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Article ; Online: Mesenteric panniculitis simulating early lymphoma recurrence.

Gil-Rodríguez, Jaime / Callejas-Rubio, José-Luis / García Martín, Paloma

2024

Title translation	Paniculitis mesentérica como simuladora de recidiva de un linfoma.
Language	Spanish
Publishing date	2024-02-19
Publishing country	Spain
Document type	Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2023.11.045
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Article: Study of the reusability and stability of nylon nanofibres as an antibody immobilisation surface.

Peraile, Inés / Gil-García, Matilde / González-López, Laura / Dabbagh-Escalante, Nushin A / Cabria-Ramos, Juan C / Lorenzo-Lozano, Paloma

Beilstein journal of nanotechnology

2024 Volume 15, Page(s) 83–94

Abstract: In the case of a biological threat, early, rapid, and specific detection is critical. In addition, ease of handling, use in the field, and low-cost production are important considerations. Immunological devices are able to respond to these needs. In the ... ...

Abstract	In the case of a biological threat, early, rapid, and specific detection is critical. In addition, ease of handling, use in the field, and low-cost production are important considerations. Immunological devices are able to respond to these needs. In the design of these immunological devices, surface antibody immobilisation is crucial. Nylon nanofibres have been described as a very good option because they allow for an increase in the surface-to-volume ratio, leading to an increase in immunocapture efficiency. In this paper, we want to deepen the study of other key points, such as the reuse and stability of these nanofibres, in order to assess their profitability. On the one hand, the reusability of nanofibres has been studied using different stripping treatments at different pH values on the nylon nanofibres with well-oriented antibodies anchored by protein A/G. Our study shows that stripping with glycine buffer pH 2.5 allows the nanofibres to be reused as long as protein A/G has been previously anchored, leaving both nanofibre and protein A/G unchanged. On the other hand, we investigated the stability of the nylon nanofibres. To achieve this, we analysed any loss of immunocapture ability of well-oriented antibodies anchored both to the nylon nanofibres and to a specialised surface with high protein binding capacity. The nanofibre immunocapture system maintained an unchanged immunocapture ability for a longer time than the specialised planar surface. In conclusion, nylon nanofibres seem to be a very good choice as an antibody immobilisation surface, offering not only higher immunocapture efficiency, but also more cost efficiency as they are reusable and stable.
Language	English
Publishing date	2024-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2583584-1
ISSN	2190-4286
ISSN	2190-4286
DOI	10.3762/bjnano.15.8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lack of Specific Immune Response after Five Doses of mRNA SARS-CoV-2 Vaccine in a Patient with CD4

Alba-Cano, Trinidad / Fernández-Cruz, Eduardo / Alonso, Roberto / Muñoz-Gómez, Sara / Pérez de Diego, Rebeca / García Martínez, Elena / Sánchez-Mateos, Paloma / Navarro Caspistegui, Joaquín / Martín López, Mónica / Gil-Herrera, Juana

Vaccines

2024 Volume 12, Issue 4

Abstract: Immunogenicity of SARS-CoV-2 mRNA vaccines is highly heterogeneous in patients with inborn errors of immunity (IEIs). This case report analyzes the immune response to mRNA COVID-19 two-dose primary vaccination followed by three boosters in an IEI patient ...

Abstract	Immunogenicity of SARS-CoV-2 mRNA vaccines is highly heterogeneous in patients with inborn errors of immunity (IEIs). This case report analyzes the immune response to mRNA COVID-19 two-dose primary vaccination followed by three boosters in an IEI patient with marked CD4
Language	English
Publishing date	2024-04-06
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12040386
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Article: Portopulmonary hypertension: Success with combined medical treatment.

Hernández, María / Esteban, Violeta / Ruiz, Paloma / Boira, Ignacio / Wickmann, Phillip / Sancho-Chust, José N / Gil, Joan

Respirology case reports

2023 Volume 11, Issue 4, Page(s) e01114

Abstract: Portopulmonary hypertension is an uncommon disease associated with high morbidity and mortality, so its early diagnosis and treatment are essential. We report here the case of a 57-year-old man with portopulmonary hypertension caused by chronic ... ...

Abstract	Portopulmonary hypertension is an uncommon disease associated with high morbidity and mortality, so its early diagnosis and treatment are essential. We report here the case of a 57-year-old man with portopulmonary hypertension caused by chronic hepatosplenic schistosomiasis and also liver cirrhosis due to hepatitis C and alcoholism. As well as treating both diseases, portopulmonary hypertension was successfully managed with tadalafil and macitentan as maintenance therapy. This case reminds clinicians that pulmonary hypertension can be multifactorial, a good diagnosis and a multidisciplinary treatment can lead to improved prognosis.
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1114
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Article ; Online: Psychosocial and sexual well-being in breast cancer survivors undergoing immediate breast reconstruction: The mediating role of breast satisfaction.

Gil-Olarte, Paloma / Gil-Olarte, M Angeles / Gómez-Molinero, Rocío / Guil, Rocío

European journal of cancer care

2022 Volume 31, Issue 6, Page(s) e13686

Abstract: Objective: This study aimed to explore (1) the levels of quality of life (psychosocial, physical and sexual well-being) and breast satisfaction in breast cancer patients (BCP) after immediate reconstruction (IR), considering surgery reason and surgical ... ...

Abstract	Objective: This study aimed to explore (1) the levels of quality of life (psychosocial, physical and sexual well-being) and breast satisfaction in breast cancer patients (BCP) after immediate reconstruction (IR), considering surgery reason and surgical technique, and (2) the explanatory and predictive capacity of psychosocial well-being on breast satisfaction, and of both on sexual well-being. Methods: This prospective study included 36 BCP who underwent IR between June 2006 and December 2014. Results: Highest levels of quality of life were found in psychosocial well-being and sexual well-being, with no statistically significant differences by surgery reason or surgical technique in any quality of life indicator or breast satisfaction. Psychosocial, physical well-being and breast satisfaction explained 56.16% of the variance in sexual well-being, where 44.67% was attributed to psychosocial well-being. In addition, breast satisfaction statistically significantly mediated the relationship between psychosocial and sexual well-being, independently of physical well-being. Conclusion: Our findings highlight the importance of IR in reducing psychological morbidity and preserving the quality of life and breast satisfaction. Furthermore, this research indicated that psychosocial well-being should be considered a useful personal resource for improving the sexual well-being of BCP undergoing IR both through its direct effect and the mediated effect of breast satisfaction.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/surgery ; Breast Neoplasms/psychology ; Cancer Survivors ; Quality of Life ; Personal Satisfaction ; Prospective Studies ; Patient Satisfaction ; Mammaplasty/methods
Language	English
Publishing date	2022-08-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1303114-4
ISSN	1365-2354 ; 0961-5423 ; 1360-5801
ISSN (online)	1365-2354
ISSN	0961-5423 ; 1360-5801
DOI	10.1111/ecc.13686
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Article ; Online: Corrigendum to "Genomic path to panresistance in a clinical isolate of Klebsiella pneumoniae" [International Journal of Antimicrobial Agents Volume 52 Issue 5 (2018) pp. 713-718].

Lázaro-Perona, Fernando / Sotillo, Alma / Troyano-Hernáez, Paloma / Gómez-Gil, Rosa / de la Vega-Bueno, Ángela / Mingorance, Jesús

International journal of antimicrobial agents

2022 Volume 59, Issue 3, Page(s) 106530

Language	English
Publishing date	2022-02-06
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2022.106530
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Article: Living and Coping with Olfactory and Taste Disorders: A Qualitative Study of People with Long-COVID-19.

Moro-López-Menchero, Paloma / Martín-Sanz, María Belén / Fernandez-de-Las-Peñas, César / Gómez-Sanchez, Stella Maris / Gil-Crujera, Antonio / Ceballos-García, Laura / Escribano-Mediavilla, Nuria I / Fuentes-Fuentes, Mª Victoria / Palacios-Ceña, Domingo

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 7

Abstract: Taste and smell disorders are common symptoms of SARS-CoV-2 acute infection. In post-COVID-19 condition, symptoms can persist leading to disruption in patients' lives, to changes in their coping skills, and to the need to develop strategies for everyday ... ...

Abstract	Taste and smell disorders are common symptoms of SARS-CoV-2 acute infection. In post-COVID-19 condition, symptoms can persist leading to disruption in patients' lives, to changes in their coping skills, and to the need to develop strategies for everyday life. This study aimed to describe the perspective of a group of patients with Long-COVID-19, a condition where loss of taste and/or smell was the most predominant symptom. A qualitative descriptive study was conducted. Participants who had suffered SARS-CoV-2 infection and had Long-COVID-19 loss of taste and/or smell were recruited. Purposive sampling was applied, and participants were recruited until data redundancy was reached. In-depth interviews were used for data collection and thematic analysis was applied. Twelve COVID-19 survivors (75% women) were recruited. The mean age of the participants was 55 years, and the mean duration of post-COVID-19 symptoms was 25 months. Three themes were identified: (a) Living with taste and smell disorders, describing the disorders they experience on a daily basis, how their life has changed and the accompanying emotions, (b) Changes and challenges resulting from the loss of taste and smell, changes in habits, self-care and risk in certain jobs or daily activities, (c) Coping with taste and smell disorders, describing the daily strategies used and the health care received. In conclusion, Long-COVID-19 taste and/or smell disorders limit daily life and involve changes in habits, meal preparation, and the ability to detect potentially dangerous situations.
Language	English
Publishing date	2024-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12070754
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Article ; Online: Uninterrupted direct-acting oral anticoagulation in patients undergoing transradial percutaneous coronary procedures: The DOAC-NOSTOP study rationale and design.

Teira Calderón, Andrea / Chiarito, Mauro / Santos, Ignacio Amat / Cao, Davide / Vaquerizo Montilla, Beatriz / Jurado Román, Alfonso / Pulido Garrido, Paloma / Tartaglia, Francesco / García-García, Héctor M / Díez-Gil, Jose Luis / Sanz-Sánchez, Jorge

Cardiovascular revascularization medicine : including molecular interventions

2024

Abstract: Background: patients with atrial fibrillation (AF) under treatment with chronic oral anticoagulation (OAC) often require coronary angiography with or without percutaneous coronary intervention (PCI). Deciding the management of OAC during this ... ...

Abstract	Background: patients with atrial fibrillation (AF) under treatment with chronic oral anticoagulation (OAC) often require coronary angiography with or without percutaneous coronary intervention (PCI). Deciding the management of OAC during this periprocedural period requires balancing the risks of hemorrhage and thrombotic complications. Guidelines recommend an uninterrupted strategy in patients receiving Vitamin-K Antagonists (VKA). However, for patients undergoing coronary angiography or PCI while on direct oral anticoagulants (DOACs), withdrawal 12-24 h prior to the procedure is still recommended. This is based on expert opinions given the lack of evidence. Therefore, whether DOAC discontinuation prior to trans-radial coronary procedures should be the strategy of choice is a matter of debate and solid evidence is needed to guide clinical decision making. Methods: The DOAC-NOSTOP study is a prospective, single-arm, open-label study evaluating the safety of DOACs continuation in 200 patients undergoing transradial percutaneous coronary procedures. DOAC treatment will not be interrupted throughout the periprocedural period. Primary outcome will be Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 events, assessed at a 30-day follow-up. Conclusions: The DOAC-NOSTOP is the first study prospectively assessing the risk of bleeding with uninterrupted DOAC in patients undergoing trans-radial percutaneous coronary procedures.
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2024.01.013
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Article ; Online: The Key Role of Emotional Repair and Emotional Clarity on Depression among Breast Cancer Survivors

Rocío Guil / Lucia Morales-Sánchez / Paula Ruiz-González / Rocío Gómez-Molinero / Paloma Gil-Olarte

International Journal of Environmental Research and Public Health, Vol 19, Iss 4652, p

2022 Volume 4652

Abstract: Breast cancer is the malignancy with the highest incidence in women worldwide. The empirical evidence is inconsistent with the prevalence of depression among breast cancer survivors (BCS), pointing to emotional competencies as protective factors against ... ...

Abstract	Breast cancer is the malignancy with the highest incidence in women worldwide. The empirical evidence is inconsistent with the prevalence of depression among breast cancer survivors (BCS), pointing to emotional competencies as protective factors against affective disorders. However, the mechanisms through which these competencies favor a more adaptive emotional state are unknown. Therefore, this study aims to explore the relationship between the experience of having survived the disease and depression levels in a group of BCS, and the mediating role of Perceived Emotional Intelligence (PEI) in this relation. This was a cross-sectional study with 237 women divided into two groups: 56 BCS and 181 healthy controls who completed the Trait Meta-Mood Scale 24 (TMMS-24) and the Hospital Anxiety and Depression Scale (HADS). Results showed that Survivorship and PEI explained and predicted 37.8% of the variance of depression, corresponding the 11.7% to the direct and/or the indirect effect of the PEI dimensions (Emotional Attention, Emotional Clarity, and Emotional Repair). In conclusion, interventions aimed at promoting an adequate PEI in this population—and in the Psycho-oncology field, in general—with a particular focus on the development of Emotional Clarity and Repair need to be implemented. Limitations and future research lines are discussed.
Keywords	perceived emotional intelligence ; emotional intelligence ; emotional repair ; emotional clarity ; depression ; breast cancer ; Medicine ; R
Subject code	150
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Idiosyncratic Profile of Perceived Emotional Intelligence and Post-Traumatic Growth in Breast Cancer Survivors: Findings of a Multiple Mediation Model.

Guil, Rocío / Ruiz-González, Paula / Morales-Sánchez, Lucía / Gómez-Molinero, Rocío / Gil-Olarte, Paloma

International journal of environmental research and public health

2022 Volume 19, Issue 14

Abstract: Psycho-oncology research suggests that positive personal changes can occur after experiencing breast cancer. These changes can be understood as post-traumatic growth (PTG) and seem to be determined by emotional self-efficacy perception. This study aims ... ...

Abstract	Psycho-oncology research suggests that positive personal changes can occur after experiencing breast cancer. These changes can be understood as post-traumatic growth (PTG) and seem to be determined by emotional self-efficacy perception. This study aims to investigate the existence of different profiles of PTG and perceived emotional intelligence (PEI) among breast cancer survivors (BCSs) and healthy controls. Moreover, it aims to study the mechanisms through which PEI may mediate the relationship between disease survival and PTG. The total sample was 636 women divided into two groups: 56 BCS and 580 healthy controls who completed TMMS-24 and PTGI. The results displayed that BCSs apparently show a different profile of PTG and PEI compared to healthy women. The mediation analyses showed that survivorship explained 1.9% of PTG, increasing to 26.5% by the effect of PEI. An indirect effect showed that cancer survival predicts reduced levels of emotional attention, decreasing PTG. However, the most statistical indirect effect evidenced that BCSs regulate their emotions appropriately, having a powerful effect on PTG and counteracting the negative effects of poor emotional attention. Knowing the implications of PEI on PTG could improve follow-up from the time of diagnosis and supporting the patient to cope with the sequelae of the disease.
MeSH term(s)	Adaptation, Psychological ; Breast Neoplasms/psychology ; Cancer Survivors/psychology ; Emotional Intelligence ; Female ; Humans ; Posttraumatic Growth, Psychological ; Stress Disorders, Post-Traumatic/psychology ; Survivors/psychology
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19148592
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