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  1. Article ; Online: Cuarenta años de Cardialysis

    Ernest Spitzer

    REC: Interventional Cardiology, Vol 5, Iss 4, Pp 250-

    una organización europea líder en investigación cardiovascular

    2023  Volume 253

    Abstract: En 1983, unos profesionales visionarios del Thoraxcenter perteneciente al Erasmus University Medical Center (EMC) fundan Cardialysis en Róterdam (Países Bajos). Cardialysis es una iniciativa que surge para cubrir la necesidad de una organización de ... ...

    Abstract En 1983, unos profesionales visionarios del Thoraxcenter perteneciente al Erasmus University Medical Center (EMC) fundan Cardialysis en Róterdam (Países Bajos). Cardialysis es una iniciativa que surge para cubrir la necesidad de una organización de investigación especializada destinada a planificar, ejecutar y publicar investigaciones clínicas colaborativas realizadas en Europa en el campo de la investigación cardiovascular1. La misión de Cardialysis es «llegar al corazón de la investigación cardiovascular» en el sentido más amplio de la frase. Para cumplir esta misión, la organización colabora con clínicos, autores de ensayos, investigadores profesionales, reguladores, representantes de la industria y organizaciones de investigación que comparten la misma pasión. Durante los primeros 40 años, su bien ganada reputación se ha cimentado sobre pilares como dedicación, diligencia y estándares líderes en la industria, ha atraído a empleados talentosos que han seguido a su lado y ha cultivado relaciones duraderas con investigadores, clientes y colaboradores. Las organizaciones similares a Cardialysis suelen englobarse como organizaciones de investigación académica (OIA) o de investigación por contrato (OIC). Las primeras, por ejemplo, unidades de ensayos clínicos y departamentos de epidemiología, suelen estar adscritas a universidades u hospitales universitarios y, por regla general, diseñan y gestionan ensayos clínicos de ámbito nacional de uno o.
    Keywords Internal medicine ; RC31-1245
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Forty years of Cardialysis

    Ernest Spitzer

    REC: Interventional Cardiology (English Ed.), Vol 5, Iss 4, Pp 250-

    a leading European cardiovascular research organization

    2023  Volume 253

    Abstract: Cardialysis was founded in 1983 by visionary professionals from the Thoraxcenter at Erasmus University Medical Center (EMC) in Rotterdam, The Netherlands. This initiative emerged to address the need for a specialized research organization able to plan, ... ...

    Abstract Cardialysis was founded in 1983 by visionary professionals from the Thoraxcenter at Erasmus University Medical Center (EMC) in Rotterdam, The Netherlands. This initiative emerged to address the need for a specialized research organization able to plan, execute, and report European cooperative clinical investigations in the field of cardiovascular research.1 The mission of Cardialysis is “to be at the heart of cardiovascular research” in the fullest sense of the phrase. To achieve this mission, the organization strives to collaborate with clinicians, trialists, research professionals, regulators, industry partners, and research organizations that share the same passion. Throughout the first 40 years, its well-established reputation has been based on dedication, diligence, and industry-leading standards. This has been made possible by attracting and retaining talented employees, as well as by cultivating long-standing relationships with investigators, clients, and partners. Organizations similar to Cardialysis are typically classified as either academic research organizations (AROs) or contract research organizations (CROs). AROs, such as clinical trial units and epidemiology departments, are typically affiliated with universities or university hospitals, and usually design and manage investigator-initiated single-center or multicenter national clinical trials. These organizations are academically-driven and their traditional objectives are to facilitate research and education, publish innovative research in.
    Keywords Medicine ; R
    Subject code 020
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Permanyer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: TAVI and The Challenges Ahead

    John O'Sullivan, Crochan / Mylotte, Darren / Spitzer, Ernest / Lauten, Alexander

    2020  

    Keywords Medicine ; transcatheter aortic valve replacement ; aortic stenosis ; interventional cardiolgy ; prosthetic heart valve ; structural heart disease ; cardiac imaging
    Size 1 electronic resource (119 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230672
    ISBN 9782889660896 ; 2889660893
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: [Forty years of Cardialysis: a leading European cardiovascular research organization].

    Spitzer, Ernest / Ren, B E N

    Zhonghua xin xue guan bing za zhi

    2023  Volume 52, Issue 1, Page(s) 107–110

    MeSH term(s) Humans ; Cardiovascular System ; Cardiovascular Diseases ; Heart
    Language Chinese
    Publishing date 2023-10-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 603425-1
    ISSN 0253-3758
    ISSN 0253-3758
    DOI 10.3760/cma.j.cn112148-20230922-00184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Device and Procedure Relatedness: Viewpoint From Members of the ARC Steering Group.

    Cutlip, Donald E / Mehran, Roxana / Spitzer, Ernest / Morice, Marie-Claude / Krucoff, Mitchell W

    JACC. Cardiovascular interventions

    2022  Volume 15, Issue 7, Page(s) 783–788

    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2022.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Echocardiography Core Laboratory Validation of a Novel Vendor-Independent Web-Based Software for the Assessment of Left Ventricular Global Longitudinal Strain.

    Spitzer, Ernest / Camacho, Benjamin / Mrevlje, Blaz / Brandendburg, Hans-Jelle / Ren, Claire B

    Journal of cardiovascular imaging

    2023  Volume 31, Issue 3, Page(s) 135–141

    Abstract: Background: Global longitudinal strain (GLS) is an accurate and reproducible parameter of left ventricular (LV) systolic function which has shown meaningful prognostic value. Fast, user-friendly, and accurate tools are required for its widespread ... ...

    Abstract Background: Global longitudinal strain (GLS) is an accurate and reproducible parameter of left ventricular (LV) systolic function which has shown meaningful prognostic value. Fast, user-friendly, and accurate tools are required for its widespread implementation. We aim to compare a novel web-based tool with two established algorithms for strain analysis and test its reproducibility.
    Methods: Thirty echocardiographic datasets with focused LV acquisitions were analyzed using three different semi-automated endocardial GLS algorithms by two readers. Analyses were repeated by one reader for the purpose of intra-observer variability. CAAS Qardia (Pie Medical Imaging) was compared with 2DCPA and AutoLV (TomTec).
    Results: Mean GLS values were -15.0 ± 3.5% from Qardia, -15.3 ± 4.0% from 2DCPA, and -15.2 ± 3.8% from AutoLV. Mean GLS between Qardia and 2DCPA were not statistically different (p = 0.359), with a bias of -0.3%, limits of agreement (LOA) of 3.7%, and an intra-class correlation coefficient (ICC) of 0.88. Mean GLS between Qardia and AutoLV were not statistically different (p = 0.637), with a bias of -0.2%, LOA of 3.4%, and an ICC of 0.89. The coefficient of variation (CV) for intra-observer variability was 4.4% for Qardia, 8.4% 2DCPA, and 7.7% AutoLV. The CV for inter-observer variability was 4.5%, 8.1%, and 8.0%, respectively.
    Conclusions: In echocardiographic datasets of good image quality analyzed at an independent core laboratory using a standardized annotation method, a novel web-based tool for GLS analysis showed consistent results when compared with two algorithms of an established platform. Moreover, inter- and intra-observer reproducibility results were excellent.
    Language English
    Publishing date 2023-07-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3020035-0
    ISSN 2586-7296 ; 2586-7210
    ISSN (online) 2586-7296
    ISSN 2586-7210
    DOI 10.4250/jcvi.2022.0130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Editorial: TAVI and the Challenges Ahead.

    Spitzer, Ernest / Mylotte, Darren / Lauten, Alexander / O'Sullivan, Crochan J

    Frontiers in cardiovascular medicine

    2020  Volume 7, Page(s) 149

    Language English
    Publishing date 2020-08-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2020.00149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Validation of a simplified intravascular ultrasound core lab analysis method in stented coronary arteries.

    Neleman, Tara / Khachabi, Jamal / Jonker, Hans / Rademaker-Havinga, Tessa / Spitzer, Ernest / Daemen, Joost

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2022  Volume 100, Issue 4, Page(s) 481–491

    Abstract: Objectives: To validate a simplified core laboratory intravascular ultrasound (IVUS) analysis method based on frames with visually determined minimal lumen areas (MLAs) as compared with a comprehensive (per frame) analysis method.: Background: IVUS- ... ...

    Abstract Objectives: To validate a simplified core laboratory intravascular ultrasound (IVUS) analysis method based on frames with visually determined minimal lumen areas (MLAs) as compared with a comprehensive (per frame) analysis method.
    Background: IVUS-guided percutaneous coronary intervention has proven to be superior to angiography-guided stenting. In clinical practice, cross-sections with visually determined MLA are measured to determine lesion severity or minimal stent area (MSA), however, its accuracy has not been compared with a comprehensive per frame analysis method.
    Methods: A total of 50 stented coronary segments of anonymized core lab datasets were analyzed using a comprehensive analysis method and reanalyzed by two core lab analysts using the simplified method including a maximum of seven frames to be analyzed (the visually determined MSA, the first and last frame, and the MLA of each reference segment). The main parameters of interest were MSA, MLA in the reference segments, and plaque burden.
    Results: The simplified method showed moderate agreement for measurement of the proximal MLA (7.51 ± 2.52 vs. 6.32 ± 1.88 mm
    Conclusions: Measuring poststenting IVUS cross-sections with visually determined MLAs by experienced core lab analysts is an accurate and reproducible method to identify MLAs.
    MeSH term(s) Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Vessels/diagnostic imaging ; Humans ; Treatment Outcome ; Ultrasonography, Interventional/methods
    Language English
    Publishing date 2022-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Should real-world evidence be incorporated into regulatory approvals?

    Spitzer, Ernest / Cannon, Christopher P / Serruys, Patrick W

    Expert opinion on drug safety

    2018  Volume 17, Issue 12, Page(s) 1155–1159

    MeSH term(s) Humans ; Research Design
    Language English
    Publishing date 2018-11-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2018.1546842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Thrombectomy in Primary Angioplasty: Do the Latest Large Studies Address the Doubts About Its Usefulness? Response.

    Spitzer, Ernest / Windecker, Stephan

    Revista espanola de cardiologia (English ed.)

    2016  Volume 69, Issue 2, Page(s) 231

    MeSH term(s) Angioplasty ; Humans ; Myocardial Infarction ; Stents ; Thrombectomy ; Treatment Outcome
    Language English
    Publishing date 2016-02
    Publishing country Spain
    Document type Comment ; Letter
    ISSN 1885-5857
    ISSN (online) 1885-5857
    DOI 10.1016/j.rec.2015.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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