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Article: Tissue-specific RNA-seq defines genes governing male tail tip morphogenesis in

Kiontke, Karin / Herrera, R Antonio / Mason, D Adam / Woronik, Alyssa / Vernooy, Stephanie / Patel, Yash / Fitch, David H A

bioRxiv : the preprint server for biology

2024

Abstract: Caenorhabditis ... ...

Abstract	Caenorhabditis elegans
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.12.575210
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Article: Cardiac Computed Tomography Angiography in CAD Risk Stratification and Revascularization Planning.

Mehta, Chirag R / Naeem, Aneeqah / Patel, Yash

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 18

Abstract: Purpose of review: Functional stress testing is frequently used to assess for coronary artery disease (CAD) in symptomatic, stable patients with low to intermediate pretest probability. However, patients with highly vulnerable plaque may have preserved ... ...

Abstract	Purpose of review: Functional stress testing is frequently used to assess for coronary artery disease (CAD) in symptomatic, stable patients with low to intermediate pretest probability. However, patients with highly vulnerable plaque may have preserved luminal patency and, consequently, a falsely negative stress test. Cardiac computed tomography angiography (CCTA) has emerged at the forefront of primary prevention screening and has excellent agency in ruling out obstructive CAD with high negative predictive value while simultaneously characterizing nonobstructive plaque for high-risk features, which invariably alters risk-stratification and pre-procedural decision making. Recent findings: We review the literature detailing the utility of CCTA in its ability to risk-stratify patients with CAD based on calcium scoring as well as high-risk phenotypic features and to qualify the functional significance of stenotic lesions. Summary: Calcium scores ≥ 100 should prompt consideration of statin and aspirin therapy. Spotty calcifications < 3 mm, increased non-calcified plaque > 4 mm
Language	English
Publishing date	2023-09-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13182902
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Article ; Online: Cardiac Computed Tomography Angiography in CAD Risk Stratification and Revascularization Planning

Chirag R. Mehta / Aneeqah Naeem / Yash Patel

Diagnostics, Vol 13, Iss 2902, p

2023 Volume 2902

Abstract: Purpose of Review: Functional stress testing is frequently used to assess for coronary artery disease (CAD) in symptomatic, stable patients with low to intermediate pretest probability. However, patients with highly vulnerable plaque may have preserved ... ...

Abstract	Purpose of Review: Functional stress testing is frequently used to assess for coronary artery disease (CAD) in symptomatic, stable patients with low to intermediate pretest probability. However, patients with highly vulnerable plaque may have preserved luminal patency and, consequently, a falsely negative stress test. Cardiac computed tomography angiography (CCTA) has emerged at the forefront of primary prevention screening and has excellent agency in ruling out obstructive CAD with high negative predictive value while simultaneously characterizing nonobstructive plaque for high-risk features, which invariably alters risk-stratification and pre-procedural decision making. Recent Findings: We review the literature detailing the utility of CCTA in its ability to risk-stratify patients with CAD based on calcium scoring as well as high-risk phenotypic features and to qualify the functional significance of stenotic lesions. Summary: Calcium scores ≥ 100 should prompt consideration of statin and aspirin therapy. Spotty calcifications < 3 mm, increased non-calcified plaque > 4 mm 3 per mm of the vessel wall, low attenuation < 30 HU soft plaque and necrotic core with a rim of higher attenuation < 130 HU, and a positive remodeling index ratio > 1.1 all confer additive risk for acute plaque rupture when present. Elevations in the perivascular fat attenuation index > −70.1 HU are a strong predictor of all-cause mortality and can further the risk stratification of patients in the setting of a non-to-minimal plaque burden. Lastly, a CT-derived fractional flow reserve (FFR CT ) < 0.75 or values from 0.76 to 0.80 in conjunction with additional risk factors is suggestive of flow-limiting disease that would benefit from invasive testing. The wealth of information available through CCTA can allow clinicians to risk-stratify patients at elevated risk for an acute ischemic event and engage in advanced revascularization planning.
Keywords	CCTA ; coronary artery disease ; risk stratification ; revascularization planning ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Double Aortic Arch in an Asymptomatic Adult.

Lee, William J / Shah, Yash K / Ku, Albert / Patel, Nidhi R / Maldjian, Pierre D

Cureus

2023 Volume 15, Issue 4, Page(s) e37437

Abstract: We present a rare double aortic arch (DAA) diagnosis incidentally on CT in a 60-year-old male who presented with pneumonia. DAA is a vascular ring that typically manifests in infants or children due to compression of the esophagus or trachea, resulting ... ...

Abstract	We present a rare double aortic arch (DAA) diagnosis incidentally on CT in a 60-year-old male who presented with pneumonia. DAA is a vascular ring that typically manifests in infants or children due to compression of the esophagus or trachea, resulting in dysphagia or dyspnea. Diagnosis of DAA in adulthood is usually due to the delayed emergence of obstructive symptoms. We present a case of DAA in an adult patient without dysphagia or dyspnea. We discuss factors that can lead to the presentation of DAA in adults. These include an absence of associated congenital disabilities, insufficient tracheal or esophageal constriction in childhood and the onset of compressive symptoms later in life from decreased vascular compliance.
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.37437
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Article ; Online: Glycolate oxidase-1 gene variants influence the risk of hyperoxaluria and renal stone development.

Patel, Yash P / Patel, Sandip B / Patel, Priyal / Parikh, Aditya / Soni, Shailesh / Srivastava, Ratika / Raval, Chintal / Ganpule, Arvind P / Desai, Mahesh R / Patel, Samir G / Pandey, Sachchida Nand

World journal of urology

2024 Volume 42, Issue 1, Page(s) 28

Abstract: ... case-control study carried out on 300 participants (150 cases and 150 controls) at Muljibhai Patel Urological ...

Abstract	Purpose: Oxalate is an excellent calcium ion attractor with great abundance in the human body, and the liver is the major source of oxalate. The Glycolate oxidase-1 (GOX1) gene is solely responsible for the glycolate and glyoxylate metabolism and produces oxalate. This study has been designed to comprehend the association of genetic variants of the GOX1 gene with the risk of hyperoxaluria and renal stone disease in the Indian population. Method: The present study is a candidate gene approach prospective case-control study carried out on 300 participants (150 cases and 150 controls) at Muljibhai Patel Urological Hospital, Gujarat, India. Biochemical parameters, including serum levels of calcium, creatinine, parathyroid hormone, and 24-h urine metabolites, were performed. The genotyping of GOX1 gene variants rs6086287, rs2235250, rs2255183, and rs2294303 was performed using a customized TaqMan assay probe by RT-PCR. Result: Parathyroid hormone, serum creatinine, and urine metabolites were significantly elevated in nephrolithiasis compared to healthy individuals. All mutated homozygous genotypes GG (rs6086287), TT (rs2235250), GG (rs2255183), and CC (rs2294303) were significantly associated with a high risk of renal stone disease. Individuals diagnosed with hyperoxaluria and carrying TG (rs6086287), AG (rs2255183), and TT (rs2294303) genotypes have a significantly high risk of renal stone disease. Moreover, haplotype analysis and correlation analysis also confirmed the strong association between genetic variants and nephrolithiasis. Conclusion: Genetic variants of the GOX1 genes were associated with renal stone disease. In the presence of risk genotype and hyperoxaluria, the susceptibility to develop renal stone disease risk gets modulated.
MeSH term(s)	Humans ; Calcium ; Case-Control Studies ; Kidney Calculi/complications ; Hyperoxaluria/genetics ; Oxalates/urine ; Parathyroid Hormone ; Creatinine ; Alcohol Oxidoreductases
Chemical Substances	Calcium (SY7Q814VUP) ; glycollate oxidase (EC 1.1.3.15) ; Oxalates ; Parathyroid Hormone ; Creatinine (AYI8EX34EU) ; Alcohol Oxidoreductases (EC 1.1.-)
Language	English
Publishing date	2024-01-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04718-z
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Article ; Online: Follow-Up Cardiovascular Magnetic Resonance Findings in Patients With COVID-19 Vaccination-Associated Acute Myocarditis.

Patel, Yash R / Shah, Nishant R / Lombardi, Kristin / Agarwal, Saurabh / Salber, Gregory / Patel, Rootu / Poppas, Athena / Atalay, Michael K

JACC. Cardiovascular imaging

2022 Volume 15, Issue 11, Page(s) 2007–2010

MeSH term(s)	Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Follow-Up Studies ; Magnetic Resonance Spectroscopy ; Myocarditis/chemically induced ; Myocarditis/diagnostic imaging ; Myocarditis/pathology ; Predictive Value of Tests ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Letter
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2022.06.009
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Book ; Online: SimCon Loss with Multiple Views for Text Supervised Semantic Segmentation

Patel, Yash / Xie, Yusheng / Zhu, Yi / Appalaraju, Srikar / Manmatha, R.

2023

Abstract: Learning to segment images purely by relying on the image-text alignment from web data can lead to sub-optimal performance due to noise in the data. The noise comes from the samples where the associated text does not correlate with the image's visual ... ...

Abstract	Learning to segment images purely by relying on the image-text alignment from web data can lead to sub-optimal performance due to noise in the data. The noise comes from the samples where the associated text does not correlate with the image's visual content. Instead of purely relying on the alignment from the noisy data, this paper proposes a novel loss function termed SimCon, which accounts for intra-modal similarities to determine the appropriate set of positive samples to align. Further, using multiple views of the image (created synthetically) for training and combining the SimCon loss with it makes the training more robust. This version of the loss is termed MV-SimCon. The empirical results demonstrate that using the proposed loss function leads to consistent improvements on zero-shot, text supervised semantic segmentation and outperforms state-of-the-art by $+3.0\%$, $+3.3\%$ and $+6.9\%$ on PASCAL VOC, PASCAL Context and MSCOCO, respectively. With test time augmentations, we set a new record by improving these results further to $58.7\%$, $26.6\%$, and $33.3\%$ on PASCAL VOC, PASCAL Context, and MSCOCO, respectively. In addition, using the proposed loss function leads to robust training and faster convergence.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2023-02-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ataxia-Telangiectasia: A Case Report and a Brief Review.

Sirajwala, Abulkalam A / Khan, Shahin / Rathod, Vaishnavi M / Gevariya, Vishwa C / Jansari, Jay R / Patel, Yash M

Cureus

2023 Volume 15, Issue 5, Page(s) e39346

Abstract: Ataxia-telangiectasia (A-T) is a rare inherited syndrome that primarily presents as ataxia due to cerebellar involvement and dilated capillaries in the oculocutaneous region. But many more serious complications of the condition exist, due to which both ... ...

Abstract	Ataxia-telangiectasia (A-T) is a rare inherited syndrome that primarily presents as ataxia due to cerebellar involvement and dilated capillaries in the oculocutaneous region. But many more serious complications of the condition exist, due to which both the quality and length of life are severely affected. Some of these include opportunistic infections due to an abnormal immune system, various malignancies, and an increased sensitivity to ionizing radiation. Due to the involvement of multiple systems in the body, diagnosis of this condition could be tricky as it may manifest with uncommon signs like dystonic head movements seen in our case. We have presented the case of a 16-year-old male born out of a consanguineous marriage, with the major symptoms of walking difficulties, frequent falls, and jerky movements of the head. Similar or related complaints had been noted in the past in his siblings. Laboratory investigations revealed elevated levels of serum alpha-fetoprotein, while the confirmatory diagnosis was made by genetic testing of the ataxia-telangiectasia mutated (ATM) gene. The patient was treated with amantadine and clonazepam, along with speech therapy, but the prognosis remained poor due to the lack of curative treatment for A-T.
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.39346
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Article ; Online: Cardiac MRI Findings in Male Patients with Acute Myocarditis in the Presence or Absence of COVID-19 Vaccination.

Patel, Yash R / Shah, Nishant R / Lombardi, Kristin / Agarwal, Saurabh / Has, Phinnara / Patel, Rootu / Poppas, Athena / Atalay, Michael K

Radiology. Cardiothoracic imaging

2022 Volume 4, Issue 3, Page(s) e220008

Abstract: By comparing phenotypic clinical characteristics and cardiovascular magnetic resonance (CMR) findings in 14 patients with COVID-19 mRNA vaccine-associated myocarditis to 14 patients with acute myocarditis from other causes, we found that patients with ... ...

Abstract	By comparing phenotypic clinical characteristics and cardiovascular magnetic resonance (CMR) findings in 14 patients with COVID-19 mRNA vaccine-associated myocarditis to 14 patients with acute myocarditis from other causes, we found that patients with COVID-19 vaccination- associated acute myocarditis have higher left ventricular ejection fraction, higher left ventricular global circumferential and radial strain, and less involvement of late gadolinium enhancement in the septal segments with less involvement of midmyocardial pattern of late gadolinium enhancement, compared to patients with acute myocarditis from other causes.
Language	English
Publishing date	2022-06-09
Publishing country	United States
Document type	Journal Article
ISSN	2638-6135
ISSN (online)	2638-6135
DOI	10.1148/ryct.220008
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Article ; Online: Non-mydriatic fundus photography as an alternative to indirect ophthalmoscopy for screening of diabetic retinopathy in community settings

Uday R Gajiwala / Swapnil Pachchigar / Dhaval Patel / Ishwar Mistry / Yash Oza / Dhaval Kundaria / Shamanna B R

BMJ Open, Vol 12, Iss

a comparative pilot study in rural and tribal India

2022 Volume 4

Keywords	Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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