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  1. Article ; Online: Healthier SG - throwing down the gauntlet for specialists to integrate.

    Dalakoti, Mayank / Foo, Roger

    The Lancet regional health. Western Pacific

    2023  Volume 37, Page(s) 100879

    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2023.100879
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  2. Article ; Online: Redirecting immune, lipid, and metabolic drivers of early cardiovascular disease: the RESET cohort study and randomized trial.

    Dalakoti, Mayank / Foo, Roger

    European heart journal

    2023  Volume 44, Issue 39, Page(s) 3939–3941

    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad543
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  3. Article ; Online: Applications of Genome Editing Technologies in CAD Research and Therapy with a Focus on Atherosclerosis.

    Mak, Michelle C E / Gurung, Rijan / Foo, Roger S Y

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Cardiovascular diseases, particularly coronary artery disease (CAD), remain the leading cause of death worldwide in recent years, with myocardial infarction (MI) being the most common form of CAD. Atherosclerosis has been highlighted as one of the ... ...

    Abstract Cardiovascular diseases, particularly coronary artery disease (CAD), remain the leading cause of death worldwide in recent years, with myocardial infarction (MI) being the most common form of CAD. Atherosclerosis has been highlighted as one of the drivers of CAD, and much research has been carried out to understand and treat this disease. However, there remains much to be better understood and developed in treating this disease. Genome editing technologies have been widely used to establish models of disease as well as to treat various genetic disorders at their root. In this review, we aim to highlight the various ways genome editing technologies can be applied to establish models of atherosclerosis, as well as their therapeutic roles in both atherosclerosis and the clinical implications of CAD.
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814057
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  4. Article ; Online: Cardiomyopathy in Asian Cohorts: Genetic and Epigenetic Insights.

    Tan, Konstanze / Foo, Roger / Loh, Marie

    Circulation. Genomic and precision medicine

    2023  Volume 16, Issue 5, Page(s) 496–506

    Abstract: Previous studies on cardiomyopathies have been particularly valuable for clarifying pathological mechanisms in heart failure, an etiologically heterogeneous disease. In this review, we specifically focus on cardiomyopathies in Asia, where heart failure ... ...

    Abstract Previous studies on cardiomyopathies have been particularly valuable for clarifying pathological mechanisms in heart failure, an etiologically heterogeneous disease. In this review, we specifically focus on cardiomyopathies in Asia, where heart failure is particularly pertinent. There has been an increase in prevalence of cardiomyopathies in Asia, in sharp contrast with the decline observed in Western countries. Indeed, important disparities in cardiomyopathy incidence, clinical characteristics, and prognosis have been reported in Asian versus White cohorts. These have been accompanied by emerging descriptions of a distinct rare and common genetic basis for disease among Asian cardiomyopathy patients marked by an increased burden of variants with uncertain significance, reclassification of variants deemed pathogenic based on evidence from predominantly White cohorts, and the discovery of Asian-specific cardiomyopathy-associated loci with underappreciated pathogenicity under conventional classification criteria. Findings from epigenetic studies of heart failure, particularly DNA methylation studies, have complemented genetic findings in accounting for the phenotypic variability in cardiomyopathy. Though extremely limited, findings from Asian ancestry-focused DNA methylation studies of cardiomyopathy have shown potential to contribute to general understanding of cardiomyopathy pathophysiology by proposing disease and cause-relevant pathophysiological mechanisms. We discuss the value of multiomics study designs incorporating genetic, methylation, and transcriptomic information for future DNA methylation studies in Asian cardiomyopathy cohorts to yield Asian ancestry-specific insights that will improve risk stratification in the Asian population.
    MeSH term(s) Humans ; Cardiomyopathies/genetics ; Cardiomyopathies/pathology ; Heart Failure/genetics ; DNA Methylation ; Prognosis ; Epigenesis, Genetic
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2574-8300
    ISSN (online) 2574-8300
    DOI 10.1161/CIRCGEN.123.004079
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  5. Article ; Online: Epigenetics in cardiovascular health and disease.

    Chew, Nicholas W S / Loong, Shaun S E / Foo, Roger

    Progress in molecular biology and translational science

    2023  Volume 197, Page(s) 105–134

    Abstract: Conrad Waddington's epigenetics landscape has provided a metaphorical framework for how cells progress from undifferentiated states to one of several discrete, distinct, differentiated cell fates. The understanding of epigenetics has evolved over time, ... ...

    Abstract Conrad Waddington's epigenetics landscape has provided a metaphorical framework for how cells progress from undifferentiated states to one of several discrete, distinct, differentiated cell fates. The understanding of epigenetics has evolved over time, with DNA methylation being the most studied epigenetic modification, followed by histone modifications and non-coding RNA. Cardiovascular diseases (CVD) are leading contributors to death worldwide, with the prevalence of CVDs increasing across the last couple of decades. Significant amount of resources being poured into researching key mechanisms and underpinnings of the various CVDs. These molecular studies looked at the genetics, epigenetics as well as the transcriptomics of various cardiovascular conditions, aiming to provide mechanistic insights. It has paved the way for therapeutics to be developed and in recent years, epi-drugs for the treatment of CVDs. This chapter aims to cover the various roles of epigenetics in the context of cardiovascular health and disease. The following will be examined in detail: the developments in basic experimental techniques used to study epigenetics, the role of epigenetics in various CVDs (hypertension, atrial fibrillation, atherosclerosis, and heart failure), and current advances in epi-therapeutics, providing a holistic view of the current concerted efforts in advancing the field of epigenetics in CVDs.
    MeSH term(s) Humans ; Epigenesis, Genetic ; Cardiovascular System/metabolism ; DNA Methylation ; Cardiovascular Diseases/drug therapy ; Protein Processing, Post-Translational
    Language English
    Publishing date 2023-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.01.002
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  6. Article ; Online: Genetics and genomics: A frontier for clinicians.

    Chan, Hwei Wuen / Loong, Shaun Seh Ern / Foo, Roger Sik Yin

    Singapore medical journal

    2023  Volume 64, Issue 1, Page(s) 2–3

    Language English
    Publishing date 2023-02-01
    Publishing country India
    Document type Editorial
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.4103/SINGAPOREMEDJ.SMJ-2021-444
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  7. Article ; Online: Mouse cardiomyocyte isolation: Filling the age gaps.

    Ackers-Johnson, Matthew / Foo, Roger S / Pavlovic, Davor

    Journal of molecular and cellular cardiology

    2022  Volume 170, Page(s) 124–125

    MeSH term(s) Animals ; Mice ; Myocytes, Cardiac
    Language English
    Publishing date 2022-07-09
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2022.07.001
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  8. Zhu, Yike / Ackers-Johnson, Matthew / Foo, Roger

    European heart journal

    2022  Volume 43, Issue 28, Page(s) 2710–2712

    MeSH term(s) Heart ; Heart Failure/therapy ; Humans ; Infant, Newborn ; Regeneration ; T-Lymphocytes
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac241
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  9. Article ; Online: Applications of Genome Editing Technologies in CAD Research and Therapy with a Focus on Atherosclerosis

    Michelle C. E. Mak / Rijan Gurung / Roger S. Y. Foo

    International Journal of Molecular Sciences, Vol 24, Iss 14057, p

    2023  Volume 14057

    Abstract: Cardiovascular diseases, particularly coronary artery disease (CAD), remain the leading cause of death worldwide in recent years, with myocardial infarction (MI) being the most common form of CAD. Atherosclerosis has been highlighted as one of the ... ...

    Abstract Cardiovascular diseases, particularly coronary artery disease (CAD), remain the leading cause of death worldwide in recent years, with myocardial infarction (MI) being the most common form of CAD. Atherosclerosis has been highlighted as one of the drivers of CAD, and much research has been carried out to understand and treat this disease. However, there remains much to be better understood and developed in treating this disease. Genome editing technologies have been widely used to establish models of disease as well as to treat various genetic disorders at their root. In this review, we aim to highlight the various ways genome editing technologies can be applied to establish models of atherosclerosis, as well as their therapeutic roles in both atherosclerosis and the clinical implications of CAD.
    Keywords atherosclerosis ; coronary artery disease ; genome editing ; CRISPR ; ZFN ; TALEN ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Unique characteristics of Asians with hypertension: what is known and what can be done?

    Loo, Germaine / Puar, Troy / Foo, Roger / Ong, Tiong Kiam / Wang, Tzung-Dau / Nguyen, Quang Ngoc / Chin, Chee Tang / Chin, Calvin W L

    Journal of hypertension

    2024  

    Abstract: Hypertension remains the leading modifiable risk factor for cardiovascular disease worldwide. Over the past 30 years, the prevalence of hypertension has been increasing in East and Southeast Asia to a greater extent as compared with other Western ... ...

    Abstract Hypertension remains the leading modifiable risk factor for cardiovascular disease worldwide. Over the past 30 years, the prevalence of hypertension has been increasing in East and Southeast Asia to a greater extent as compared with other Western countries. Asians with hypertension have unique characteristics. This can be attributed to increased impact of obesity on Asians with hypertension, excessive salt intake and increased salt sensitivity, loss of diurnal rhythm in blood pressure and primary aldosteronism. The impact of hypertension on cardiovascular (particularly strokes) and chronic kidney disease is greater in Asians. These unique characteristics underpinned by the diverse socioeconomic backgrounds pose its own challenges in the diagnosis and management of hypertension in Asia.
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003706
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