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Article ; Online: We Agree: Cardiopulmonary Bypass Is a Team Sport: Reply.

Fiedler, Amy G / Lewis, Erik E / Hermsen, Joshua L

2020 Volume 110, Issue 4, Page(s) 1437–1438

MeSH term(s)	Cardiopulmonary Bypass ; Humans
Language	English
Publishing date	2020-04-23
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2020.03.055
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Zs.A 252: Show issues

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Article ; Online: Cardiopulmonary Bypass: How I Teach It.

Fiedler, Amy G / Lewis, Erik E / Hermsen, Joshua L

The Annals of thoracic surgery

2020 Volume 109, Issue 3, Page(s) 645–648

MeSH term(s)	Cardiopulmonary Bypass/education ; Cardiopulmonary Bypass/methods ; Curriculum ; Education, Medical, Graduate/methods ; Fellowships and Scholarships ; Humans ; Internship and Residency ; Teaching ; Wisconsin
Language	English
Publishing date	2020-01-16
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2020.01.001
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Article:

de Souza, Élvia Rodrigues / de Almeida, Priscilla Gomes C / Rocha, Lamarck / Koenen, Erik J M / Burgos, Margoth Atahuachi / Lewis, Gwilym P / Hughes, Colin E

PhytoKeys

2022 Volume 205, Page(s) 439–452

Abstract: Phylogenetic analyses of DNA sequence data sampling all species ... ...

Abstract	Phylogenetic analyses of DNA sequence data sampling all species of
Language	English
Publishing date	2022-08-22
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2579891-1
ISSN	1314-2003 ; 1314-2011
ISSN (online)	1314-2003
ISSN	1314-2011
DOI	10.3897/phytokeys.205.82256
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Article ; Online: Circulating Biomarkers Specific to Myocardial Extracellular Matrix Are Required to Embrace the Heterogeneity of HFpEF.

Lewis, Gavin A / Schelbert, Erik B / Kadler, Karl E / Miller, Christopher A

Journal of the American College of Cardiology

2020 Volume 76, Issue 20, Page(s) 2416–2417

MeSH term(s)	Aminobutyrates ; Biomarkers ; Biphenyl Compounds ; Drug Combinations ; Extracellular Matrix ; Heart Failure/diagnosis ; Humans ; Stroke Volume ; Tetrazoles ; Valsartan
Chemical Substances	Aminobutyrates ; Biomarkers ; Biphenyl Compounds ; Drug Combinations ; Tetrazoles ; Valsartan (80M03YXJ7I) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
Language	English
Publishing date	2020-10-27
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2020.08.084
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article: One hundred cases of primary spontaneous pneumomediastinum: leukocytosis is common, pleural effusions and age over 40 are rare.

Morgan, Clinton T / Kanne, Jeffrey P / Lewis, Erik E / Maloney, James D / DeCamp, Malcolm M / McCarthy, Daniel P

Journal of thoracic disease

2023 Volume 15, Issue 3, Page(s) 1155–1162

Abstract: ... age 40 with a known precipitating event or risk factors for PSPM (e.g., asthma, smoking) if they have ...

Abstract	Background: Primary spontaneous pneumomediastinum (PSPM) is a benign condition, but it can be difficult to discriminate from Boerhaave syndrome. The diagnostic difficulty is attributable to a shared constellation of history, signs, and symptoms combined with a poor understanding of the basic vital signs, labs, and diagnostic findings characterizing PSPM. These challenges likely contribute to high resource utilization for diagnosis and management of a benign process. Methods: Patients aged 18 years or older with PSPM were identified from our radiology department's database. A retrospective chart review was performed. Results: Exactly 100 patients with PSPM were identified between March 2001 and November 2019. Demographics and histories correlated well with prior studies: mean age (25 years); male predominance (70%); association with cough (34%), asthma (27%), retching or emesis (24%), tobacco abuse (11%), and physical activity (11%); acute chest pain (75%), and dyspnea (57%) as the first and second most frequent symptoms and subcutaneous emphysema (33%) as the most common sign. We provide the first robust data on presenting vital signs and laboratory values of PSPM, showing that tachycardia (31%) and leukocytosis (30%) were common. No pleural effusion was found in the 66 patients who underwent computed tomography (CT) of the chest. We provide the first data on inter-hospital transfer rates (27%). 79% of transfers were due to concern for esophageal perforation. Most patients were admitted (57%), with an average length of stay (LOS) of 2.3 days, and 25% received antibiotics. Conclusions: PSPM patients frequently present in their twenties with chest pain, subcutaneous emphysema, tachycardia, and leukocytosis. Approximately 25% have a history of retching or emesis and it is this population that must be discriminated from those with Boerhaave syndrome. An esophagram is rarely indicated and observation alone is appropriate in patients under age 40 with a known precipitating event or risk factors for PSPM (e.g., asthma, smoking) if they have no history of retching or emesis. Fever, pleural effusion, and age over 40 are rare in PSPM and should raise concern for esophageal perforation in a patient with a history of retching, emesis, or both.
Language	English
Publishing date	2023-03-02
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-22-1136
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Article ; Online: Novel Husbandry Practices Result in Rapid Rates of Growth and Sexual Maturation Without Impacting Adult Behavior in the Blind Mexican Cavefish.

Kozol, Robert A / Yuiska, Anders / Han, Ji Heon / Tolentino, Bernadeth / Lopatto, Arthur / Lewis, Peter / Paz, Alexandra / Keene, Alex C / Kowalko, Johanna E / Duboué, Erik R

Zebrafish

2023 Volume 20, Issue 2, Page(s) 86–94

Abstract: Animal model systems are dependent on the standardization of husbandry protocols that maximize growth and reduce generation time. The Mexican tetra, ...

Abstract	Animal model systems are dependent on the standardization of husbandry protocols that maximize growth and reduce generation time. The Mexican tetra,
MeSH term(s)	Animals ; Sexual Maturation ; Biological Evolution ; Zebrafish ; Characidae/genetics ; Feeding Behavior
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2156020-1
ISSN	1557-8542 ; 1545-8547
ISSN (online)	1557-8542
ISSN	1545-8547
DOI	10.1089/zeb.2023.0001
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Article ; Online: Cardiothoracic Education in the Time of COVID-19: How I Teach It.

Lewis, Erik E / Taylor, Lauren J / Hermsen, Joshua L / McCarthy, Daniel P / Fiedler, Amy G

The Annals of thoracic surgery

2020 Volume 110, Issue 2, Page(s) 362–363

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Curriculum ; Education, Distance ; Education, Medical, Graduate/methods ; Humans ; Internship and Residency ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Thoracic Surgery/education
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2020.04.002
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Zs.A 252: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Matching the Outcomes to Treatment Targets of Exercise for Low Back Pain: Does it Make a Difference? Results of Secondary Analyses From Individual Patient Data of Randomised Controlled Trials and Pooling of Results Across Trials in Comparative Meta-analysis.

Wood, Lianne / Foster, Nadine E / Lewis, Martyn / Bronfort, Gert / Groessl, Erik J / Hewitt, Catherine / Miyamoto, Gisela C / Reme, Silje E / Bishop, Annette

Archives of physical medicine and rehabilitation

2022 Volume 104, Issue 2, Page(s) 218–228

Abstract: Objective: To explore whether using a single matched or composite outcome might affect the results of previous randomized controlled trials (RCTs) testing exercise for non-specific low back pain (NSLBP). The first objective was to explore whether a ... ...

Abstract	Objective: To explore whether using a single matched or composite outcome might affect the results of previous randomized controlled trials (RCTs) testing exercise for non-specific low back pain (NSLBP). The first objective was to explore whether a single matched outcome generated greater standardized mean differences (SMDs) when compared with the original unmatched primary outcome SMD. The second objective was to explore whether a composite measure, composed of matched outcomes, generated a greater SMD when compared with the original primary outcome SMD. Design: We conducted exploratory secondary analyses of data. Setting: Seven RCTs were included, of which 2 were based in the USA (University research clinic, Veterans Affairs medical center) and the UK (primary care clinics, nonmedical centers). One each were based in Norway (clinics), Brazil (primary care), and Japan (outpatient clinics). Participants: The first analysis comprised 1) 5 RCTs (n=1033) that used an unmatched primary outcome but included (some) matched outcomes as secondary outcomes, and the second analysis comprised 2) 4 RCTs (n=864) that included multiple matched outcomes by developing composite outcomes (N=1897). Intervention: Exercise compared with no exercise. Main outcome measures: The composite consisted of standardized averaged matched outcomes. All analyses replicated the RCTs' primary outcome analyses. Results: Of 5 RCTs, 3 had greater SMDs with matched outcomes (pooled effect SMD 0.30 [95% confidence interval {CI} 0.04, 0.56], P=.02) compared with an unmatched primary outcome (pooled effect SMD 0.19 [95% CI -0.03, 0.40] P=.09). Of 4 composite outcome analyses, 3 RCTs had greater SMDs in the composite outcome (pooled effect SMD 0.28 [95% CI 0.05, 0.51] P=.02) compared with the primary outcome (pooled effect SMD 0.24 [95% CI -0.04, 0.53] P=.10). Conclusions: These exploratory analyses suggest that using an outcome matched to exercise treatment targets in NSLBP RCTs may produce greater SMDs than an unmatched primary outcome. Composite outcomes could offer a meaningful way of investigating superiority of exercise than single domain outcomes.
MeSH term(s)	Humans ; Low Back Pain/therapy ; Exercise ; Brazil ; Japan ; Norway ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80057-0
ISSN	1532-821X ; 0003-9993
ISSN (online)	1532-821X
ISSN	0003-9993
DOI	10.1016/j.apmr.2022.07.012
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Article ; Online: US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants.

Levin, Ronnie / Villanueva, Cristina M / Beene, Daniel / Cradock, Angie L / Donat-Vargas, Carolina / Lewis, Johnnye / Martinez-Morata, Irene / Minovi, Darya / Nigra, Anne E / Olson, Erik D / Schaider, Laurel A / Ward, Mary H / Deziel, Nicole C

Journal of exposure science & environmental epidemiology

2023 Volume 34, Issue 1, Page(s) 3–22

Abstract: Background: Advances in drinking water infrastructure and treatment throughout the 20: Objective/methods: In this review, we summarize exposure risk profiles and health effects for seven legacy and emerging drinking water contaminants or contaminant ... ...

Abstract	Background: Advances in drinking water infrastructure and treatment throughout the 20 Objective/methods: In this review, we summarize exposure risk profiles and health effects for seven legacy and emerging drinking water contaminants or contaminant groups: arsenic, disinfection by-products, fracking-related substances, lead, nitrate, per- and polyfluorinated alkyl substances (PFAS) and uranium. We begin with an overview of US public water systems, and US and global drinking water regulation. We end with a summary of cross-cutting challenges that burden US drinking water systems: aging and deteriorated water infrastructure, vulnerabilities for children in school and childcare facilities, climate change, disparities in access to safe and reliable drinking water, uneven enforcement of drinking water standards, inadequate health assessments, large numbers of chemicals within a class, a preponderance of small water systems, and issues facing US Indigenous communities. Results: Research and data on US drinking water contamination show that exposure profiles, health risks, and water quality reliability issues vary widely across populations, geographically and by contaminant. Factors include water source, local and regional features, aging water infrastructure, industrial or commercial activities, and social determinants. Understanding the risk profiles of different drinking water contaminants is necessary for anticipating local and general problems, ascertaining the state of drinking water resources, and developing mitigation strategies. Impact statement: Drinking water contamination is widespread, even in the US. Exposure risk profiles vary by contaminant. Understanding the risk profiles of different drinking water contaminants is necessary for anticipating local and general public health problems, ascertaining the state of drinking water resources, and developing mitigation strategies.
MeSH term(s)	Child ; Humans ; Water Quality ; Drinking Water ; Reproducibility of Results ; Aging ; Arsenic
Chemical Substances	Drinking Water ; Arsenic (N712M78A8G)
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2218551-3
ISSN	1559-064X ; 1559-0631
ISSN (online)	1559-064X
ISSN	1559-0631
DOI	10.1038/s41370-023-00597-z
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Article: Novel and improved

Moya, Nicolas D / Stevens, Lewis / Miller, Isabella R / Sokol, Chloe E / Galindo, Joseph L / Bardas, Alexandra D / Koh, Edward S H / Rozenich, Justine / Yeo, Cassia / Xu, Maryanne / Andersen, Erik C

bioRxiv : the preprint server for biology

2023

Abstract: Background: The nematode : Results: We designed a detailed workflow to train a team of nine students to manually curate genes using RNA read alignments and predicted gene models. We manually inspected the gene models using the genome annotation ... ...

Abstract	Background: The nematode Results: We designed a detailed workflow to train a team of nine students to manually curate genes using RNA read alignments and predicted gene models. We manually inspected the gene models using the genome annotation editor, Apollo, and proposed corrections to the coding sequences of over 8,000 genes. Additionally, we modeled thousands of putative isoforms and untranslated regions. We exploited the conservation of protein sequence length between Conclusions: Community-based, manual curation using transcriptome data is an effective approach to improve the quality of software-derived protein-coding genes. Comparative genomic analysis using a related species with high-quality reference genome(s) and gene models can be used to quantify improvements in gene model quality in a newly sequenced genome. The detailed protocols provided in this work can be useful for future large-scale manual curation projects in other species. The chromosome-level reference genome for the
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.16.541014
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