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  1. Book ; Online: Chapter Selected endothelial responses after ionizing radiation exposure

    Aerts, An / Ramadan, Raghda / MohammedBenotmane, Abderrafi / Baselet, Bjorn / Sonveaux, Pierre / Baatout, Sarah

    2018  

    Keywords Cardiovascular medicine ; ionizing radiation, radiation therapy, X-ray diagnostics, cardiovascular disease, atherosclerosis, endothelial dysfunction, inflammation, DNA damage, apoptosis, cell cycle, oxidative stress, mitochondrial dysfunction and metabolic changes, premature senescence, intercellular communication
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047874
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Bioprinting of Cardiac Tissue in Space: Where Are We?

    Tabury, Kevin / Rehnberg, Emil / Baselet, Bjorn / Baatout, Sarah / Moroni, Lorenzo

    Advanced healthcare materials

    2023  Volume 12, Issue 23, Page(s) e2203338

    Abstract: Bioprinting in space is the next frontier in tissue engineering. In the absence of gravity, novel opportunities arise, as well as new challenges. The cardiovascular system needs particular attention in tissue engineering, not only to develop safe ... ...

    Abstract Bioprinting in space is the next frontier in tissue engineering. In the absence of gravity, novel opportunities arise, as well as new challenges. The cardiovascular system needs particular attention in tissue engineering, not only to develop safe countermeasures for astronauts in future deep and long-term space missions, but also to bring solutions to organ transplantation shortage. In this perspective, the challenges encountered when using bioprinting techniques in space and current gaps that need to be overcome are discussed. The recent developments that have been made in the bioprinting of heart tissues in space and an outlook on potential future bioprinting opportunities in space are described.
    MeSH term(s) Bioprinting/methods ; Printing, Three-Dimensional ; Tissue Engineering/methods ; Heart ; Tissue Scaffolds
    Language English
    Publishing date 2023-06-14
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202203338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Spaceflight Stressors and Skin Health.

    Radstake, Wilhelmina E / Baselet, Bjorn / Baatout, Sarah / Verslegers, Mieke

    Biomedicines

    2022  Volume 10, Issue 2

    Abstract: Traveling to space puts astronauts at risk of developing serious health problems. Of particular interest is the skin, which is vitally important in protecting the body from harmful environmental factors. Although data obtained from long-duration ... ...

    Abstract Traveling to space puts astronauts at risk of developing serious health problems. Of particular interest is the skin, which is vitally important in protecting the body from harmful environmental factors. Although data obtained from long-duration spaceflight studies are inconsistent, there have been indications of increased skin sensitivity and signs of dermal atrophy in astronauts. To better understand the effects of spaceflight stressors including microgravity, ionizing radiation and psychological stress on the skin, researchers have turned to in vitro and in vivo simulation models mimicking certain aspects of the spaceflight environment. In this review, we provide an overview of these simulation models and highlight studies that have improved our understanding on the effect of simulation spaceflight stressors on skin function. Data show that all aforementioned spaceflight stressors can affect skin health. Nevertheless, there remains a knowledge gap regarding how different spaceflight stressors in combination may interact and affect skin health. In future, efforts should be made to better simulate the spaceflight environment and reduce uncertainties related to long-duration spaceflight health effects.
    Language English
    Publishing date 2022-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10020364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Next generation of astronauts or ESA astronaut 2.0 concept and spotlight on immunity.

    Jacob, Pauline / Oertlin, Christian / Baselet, Bjorn / Westerberg, Lisa S / Frippiat, Jean-Pol / Baatout, Sarah

    NPJ microgravity

    2023  Volume 9, Issue 1, Page(s) 51

    Abstract: Although we have sent humans into space for more than 50 years, crucial questions regarding immune response in space conditions remain unanswered. There are many complex interactions between the immune system and other physiological systems in the human ... ...

    Abstract Although we have sent humans into space for more than 50 years, crucial questions regarding immune response in space conditions remain unanswered. There are many complex interactions between the immune system and other physiological systems in the human body. This makes it difficult to study the combined long-term effects of space stressors such as radiation and microgravity. In particular, exposure to microgravity and cosmic radiation may produce changes in the performance of the immune system at the cellular and molecular levels and in the major physiological systems of the body. Consequently, abnormal immune responses induced in the space environment may have serious health consequences, especially in future long-term space missions. In particular, radiation-induced immune effects pose significant health challenges for long-duration space exploration missions with potential risks to reduce the organism's ability to respond to injuries, infections, and vaccines, and predispose astronauts to the onset of chronic diseases (e.g., immunosuppression, cardiovascular and metabolic diseases, gut dysbiosis). Other deleterious effects encountered by radiation may include cancer and premature aging, induced by dysregulated redox and metabolic processes, microbiota, immune cell function, endotoxin, and pro-inflammatory signal production
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2823626-9
    ISSN 2373-8065
    ISSN 2373-8065
    DOI 10.1038/s41526-023-00294-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice.

    Emanuelsson, Eric B / Baselet, Bjorn / Neefs, Mieke / Baatout, Sarah / Proesmans, Brit / Daenen, Lisa / Sundberg, Carl Johan / Rundqvist, Helene / Fernandez-Gonzalo, Rodrigo

    NPJ microgravity

    2023  Volume 9, Issue 1, Page(s) 40

    Abstract: The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal ... ...

    Abstract The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823626-9
    ISSN 2373-8065
    ISSN 2373-8065
    DOI 10.1038/s41526-023-00289-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Spaceflight Stressors and Skin Health

    Wilhelmina E. Radstake / Bjorn Baselet / Sarah Baatout / Mieke Verslegers

    Biomedicines, Vol 10, Iss 364, p

    2022  Volume 364

    Abstract: Traveling to space puts astronauts at risk of developing serious health problems. Of particular interest is the skin, which is vitally important in protecting the body from harmful environmental factors. Although data obtained from long-duration ... ...

    Abstract Traveling to space puts astronauts at risk of developing serious health problems. Of particular interest is the skin, which is vitally important in protecting the body from harmful environmental factors. Although data obtained from long-duration spaceflight studies are inconsistent, there have been indications of increased skin sensitivity and signs of dermal atrophy in astronauts. To better understand the effects of spaceflight stressors including microgravity, ionizing radiation and psychological stress on the skin, researchers have turned to in vitro and in vivo simulation models mimicking certain aspects of the spaceflight environment. In this review, we provide an overview of these simulation models and highlight studies that have improved our understanding on the effect of simulation spaceflight stressors on skin function. Data show that all aforementioned spaceflight stressors can affect skin health. Nevertheless, there remains a knowledge gap regarding how different spaceflight stressors in combination may interact and affect skin health. In future, efforts should be made to better simulate the spaceflight environment and reduce uncertainties related to long-duration spaceflight health effects.
    Keywords spaceflight ; skin ; microgravity ; ionizing radiation ; psychological stress ; space simulation models ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Monitoring functional immune responses with a cytokine release assay: ISS flight hardware design and experimental protocol for whole blood cultures executed under microgravity conditions.

    Buchheim, Judith-Irina / Feuerecker, Matthias / Balsamo, Michele / Vukich, Marco / Van Walleghem, Merel / Tabury, Kevin / Quintens, Roel / Vermeesen, Randy / Baselet, Bjorn / Baatout, Sarah / Rattenbacher, Bernd / Antunes, Inês / Ngo-Anh, Thu Jennifer / Crucian, Brian / Choukér, Alexander

    Frontiers in physiology

    2024  Volume 14, Page(s) 1322852

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1322852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors.

    Miranda, Silvana / Vermeesen, Randy / Radstake, Wilhelmina E / Parisi, Alessio / Ivanova, Anna / Baatout, Sarah / Tabury, Kevin / Baselet, Bjorn

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: The space environment will expose astronauts to stressors like ionizing radiation, altered gravity fields and elevated cortisol levels, which pose a health risk. Understanding how the interplay between these stressors changes T cells' response is ... ...

    Abstract The space environment will expose astronauts to stressors like ionizing radiation, altered gravity fields and elevated cortisol levels, which pose a health risk. Understanding how the interplay between these stressors changes T cells' response is important to better characterize space-related immune dysfunction. We have exposed stimulated Jurkat cells to simulated space stressors (1 Gy, carbon ions/1 Gy photons, 1 µM hydrocortisone (HC), Mars, moon, and microgravity) in a single or combined manner. Pro-inflammatory cytokine IL-2 was measured in the supernatant of Jurkat cells and at the mRNA level. Results show that alone, HC, Mars gravity and microgravity significantly decrease IL-2 presence in the supernatant. 1 Gy carbon ion irradiation showed a smaller impact on IL-2 levels than photon irradiation. Combining exposure to different simulated space stressors seems to have less immunosuppressive effects. Gene expression was less impacted at the time-point collected. These findings showcase a complex T cell response to different conditions and suggest the importance of elevated cortisol levels in the context of space flight, also highlighting the need to use simulated partial gravity technologies to better understand the immune system's response to the space environment.
    MeSH term(s) Humans ; Interleukin-2 ; Hydrocortisone ; Space Flight ; Weightlessness ; Carbon
    Chemical Substances Interleukin-2 ; Hydrocortisone (WI4X0X7BPJ) ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Dusty Road for Astronauts.

    Miranda, Silvana / Marchal, Shannon / Cumps, Lina / Dierckx, Jenne / Krüger, Marcus / Grimm, Daniela / Baatout, Sarah / Tabury, Kevin / Baselet, Bjorn

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: The lunar dust problem was first formulated in 1969 with NASA's first successful mission to land a human being on the surface of the Moon. Subsequent Apollo missions failed to keep the dust at bay, so exposure to the dust was unavoidable. In 1972, ... ...

    Abstract The lunar dust problem was first formulated in 1969 with NASA's first successful mission to land a human being on the surface of the Moon. Subsequent Apollo missions failed to keep the dust at bay, so exposure to the dust was unavoidable. In 1972, Harrison Schmitt suffered a brief sneezing attack, red eyes, an itchy throat, and congested sinuses in response to lunar dust. Some additional Apollo astronauts also reported allergy-like symptoms after tracking dust into the lunar module. Immediately following the Apollo missions, research into the toxic effects of lunar dust on the respiratory system gained a lot of interest. Moreover, researchers believed other organ systems might be at risk, including the skin and cornea. Secondary effects could translocate to the cardiovascular system, the immune system, and the brain. With current intentions to return humans to the moon and establish a semi-permanent presence on or near the moon's surface, integrated, end-to-end dust mitigation strategies are needed to enable sustainable lunar presence and architecture. The characteristics and formation of Martian dust are different from lunar dust, but advances in the research of lunar dust toxicity, mitigation, and protection strategies can prove strategic for future operations on Mars.
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11071921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance.

    Konings, Katrien / Vandevoorde, Charlot / Baselet, Bjorn / Baatout, Sarah / Moreels, Marjan

    Frontiers in oncology

    2020  Volume 10, Page(s) 128

    Abstract: Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades, remarkable technological progress has been made in the field of conventional radiotherapy. In addition, the use of charged particles (e.g., protons and carbon ... ...

    Abstract Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades, remarkable technological progress has been made in the field of conventional radiotherapy. In addition, the use of charged particles (e.g., protons and carbon ions) makes it possible to further improve dose deposition to the tumor, while sparing the surrounding healthy tissues. Despite these improvements, radioresistance and tumor recurrence are still observed. Although the mechanisms underlying resistance to conventional radiotherapy are well-studied, scientific evidence on the impact of charged particle therapy on cancer cell radioresistance is restricted. The purpose of this review is to discuss the potential role that charged particles could play to overcome radioresistance. This review will focus on hypoxia, cancer stem cells, and specific signaling pathways of EGFR, NFκB, and Hedgehog as well as DNA damage signaling involving PARP, as mechanisms of radioresistance for which pharmacological targets have been identified. Finally, new lines of future research will be proposed, with a focus on novel molecular inhibitors that could be used in combination with charged particle therapy as a novel treatment option for radioresistant tumors.
    Language English
    Publishing date 2020-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.00128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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