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  1. Article: Trends in outcomes of hospitalizations from acute exacerbations of chronic obstructive pulmonary disease during the COVID-19 pandemic.

    Balavenkataraman, Arvind / Saunders, Hollie / Helgeson, Scott A

    Lung India : official organ of Indian Chest Society

    2024  Volume 41, Issue 1, Page(s) 77–79

    Language English
    Publishing date 2024-01-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_472_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Patient-reported penicillin allergy and intensive care unit outcomes in sepsis.

    Saunders, Hollie / Shrestha, Rabi / Khadka, Subekshya / Helgeson, Scott A

    The journal of allergy and clinical immunology. In practice

    2023  Volume 12, Issue 2, Page(s) 519–521

    MeSH term(s) Humans ; Penicillins/adverse effects ; Anti-Bacterial Agents/adverse effects ; Intensive Care Units ; Sepsis/epidemiology ; Patient Reported Outcome Measures ; Hypersensitivity ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology
    Chemical Substances Penicillins ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.10.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  3. Article: Impact of concomitant gastroesophageal reflux disease symptomology on prognosis and pulmonary function of chronic hypersensitivity pneumonitis.

    Elkhatib, Wiaam Y / Helgeson, Scott A / Baig, Hassan Z / Lee, Augustine S

    Lung India : official organ of Indian Chest Society

    2023  Volume 40, Issue 5, Page(s) 406–411

    Abstract: Background and objectives: Comorbid risk factors in chronic hypersensitivity pneumonitis (CHP) are poorly characterised. Gastroesophageal reflux disease (GERD) is linked to interstitial lung diseases like idiopathic pulmonary fibrosis (IPF), but its ... ...

    Abstract Background and objectives: Comorbid risk factors in chronic hypersensitivity pneumonitis (CHP) are poorly characterised. Gastroesophageal reflux disease (GERD) is linked to interstitial lung diseases like idiopathic pulmonary fibrosis (IPF), but its association and treatment in CHP is less understood. This study aims to understand the role and prevalence of GERD in CHP, plus the effect of GERD treatment on lung function and mortality.
    Methods: A tertiary referral centre panel was retrospectively reviewed for 214 patients diagnosed with CHP based on clinical history, bronchoalveolar lavage fluid analysis, imaging and histopathology. GERD diagnostic criteria included symptomology, acid suppressive therapy use and diagnostic testing. CHP patients with GERD (n = 89) and without GERD (n = 125) were compared via descriptive statistical analysis. Pulmonary function, GERD diagnosis plus treatment and other comorbidities were evaluated against CHP outcomes.
    Results: Respective differences between diagnosis and study termination dates in the GERD population versus without GERD for functional vital capacity (FVC) were - 1 L vs - 2.5 L, diffusing capacity of the lungs for carbon monoxide (DLCO) were - 2 mL/min/mmHg versus - 1 mL/min/mmHg, per cent alive at the time of study 88% versus 81%, median date of survival 574.5 versus 850 and supplemental oxygen requirement 41% versus 37%. GERD prevalence was higher in CHP patients relative to the general population. No statistical significance was found between survival curves, oxygen requirement, smoking history, FVC, or DLCO.
    Conclusions: GERD could be a harmful comorbidity in CHP though may not necessarily affect survival or functional outcomes. This aligns with previous IPF studies, though remains controversial. Further research is needed regarding this association and treatment benefit.
    Language English
    Publishing date 2023-09-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_107_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What's New in Spine Surgery.

    Helgeson, Melvin D / Pisano, Alfred J / Fredericks, Donald R / Wagner, Scott C

    The Journal of bone and joint surgery. American volume

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.24.00133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.58/1: Show issues Location:
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    Zs.MO 464: Show issues

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  5. Article ; Online: Improved needs identification in medical intensive care and palliative medicine: retrospective cohort study.

    Rossnan, Olivia / Hanson, Abby / Spaulding, Aaron / Satashia, Parthkumar / Bhakta, Shivang / Robinson, Maisha / Helgeson, Scott A / Moreno-Franco, Pablo / Sanghavi, Devang

    BMJ supportive & palliative care

    2023  

    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Letter
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/spcare-2023-004205
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  6. Article ; Online: Pathophysiologic Spine Adaptations and Countermeasures for Prolonged Spaceflight.

    Schlaff, Cody D / Helgeson, Melvin D / Wagner, Scott C

    Clinical spine surgery

    2023  Volume 37, Issue 2, Page(s) 43–48

    Abstract: Low back pain due to spaceflight is a common complaint of returning astronauts. Alterations in musculoskeletal anatomy during spaceflight and the effects of microgravity (μg) have been well-studied; however, the mechanisms behind these changes remain ... ...

    Abstract Low back pain due to spaceflight is a common complaint of returning astronauts. Alterations in musculoskeletal anatomy during spaceflight and the effects of microgravity (μg) have been well-studied; however, the mechanisms behind these changes remain unclear. The National Aeronautics and Space Administration has released the Human Research Roadmap to guide investigators in developing effective countermeasure strategies for the Artemis Program, as well as commercial low-orbit spaceflight. Based on the Human Research Roadmap, the existing literature was examined to determine the current understanding of the effects of microgravity on the musculoskeletal components of the spinal column. In addition, countermeasure strategies will be required to mitigate these effects for long-duration spaceflight. Current pharmacologic and nonpharmacologic countermeasure strategies are suboptimal, as evidenced by continued muscle and bone loss, alterations in muscle phenotype, and bone metabolism. However, studies incorporating the use of ultrasound, beta-blockers, and other pharmacologic agents have shown some promise. Understanding these mechanisms will not only benefit space technology but likely lead to a return on investment for the management of Earth-bound diseases.
    MeSH term(s) Humans ; Space Flight ; Astronauts ; Spine ; Weightlessness/adverse effects ; Low Back Pain
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001488
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2427: Show issues Location:
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  7. Article ; Online: Remote 6-minute-Walk Testing in Patients with Pulmonary Hypertension: Further Validation Needed?

    Helgeson, Scott A / Burger, Charles D / Moss, John E / Zeiger, Tonya K / Taylor, Bryan J

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 5, Page(s) 650–651

    MeSH term(s) Exercise Test ; Humans ; Hypertension, Pulmonary/diagnosis ; Walk Test ; Walking
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202204-0762LE
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    Uh II Zs.80: Show issues Location:
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  8. Article ; Online: Does COVID-19 impair V̇o

    Fernandes, Igor A / Balavenkataraman, Arvind / Bonvie-Hill, Natalie E / Patel, Neal M / Taylor, Bryan J / Helgeson, Scott A

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Volume 135, Issue 5, Page(s) 1146–1156

    Abstract: Reduced exercise capacity has been suggested as a cardinal sequela of COVID-19. However, only cross-sectional approaches that either do not consider individuals with concomitant cardiorespiratory disease or account for exercise capacity before infection ... ...

    Abstract Reduced exercise capacity has been suggested as a cardinal sequela of COVID-19. However, only cross-sectional approaches that either do not consider individuals with concomitant cardiorespiratory disease or account for exercise capacity before infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) support this assumption. Is reduced exercise capacity a sequela of SARS-CoV-2 infection in patients with concomitant cardiorespiratory disease? We retrospectively reviewed cardiopulmonary exercise testing (CPET) data collected across three hospitals between October 2018 and March 2022. Forty-two patients who completed a CPET before and after COVID-19 and 25 patients who performed two separate CPETs but did not contract COVID-19 (CTL) were included. Within each patient, the same test protocol was performed at the first and second CPETs. The time between CPETs was similar between the groups (COVID-19 489 ± 534 vs. CTL 534 ± 257 days,
    MeSH term(s) Humans ; COVID-19 ; Retrospective Studies ; Cross-Sectional Studies ; SARS-CoV-2 ; Exercise Test/methods
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00357.2023
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    Uc I Zs.249: Show issues Location:
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  9. Article ; Online: Systemic and Inhaled Corticosteroids, with or without Beta Agonists, as Adjuvant Therapy in Community Acquired Pneumonia.

    Helgeson, Scott A / Levitt, Joseph E / Festic, Emir

    Acta medica academica

    2020  Volume 49, Issue 1, Page(s) 9–20

    Abstract: The aim is to provide a narrative review of the role of corticosteroids, with and without inhaled beta agonist, in communityacquired pneumonia. Community and health-care associated pneumonia remain leading causes of morbidity and mortality despite ... ...

    Abstract The aim is to provide a narrative review of the role of corticosteroids, with and without inhaled beta agonist, in communityacquired pneumonia. Community and health-care associated pneumonia remain leading causes of morbidity and mortality despite appropriate antibiotic therapy. The pneumonia-associated adverse outcomes are not only related to the infectious organism, but also to a dysfunctional host-immune response resulting in overwhelming inflammation. Use of systemic corticosteroids as adjuvant therapy in pneumonia remains controversial. Multiple randomized clinical trials evaluating corticosteroids in patients with community acquired pneumonia have found discrepant results in terms of benefits and adverse effects. Inhaled delivery of corticosteroids offer the potential advantage of providing therapeutic benefits directly to the lung, with minimal to no adverse systemic effects. CONCLUSION: Although meta-analyses suggest potential benefits in a select group of patients with more severe pneumonia, the ideal timing, dose, route of delivery, duration, and patient selection remain to be established. A smaller body of literature suggests benefit of inhaled corticosteroids, with or without inhaled beta agonists, but future large scale clinical trials are needed to establish clinical benefit with inhaled delivery.
    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Adrenergic beta-Agonists/therapeutic use ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/etiology ; Lung/pathology ; Pneumonia/complications ; Pneumonia/drug therapy
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-Agonists ; Anti-Inflammatory Agents
    Language English
    Publishing date 2020-07-05
    Publishing country Bosnia and Herzegovina
    Document type Journal Article ; Review
    ZDB-ID 2558604-X
    ISSN 1840-2879 ; 1840-1848
    ISSN (online) 1840-2879
    ISSN 1840-1848
    DOI 10.5644/ama2006-124.279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Association between Non-Invasive Ventilation and the Rate of Ventilator-Associated Pneumonia.

    Saunders, Hollie / Khadka, Subekshya / Shrestha, Rabi / Balavenkataraman, Arvind / Hochwald, Alexander / Ball, Colleen / Helgeson, Scott A

    Diseases (Basel, Switzerland)

    2023  Volume 11, Issue 4

    Abstract: Ventilator-associated pneumonia (VAP) has significant effects on patient outcomes, including prolonging the duration of both mechanical ventilation and stay in the intensive care unit (ICU). The aim of this study was to assess the association between non- ...

    Abstract Ventilator-associated pneumonia (VAP) has significant effects on patient outcomes, including prolonging the duration of both mechanical ventilation and stay in the intensive care unit (ICU). The aim of this study was to assess the association between non-invasive ventilation/oxygenation (NIVO) prior to intubation and the rate of subsequent VAP. This was a multicenter retrospective cohort study of adult patients who were admitted to the medical ICU from three tertiary care academic centers in three distinct regions. NIVO was defined as continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP), or high-flow nasal cannula (HFNC) for any duration during the hospitalization prior to intubation. The primary outcome variable was VAP association with NIVO. A total of 17,302 patients were included. VAP developed in 2.6% of the patients (444/17,302), 2.3% (285/12,518) of patients among those who did not have NIVO, 1.6% (30/1879) of patients who had CPAP, 2.5% (17/690) of patients who had HFNC, 8.1% (16/197) of patients who had BiPAP, and 4.8% (96/2018) of patients who had a combination of NIVO types. Compared to those who did not have NIVO, VAP was more likely to develop among those who had BiPAP (adj OR 3.11, 95% CI 1.80-5.37,
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases11040151
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