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Article: Possible effects of melatonin on reperfusion injury following coronary artery bypass graft surgery.

Hajhossein-Talasaz, Azita / Dianatkhah, Mehrnoush / Ghaeli, Padideh / Salehiomran, Abbass / Dianatkhah, Minoo

ARYA atherosclerosis

2023 Volume 18, Issue 2, Page(s) 1–7

Abstract: Background: Although coronary artery bypass graft (CABG) surgery has been reported to be one of the most effective internentions in terms of myocardial salvage, reperfusion itself can cause additional damage to the myocardium. Since there is strong ... ...

Abstract	Background: Although coronary artery bypass graft (CABG) surgery has been reported to be one of the most effective internentions in terms of myocardial salvage, reperfusion itself can cause additional damage to the myocardium. Since there is strong evidence that free radicals are the principal offender in ischemia-reperfusion (I/R) injury, it has been suggested that treatment with antioxidant agents can be protective. Investigations have shown that melatonin secretion is partially disturbed in CABG patients. The aim of this study was to evaluate the protective effect of melatonin as an antioxidant agent on I/R injury. Methods: 164 elective CABG candidates participated in this randomized clinical trial during the preoperative period. The candidates were randomized to receive 3 mg of melatonin tablets (physiologic dose) from 3 days before surgery until the day of discharge. Cardiac biomarkers [troponin and creatine kinase myocardial band (CKMB)] were assessed once before surgery (24 hours before surgery), and 8 and 24 hours after surgery. Results: Finally, 130 patients, 65 (50%) patients in the melatonin group and 65 (50%) in the control arm finished our study. Mean age of melatonin and control groups was 59.90 ± 9.59 and 60.80 ± 8.00 years, respectively; moreover, 47 (72.30%) in melatonin and 45 (69.23%) in control group were men. No significant difference was seen in baseline cardiac biomarkers between two groups (P > 0.05). In both groups, cardiac biomarkers (CKMB and troponin) elevated after surgery in comparison to their preoperative values. There was no statistically significant difference between the control and melatonin groups regarding the 8-hour and 24-hour troponin and CKMB when adjusted for interacting factors (P > 0.05). Conclusion: Although physiological concentration of melatonin is protective against I/R injury, substitution of endogenous melatonin with the oral supplement which creates physiologic concentration may not prevent I/R injury. In order to have antioxidant effect, pharmacologic doses of melatonin should be employed.
Language	English
Publishing date	2023-02-11
Publishing country	Iran
Document type	Journal Article
ISSN	1735-3955
ISSN	1735-3955
DOI	10.48305/arya.v18i0.2208
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Article ; Online: Efficacy and Safety of the Fixed-Dose Versus Variable-Dose of 4-PCC for Vitamin K Antagonist Reversal: A Comprehensive Systematic Review and Meta-Analysis.

Mohammadi, Keyhan / Yaribash, Shakila / Sani, Mahmood Alizadeh / Talasaz, Azita Hajhossein

Cardiovascular drugs and therapy

2021 Volume 36, Issue 3, Page(s) 533–546

Abstract: Background: The optimal dosing strategy of four-factor prothrombin complex concentrate (4F-PCC) for vitamin K antagonists (VKAs) reversal is unknown.: Methods: We conducted systematic search on the PubMed, SCOPUS, and Embase databases from inception ... ...

Abstract	Background: The optimal dosing strategy of four-factor prothrombin complex concentrate (4F-PCC) for vitamin K antagonists (VKAs) reversal is unknown. Methods: We conducted systematic search on the PubMed, SCOPUS, and Embase databases from inception to December 2020 for clinical studies that compared the fixed-dose versus variable-dose of 4-PCC for VKAs reversal with at least one reported clinical outcome. The treatment effects were expressed as relative ratios (RR) with 95% confidence intervals (CIs) and pooled by a random-effects model. Results: Ten studies, including 988 patients, were included. Fixed-dose 4-PCC was associated with lower rate of mortality (RR= 0.65, 95% CI 0.47 to 0.9, p= 0.009), comparable rate of thromboembolic event (TEE) (RR= 1.10, 95%CI 0.44 to 2.80, p= 0.826), and lower goal INR reached (RR= 0.87, 95%CI 0.78 to 0.96, p= 0.007). Less 4-PCC cumulative dose, shorter duration of order-to-needle time, similar hospital length of stay, the comparable time required for INR reversal, higher post-4-PCC INR, and a higher need for additional dose were observed in fixed-dose. Conclusions: The use of a fixed-dose of 4-PCC may be considered an effective and safe dosing strategy for VKAs reversal in various clinical situations. However, further well-designed, controlled studies should be conducted focusing on clinical outcomes to determine the optimal dose of 4-PCC for VKAs reversal.
MeSH term(s)	Anticoagulants/adverse effects ; Fibrinolytic Agents ; Humans ; International Normalized Ratio ; Retrospective Studies ; Thromboembolism/drug therapy ; Vitamin K
Chemical Substances	Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
Language	English
Publishing date	2021-04-17
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-021-07192-0
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Article ; Online: The potential role of clinical pharmacy services in patients with cardiovascular diseases.

Talasaz, Azita Hajhossein

The journal of Tehran Heart Center

2012 Volume 7, Issue 2, Page(s) 41–46

Abstract: Clinical pharmacy is deemed an integral component of a health care system. The presence of clinical pharmacists in medical rounds could assist physicians in optimizing patients' pharmacotherapy. Moreover, clinical pharmacists may reduce adverse effects ... ...

Abstract	Clinical pharmacy is deemed an integral component of a health care system. The presence of clinical pharmacists in medical rounds could assist physicians in optimizing patients' pharmacotherapy. Moreover, clinical pharmacists may reduce adverse effects and medication errors insofar as they contribute significantly to the detection and management of drug-related problems, not least in patients with cardiovascular diseases, who have the highest rank in the frequency of medication errors. Clinical pharmacists can also collaborate with physicians in the management of cardiovascular risk factors as well as anticoagulation therapy based on patients' specific situations.In summary, the practice of clinical pharmacy is considered a crucial part of a health care team to improve the level of patients' care by increasing the quality of therapy with the least expense for a health care system.
Language	English
Publishing date	2012-05-31
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2476998-8
ISSN	2008-2371 ; 1735-8620 ; 1735-5370
ISSN (online)	2008-2371
ISSN	1735-8620 ; 1735-5370
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Article: Relationship between Vitamin D Levels and the Incidence of Post Coronary Artery Bypass Graft Surgery Atrial Fibrillation.

Daie, Maryam / Hajhossein Talasaz, Azita / Karimi, Abbasali / Gholami, Kheirollah / Salehiomran, Abbas / Ariannejad, Hamid / Jalali, Arash

The journal of Tehran Heart Center

2019 Volume 13, Issue 4, Page(s) 159–165

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-03-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2476998-8
ISSN	2008-2371 ; 1735-5370 ; 1735-8620
ISSN (online)	2008-2371
ISSN	1735-5370 ; 1735-8620
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Article ; Online: Preventive effect of l-carnitine and its derivatives on endothelial dysfunction and platelet aggregation.

Mohammadi, Mohammad / Hajhossein Talasaz, Azita / Alidoosti, Mohammad

Clinical nutrition ESPEN

2016 Volume 15, Page(s) 1–10

Abstract: Background and aim: Oxidative stress plays an important role in platelet activation and endothelial dysfunction. Exogenous and endogenous reactive oxygen species are associated with platelet activation and vascular dysfunction. Antioxidants have been ... ...

Abstract	Background and aim: Oxidative stress plays an important role in platelet activation and endothelial dysfunction. Exogenous and endogenous reactive oxygen species are associated with platelet activation and vascular dysfunction. Antioxidants have been shown to attenuate oxidative stress and consequently endothelial dysfunction by preventing inflammation, regulating vascular tone, and promoting antiadhesive and antithrombotic properties. l-carnitine and its derivatives have been demonstrated to improve endothelial and platelet function against oxidative stress by several mechanisms, some of which cannot be found in other antioxidants. The role of l-carnitine and its derivatives in endothelial dysfunction and platelet activation will be reviewed here from the perspective of basic and clinical research. Method: This study reviews in vitro and in vivo studies, clinical trials, and abstracts in the English language that have examined the protective effects of l-carnitine and its derivatives on endothelial dysfunction and platelet aggregation in pathological conditions. We searched experimental studies, clinical trials, and other review articles to obtain the materials. Conclusions: Although in vitro physiological models, animal studies on vascular and platelet function, and some human studies on these systems are in favor of the preventive effects of l-carnitine and its derivatives on endothelial dysfunction and platelet aggregation, more clinical trials are needed to clarify the clinical importance of l-carnitine as a supportive option to maintain the normal homeostatic function of the vasculature and to prevent platelet activation.
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article ; Review
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2016.06.009
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Article ; Online: The Potential Role of Clinical Pharmacy Services in Patients with Cardiovascular Diseases

Azita Hajhossein Talasaz

Journal of Tehran University Heart Center, Vol 7, Iss 2, Pp 41-

2012 Volume 46

Abstract: Clinical pharmacy is deemed an integral component of a health care system. The presence of clinical pharmacists in medical rounds could assist physicians in optimizing patients pharmacotherapy. Moreover, clinical pharmacists may reduce adverse effects ... ...

Abstract	Clinical pharmacy is deemed an integral component of a health care system. The presence of clinical pharmacists in medical rounds could assist physicians in optimizing patients pharmacotherapy. Moreover, clinical pharmacists may reduce adverse effects and medication errors insofar as they contribute significantly to the detection and management of drug-related problems, not least in patients with cardiovascular diseases, who have the highest rank in the frequency of medication errors. Clinical pharmacists can also collaborate with physicians in the management of cardiovascular risk factors as well as anticoagulation therapy based on patients specific situations. In summary, the practice of clinical pharmacy is considered a crucial part of a health care team to improve the level of patients care by increasing the quality of therapy with the least expense for a health care system.
Keywords	Pharmacy ; Cardiovascular Diseases ; Professional Role ; Patient Care Team ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: S2P peptide-conjugated PLGA-Maleimide-PEG nanoparticles containing Imatinib for targeting drug delivery to atherosclerotic plaques.

Esfandyari-Manesh, Mehdi / Abdi, Masoome / Talasaz, Azita Hajhossein / Ebrahimi, Seyedeh Masoumeh / Atyabi, Fatemeh / Dinarvand, Rassoul

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

2020 Volume 28, Issue 1, Page(s) 131–138

Abstract: Background: Imatinib is a platelet-derived growth factor receptor (PDGFR) inhibitor with very low water solubility. Previous studies in atherosclerosis have shown that PDGFR activity has an egregious effect on vascular disease and progression of ... ...

Abstract	Background: Imatinib is a platelet-derived growth factor receptor (PDGFR) inhibitor with very low water solubility. Previous studies in atherosclerosis have shown that PDGFR activity has an egregious effect on vascular disease and progression of atherosclerosis. Specific ligands of atherosclerotic plaques can be used for targeting of nanoparticles. Studies in atherosclerosis proved that stabilin-2 is a glycoprotein which exists abundantly in atherosclerotic plaques and it is produced from both macrophages and endothelial cells. Objectives: The objective of this study is the targeting drug delivery to atherosclerotic plaques by using imatinib-loaded nanoparticles modified by S2P peptide. Methods: The imatinib-loaded nanoparticles were fabricated through a modified emulsion/solvent evaporation technique. After fabricating PLGA nanoparticles, maleimide PEG was used as linker between PLGA nanoparticles and S2P peptide. Because of presence cysteine in both side of S2P peptide, maleimide formed a thiolether linkage by thiol group of cysteine. Then the physicochemical analysis like H-NMR, FT-IR, DSC, SEM, particle size, zeta potential, and drug release were studied. Results: Stabilin-2 peptide with sequence of CRTLTVRKC is a specific ligand to stabilin-2, so it was synthesized for using as the targeting agent for atherosclerosis. S2P peptide conjugation to the surface of nanoparticles was proved by H-NMR and FT-IR, and the percentage of S2P peptide in nanoparticles was 1.3%. The final nanoparticles were spherical and their size were 183 nm. The loading capacity of the imatinib-loaded nanoparticles was 5.05%. The sustained release profile was observed for peptide targeted nanoparticles. Conclusion: The chosen method was simple, reproducible, and specific in peptide conjugation of nanoparticles for targeting delivery to atherosclerotic regions. Graphical abstract .
MeSH term(s)	Drug Delivery Systems ; Drug Liberation ; Imatinib Mesylate/chemistry ; Maleimides/chemistry ; Nanoparticles/chemistry ; Oligopeptides/chemistry ; Plaque, Atherosclerotic ; Polyethylene Glycols/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Protein Kinase Inhibitors/chemistry
Chemical Substances	Maleimides ; Oligopeptides ; Protein Kinase Inhibitors ; S2P peptide ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; maleimide (2519R1UGP8) ; Polyethylene Glycols (3WJQ0SDW1A) ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2020-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2129183-4
ISSN	2008-2231 ; 1560-8115
ISSN (online)	2008-2231
ISSN	1560-8115
DOI	10.1007/s40199-019-00324-w
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Article ; Online: Acute Pulmonary Embolism in Women

Hassan Aghajani / Amine Ghram / Yaser Jenab / Mahboobeh Aghajani / Saeed ghodsi / Azita Hajhossein Talasaz / saeed tofighi

Acta Medica Iranica, Vol 59, Iss

Focus on Estrogen Therapy as a Predisposing Factor

2021 Volume 6

Abstract: Objectives:Acute pulmonary embolism (APE) is a potentially fatal disorder. The literature shows that estrogen therapy is correlated with an increase in mortality and morbidity. Accordingly, the purpose of the present study was to investigate the ... ...

Abstract	Objectives:Acute pulmonary embolism (APE) is a potentially fatal disorder. The literature shows that estrogen therapy is correlated with an increase in mortality and morbidity. Accordingly, the purpose of the present study was to investigate the prevalence and prognostic significance of recent history of estrogen therapy in women with APE. Methods: This study was conducted on female patients admitted to our hospital between January 2008 and January 2016. A total of 276 patients (mean age = 62.66 ± 08 y) with confirmed APE were divided into groups with and without recent estrogen therapy. The relationships between estrogen and clinical findings, risk factors, imaging findings, and in-hospital mortality were analyzed. Results: Among the 276 women with APE at presentation, 37 (13.4%) patients had a recent history of estrogen therapy. The estrogen group had a lower frequency of hypertension (21.6% vs49.8%; P< .001), immobilization of at least 3 days (16.2% vs 33.5%; P = .035), and pleural effusion (0% vs16.7%; P = .007) than the group without recent estrogen use. Among the 276 patients, the rate of 1 year’s mortality was 15.8% for the group without recent estrogen therapy. No death occurred in the estrogen group. Conclusion: older age, tachycardia, tachypnea, malignancy, and lack of obesity were the predictors of 1 year’s mortality. Among the patients with APE in our study, 13.4% had a history of recent estrogen therapy. No death occurred during the 1-year follow-up of these patients.
Keywords	Pulmonary embolism ; Estrogen ; Mortality ; Thromboembolism ; Deep vein thrombosis ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article: Potential Role of Vitamin C Intracoronary Administration in Preventing Cardiac Injury After Primary Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction.

Shafaei-Bajestani, Negar / Talasaz, Azita Hajhossein / Salarifar, Mojtaba / Pourhosseini, Hamidreza / Sadri, Farshad / Jalali, Arash

Journal of research in pharmacy practice

2019 Volume 8, Issue 2, Page(s) 75–82

Abstract: Objective: The aim of the present study was to determine the effects of intravenous (IV) and intracoronary administration of Vitamin C on the incidence of periprocedural myocardial injury in patients undergoing primary percutaneous coronary intervention ...

Abstract	Objective: The aim of the present study was to determine the effects of intravenous (IV) and intracoronary administration of Vitamin C on the incidence of periprocedural myocardial injury in patients undergoing primary percutaneous coronary intervention (PCI). Methods: In this prospective, double-blind, randomized clinical trial, that was conducted in Tehran Heart Center, Iran, between October 2016 and March 2017, 252 patients undergoing primary PCI were enrolled to receive either 3 g of IV Vitamin C before PCI and 100 mg of intracoronary Vitamin C during PCI in addition to the routine treatment ( Findings: In the patients who received Vitamin C, the serum levels of troponin T after 12 h and creatine kinase-MB after 6 h were significantly lower than those in the placebo group ( Conclusion: In primary PCI patients, the prophylactic use of IV and intracoronary Vitamin C can confer additional clinical benefits such as cardioprotection.
Language	English
Publishing date	2019-07-23
Publishing country	India
Document type	Journal Article
ZDB-ID	2734861-1
ISSN	2279-042X ; 2319-9644
ISSN (online)	2279-042X
ISSN	2319-9644
DOI	10.4103/jrpp.JRPP_18_78
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Article ; Online: Sodium-glucose cotransporter 2 inhibitors: A comprehensive review from cells to bedside.

Bagheri, Bahador / Yaribeygi, Habib / Taherifard, Erfan / Talasaz, Azita Hajhossein / Bagheri, Haleh / Darban, Mahboubeh / Tabrizi, Reza / Najafi, Siamak / Khodadost, Mahmoud / Akbari, Maryam

Fundamental & clinical pharmacology

2022 Volume 37, Issue 3, Page(s) 481–492

Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2is) are oral medications approved for type 2 diabetes mellitus. Interestingly, during recent years, they have been promisingly considered as new medications for cardiovascular and kidney diseases. ... ...

Abstract	Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2is) are oral medications approved for type 2 diabetes mellitus. Interestingly, during recent years, they have been promisingly considered as new medications for cardiovascular and kidney diseases. However, the mechanisms underlying these new benefits are not fully understood. Thanks to the discovery of multiple modes of action, the simple picture about mechanisms of action of SGLT2is has become more and more complex. Besides their effects in diabetes, there is increasing evidence for their beneficial effects in heart failure and chronic kidney diseases. In addition, many studies have provided evidence for the fruitful effects of SGLT2is in atherosclerotic cardiovascular disease. In this study, we present mounting evidence for the complex action modes of SGLT2is and their current applications in clinical practice.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Glucose ; Sodium ; Cardiovascular Diseases/drug therapy
Chemical Substances	Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2022-12-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12852
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