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Article: HMB Improves Lipid Metabolism of Bama Xiang Mini-Pigs via Modulating the

Zheng, Jie / Zheng, Changbing / Song, Bo / Guo, Qiuping / Zhong, Yinzhao / Zhang, Shiyu / Zhang, Lingyu / Duan, Geyan / Li, Fengna / Duan, Yehui

Frontiers in microbiology

2021 Volume 12, Page(s) 736997

Abstract: Here, we used Bama Xiang mini-pigs to explore the effects of different dietary β-hydroxy-β ...

Abstract	Here, we used Bama Xiang mini-pigs to explore the effects of different dietary β-hydroxy-β-methylbutyrate (HMB) levels (0, 0.13, 0.64 or 1.28%) on lipid metabolism of adipose tissue. Results showed that HMB decreased the fat percentage of pigs (linearly,
Language	English
Publishing date	2021-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.736997
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Cao-Xiang-Wei-Kang formula attenuates the progression of experimental colitis by restoring the homeostasis of the microbiome and suppressing inflammation.

Yu, Wei / Li, Qi / Shao, Changlei / Zhang, Yijia / Kang, Cai / Zheng, Yang / Liu, Xihao / Liu, Xincheng / Yan, Jing

Frontiers in pharmacology

2022 Volume 13, Page(s) 946065

Abstract: ... Xiang-Wei-Kang (CW) formula has been utilized to treat gastrointestinal disorders in the clinic ...

Abstract	Inflammatory bowel disease (IBD) is pathologically characterized by an immune response accommodative insufficiency and dysbiosis accompanied by persistent epithelial barrier dysfunction. The Cao-Xiang-Wei-Kang (CW) formula has been utilized to treat gastrointestinal disorders in the clinic. The present study was designed to delineate the pharmacological mechanisms of this formula from different aspects of the etiology of ulcerative colitis (UC), a major subtype of IBD. Dextran sodium sulfate (DSS) was given to mice for a week at a concentration of 2%, and the CW solution was administered for 3 weeks. 16S rRNA gene sequencing and untargeted metabolomics were conducted to examine the changes in the microbiome profile, and biochemical experiments were performed to confirm the therapeutic functions predicted by system pharmacology analysis. The CW treatment hampered DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis, which was corroborated by suppressed caspase 3 (Casp3) and interleukin-1b (IL-1b) and increased cleaved caspase 3 expression and casp-3 activity in the colon samples from colitis mice subjected to the CW therapy. Moreover, the CW therapy rescued the decreased richness and diversity, suppressed the potentially pathogenic phenotype of the gut microorganisms, and reversed the altered linoleic acid metabolism and cytochrome P450 activity in murine colitis models. In our
Language	English
Publishing date	2022-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.946065
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integration of non-targeted multicomponent profiling, targeted characteristic chromatograms and quantitative to accomplish systematic quality evaluation strategy of Huo-Xiang-Zheng-Qi oral liquid.

Li, Xuejuan / Wu, Mengfan / Ding, Hui / Li, Wei / Yin, Jiaxin / Lin, Ruimei / Wu, Xinlong / Han, Lifeng / Yang, Wenzhi / Bie, Songtao / Li, Fangyi / Song, Xinbo / Yu, Heshui / Dong, Ziliang / Li, Zheng

Journal of pharmaceutical and biomedical analysis

2023 Volume 236, Page(s) 115715

Abstract: Huo-Xiang-Zheng-Qi oral liquid (HXZQOL) is a well-known traditional Chinese medicine formula ...

Abstract	Huo-Xiang-Zheng-Qi oral liquid (HXZQOL) is a well-known traditional Chinese medicine formula for the treatment of gastrointestinal diseases, with the pharmacologic effects of antiinflammatory, immune protection and gastrointestinal motility regulation. More significantly, HXZQOL is recommended for the treatment of COVID-19 patients with gastrointestinal symptoms, and it has been clinically proven to reduce the inflammatory response in patients with COVID-19. However, the effective and overall quality control of HXZQOL is currently limited due to its complex composition, especially the large amount of volatile and non-volatile active components involved. In this study, aimed to fully develop a comprehensive strategy based on non-targeted multicomponent identification, targeted authentication and quantitative analysis for quality evaluation of HXZQOL from different batches. Firstly, the non-targeted high-definition MS
MeSH term(s)	Humans ; Qi ; Chromatography, High Pressure Liquid/methods ; COVID-19 ; Medicine, Chinese Traditional ; Mass Spectrometry ; Drugs, Chinese Herbal/analysis
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115715
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Article ; Online: Metabolomics Characterize the Differential Metabolic Markers between Bama Xiang Pig and Debao Pig to Identify Pork

Chen, Changyi / Zheng, Junwen / Xiong, Chenyong / Zhou, Hongjin / Wei, Chuntao / Hu, Xin / Qian, Xinxiu / He, Mengyi / Shi, Yandi / Liu, Yuwen / Li, Zongqiang

Foods. 2022 Dec. 20, v. 12, no. 1

2022

Abstract: The Bama Xiang pig (BM) is a unique pig species in Guangxi Province, China. Compared ... resistant to rough feeding and strong in stress resistance. These unique advantages of Bama Xiang pigs make ... Bama Xiang pigs (BM) and Debao pigs (DB) are largely unexplored. Here, we identified 214 differential ...

Abstract	The Bama Xiang pig (BM) is a unique pig species in Guangxi Province, China. Compared to other breeds of domestic pig, such as the Debao pig (DB), it is smaller in size, better in meat quality, resistant to rough feeding and strong in stress resistance. These unique advantages of Bama Xiang pigs make them of great edible value and scientific research value. However, the differences in muscle metabolites between Bama Xiang pigs (BM) and Debao pigs (DB) are largely unexplored. Here, we identified 214 differential metabolites between these two pig breeds by LC-MS. Forty-one such metabolites are enriched into metabolic pathways, and these metabolites correspond to 11 metabolic pathways with significant differences. In Bama pigs, the abundance of various metabolites such as creatine, citric acid, L-valine and hypoxanthine is significantly higher than in Debao pigs, while the abundance of other metabolites, such as carnosine, is significantly lower. Among these, we propose six differential metabolites: L-proline, citric acid, ribose 1-phosphate, L-valine, creatine, and L-arginine, as well as four potential differential metabolites (without the KEGG pathway), alanyl-histidine, inosine 2′-phosphate, oleoylcarnitine, and histidinyl hydroxyproline, as features for evaluating the meat quality of Bama pigs and for differentiating pork from Bama pigs and Debao pigs. This study provides a proof-of-concept example of distinguishing pork from different pig breeds at the metabolite level and sheds light on elucidating the biological processes underlying meat quality differences. Our pork metabolites data are also of great value to the genomics breeding community in meat quality improvement.
Keywords	arginine ; carnosine ; citric acid ; creatine ; genomics ; hydroxyproline ; hypoxanthine ; inosine ; meat quality ; metabolites ; metabolomics ; muscles ; pork ; proline ; ribose ; stress tolerance ; swine ; valine ; China
Language	English
Dates of publication	2022-1220
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12010005
Database	NAL-Catalogue (AGRICOLA)

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Article: Alterations of the Muscular Fatty Acid Composition and Serum Metabolome in Bama Xiang Mini-Pigs Exposed to Dietary Beta-Hydroxy Beta-Methyl Butyrate.

Zheng, Changbing / Song, Bo / Guo, Qiuping / Zheng, Jie / Li, Fengna / Duan, Yehui / Peng, Can

Animals : an open access journal from MDPI

2021 Volume 11, Issue 5

Abstract: ... supplementation on muscular lipid metabolism in Bama Xiang mini-pigs. Thirty-two piglets (8.58 ± 0.40 kg, barrow ...

Abstract	This study aimed to investigate the effects of dietary beta-hydroxy beta-methyl butyrate (HMB) supplementation on muscular lipid metabolism in Bama Xiang mini-pigs. Thirty-two piglets (8.58 ± 0.40 kg, barrow) were selected and fed a basal diet supplemented either with 0 (control), 0.13%, 0.64%, or 1.28% HMB for 60 days. Throughout the experiments, they had free access to clean drinking water and diets. Data of this study were analyzed by one-way ANOVA using the SAS 8.2 software package, followed by a Tukey's studentized range test to explore treatment effects. The results showed that compared to the control, 0.13% HMB decreased the intramuscular fat (IMF) content and increased polyunsaturated fatty acids (PUFAs) in
Language	English
Publishing date	2021-04-21
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11051190
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dietary beta-hydroxy-beta-methyl butyrate supplementation improves meat quality of Bama Xiang mini-pigs through manipulation of muscle fiber characteristics

Zheng, Changbing / Zhang, Shiyu / Duan, Yehui / Li, Fengna / Song, Bo / Guo, Qiuping / Zheng, Jie / Zhang, Lingyu / Lian, Guoqi / Duan, Geyan

Journal of functional foods. 2022 Jan., v. 88

2022

Abstract: ... Xiang mini-pigs was selected and fed 1 of 4 diets for 60 days: HMB deficient group (0%, control), low ... 13% HMB group. These results suggest that low HMB levels improved meat quality of Bama Xiang ...

Abstract	To analyse the effects of dietary beta-hydroxy-beta-methyl butyrate (HMB) on meat quality, 32 Bama Xiang mini-pigs was selected and fed 1 of 4 diets for 60 days: HMB deficient group (0%, control), low, moderate, and high levels of HMB group (0.13%, 0.64%, 1.28%, respectively). We found quadratic effects for backfat thickness and lean percentage (P < 0.05) as well as a* value in selected muscles (0.05 < P < 0.10), and the best effects were noted in the 0.13% HMB group. Moreover, dietary HMB quadratically increased the mRNA expression levels of MyHC I, AMPKα, and Sirt1 in selected muscles, the highest values were observed in the 0.13% HMB group. These results suggest that low HMB levels improved meat quality of Bama Xiang mini-pigs via the changed myofiber characteristics induced by AMPKα-Sirt1 axis.
Keywords	backfat ; butyrates ; gene expression ; meat quality ; miniature swine ; muscle fibers
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2021.104885
Database	NAL-Catalogue (AGRICOLA)

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Article: Alterations of the Muscular Fatty Acid Composition and Serum Metabolome in Bama Xiang Mini-Pigs Exposed to Dietary Beta-Hydroxy Beta-Methyl Butyrate

Zheng, Changbing / Song, Bo / Guo, Qiuping / Zheng, Jie / Li, Fengna / Duan, Yehui / Peng, Can

Animals. 2021 Apr. 21, v. 11, no. 5

2021

Abstract: ... supplementation on muscular lipid metabolism in Bama Xiang mini-pigs. Thirty-two piglets (8.58 ± 0.40 kg, barrow ... profiling showed that in both LTM and SM of Bama Xiang mini-pigs, N-Methyl-l-glutamate was positively ...

Abstract	This study aimed to investigate the effects of dietary beta-hydroxy beta-methyl butyrate (HMB) supplementation on muscular lipid metabolism in Bama Xiang mini-pigs. Thirty-two piglets (8.58 ± 0.40 kg, barrow) were selected and fed a basal diet supplemented either with 0 (control), 0.13%, 0.64%, or 1.28% HMB for 60 days. Throughout the experiments, they had free access to clean drinking water and diets. Data of this study were analyzed by one-way ANOVA using the SAS 8.2 software package, followed by a Tukey’s studentized range test to explore treatment effects. The results showed that compared to the control, 0.13% HMB decreased the intramuscular fat (IMF) content and increased polyunsaturated fatty acids (PUFAs) in Longissimus thoracis muscle (LTM), and increased the n3 PUFAs in soleus muscles (SM, p < 0.05). Moreover, HMB supplementation led to alterations in the mRNA expression of genes related to lipid metabolism. Serum metabolome profiling showed that in both LTM and SM of Bama Xiang mini-pigs, N-Methyl-l-glutamate was positively correlated with SFA and nummularine A was negatively correlated with C18:3n3 PUFA (p < 0.05). Therefore, N-Methyl-l-glutamate and nummularine A might be potential biomarkers of the HMB-supplemented group. These results suggested that dietary HMB supplementation could decrease the IMF content and increase n3 PUFAs as well as regulate the related metabolites (N-Methyl-l-glutamate and nummularine A) in the serum of pigs.
Keywords	barrows ; biomarkers ; blood serum ; butyrates ; computer software ; diet ; fatty acid composition ; gene expression ; intramuscular fat ; lipid metabolism ; longissimus muscle ; metabolites ; metabolome ; miniature swine
Language	English
Dates of publication	2021-0421
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ISSN	2076-2615
DOI	10.3390/ani11051190
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Alterations of the Muscular Fatty Acid Composition and Serum Metabolome in Bama Xiang Mini-Pigs Exposed to Dietary Beta-Hydroxy Beta-Methyl Butyrate

Changbing Zheng / Bo Song / Qiuping Guo / Jie Zheng / Fengna Li / Yehui Duan / Can Peng

Animals, Vol 11, Iss 1190, p

2021 Volume 1190

Abstract	This study aimed to investigate the effects of dietary beta-hydroxy beta-methyl butyrate (HMB) supplementation on muscular lipid metabolism in Bama Xiang mini-pigs. Thirty-two piglets (8.58 ± 0.40 kg, barrow) were selected and fed a basal diet supplemented either with 0 (control), 0.13%, 0.64%, or 1.28% HMB for 60 days. Throughout the experiments, they had free access to clean drinking water and diets. Data of this study were analyzed by one-way ANOVA using the SAS 8.2 software package, followed by a Tukey’s studentized range test to explore treatment effects. The results showed that compared to the control, 0.13% HMB decreased the intramuscular fat (IMF) content and increased polyunsaturated fatty acids (PUFAs) in Longissimus thoracis muscle (LTM), and increased the n3 PUFAs in soleus muscles (SM, p < 0.05). Moreover, HMB supplementation led to alterations in the mRNA expression of genes related to lipid metabolism. Serum metabolome profiling showed that in both LTM and SM of Bama Xiang mini-pigs, N -Methyl- l -glutamate was positively correlated with SFA and nummularine A was negatively correlated with C18:3n3 PUFA ( p < 0.05). Therefore, N -Methyl- l -glutamate and nummularine A might be potential biomarkers of the HMB-supplemented group. These results suggested that dietary HMB supplementation could decrease the IMF content and increase n3 PUFAs as well as regulate the related metabolites ( N -Methyl- l -glutamate and nummularine A) in the serum of pigs.
Keywords	beta-hydroxy beta-methyl butyrate ; intramuscular fat ; n3 fatty acids ; N -Methyl- l -glutamate ; nummularine A ; pigs ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu.

Li, Qiulu / Pang, Peng / Zheng, Ke / Sun, Li / Wang, Jing / Chen, Xiaoyin

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2018 Volume 108, Page(s) 201–207

Abstract: ... and mechanism of Xin-Jia-Xiang-Ru-Yin. The results of RT-qPCR verified virus replication ... by PCR and immunohistochemistry. We concluded that Xin-Jia-Xiang-Ru-Yin, which combined antiviral therapy ...

Abstract	Seasonal influenza is an acute viral infection caused by influenza virus, which is often prevalent in summer and winter. In contrast to the prevalent focus on winter flu, summer flu is often ignored by epidemiological researchers. However, summer flu should be studied because of the special immune status and the influenza spread mechanism in the hot and humid environment. Moreover, people are more likely to catch a summertime cold upon suddenly entering relatively cool air conditioning from the hot and humid environment. To simulate summer flu, we established a flu animal model under a high temperature and humidity environment during the day with a relatively low temperature at night to investigate the anti-influenza virus effect and mechanism of Xin-Jia-Xiang-Ru-Yin. The results of RT-qPCR verified virus replication, while pathological sections showed inflammation. The expression of the IFN-γ-related regulatory pathway was measured by PCR and immunohistochemistry. We concluded that Xin-Jia-Xiang-Ru-Yin, which combined antiviral therapy and immune modulation effects, might have important therapeutic benefits against summer flu.
MeSH term(s)	Acute Lung Injury/drug therapy ; Acute Lung Injury/virology ; Animals ; Body Weight/drug effects ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Influenza A Virus, H1N1 Subtype/drug effects ; Influenza A Virus, H1N1 Subtype/physiology ; Interferon-gamma/metabolism ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Male ; Mice, Inbred C57BL ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/pathology ; Orthomyxoviridae Infections/virology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; STAT1 Transcription Factor/metabolism ; Seasons ; Virus Replication/drug effects
Chemical Substances	Drugs, Chinese Herbal ; RNA, Messenger ; STAT1 Transcription Factor ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2018-09-13
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2018.09.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Wan qing si xiang shi

Zheng, Dahua

2005

Author's details	Zheng da hua zhu
Keywords	China
Language	Chinese
Size	2, 4, 473 p, 24 cm
Edition	Di 1 ban
Publisher	Hu nan shi fan da xue chu ban she
Publishing place	Chang sha
Document type	Book
Note	Includes bibliographical references (p. 468-471)
ISBN	7810815512 ; 9787810815512
Database	Former special subject collection: coastal and deep sea fishing

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