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Article ; Online: Simple simultaneous determination of moxifloxacin and metronidazole in complex biological matrices.

El-Yazbi, Amira F / Aboukhalil, Faten M / Khamis, Essam F / Elkhatib, Mohammed A W / El-Sayed, Mahmoud A / Youssef, Rasha M

RSC advances

2022 Volume 12, Issue 25, Page(s) 15694–15704

Abstract: A simple, sensitive and rapid RP-HPLC method is presented, for the first time, for the simultaneous determination of moxifloxacin hydrochloride and metronidazole in different biological fluids including saliva and plasma without any matrix interference. ... ...

Abstract	A simple, sensitive and rapid RP-HPLC method is presented, for the first time, for the simultaneous determination of moxifloxacin hydrochloride and metronidazole in different biological fluids including saliva and plasma without any matrix interference. The separation was performed using ACN and phosphate buffer (30 : 70% v/v) as the mobile phase on a Zorbax Eclipse Plus-C18 column attached to a guard column. The method was validated according to the FDA guidelines for bioanalytical method validation and was successfully applied for simultaneous determination of the studied drugs in saliva and plasma samples. The good precision and selectivity of the developed method allow it to be used for routine therapeutic drug monitoring of such drugs and it presents a simple and sensitive analytical tool for performing versatile pharmacokinetics and bioavailability studies. A DAD detector is valuable to determine each drug at its maximum wavelength to ensure high sensitivity. Determination of such a combination in saliva introduces a quick and non-invasive alternative to blood analysis.
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra01631a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: What are the current recommendations for antibiotic prophylaxis for dental work and colonoscopies in HD patients?

Elsayed, Essam F

Seminars in dialysis

2011 Volume 24, Issue 4, Page(s) 376–377

MeSH term(s)	Antibiotic Prophylaxis/standards ; Colonoscopy ; Dental Care for Chronically Ill ; Humans ; Practice Guidelines as Topic ; Renal Dialysis
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028193-9
ISSN	1525-139X ; 0894-0959
ISSN (online)	1525-139X
ISSN	0894-0959
DOI	10.1111/j.1525-139X.2011.00884.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In situ green analytical methods for the rapid and sensitive determination of a newly launched orphan anticancer drug; Tigecycline in infusion bags

Amira F. El-Yazbi / Faten M. Aboukhalil / Essam F. Khamis / Rasha M. Youssef / Mahmoud A. El-Sayed

Beni-Suef University Journal of Basic and Applied Sciences, Vol 11, Iss 1, Pp 1-

comparative study

2022 Volume 15

Abstract: Abstract Background Tigecycline (TIG), an antimicrobial agent indicated for complex bacterial infections, is now approved by FDA as an orphan chemotherapeutic agent for the treatment of acute myeloid leukemia due to its inhibitory effects on pathways of ... ...

Abstract	Abstract Background Tigecycline (TIG), an antimicrobial agent indicated for complex bacterial infections, is now approved by FDA as an orphan chemotherapeutic agent for the treatment of acute myeloid leukemia due to its inhibitory effects on pathways of activating, signaling and abnormal mitochondrial function in cancer cells. TIG is mainly administered as intravenous infusion through centralized unit of oncology centers. This necessitates the continuous analytical quality control of the prepared solution in order to identify and quantify TIG for safe intravenous administration to patients. Moreover, the clinical staff exposure risk to toxic drugs during daily handling must be considered. Such concerns require a fast, cost-effective and green analytical procedure for sensitive determination of TIG directly in infusion bags. In this work, we propose a simple, rapid and green capillary zone electrophoretic (CZE) method for the sensitive assay of TIG directly in infusion bags, in addition to three simple and green spectrophotometric methods. Results TIG solutions corresponding to clinical ranges were detected in 5%glucose. Validation of all the proposed methods was according to ICH guidelines. Greenness assessment was performed depending on Green Analytical Procedure Index (GAPI) and the Eco-scale approach which showed that the proposed methods are better eco-friendly methods than reported ones. It also revealed the superiority of our proposed methods in terms of simplicity and sensitivity for TIG determination in infusion bags. Quantification limits obtained were significantly lower than the administered range of TIG in infusion bags and lower than its maximum serum concentration (C max). This promotes the application of the proposed methods for the pharmacokinetics and bioavailability studies of TIG in various biological fluids. Conclusions This work reports, for the first time, CZE method for the direct and rapid determination of TIG and its separation from other components in intravenous infusion solution. The ...
Keywords	Tigecycline ; Capillary electrophoresis ; Spectrophotometric methods ; Infusion bags ; Medicine (General) ; R5-920 ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Simple simultaneous determination of moxifloxacin and metronidazole in complex biological matrices

El-Yazbi, Amira F. / Aboukhalil, Faten M. / Khamis, Essam F. / Elkhatib, Mohammed A. W. / El-Sayed, Mahmoud A. / Youssef, Rasha M.

RSC advances. 2022 May 23, v. 12, no. 25

2022

Abstract	A simple, sensitive and rapid RP-HPLC method is presented, for the first time, for the simultaneous determination of moxifloxacin hydrochloride and metronidazole in different biological fluids including saliva and plasma without any matrix interference. The separation was performed using ACN and phosphate buffer (30 : 70% v/v) as the mobile phase on a Zorbax Eclipse Plus-C18 column attached to a guard column. The method was validated according to the FDA guidelines for bioanalytical method validation and was successfully applied for simultaneous determination of the studied drugs in saliva and plasma samples. The good precision and selectivity of the developed method allow it to be used for routine therapeutic drug monitoring of such drugs and it presents a simple and sensitive analytical tool for performing versatile pharmacokinetics and bioavailability studies. A DAD detector is valuable to determine each drug at its maximum wavelength to ensure high sensitivity. Determination of such a combination in saliva introduces a quick and non-invasive alternative to blood analysis.
Keywords	bioavailability ; hematologic tests ; metronidazole ; moxifloxacin ; pharmacokinetics ; phosphates ; saliva ; therapeutics ; wavelengths
Language	English
Dates of publication	2022-0523
Size	p. 15694-15704.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d2ra01631a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Chlorella vulgaris enriched diet on growth performance, hemato-immunological responses, antioxidant and transcriptomics profile disorders caused by deltamethrin toxicity in Nile tilapia (Oreochromis niloticus).

Mahmoud, Essam A / El-Sayed, Badawi M / Mahsoub, Yasser H / El-Murr, Abd Elhakeem I / Neamat-Allah, Ahmed N F

Fish & shellfish immunology

2020 Volume 102, Page(s) 422–429

Abstract: The toxic effect of deltamethrin (DM) was documented in aquaculture. There is no obtainable data on the effect of Chlorella vulgaris against DM toxicity. The current study focused on the effect of dietary supplementation with C. vulgaris (CV) on growth ... ...

Abstract	The toxic effect of deltamethrin (DM) was documented in aquaculture. There is no obtainable data on the effect of Chlorella vulgaris against DM toxicity. The current study focused on the effect of dietary supplementation with C. vulgaris (CV) on growth performance, innate immune response, antioxidant activities, and transcriptomics disorders induced by sub-lethal dose of DM in Oreochromis niloticus. A total number of 216 O. niloticus divided into four groups with tri-replicates. The 1
MeSH term(s)	Animal Feed/analysis ; Animals ; Antioxidants/metabolism ; Chlorella vulgaris/chemistry ; Cichlids/blood ; Cichlids/growth & development ; Cichlids/immunology ; Diet/veterinary ; Dietary Supplements/analysis ; Insecticides/toxicity ; Nitriles/toxicity ; Pyrethrins/toxicity ; Transcriptome/drug effects ; Water Pollutants, Chemical/toxicity
Chemical Substances	Antioxidants ; Insecticides ; Nitriles ; Pyrethrins ; Water Pollutants, Chemical ; decamethrin (2JTS8R821G)
Language	English
Publishing date	2020-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2020.04.061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dietary phosphate: what do we know about its toxicity.

Jain, Nishank / Elsayed, Essam F

Journal of nephrology

2013 Volume 26, Issue 5, Page(s) 856–864

Abstract: Unlabelled: Inorganic phosphate (Pi) is an essential mineral required for diverse cellular processes. Recent genetic and dietary experiments in animal models indicate that Pi may be toxic to a variety of biological processes. High dietary Pi load in ... ...

Abstract	Unlabelled: Inorganic phosphate (Pi) is an essential mineral required for diverse cellular processes. Recent genetic and dietary experiments in animal models indicate that Pi may be toxic to a variety of biological processes. High dietary Pi load in such animal models resulted in an increase in oxidative stress, DNA damage that resulted in phenotypic expression of premature aging, and short life span. Further, high Pi load was reported to induce carcinogenesis in lung and skin cancer animal models. So far, translational research is limited to observational studies that show an independent association of Pi intake with morbidity and mortality across all strata of kidney function. Fast-food and processed-food consumption in an average American diet leads to large increases in daily phosphate intake. Whether such dietary patterns explain the epidemiology of disease processes in humans remains to be further investigated. Conclusion: Phosphotoxicity is a novel concept with a potential for a large public health impact in future, but urgent studies are needed to prove reducing Pi intake to a certain target generates better clinical outcomes.
MeSH term(s)	Aging/drug effects ; Aging, Premature/chemically induced ; Animals ; Cardiovascular Diseases/mortality ; Cause of Death ; DNA Repair ; Diet ; Humans ; Longevity/drug effects ; Models, Animal ; Neoplasms/chemically induced ; Oxidative Stress ; Phosphates/administration & dosage ; Phosphates/adverse effects ; Phosphates/metabolism ; Phosphorus, Dietary/administration & dosage ; Phosphorus, Dietary/adverse effects
Chemical Substances	Phosphates ; Phosphorus, Dietary
Language	English
Publishing date	2013-09
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.5301/jn.5000242
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3369: Show issues

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Article: Green analytical methods for simultaneous determination of compounds having relatively disparate absorbance; application to antibiotic formulation of azithromycin and levofloxacin.

El-Yazbi, Amira F / Khamis, Essam F / Youssef, Rasha M / El-Sayed, Mahmoud A / Aboukhalil, Faten M

Heliyon

2020 Volume 6, Issue 9, Page(s) e04819

Abstract: Green validated spectrophotometric methods are developed for simultaneous determination of Azithromycin (AZI) and Levofloxacin (LEVO) antibiotic mixture. Determination of AZI presents a real analytical challenge as its structure lacks any chromophore, ... ...

Abstract	Green validated spectrophotometric methods are developed for simultaneous determination of Azithromycin (AZI) and Levofloxacin (LEVO) antibiotic mixture. Determination of AZI presents a real analytical challenge as its structure lacks any chromophore, and hence it cannot be determined by direct spectrophotometry. However, the reaction of AZI with perchloric acid produces a green product that can be accurately determined spectrophotometrically. Thus, the work presented demonstrates simple green and sensitive methods for the simultaneous determination of AZI and LEVO mixture. Method I depends on direct measurement of absorbance of azithromycin and levofloxacin in perchloric acid methanolic solution at 482 nm and 224 nm, respectively. While, Method II depends on measuring the first derivative spectrophotometric peak-to-peak amplitudes of AZI and LEVO in perchloric acid methanolic solution at 475-490 nm and 280-253 nm, respectively. Regression analysis shows good linearity for AZI and LEVO over the concentration ranges of 5-50 and 2.5-20 μg/mL for method I and 5-50 and 5-40 μg/mL for method II for AZI and LEVO, respectively. The proposed methods were validated in compliance with ICH guidelines. The suggested procedures are successfully applied for the assay of AZI and LEVO mixture in bulk powder and laboratory-prepared tablets. Greenness profile of the proposed methods were compared with other published methods through applying the Eco-scale protocol. Assessment results demonstrated that the proposed methods are greener than other reported methods. Moreover, upon comparison with other methods, the proposed methods showed better or comparable sensitivity in addition to being selective and rapid with no requirement for laborious extraction techniques. These advantages encourage the application of the proposed methods in routine analysis of AZI and LEVO in quality control laboratories as green and simple analytical tool.
Language	English
Publishing date	2020-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e04819
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pro-Reactive Approach for Project Scheduling Under Unpredictable Disruptions.

Zaman, Forhad / Elsayed, Saber / Sarker, Ruhul / Essam, Daryl / Coello, Carlos A Coello

IEEE transactions on cybernetics

2022 Volume 52, Issue 11, Page(s) 11299–11312

Abstract: Existing solution approaches for handling disruptions in project scheduling use either proactive or reactive methods. However, both techniques suffer from some drawbacks that affect the performance of the optimization process in obtaining good quality ... ...

Abstract	Existing solution approaches for handling disruptions in project scheduling use either proactive or reactive methods. However, both techniques suffer from some drawbacks that affect the performance of the optimization process in obtaining good quality schedules. Therefore, in this article, we develop an auto-configured multioperator evolutionary approach, with a novel pro-reactive scheme for handling disruptions in multimode resource-constrained project scheduling problems (MM-RCPSPs). In this article, our primary objective is to minimize the makespan of a project. However, we also have secondary objectives, such as maximizing the free resources (FRs) and minimizing the deviation of activity finishing time. As the existence of FR may lead to a suboptimal solution, we propose a new operator for the evolutionary approach and two new heuristics to enhance the algorithm's performance. The proposed methodology is tested and analyzed by solving a set of benchmark problems, with its results showing its superiority with respect to state-of-the-art algorithms in terms of the quality of the solutions obtained.
MeSH term(s)	Algorithms
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2021.3097312
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Article ; Online: Green analytical methods for simultaneous determination of compounds having relatively disparate absorbance; application to antibiotic formulation of azithromycin and levofloxacin

Amira F. El-Yazbi / Essam F. Khamis / Rasha M. Youssef / Mahmoud A. El-Sayed / Faten M. Aboukhalil

Heliyon, Vol 6, Iss 9, Pp e04819- (2020)

2020

Abstract	Green validated spectrophotometric methods are developed for simultaneous determination of Azithromycin (AZI) and Levofloxacin (LEVO) antibiotic mixture. Determination of AZI presents a real analytical challenge as its structure lacks any chromophore, and hence it cannot be determined by direct spectrophotometry. However, the reaction of AZI with perchloric acid produces a green product that can be accurately determined spectrophotometrically. Thus, the work presented demonstrates simple green and sensitive methods for the simultaneous determination of AZI and LEVO mixture. Method I depends on direct measurement of absorbance of azithromycin and levofloxacin in perchloric acid methanolic solution at 482 nm and 224 nm, respectively. While, Method II depends on measuring the first derivative spectrophotometric peak-to-peak amplitudes of AZI and LEVO in perchloric acid methanolic solution at 475–490 nm and 280–253 nm, respectively. Regression analysis shows good linearity for AZI and LEVO over the concentration ranges of 5–50 and 2.5–20 μg/mL for method I and 5–50 and 5–40 μg/mL for method II for AZI and LEVO, respectively. The proposed methods were validated in compliance with ICH guidelines. The suggested procedures are successfully applied for the assay of AZI and LEVO mixture in bulk powder and laboratory-prepared tablets. Greenness profile of the proposed methods were compared with other published methods through applying the Eco-scale protocol. Assessment results demonstrated that the proposed methods are greener than other reported methods. Moreover, upon comparison with other methods, the proposed methods showed better or comparable sensitivity in addition to being selective and rapid with no requirement for laborious extraction techniques. These advantages encourage the application of the proposed methods in routine analysis of AZI and LEVO in quality control laboratories as green and simple analytical tool.
Keywords	Azithromycin ; Levofloxacin ; Spectrophotometric methods ; Perchloric acid ; ICH guidelines ; Analytical chemistry ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	600
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Green analytical methods for simultaneous determination of compounds having relatively disparate absorbance; application to antibiotic formulation of azithromycin and levofloxacin

El-Yazbi, Amira F / Khamis, Essam F / Youssef, Rasha M / El-Sayed, Mahmoud A / Aboukhalil, Faten M

Heliyon. 2020 Sept., v. 6, no. 9

2020

Abstract	Green validated spectrophotometric methods are developed for simultaneous determination of Azithromycin (AZI) and Levofloxacin (LEVO) antibiotic mixture. Determination of AZI presents a real analytical challenge as its structure lacks any chromophore, and hence it cannot be determined by direct spectrophotometry. However, the reaction of AZI with perchloric acid produces a green product that can be accurately determined spectrophotometrically. Thus, the work presented demonstrates simple green and sensitive methods for the simultaneous determination of AZI and LEVO mixture. Method I depends on direct measurement of absorbance of azithromycin and levofloxacin in perchloric acid methanolic solution at 482 nm and 224 nm, respectively. While, Method II depends on measuring the first derivative spectrophotometric peak-to-peak amplitudes of AZI and LEVO in perchloric acid methanolic solution at 475–490 nm and 280–253 nm, respectively. Regression analysis shows good linearity for AZI and LEVO over the concentration ranges of 5–50 and 2.5–20 μg/mL for method I and 5–50 and 5–40 μg/mL for method II for AZI and LEVO, respectively. The proposed methods were validated in compliance with ICH guidelines. The suggested procedures are successfully applied for the assay of AZI and LEVO mixture in bulk powder and laboratory-prepared tablets. Greenness profile of the proposed methods were compared with other published methods through applying the Eco-scale protocol. Assessment results demonstrated that the proposed methods are greener than other reported methods. Moreover, upon comparison with other methods, the proposed methods showed better or comparable sensitivity in addition to being selective and rapid with no requirement for laborious extraction techniques. These advantages encourage the application of the proposed methods in routine analysis of AZI and LEVO in quality control laboratories as green and simple analytical tool.
Keywords	absorbance ; azithromycin ; compliance ; levofloxacin ; perchloric acid ; quality control ; regression analysis ; spectroscopy
Language	English
Dates of publication	2020-09
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e04819
Database	NAL-Catalogue (AGRICOLA)

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