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  1. Article ; Online: Right ventricular failure is strongly associated with mortality in patients with moderate-to-severe COVID-19-related ARDS and appears related to respiratory worsening.

    Evrard, Bruno / Goudelin, Marine / Giraudeau, Bruno / François, Bruno / Vignon, Philippe

    Intensive care medicine

    2022  Volume 48, Issue 6, Page(s) 765–767

    MeSH term(s) COVID-19/complications ; Heart Failure ; Humans ; Respiratory Distress Syndrome/etiology ; SARS-CoV-2
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06730-0
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    Zs.A 1089: Show issues Location:
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  2. Article ; Online: Prevalence and impact of Eustachian valve on the diagnosis of patent foramen ovale in patients ventilated for an acute respiratory distress syndrome.

    Sanchez, Florence / Goudelin, Marine / Evrard, Bruno / Vignon, Philippe

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 392

    MeSH term(s) Humans ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/epidemiology ; Prevalence ; Echocardiography, Transesophageal ; Vena Cava, Inferior/diagnostic imaging ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04670-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  3. Article ; Online: The Aortic Pulsatility Index: A New Sign of Severe Acute Aortic Regurgitation.

    Sanchez, Florence / Goudelin, Marine / Evrard, Bruno / Vignon, Philippe

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2022  Volume 35, Issue 9, Page(s) 1006–1007

    MeSH term(s) Aorta/diagnostic imaging ; Aortic Valve Insufficiency/diagnostic imaging ; Blood Flow Velocity ; Humans
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Letter
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2022.04.008
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    Zs.A 2638: Show issues Location:
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  4. Article ; Online: Severe Acute Cor Pulmonale in Patients with COVID-19 Acute Respiratory Distress Syndrome: Caution with Left Turn.

    Evrard, Bruno / Goudelin, Marine / Vaidie, Julien / Fedou, Anne-Laure / Vignon, Philippe

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 8, Page(s) 961–964

    MeSH term(s) COVID-19/complications ; Heart Failure ; Humans ; Hypertension, Pulmonary ; Pulmonary Heart Disease/etiology ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202107-1568LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transesophageal Echocardiography Remains Essential and Safe during Prone Ventilation for Hemodynamic Monitoring of Patients with COVID-19.

    Evrard, Bruno / Goudelin, Marine / Vignon, Philippe

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2020  Volume 33, Issue 8, Page(s) 1057–1059

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Echocardiography ; Echocardiography, Transesophageal ; Hemodynamic Monitoring ; Hemodynamics ; Humans ; Pandemics ; Pneumonia, Viral ; Respiration, Artificial ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2020.05.018
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  6. Article ; Online: Left ventricular overloading is the leading mechanism in extubation failure of patients at high-risk of weaning-induced pulmonary edema.

    Goudelin, Marine / Evrard, Bruno / Vignon, Philippe

    Intensive care medicine

    2020  Volume 46, Issue 10, Page(s) 1962–1964

    MeSH term(s) Airway Extubation/adverse effects ; Critical Care ; Echocardiography ; Humans ; Pulmonary Edema/etiology ; Ventilator Weaning ; Weaning
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-06201-4
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    Zs.A 1089: Show issues Location:
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  7. Article ; Online: An innovative one step green supercritical CO

    Penoy, Noémie / Delma, Kouka Luc / Tonakpon, Hermane Avohou / Grignard, Bruno / Evrard, Brigitte / Piel, Géraldine

    International journal of pharmaceutics

    2022  Volume 627, Page(s) 122212

    Abstract: Budesonide and salbutamol-loaded liposomes were prepared using an innovative one step supercritical ... ...

    Abstract Budesonide and salbutamol-loaded liposomes were prepared using an innovative one step supercritical CO
    MeSH term(s) Liposomes/chemistry ; Carbon Dioxide/chemistry ; Trehalose ; Budesonide ; Albuterol ; Phosphatidylcholines ; Cholesterol ; Solvents ; Polyethylene Glycols ; Particle Size
    Chemical Substances Liposomes ; Carbon Dioxide (142M471B3J) ; Trehalose (B8WCK70T7I) ; Budesonide (51333-22-3) ; Albuterol (QF8SVZ843E) ; Phosphatidylcholines ; Cholesterol (97C5T2UQ7J) ; Solvents ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2022-09-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.122212
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    Zs.A 1409: Show issues Location:
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  8. Article ; Online: Development and optimization of a one step process for the production and sterilization of liposomes using supercritical CO

    Penoy, Noémie / Delma, Kouka Luc / Homkar, Nirmayi / Karim Sakira, Abdoul / Egrek, Sabrina / Sacheli, Rosalie / Sacré, Pierre-Yves / Grignard, Bruno / Hayette, Marie-Pierre / Somé, Touridomon Issa / Semdé, Rasmané / Evrard, Brigitte / Piel, Géraldine

    International journal of pharmaceutics

    2024  Volume 651, Page(s) 123769

    Abstract: Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that ... ...

    Abstract Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that can potentially overcome these limitations. The aim of this study was to optimize a one-step process for producing and sterilizing liposomes using supercritical CO
    MeSH term(s) Humans ; Liposomes/chemistry ; Carbon Dioxide/chemistry ; Drug Delivery Systems ; Sterilization ; Infertility
    Chemical Substances Liposomes ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-01-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.123769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1409: Show issues Location:
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  9. Article ; Online: A supercritical fluid technology for liposome production and comparison with the film hydration method.

    Penoy, Noémie / Grignard, Bruno / Evrard, Brigitte / Piel, Géraldine

    International journal of pharmaceutics

    2020  Volume 592, Page(s) 120093

    Abstract: Liposomes were produced by an innovative method using supercritical carbon dioxide as a dispersing agent. A quality by design strategy was used to find optimal production conditions with specific parameters (lipid concentration, dispersion volume, ... ...

    Abstract Liposomes were produced by an innovative method using supercritical carbon dioxide as a dispersing agent. A quality by design strategy was used to find optimal production conditions with specific parameters (lipid concentration, dispersion volume, agitation rate, temperature and pressure) allowing the production of liposomes with predicted physicochemical characteristics (particles size and PdI). Two conditions were determined with specific production parameters. It was shown that these two conditions allowed the production of liposomes of different compositions and that most of the liposome formulations had size and dispersity in accordance with the prediction values. The condition involving the higher lipid concentration showed a higher variability in terms of size and dispersity. However, this variability remained acceptable. This innovative supercritical method allowed the production of liposomes with physicochemical characteristics similar to those obtained by the conventional thin film hydration method. This new supercritical carbon dioxide method easily scalable in GMP conditions is a one-step production method contrarily to conventional methods which generally need an additional step as extrusion to homogenize the size of liposomes.
    MeSH term(s) Carbon Dioxide ; Drug Compounding ; Liposomes ; Particle Size ; Technology
    Chemical Substances Liposomes ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2020-11-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2020.120093
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    Zs.A 1409: Show issues Location:
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  10. Article: Diagnosis and Management of Pregnant Women With Placental Abruption and Neonatal Outcomes.

    Alouini, Souhail / Valery, Antoine / Lemaire, Bruno / Evrard, Marie-Liesse / Belin, Olivier

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21120

    Abstract: Background Placenta abruptio (PA) remains a serious materno-fetal complication. According to progress realized in maternal-fetal medicine, we aimed to evaluate the diagnosis and management of PA and neonatal outcomes. Methods We conducted a retrospective ...

    Abstract Background Placenta abruptio (PA) remains a serious materno-fetal complication. According to progress realized in maternal-fetal medicine, we aimed to evaluate the diagnosis and management of PA and neonatal outcomes. Methods We conducted a retrospective study that involved all the patients that were diagnosed with PA in a tertiary maternity hospital between 2006 and 2013. Data were analyzed to determine mean and standard deviation and statistically analyzed using the Chi-square test. Results In total, 201 patients were diagnosed with PA out of 35184 deliveries (0.56%). The mean age of patients was 30 years and most of them were multiparous (56.2%). Thirty-six out of 201 patients (17.9%) smoked tobacco or consumed alcohol during the pregnancy. Three patients came from their homes. Twenty-eight patients had preeclampsia and 105 presented with high blood pressure. Furthermore, 117 patients presented metrorrhagia (58.2%) and 39% of patients exhibited abdominal pain. We reported fetal heart rate abnormalities in 57% of the cases. Ultrasound examination revealed PA in only 48 patients (23.9%). One hundred eighty out of 201 patients (84.6%) underwent an emergency caesarean section. One hundred sixty-seven fetuses were born prematurely. Thirteen out of 201 fetuses died, and 98 newborns needed neonatal resuscitation. In total, 31 fetuses had an umbilical artery (UA) with pH ≤ 7 (31/188). The mean time for delivery was 18.7 min. However, UA pH did not differ when the delivery time was shorter (p = 0.09). Seventy-six percent of cases came from their homes. The mean UA pH was significantly lower for PA cases who came from their homes compared to hospitalized women (p = 0.0015). Histological examination of the placenta confirmed the diagnosis in 71 out of 148 cases (47.9%). The mean duration of hospital stay of the newborns was 17 days. Conclusion PA remains a serious materno-fetal emergency with a bad fetal prognosis for many newborns. Many fetuses either died or exhibited severe acidosis. Clinical signs and radiological images of PA are absent in many cases. There was more fetal acidosis for mothers who came from their homes at the time of delivery. We recommend that the delivery should not be delayed and a cesarean section must be the preferred mode of delivery. Pregnant women with vascular and metabolic diseases should be carefully monitored and informed on the risk of PA.
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21120
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