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Article ; Online: Overcoming the diagnostic challenges in a high-risk invasive primary cardiac lymphoma.

Wang, Stephani C / Pan, Chris W

European heart journal. Cardiovascular Imaging

2020 Volume 21, Issue 6, Page(s) 707

MeSH term(s)	Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Humans ; Lymphoma/diagnostic imaging
Language	English
Publishing date	2020-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jez324
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Article ; Online: Cardiovascular protective properties of oxytocin against COVID-19.

Wang, Stephani C / Wang, Yu-Feng

Life sciences

2021 Volume 270, Page(s) 119130

Abstract: SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of ... ...

Abstract	SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approaches managing cardiovascular complications is essential in controlling the disease progression and preventing long-term complications. Oxytocin (OXT), an immune-regulating neuropeptide, has recently emerged as a strong candidate for treatment and prevention of COVID-19 pandemic. OXT carries special functions in immunologic defense, homeostasis and surveillance. It suppresses neutrophil infiltration and inflammatory cytokine release, activates T-lymphocytes, and antagonizes negative effects of angiotensin II and other key pathological events of COVID-19. Additionally, OXT can promote γ-interferon expression to inhibit cathepsin L and increases superoxide dismutase expression to reduce heparin and heparan sulphate fragmentation. Through these mechanisms, OXT can block viral invasion, suppress cytokine storm, reverse lymphocytopenia, and prevent progression to ARDS and multiple organ failures. Importantly, besides prevention of metabolic disorders associated with atherosclerosis and diabetes mellitus, OXT can protect the heart and vasculature through suppressing hypertension and brain-heart syndrome, and promoting regeneration of injured cardiomyocytes. Unlike other therapeutic agents, exogenous OXT can be used safely without the side-effects seen in remdesivir and corticosteroid. Importantly, OXT can be mobilized endogenously to prevent pathogenesis of COVID-19. This article summarizes our current understandings of cardiovascular pathogenesis caused by COVID-19, explores the protective potentials of OXT against COVID-19-associated cardiovascular diseases, and discusses challenges in applying OXT in treatment and prevention of COVID-19. CHEMICAL COMPOUNDS: Angiotensin-converting enzyme 2 (ACE2); atrial natriuretic peptide (ANP); cathepsin L; heparan sulphate proteoglycans (HSPGs); interferon; interleukin; oxytocin; superoxide dismutase; transmembrane serine protease isoform 2 (TMPRSS2).
MeSH term(s)	Animals ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/prevention & control ; COVID-19/virology ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/virology ; Comorbidity ; Humans ; Oxytocin/adverse effects ; Oxytocin/therapeutic use ; SARS-CoV-2/physiology
Chemical Substances	Oxytocin (50-56-6)
Language	English
Publishing date	2021-01-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119130
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Article: On the elastic properties of arteries, by Stephanis, C.G., et al., 2000.; Journal of Biomechanics 36, 1727-1731.

Wang, S-J Shyh-Jen / Wang, S-Y Shyh-Yau

Journal of biomechanics

2005 Volume 38, Issue 1, Page(s) 191; author reply 193

MeSH term(s)	Arteries/physiology ; Biomechanical Phenomena ; Elasticity ; Humans ; Models, Cardiovascular
Language	English
Publishing date	2005-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2004.03.023
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Article ; Online: Early recognition of mitral annular disjunction induced ventricular fibrillation: role of multimodality imaging.

Wang, Stephani C / Lee, Mark / Cami, Elvis / Kern, Morton

European heart journal. Cardiovascular Imaging

2021 Volume 23, Issue 3, Page(s) e126

MeSH term(s)	Arrhythmias, Cardiac ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Mitral Valve Prolapse ; Ventricular Fibrillation/diagnostic imaging ; Ventricular Fibrillation/etiology ; Ventricular Fibrillation/therapy
Language	English
Publishing date	2021-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeab197
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Article: Cardiovascular protective properties of oxytocin against COVID-19

Wang, Stephani C / Wang, Yu-Feng

Life sciences. 2021 Apr. 01, v. 270

2021

Abstract	SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approaches managing cardiovascular complications is essential in controlling the disease progression and preventing long-term complications. Oxytocin (OXT), an immune-regulating neuropeptide, has recently emerged as a strong candidate for treatment and prevention of COVID-19 pandemic. OXT carries special functions in immunologic defense, homeostasis and surveillance. It suppresses neutrophil infiltration and inflammatory cytokine release, activates T-lymphocytes, and antagonizes negative effects of angiotensin II and other key pathological events of COVID-19. Additionally, OXT can promote γ-interferon expression to inhibit cathepsin L and increases superoxide dismutase expression to reduce heparin and heparan sulphate fragmentation. Through these mechanisms, OXT can block viral invasion, suppress cytokine storm, reverse lymphocytopenia, and prevent progression to ARDS and multiple organ failures. Importantly, besides prevention of metabolic disorders associated with atherosclerosis and diabetes mellitus, OXT can protect the heart and vasculature through suppressing hypertension and brain-heart syndrome, and promoting regeneration of injured cardiomyocytes. Unlike other therapeutic agents, exogenous OXT can be used safely without the side-effects seen in remdesivir and corticosteroid. Importantly, OXT can be mobilized endogenously to prevent pathogenesis of COVID-19. This article summarizes our current understandings of cardiovascular pathogenesis caused by COVID-19, explores the protective potentials of OXT against COVID-19-associated cardiovascular diseases, and discusses challenges in applying OXT in treatment and prevention of COVID-19.Angiotensin-converting enzyme 2 (ACE2); atrial natriuretic peptide (ANP); cathepsin L; heparan sulphate proteoglycans (HSPGs); interferon; interleukin; oxytocin; superoxide dismutase; transmembrane serine protease isoform 2 (TMPRSS2).
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; T-lymphocytes ; acute respiratory distress syndrome ; adrenal cortex hormones ; adverse effects ; atherosclerosis ; atrial natriuretic peptide ; cardiomyocytes ; cathepsin L ; diabetes mellitus ; disease progression ; heparan sulfate ; heparin ; homeostasis ; hypertension ; interleukins ; monitoring ; morbidity ; mortality ; neuropeptides ; neutrophils ; oxytocin ; pandemic ; pathogenesis ; proteoglycans ; serine proteinases ; superoxide dismutase ; therapeutics
Language	English
Dates of publication	2021-0401
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119130
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Astroglial Regulation of Magnocellular Neuroendocrine Cell Activities in the Supraoptic Nucleus.

Wang, Stephani C / Parpura, Vladimir / Wang, Yu-Feng

Neurochemical research

2020 Volume 46, Issue 10, Page(s) 2586–2600

Abstract: Studies on the interactions between astrocytes and neurons in the hypothalamo-neurohypophysial system have significantly facilitated our understanding of the regulation of neural activities. This has been exemplified in the interactions between ... ...

Abstract	Studies on the interactions between astrocytes and neurons in the hypothalamo-neurohypophysial system have significantly facilitated our understanding of the regulation of neural activities. This has been exemplified in the interactions between astrocytes and magnocellular neuroendocrine cells (MNCs) in the supraoptic nucleus (SON), specifically during osmotic stimulation and lactation. In response to changes in neurochemical environment in the SON, astrocytic morphology and functions change significantly, which further modulates MNC activity and the secretion of vasopressin and oxytocin. In osmotic regulation, short-term dehydration or water overload causes transient retraction or expansion of astrocytic processes, which increases or decreases the activity of SON neurons, respectively. Prolonged osmotic stimulation causes adaptive change in astrocytic plasticity in the SON, which allows osmosensory neurons to reserve osmosensitivity at new levels. During lactation, changes in neurochemical environment cause retraction of astrocytic processes around oxytocin neurons, which increases MNC's ability to secrete oxytocin. During suckling by a baby/pup, astrocytic processes in the mother/dams exhibit alternative retraction and expansion around oxytocin neurons, which mirrors intermittently synchronized activation of oxytocin neurons and the post-excitation inhibition, respectively. The morphological and functional plasticities of astrocytes depend on a series of cellular events involving glial fibrillary acidic protein, aquaporin 4, volume regulated anion channels, transporters and other astrocytic functional molecules. This review further explores mechanisms underlying astroglial regulation of the neuroendocrine neuronal activities in acute processes based on the knowledge from studies on the SON.
MeSH term(s)	Animals ; Aquaporin 4/metabolism ; Astrocytes/metabolism ; Glial Fibrillary Acidic Protein/metabolism ; Lactation/physiology ; Neuroendocrine Cells/metabolism ; Neuronal Plasticity/physiology ; Osmoregulation/physiology ; Supraoptic Nucleus/cytology ; Supraoptic Nucleus/metabolism
Chemical Substances	Aquaporin 4 ; Glial Fibrillary Acidic Protein
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-020-03172-2
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Zs.A 1368: Show issues

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Article ; Online: Native aortic valve thrombosis confined to noncoronary cusp of aortic valve.

Wang, Stephani C / Guccione, Jack / Kim, Cy / Patel, Pranav M

Acta cardiologica

2020 Volume 76, Issue 6, Page(s) 672–673

MeSH term(s)	Aortic Diseases ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnosis ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Heart Valve Diseases/diagnosis ; Humans ; Thrombosis/diagnosis ; Thrombosis/etiology
Language	English
Publishing date	2020-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2020.1764209
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Article ; Online: Sex Differences Remain Under-Reported in Cardiovascular Publications.

Wang, Stephani C / Koutroumpakis, Efstratios / Schulman-Marcus, Joshua / Tosh, Traci / Volgman, Annabelle Santos / Lyubarova, Radmila

Journal of women's health (2002)

2021 Volume 30, Issue 9, Page(s) 1253–1258

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Female ; Humans ; Male ; National Institutes of Health (U.S.) ; Sex Characteristics ; United States
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1139774-3
ISSN	1931-843X ; 1059-7115 ; 1540-9996
ISSN (online)	1931-843X
ISSN	1059-7115 ; 1540-9996
DOI	10.1089/jwh.2020.8561
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Article: Regional Strain Pattern and Correlation with Cardiac Magnetic Resonance Imaging in Fabry Disease.

Wang, Stephani C / Tapia, Daisy / Kimonis, Virginia E / Lombardo, Dawn M

Journal of cardiovascular echography

2021 Volume 31, Issue 3, Page(s) 131–136

Abstract: Background: Cardiovascular disease is the most common cause of death among Fabry disease patients, who carry significantly increased risk for heart failure and sudden cardiac death. Echocardiographic strain imaging and cardiac MRI are important clinical ...

Abstract	Background: Cardiovascular disease is the most common cause of death among Fabry disease patients, who carry significantly increased risk for heart failure and sudden cardiac death. Echocardiographic strain imaging and cardiac MRI are important clinical tools for early detection of cardiomyopathy before onset of systolic or diastolic dysfunction. However, studies on these imaging modalities are limited among Fabry patients. Aim and objective: To evaluate echocardiographic strain pattern and correlation with cardiac MRI in Fabry disease. Materials and methods: We performed a detailed analysis of global longitudinal strain and correlation with cardiac MRI finding in 9 patients diagnosed with Fabry disease. Results: Despite normal left ventricular ejection fraction, basal and mid inferior segments are more likely to demonstrate strain abnormalities compared to other regions. Additionally, increased interventricular septal and left ventricular posterior wall thickness are correlated with greater strain abnormalities. Finally, MRI evidence of fibrosis and infiltration are detected among most patients with strain abnormalities, but in some cases, strain imaging were able to detect early evidence of cardiomyopathy even before MRI was fully able to detect the change. Basal and mid inferoseptal segment strain abnormalities are early signs of developing cardiomyopathy among patients with Fabry disease. Conclusion: Though cardiac MRIs are critical tools for detection of myocardial infiltration and scarring, these findings may not always be detectable in early phases of the disease. Multiple imaging modalities maybe considered in monitoring and evaluation of cardiomyopathy in Fabry disease.
Language	English
Publishing date	2021-10-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/jcecho.jcecho_119_20
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Article ; Online: Characteristics of VCP mutation-associated cardiomyopathy.

Wang, Stephani C / Smith, Charles D / Lombardo, Dawn M / Kimonis, Virginia

Neuromuscular disorders : NMD

2021 Volume 31, Issue 8, Page(s) 701–705

Abstract: VCP associated inclusion body myopathy, Paget's disease of bone, and Frontotemporal Dementia (IBMPFD, VCP disease, or multisystem proteinopathy type 1 (MSP1)) is an autosomal dominant disease caused by missense mutations in the VCP gene, which plays a ... ...

Abstract	VCP associated inclusion body myopathy, Paget's disease of bone, and Frontotemporal Dementia (IBMPFD, VCP disease, or multisystem proteinopathy type 1 (MSP1)) is an autosomal dominant disease caused by missense mutations in the VCP gene, which plays a crucial role in ubiquitin-proteasome dependent degradation of cytosolic proteins. Those diagnosed with the disorder often suffer from cardiovascular complications in the advanced stages. We conducted an observational cross-section study to investigate echocardiographic features of asymptomatic carriers and those affected by the disease to determine the differences and potential early features of the VCP-associated cardiomyopathy. The study cohort constituted of 32 patients with VCP mutations including 23 affected individuals diagnosed with myopathy +/- Paget disease of bone, and 9 asymptomatic carriers. Among the affected individuals, 95.7% had myopathy, 43.5% had Paget's disease of bone, and none had frontotemporal dementia, and the carriers were asymptomatic. Not surprisingly the carriers were younger (mean age 38.4 ± 3.8 years), than the affected cohort (mean age 50.6 ± 9.1 years; p < 0.001). There was a 43.5% prevalence of diastolic dysfunction on echocardiogram among patients who were symptomatic from VCP disease, whereas none of the two asymptomatic carriers manifested diastolic dysfunction (p = 0.017). Among the 5 affected individuals who had consequential echocardiograms 2-3 years apart, three affected individuals developed diastolic dysfunction, and two already had diastolic dysfunction on the initial study. The two carriers did not develop diastolic function changes. This present study represents the largest series of echocardiograms performed in patients and asymptomatic carriers with VCP myopathy, and will pave the way for future, large-scale studies that may include other imaging modalities such as cardiac MRI and strain evaluation in patients at all stages of the disease.
MeSH term(s)	Adult ; Cohort Studies ; Cross-Sectional Studies ; Echocardiography ; Female ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/genetics ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Muscular Dystrophies, Limb-Girdle/diagnostic imaging ; Muscular Dystrophies, Limb-Girdle/genetics ; Mutation ; Mutation, Missense ; Myositis, Inclusion Body/diagnostic imaging ; Myositis, Inclusion Body/genetics ; Osteitis Deformans/diagnostic imaging ; Osteitis Deformans/genetics ; Pedigree ; Ubiquitin/metabolism ; Valosin Containing Protein/genetics
Chemical Substances	Ubiquitin ; Valosin Containing Protein (EC 3.6.4.6)
Language	English
Publishing date	2021-06-12
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1077681-3
ISSN	1873-2364 ; 0960-8966
ISSN (online)	1873-2364
ISSN	0960-8966
DOI	10.1016/j.nmd.2021.06.005
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