduced (107 ± 16 vs. 78 ± 15 bpm [P < 0.0001], 116 ± 24 vs. 107 ± 28 mmHg [P = 0.002] and 71 ± 18 vs. 58 ± 20 mmHg [P < 0.0001]), respectively, while left cervical vagal stimulation had minimal changes. CV stimulation was associated with greater hemodynamic changes than TV stimulation. Left and right SG stimulation significantly increased systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR at 5 V and 10 V, which could be observed within 30 s after stimulation. An output-dependent increase in hemodynamic parameters was seen with both left and right SG stimulation. No difference between left and right SG stimulation was seen. SG stimulation overlay significantly increased HR, BP, and CO from baseline vagal stimulation bilaterally. Conclusions: Stellate ganglia stimulation leads to increased HR and BP despite significant vagal stimulation. This may be exploited therapeutically in the management of vasovagal syncope.
Language	English
Publishing date	2023-03-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-023-01516-w
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Article ; Online: Longitudinal Change and Predictors of Early and Late Improvement in Ejection Fraction in Patients With Cardiomyopathy After Atrial Fibrillation Ablation.

Aroudaky, Ahmad / Almerstani, Muaaz / Frankel, Samuel / Shin, David / Tsai, Shane / Windle, John / Anderson, Daniel / Lundgren, Scott W / Goyal, Neha / Naksuk, Niyada

The American journal of cardiology

2023 Volume 210, Page(s) 217–218

Language	English
Publishing date	2023-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.10.026
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Article ; Online: Visualizing Risk for and Optimizing Prevention of Sudden Cardiac Death.

Naksuk, Niyada / Asirvatham, Samuel J

Journal of cardiovascular electrophysiology

2015 Volume 26, Issue 11, Page(s) 1247–1249

Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.12819
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Article ; Online: Lyme carditis atrioventricular block: management strategies-Authors' reply.

Isath, Ameesh / Padmanabhan, Deepak / Naksuk, Niyada / Kella, Danesh / Friedman, Paul

2019 Volume 21, Issue 8, Page(s) 1282

MeSH term(s)	Atrioventricular Block ; Humans ; Lyme Disease ; Myocarditis ; Pacemaker, Artificial
Language	English
Publishing date	2019-06-05
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euz111
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Article ; Online: Improvement of left ventricular function with surgical revascularization in patients eligible for implantable cardioverter-defibrillator.

Adabag, Selçuk / Carlson, Selma / Gravely, Amy / Buelt-Gebhardt, Melissa / Madjid, Mohammad / Naksuk, Niyada

Journal of cardiovascular electrophysiology

2021 Volume 33, Issue 2, Page(s) 244–251

Abstract: Introduction: Left ventricular ejection fraction (EF) ≤ 35% is the cornerstone criterion for implantable cardioverter-defibrillator (ICD) eligibility. Improvement in EF may occur in ICD-eligible patients after coronary artery bypass graft surgery (CABG). ...

Abstract	Introduction: Left ventricular ejection fraction (EF) ≤ 35% is the cornerstone criterion for implantable cardioverter-defibrillator (ICD) eligibility. Improvement in EF may occur in ICD-eligible patients after coronary artery bypass graft surgery (CABG). However, the incidence, predictors, and outcomes of this process are unclear. Methods and results: We studied 427 patients with EF ≤ 35% who underwent CABG in the Surgical Treatment for Ischemic Heart Failure (STICH) trial and had a systematic pre- and postoperative (4 months) EF assessment using the identical cardiac imaging modality. All imaging studies were interpreted at a core laboratory. Improvement in EF was defined as postoperative EF > 35% and >5% absolute improvement from baseline. Of the 427 patients (mean age 61.8 ± 9.5 and 50 women), 125 (29.2%) had EF improvement. Their mean EF increased from 26.8% (±5.8%) to 43.3% (±6.5%) (p < .0001). EF improvement occurred in only 20% of patients with a preoperative EF < 25%. The odds of EF improvement were 1.96 times higher (95% confidence interval [CI]: 0.91-4.23, p = .09) in patients with myocardial viability. In adjusted analyses, EF improvement was associated with a significantly lower risk of all-cause mortality (hazard ratio [HR]: 0.58, 95% CI: 0.35-0.96; p = .03) and heart failure mortality (HR: 0.31, 95% CI: 0.11-0.87; p = .027). Conclusion: Nearly 1/3rd of ICD-eligible patients undergoing CABG had significant improvement in EF, obviating the need for primary prevention ICD implantation. These results provide patients and clinicians data on the likelihood of ICD eligibility after CABG and support the practice of reassessment of EF after revascularization.
MeSH term(s)	Aged ; Coronary Artery Bypass ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Female ; Humans ; Middle Aged ; Stroke Volume ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/therapy ; Ventricular Function, Left
Language	English
Publishing date	2021-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.15315
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Article ; Online: Supraventricular Arrhythmias: Clinical Framework and Common Scenarios for the Internist.

DeSimone, Christopher V / Naksuk, Niyada / Asirvatham, Samuel J

Mayo Clinic proceedings

2018 Volume 93, Issue 12, Page(s) 1825–1841

Abstract: Supraventricular arrhythmias can cause uncomfortable symptoms for patients. Often, the first point of contact is in the primary care setting, and thus, it is imperative for the general internist to have a clinical framework in place to recognize this ... ...

Abstract	Supraventricular arrhythmias can cause uncomfortable symptoms for patients. Often, the first point of contact is in the primary care setting, and thus, it is imperative for the general internist to have a clinical framework in place to recognize this cluster of cardiac arrhythmias, be familiar with immediate and long-term management of supraventricular tachycardias, and understand when cardiac electrophysiologic consultation is necessary. The electrocardiographic characteristics can have subtle but important clues to the diagnosis and initial management. An understanding of the mechanisms of these arrhythmias is essential to provide proper therapy to the patient. In addition, there are common practice strategies that should be emphasized to avoid common misperceptions that could pose risk to the patient. In this review, we provide a framework to more easily recognize and classify these arrhythmias. We also illustrate the mechanism for these arrhythmias to provide an understanding of the interventions generally used.
MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Anticoagulants/therapeutic use ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/therapy ; Atrial Flutter/diagnosis ; Atrial Flutter/therapy ; Catheter Ablation ; Electrocardiography ; Humans ; Tachycardia, Supraventricular/classification ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/therapy
Chemical Substances	Adrenergic beta-Antagonists ; Anti-Arrhythmia Agents ; Anticoagulants
Language	English
Publishing date	2018-11-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2018.07.019
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