LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 630

Search options

  1. Book: Coenzyme Q

    Kagan, Valerian E.

    molecular mechanisms in health and disease

    2001  

    Author's details ed. by Valerian E. Kagan
    Keywords Ubiquinone / physiology ; Molecular Biology ; Ubichinone ; Molekularbiologie
    Subject Molekulare Biologie ; Coenzym Q ; Mitochinone
    Language English
    Size 390 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013282354
    ISBN 0-8493-8732-9 ; 978-0-8493-8732-6
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 1703 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Functional states of myeloid cells in cancer.

    van Vlerken-Ysla, Lilian / Tyurina, Yulia Y / Kagan, Valerian E / Gabrilovich, Dmitry I

    Cancer cell

    2023  Volume 41, Issue 3, Page(s) 490–504

    Abstract: Myeloid cells, comprised of macrophages, dendritic cells, monocytes, and granulocytes, represent a major component of the tumor microenvironment (TME) and are critically involved in regulation of tumor progression and metastasis. In recent years, single- ... ...

    Abstract Myeloid cells, comprised of macrophages, dendritic cells, monocytes, and granulocytes, represent a major component of the tumor microenvironment (TME) and are critically involved in regulation of tumor progression and metastasis. In recent years, single-cell omics technologies have identified multiple phenotypically distinct subpopulations. In this review, we discuss recent data and concepts suggesting that the biology of myeloid cells is largely defined by a very limited number of functional states that transcend the narrowly defined cell populations. These functional states are primarily centered around classical and pathological states of activation, with the latter state commonly defined as myeloid-derived suppressor cells. We discuss the concept that lipid peroxidation of myeloid cells represents a major mechanism that governs their pathological state of activation in the TME. Lipid peroxidation is associated with ferroptosis mediating suppressive activity of these cells and thus could be considered an attractive target for therapeutic intervention.
    MeSH term(s) Humans ; Myeloid Cells ; Neoplasms/therapy ; Macrophages/pathology ; Monocytes/pathology ; Myeloid-Derived Suppressor Cells/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2023.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Vitamin C Is Mandatory for the Tricarboxylic Acid Cycle Production of Antiinflammatory Itaconate.

    Soysal, Elif / Castellano, Elizabeth / Korkmaz, Aybike / Mullett, Steven J / Kim-Campbell, Nahmah / Epperly, Michael / Wendell, Stacy / Kagan, Valerian E / Bayır, Hülya

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 11, Page(s) 1234–1238

    MeSH term(s) Humans ; Citric Acid Cycle ; Ascorbic Acid/therapeutic use ; Succinates/therapeutic use ; Vitamins ; Anti-Inflammatory Agents
    Chemical Substances itaconic acid (Q4516562YH) ; Ascorbic Acid (PQ6CK8PD0R) ; Succinates ; Vitamins ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202304-0636LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney.

    Bayır, Hülya / Dixon, Scott J / Tyurina, Yulia Y / Kellum, John A / Kagan, Valerian E

    Nature reviews. Nephrology

    2023  Volume 19, Issue 5, Page(s) 315–336

    Abstract: Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can be inhibited by glutathione peroxidase 4. Morphologically, it is characterized by cellular, organelle and ...

    Abstract Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can be inhibited by glutathione peroxidase 4. Morphologically, it is characterized by cellular, organelle and cytoplasmic swelling and the loss of plasma membrane integrity, with the release of intracellular components. Ferroptosis is triggered in cells with dysregulated iron and thiol redox metabolism, whereby the initial robust but selective accumulation of hydroperoxy polyunsaturated fatty acid-containing phospholipids is further propagated through enzymatic and non-enzymatic secondary mechanisms, leading to formation of oxidatively truncated electrophilic species and their adducts with proteins. Thus, ferroptosis is dependent on the convergence of iron, thiol and lipid metabolic pathways. The kidney is particularly susceptible to redox imbalance. A growing body of evidence has linked ferroptosis to acute kidney injury in the context of diverse stimuli, such as ischaemia-reperfusion, sepsis or toxins, and to chronic kidney disease, suggesting that ferroptosis may represent a novel therapeutic target for kidney disease. However, further work is needed to address gaps in our understanding of the triggers, execution and spreading mechanisms of ferroptosis.
    MeSH term(s) Humans ; Lipid Peroxidation/physiology ; Iron/metabolism ; Oxidation-Reduction ; Kidney/metabolism ; Ferroptosis/physiology
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00689-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6334: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 107: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Vitamin E/Coenzyme Q-Dependent "Free Radical Reductases": Redox Regulators in Ferroptosis.

    Kagan, Valerian E / Straub, Adam C / Tyurina, Yulia Y / Kapralov, Alexandr A / Hall, Robert / Wenzel, Sally E / Mallampalli, Rama K / Bayir, Hülya

    Antioxidants & redox signaling

    2023  Volume 40, Issue 4-6, Page(s) 317–328

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Ubiquinone ; Vitamin E ; Ferroptosis ; Oxidation-Reduction ; Oxidoreductases/metabolism ; Lipid Peroxidation ; Free Radicals/metabolism ; Electron Transport Complex I/metabolism
    Chemical Substances free radical reductase (EC 1.8.4.-) ; Ubiquinone (1339-63-5) ; Vitamin E (1406-18-4) ; Oxidoreductases (EC 1.-) ; Free Radicals ; Electron Transport Complex I (EC 7.1.1.2)
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2022.0154
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Myeloid Cell-Derived Oxidized Lipids and Regulation of the Tumor Microenvironment.

    Hicks, Kristin C / Tyurina, Yulia Y / Kagan, Valerian E / Gabrilovich, Dmitry I

    Cancer research

    2021  Volume 82, Issue 2, Page(s) 187–194

    Abstract: Immunosuppressive myeloid cells play a major role in cancer by negatively regulating immune responses, promoting tumor progression, and limiting the efficacy of cancer immunotherapy. Immunosuppression is mediated by various mechanisms dependent upon the ... ...

    Abstract Immunosuppressive myeloid cells play a major role in cancer by negatively regulating immune responses, promoting tumor progression, and limiting the efficacy of cancer immunotherapy. Immunosuppression is mediated by various mechanisms dependent upon the type of myeloid cell involved. In recent years, a more universal mechanism of immunosuppressive activity of myeloid cells has emerged: Generation of oxidized lipids. Oxidized lipids accumulate in all types of myeloid cells and are often transferred between cells. In this review, we discuss mechanisms involved in the generation and biological role of myeloid cell-derived oxidized lipids in cancer.
    MeSH term(s) Animals ; Humans ; Immune Tolerance ; Lipid Metabolism/immunology ; Myeloid Cells/immunology ; Myeloid Cells/metabolism ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidation-Reduction ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-21-3054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book: Lipid peroxidation in biomembranes

    Kagan, Valerian E.

    1988  

    Keywords Lipid Peroxidation ; Membrane Lipids ; Biomembran ; Lipidperoxidation ; Lipide ; Peroxidation ; Membranlipide
    Subject Fettähnliche Stoffe ; Lipoide ; Biologische Membran ; Einheitsmembran ; Zelle ; Zellmembran
    Size 181 S. : Ill., graph. Darst.
    Publisher CRC Pr
    Publishing place Boca Raton, Fla
    Publishing country United States
    Document type Book
    HBZ-ID HT003291182
    ISBN 0-8493-6923-1 ; 978-0-8493-6923-0
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 1825 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production.

    Kruglov, Oleg / Vats, Kavita / Soman, Vishal / Tyurin, Vladimir A / Tyurina, Yulia Y / Wang, Jiefei / Williams, Li'an / Zhang, Jiying / Donahue Carey, Cara / Jaklitsch, Erik / Chandran, Uma R / Bayir, Hülya / Kagan, Valerian E / Bunimovich, Yuri L

    Oncoimmunology

    2023  Volume 12, Issue 1, Page(s) 2192098

    Abstract: Peripheral glia, specifically the Schwann cells (SCs), have been implicated in the formation of the tumor microenvironment (TME) and in cancer progression. However, ...

    Abstract Peripheral glia, specifically the Schwann cells (SCs), have been implicated in the formation of the tumor microenvironment (TME) and in cancer progression. However,
    MeSH term(s) Mice ; Animals ; Cyclooxygenase 2/metabolism ; Arachidonate 15-Lipoxygenase/metabolism ; Schwann Cells/metabolism ; Schwann Cells/pathology ; Melanoma ; Eicosanoids/metabolism ; T-Lymphocytes ; Tumor Microenvironment
    Chemical Substances Cyclooxygenase 2 (EC 1.14.99.1) ; Arachidonate 15-Lipoxygenase (EC 1.13.11.33) ; Eicosanoids
    Language English
    Publishing date 2023-03-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-402X
    ISSN (online) 2162-402X
    ISSN 2162-402X
    DOI 10.1080/2162402X.2023.2192098
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Visualizing Cardiolipin In Situ with HKCL-1M, a Highly Selective and Sensitive Fluorescent Probe.

    Wang, Wei / Wong, Nai-Kei / Bok, Siu-Lun / Xu, You / Guo, Yang / Xu, Lu / Zuo, Meiling / St Croix, Claudette M / Mao, Gaowei / Kapralov, Alexandr / Bayir, Hülya / Kagan, Valerian E / Yang, Dan

    Journal of the American Chemical Society

    2023  Volume 145, Issue 20, Page(s) 11311–11322

    Abstract: Reliable probing of cardiolipin (CL) content in dynamic cellular milieux presents significant challenges and great opportunities for understanding mitochondria-related diseases, including cancer, neurodegeneration, and diabetes mellitus. In intact ... ...

    Abstract Reliable probing of cardiolipin (CL) content in dynamic cellular milieux presents significant challenges and great opportunities for understanding mitochondria-related diseases, including cancer, neurodegeneration, and diabetes mellitus. In intact respiring cells, selectivity and sensitivity for CL detection are technically demanding due to structural similarities among phospholipids and compartmental secludedness of the inner mitochondrial membrane. Here, we report a novel "turn-on" fluorescent probe
    MeSH term(s) Fluorescent Dyes/chemistry ; Cardiolipins/chemistry ; Mitochondria/chemistry ; Phospholipids/analysis ; Mitochondrial Membranes
    Chemical Substances Fluorescent Dyes ; Cardiolipins ; Phospholipids
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c00243
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.

    Yang, Xin / Wang, Zhe / Samovich, Svetlana N / Kapralov, Alexander A / Amoscato, Andrew A / Tyurin, Vladimir A / Dar, Haider H / Li, Zhiming / Duan, Shoufu / Kon, Ning / Chen, Delin / Tycko, Benjamin / Zhang, Zhiguo / Jiang, Xuejun / Bayir, Hülya / Stockwell, Brent R / Kagan, Valerian E / Gu, Wei

    Cell metabolism

    2024  Volume 36, Issue 4, Page(s) 762–777.e9

    Abstract: Although the role of ferroptosis in killing tumor cells is well established, recent studies indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils and thus unexpectedly stimulate tumor growth, raising a serious issue ... ...

    Abstract Although the role of ferroptosis in killing tumor cells is well established, recent studies indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils and thus unexpectedly stimulate tumor growth, raising a serious issue about whether ferroptosis effectively suppresses tumor development in vivo. Through genome-wide CRISPR-Cas9 screenings, we discover a pleckstrin homology-like domain family A member 2 (PHLDA2)-mediated ferroptosis pathway that is neither ACSL4-dependent nor requires common ferroptosis inducers. PHLDA2-mediated ferroptosis acts through the peroxidation of phosphatidic acid (PA) upon high levels of reactive oxygen species (ROS). ROS-induced ferroptosis is critical for tumor growth in the absence of common ferroptosis inducers; strikingly, loss of PHLDA2 abrogates ROS-induced ferroptosis and promotes tumor growth but has no obvious effect in normal tissues in both immunodeficient and immunocompetent mouse tumor models. These data demonstrate that PHLDA2-mediated PA peroxidation triggers a distinct ferroptosis response critical for tumor suppression and reveal that PHLDA2-mediated ferroptosis occurs naturally in vivo without any treatment from ferroptosis inducers.
    MeSH term(s) Animals ; Mice ; Disease Models, Animal ; Lipid Peroxidation/physiology ; Neoplasms ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; Phldb2 protein, mouse
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2024.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top