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  1. Article ; Online: Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases.

    Mangione, MariaSanta C / Wen, Jinhua / Cao, Dian J

    Journal of molecular and cellular cardiology

    2023  Volume 186, Page(s) 111–124

    Abstract: The mechanistic target of rapamycin (mTOR) is evolutionarily conserved from yeast to humans and is one of the most fundamental pathways of living organisms. Since its discovery three decades ago, mTOR has been recognized as the center of nutrient sensing ...

    Abstract The mechanistic target of rapamycin (mTOR) is evolutionarily conserved from yeast to humans and is one of the most fundamental pathways of living organisms. Since its discovery three decades ago, mTOR has been recognized as the center of nutrient sensing and growth, homeostasis, metabolism, life span, and aging. The role of dysregulated mTOR in common diseases, especially cancer, has been extensively studied and reported. Emerging evidence supports that mTOR critically regulates innate immune responses that govern the pathogenesis of various cardiovascular diseases. This review discusses the regulatory role of mTOR in macrophage functions in acute inflammation triggered by ischemia and in atherosclerotic cardiovascular disease (ASCVD) and heart failure with preserved ejection fraction (HFpEF), in which chronic inflammation plays critical roles. Specifically, we discuss the role of mTOR in trained immunity, immune senescence, and clonal hematopoiesis. In addition, this review includes a discussion on the architecture of mTOR, the function of its regulatory complexes, and the dual-arm signals required for mTOR activation to reflect the current knowledge state. We emphasize future research directions necessary to understand better the powerful pathway to take advantage of the mTOR inhibitors for innovative applications in patients with cardiovascular diseases associated with aging and inflammation.
    MeSH term(s) Humans ; Cardiovascular Diseases ; Sirolimus/pharmacology ; Heart Failure ; Stroke Volume ; TOR Serine-Threonine Kinases/metabolism ; Inflammation ; Macrophages/metabolism ; Mechanistic Target of Rapamycin Complex 1
    Chemical Substances Sirolimus (W36ZG6FT64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2023.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 426: Show issues Location:
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  2. Article ; Online: Macrophages in Cardiovascular Homeostasis and Disease.

    Cao, Dian J

    Circulation

    2018  Volume 138, Issue 22, Page(s) 2452–2455

    MeSH term(s) Aging ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/pathology ; DNA (Cytosine-5-)-Methyltransferases/genetics ; HMGB1 Protein/metabolism ; Heart/physiology ; Hematopoietic Stem Cells/metabolism ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Polymorphism, Single Nucleotide ; Regeneration
    Chemical Substances HMGB1 Protein ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNA methyltransferase 3A (EC 2.1.1.37)
    Language English
    Publishing date 2018-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.035736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epigenetic regulation and heart failure.

    Cao, Dian J

    Expert review of cardiovascular therapy

    2014  Volume 12, Issue 9, Page(s) 1087–1098

    Abstract: Heart failure has become a huge public health problem. The treatment options for heart failure, however, are considerably limited. The significant disparity between the scope of a prominent health problem and the restricted means of therapy propagates ... ...

    Abstract Heart failure has become a huge public health problem. The treatment options for heart failure, however, are considerably limited. The significant disparity between the scope of a prominent health problem and the restricted means of therapy propagates heart failure epidemics. Delineating novel mechanisms of heart failure is imperative. Emerging evidence suggests that epigenetic regulation may take part in the pathogenesis of heart failure. Epigenetic regulation involves DNA and histone modifications that lead to changes in DNA-based transcriptional programs without altering the DNA sequence. Although more and more mechanisms are being discovered, the best understood epigenetic modifications are achieved through covalent biochemical reactions including histone acetylation, histone methylation and DNA methylation. Connecting environmental stimuli with genomic programs, epigenetic regulation remains important in maintaining homeostases and the pathogeneses of diseases. This review summarizes the most recent developments regarding individual epigenetic modifications and their implications in the pathogenesis of heart failure. Understanding this strategically important mechanism is potentially the key for developing powerful interventions in the future.
    MeSH term(s) Acetylation ; Animals ; DNA Methylation ; Epigenesis, Genetic ; Heart Failure/genetics ; Heart Failure/physiopathology ; Heart Failure/therapy ; Histones/metabolism ; Humans
    Chemical Substances Histones
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1586/14779072.2014.942285
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  4. Article ; Online: The mechanistic target of rapamycin complex 1 critically regulates the function of mononuclear phagocytes and promotes cardiac remodeling in acute ischemia.

    Chen, GuiHao / Phan, Vincent / Luo, Xiang / Cao, Dian J

    Journal of molecular and cellular cardiology

    2021  Volume 159, Page(s) 62–79

    Abstract: Monocytes and macrophages are cellular forces that drive and resolve inflammation triggered by acute myocardial ischemia. One of the most important but least understood regulatory mechanisms is how these cells sense cues from the micro-milieu and ... ...

    Abstract Monocytes and macrophages are cellular forces that drive and resolve inflammation triggered by acute myocardial ischemia. One of the most important but least understood regulatory mechanisms is how these cells sense cues from the micro-milieu and integrate environmental signals with their response that eventually determines the outcome of myocardial repair. In the current study, we investigated if the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) plays this role. We present evidence that support a robustly activated mTORC1 pathway in monocytes and macrophages in the infarcting myocardium.. Specific mTORC1 inhibition transformed the landscape of cardiac monocytes and macrophages into reparative cells that promoted myocardial healing. As the result, mTORC1 inhibition diminished remodeling and reduced mortality from acute ischemia by 80%. In conclusion, our data suggest a critical role of mTORC1 in regulating the functions of cardiac monocytes and macrophages, and specific mTORC1 inhibition protects the heart from inflammatory injury in acute ischemia. As mTOR/mTORC1 is a master regulator that integrates external signals with cellular responses, the study sheds light on how the cardiac monocytes and macrophages sense and respond to the ischemic environment..
    MeSH term(s) Animals ; Heart/physiopathology ; Macrophages/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Myocardial Infarction/metabolism ; Myocardial Ischemia/metabolism ; Myocardium/metabolism ; Phagocytes/metabolism ; Signal Transduction/physiology ; Ventricular Remodeling/physiology
    Chemical Substances Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2021.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Copper futures: ceruloplasmin and heart failure.

    Cao, Dian J / Hill, Joseph A

    Circulation research

    2014  Volume 114, Issue 11, Page(s) 1678–1680

    MeSH term(s) Ceruloplasmin/metabolism ; Cysteine/metabolism ; Female ; Heart Failure/metabolism ; Heart Failure/mortality ; Humans ; Male ; Peroxynitrous Acid/metabolism ; Tyrosine/metabolism
    Chemical Substances Peroxynitrous Acid (14691-52-2) ; Tyrosine (42HK56048U) ; Ceruloplasmin (EC 1.16.3.1) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2014-05-22
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.114.304091
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  6. Article ; Online: Parkin Gone Wild: Unbridled Ubiquitination.

    Cao, Dian J / Lavandero, Sergio / Hill, Joseph A

    Circulation research

    2015  Volume 117, Issue 4, Page(s) 311–313

    MeSH term(s) Animals ; Cardiomyopathies/metabolism ; Mitochondria, Heart/metabolism ; Mitochondrial Degradation ; Mitochondrial Dynamics ; Myocardium/metabolism ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2015-07-31
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.115.307022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Titrating autophagy in cardiac plasticity.

    Cao, Dian J / Hill, Joseph A

    Autophagy

    2011  Volume 7, Issue 9, Page(s) 1078–1079

    Abstract: The heart is a highly plastic organ. In a recent study, we found that autophagy is a required element in load-induced cardiomyocyte growth; when autophagy is suppressed, the heart does not grow. Conversely, afterload stress triggers a transient increase ... ...

    Abstract The heart is a highly plastic organ. In a recent study, we found that autophagy is a required element in load-induced cardiomyocyte growth; when autophagy is suppressed, the heart does not grow. Conversely, afterload stress triggers a transient increase in cardiomyocyte autophagic activity which settles to a new--higher--baseline once the heart has re-achieved steady-state size. Our work went on to decipher the role of histone deacetylases in this biology.
    MeSH term(s) Animals ; Apoptosis Regulatory Proteins/metabolism ; Autophagy/drug effects ; Heart/anatomy & histology ; Heart/drug effects ; Heart/growth & development ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Mice ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Organ Size/physiology
    Chemical Substances Apoptosis Regulatory Proteins ; Histone Deacetylase Inhibitors
    Language English
    Publishing date 2011-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.4161/auto.7.9.16176
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  8. Article ; Online: SM-CycleGAN: crop image data enhancement method based on self-attention mechanism CycleGAN.

    Liu, Dian / Cao, Yang / Yang, Jing / Wei, Jianyu / Zhang, Jili / Rao, Chenglin / Wu, Banghong / Zhang, Dabin

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9277

    Abstract: Crop disease detection and crop baking stage judgement require large image data to improve accuracy. However, the existing crop disease image datasets have high asymmetry, and the poor baking environment leads to image acquisition difficulties and colour ...

    Abstract Crop disease detection and crop baking stage judgement require large image data to improve accuracy. However, the existing crop disease image datasets have high asymmetry, and the poor baking environment leads to image acquisition difficulties and colour distortion. Therefore, we explore the potential of the self-attention mechanism on crop image datasets and propose an innovative crop image data-enhancement method for recurrent generative adversarial networks (GANs) fused with the self-attention mechanism to significantly enhance the perception and information capture capabilities of recurrent GANs. By introducing the self-attention mechanism module, the cycle-consistent GAN (CycleGAN) is more adept at capturing the internal correlations and dependencies of image data, thus more effectively capturing the critical information among image data. Furthermore, we propose a new enhanced loss function for crop image data to optimise the model performance and meet specific task requirements. We further investigate crop image data enhancement in different contexts to validate the performance and stability of the model. The experimental results show that, the peak signal-to-noise ratio of the SM-CycleGAN for tobacco images and tea leaf disease images are improved by 2.13% and 3.55%, and the structural similarity index measure is improved by 1.16% and 2.48% compared to CycleGAN, respectively.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59918-3
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  9. Article ; Online: Field-Assisted Regulation Induced by Cobalt-Doped ZnO for Dendrite-Free Lithium Metal Anodes.

    Cao, Wen / Wu, Zhuorun / Yang, Yunfei / Chen, Zhiyuan / Wu, Jie / Zhao, Dian / Gao, Xuehui

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 30, Issue 2, Page(s) e202302867

    Abstract: Lithium metal batteries are deemed as an optimal candidate for the next generation of durable energy storage devices. However, the growth of lithium dendrite and significant volume expansion pose as obstacles that impede the application of lithium metal ... ...

    Abstract Lithium metal batteries are deemed as an optimal candidate for the next generation of durable energy storage devices. However, the growth of lithium dendrite and significant volume expansion pose as obstacles that impede the application of lithium metal batteries. In this work, a functional copper current collector was designed by coating it with Co-doped ZnO (Co/ZnO) to enhance the lithiophilicity through local electric fields and built-in magnetic fields induced by the ferromagnetic material. The incorporation of Co not only induces a local electric field and thus accelerating electron transfer, but also imparts the ferromagnetic behavior to ZnO, resulting in an internal magnetic field to regulate the dynamic trajectory. Profiting from the above advantages, the symmetric cells have excellent cycle stability in 1 mA cm
    Language English
    Publishing date 2023-11-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202302867
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  10. Article: 

    Zou, Dian-Yang / Cao, Guan-Long / Zhang, Jin-Guo / Li, Lang / Li, Jie

    PhytoKeys

    2023  Volume 224, Page(s) 183–192

    Abstract: ... ...

    Abstract Endiandramacrocarpa
    Language English
    Publishing date 2023-04-07
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.224.102752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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