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  1. Article ; Online: Cardiovascular disease in systemic lupus erythematosus: the role of traditional and lupus related risk factors.

    Zeller, Carlos Borelli / Appenzeller, Simone

    Current cardiology reviews

    2009  Volume 4, Issue 2, Page(s) 116–122

    Abstract: Atherosclerosis is a chronic inflammatory disorder characterized by immune cell activation, inflammation driven plaque formation and subsequent destabilization. In other disorders of an inflammatory nature, the chronic inflammatory state per se has been ... ...

    Abstract Atherosclerosis is a chronic inflammatory disorder characterized by immune cell activation, inflammation driven plaque formation and subsequent destabilization. In other disorders of an inflammatory nature, the chronic inflammatory state per se has been linked to acceleration of the atherosclerotic process which is underlined by an increased incidence of cardiovascular disease (CVD) in disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and antiphopholipid (Hughes) syndrome (APS). SLE is an autoimmune disease that may affect any organ. Premature coronary heart disease has emerged as a major cause of morbidity and mortality in SLE. In addition to mortality, cardiovascular morbidity is also markedly increased in these patients, compared with the general population. The increased cardiovascular risk can be explained only partially by an increased prevalence of classical risk factors for cardiovascular disease; it also appears to be related to inflammation. Inflammation is increasingly being considered central to the pathogenesis of atherosclerosis and an important risk factor for vascular disease. Recent epidemiologic and pathogenesis studies have suggested a great deal in common between the pathogenesis of prototypic autoimmune disease such as SLE and that of atherosclerosis.We will review traditional risk factors for CVD in SLE. We will also discuss the role of inflammation in atherosclerosis, as well as possible treatment strategies in these patients.
    Language English
    Publishing date 2009-11-20
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6557
    ISSN (online) 1875-6557
    DOI 10.2174/157340308784245775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Nutritional state and herniorrhaphy in premature infants.

    Barreto, Maria Weber Guimarães / Melo-Filho, Antonio Aldo / Neto, Jaime Oliveira / Zeller, Carlos Borelli / Marba, Sérgio / Sbragia, Lourenço

    Pediatric surgery international

    2004  Volume 20, Issue 9, Page(s) 699–703

    Abstract: The incidence of inguinal hernia in premature infants is significantly high, and the optimal timing for its correction is controversial. Furthermore, whether the nutritional status of neonates will alter hernia diagnosis and postoperative results has not ...

    Abstract The incidence of inguinal hernia in premature infants is significantly high, and the optimal timing for its correction is controversial. Furthermore, whether the nutritional status of neonates will alter hernia diagnosis and postoperative results has not been demonstrated. The aim of this study was to analyze the results of premature neonates who underwent inguinal hernia repair before hospital discharge, comparing clinical features and perioperative data of two distinct nutritional groups. It was verified that early inguinal hernia repair is feasible without an escalation in the incidence of complications, thereby reducing the risk of incarceration and avoiding subsequent hospitalization. Moreover, premature infants had similar postoperative outcomes regardless of their nutritional status.
    MeSH term(s) Female ; Hernia, Inguinal/surgery ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/surgery ; Infant, Small for Gestational Age ; Male ; Nutritional Status ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2004-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 0179-0358
    ISSN 0179-0358
    DOI 10.1007/s00383-004-1278-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Cerebral venous thrombosis: influence of risk factors and imaging findings on prognosis.

    Appenzeller, Simone / Zeller, Carlos Borelli / Annichino-Bizzachi, Joyce M / Costallat, Lilian T L / Deus-Silva, Leonardo / Voetsch, Barbara / Faria, Andreia V / Zanardi, Verônica A / Damasceno, Benito P / Cendes, Fernando

    Clinical neurology and neurosurgery

    2005  Volume 107, Issue 5, Page(s) 371–378

    Abstract: Purpose: To investigate imaging findings, risk factors and outcome in patients with cerebral venous thrombosis (CVT).: Methods: Records of all patients with diagnosis of CVT between 1992 and 2002 were reviewed. Patients with CNS infection and with ... ...

    Abstract Purpose: To investigate imaging findings, risk factors and outcome in patients with cerebral venous thrombosis (CVT).
    Methods: Records of all patients with diagnosis of CVT between 1992 and 2002 were reviewed. Patients with CNS infection and with CVT secondary to invasive procedures were excluded. Inherited and acquired thrombophilia were searched in all patients.
    Results: Twenty-four patients (18 women, 6 men) with mean age of 29.5 years (range 3-48 years) were identified. Mean follow-up was 44 months (range 11-145 months). The most common symptoms were headache (75%), vomiting (33%) and impairment of consciousness (21%). Probable causes of CVT could be determined in 21 (88%) patients: pregnancy or puerperium in six (25%), oral contraceptive use in four (17%), head trauma in two (8%), mastoiditis in one (4%), nephrotic syndrome in one (4%), systemic disease in three (13%), and inherited thrombotic risk factors in four (17%) patients. CVT associated with pregnancy, puerperium and use of oral contraceptives had a significant better outcome than CVT caused by inherited thrombophilia or systemic disease (OR=14.4; p=0.02). CT scans were abnormal in 15 (62.5%) patients and MRI with gadolinium was abnormal in all. Those with parenchymal involvement had neurological sequelae during follow-up. All were treated with heparin followed by oral anticoagulants, and none had new or worsening of pre-existing intracerebral hemorrhage.
    Conclusion: MRI is superior to conventional CT for diagnosing CVT. Patients with parenchymal lesions, thrombophilia and antiphospholipid syndrome had greater risk to be left with neurological sequelae. Anticoagulant therapy did not predispose to further intracerebral hemorrhage.
    MeSH term(s) Adolescent ; Adult ; Brain/diagnostic imaging ; Brain/pathology ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Intracranial Thrombosis/diagnosis ; Intracranial Thrombosis/etiology ; Intracranial Thrombosis/therapy ; Male ; Middle Aged ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnosis ; Pregnancy Complications, Cardiovascular/etiology ; Pregnancy Complications, Cardiovascular/therapy ; Radiography ; Retrospective Studies ; Risk Factors ; Thrombophilia/complications ; Treatment Outcome ; Venous Thrombosis/diagnosis ; Venous Thrombosis/etiology ; Venous Thrombosis/therapy
    Language English
    Publishing date 2005-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2004.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.53: Show issues Location:
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