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Article: Thyroid Incidentalomas: Scrutinizing the Mode of Detection and Evaluating its Contribution to Thyroid Cancer Diagnosis.

Girardi, Fábio Muradás / Wagner, Vivian P / Martins, Manoela Domingues

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 76, Issue 2, Page(s) 1733–1740

Abstract: There is an ongoing debate about the reasons behind the increasing incidence of thyroid cancer in the last two to three decades. Here, we investigate how thyroid nodules were detected in a large series of consultations for thyroid nodular pathology.: ... ...

Abstract	There is an ongoing debate about the reasons behind the increasing incidence of thyroid cancer in the last two to three decades. Here, we investigate how thyroid nodules were detected in a large series of consultations for thyroid nodular pathology. Methods: In total, 576 patients were analyzed, with a total of 1014 nodules described. Results: In 347 (60.2%) cases, the diagnosis of a thyroid nodule was incidental, mostly during imaging tests for other reasons. Incidental diagnosis occurred among all ranges of nodule diameter and between palpable and non-palpable cases, even within a small proportion of symptomatic cases. In univariate analysis, incidental diagnosis was associated with smaller nodule diameter, non-palpable nodules, asymptomatic cases, older patient age, less advanced stages (T1-2), and conservative management. After multivariate analysis, older age, euthyroidism, and smaller diameter were statistically significant. Incidental diagnosis contributed to the diagnosis of 53.8% of the cases of cancer. Advanced T stages (T3-4) were more common in non-incidental diagnoses. Conclusion: Our results indicate that incidental diagnosis of thyroid nodules is a significant contributor to thyroid cancer diagnosis in all ranges of nodule diameter, especially at earlier stages.
Language	English
Publishing date	2023-11-28
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04392-y
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Article ; Online: Epidemiology trends and progress in breast cancer survival: earlier diagnosis, new therapeutics.

Amato, Ottavia / Guarneri, Valentina / Girardi, Fabio

Current opinion in oncology

2023 Volume 35, Issue 6, Page(s) 612–619

Abstract: Purpose of review: In this review we will critically appraise the latest evidence on breast cancer (BC) survival trends and discuss how these may reflect breakthroughs in early diagnosis and treatment approaches. We will address the wide global ... ...

Abstract	Purpose of review: In this review we will critically appraise the latest evidence on breast cancer (BC) survival trends and discuss how these may reflect breakthroughs in early diagnosis and treatment approaches. We will address the wide global inequalities in BC survival and review the ongoing initiatives aimed at improving cancer control worldwide. Recent findings: BC outcomes have improved in high-income countries during the last decades, following the implementation of strategies for early detection and optimal multimodality treatment. Novel therapeutics, such as anti-HER2 targeted treatments, have also contributed to the progress in BC survival. However, BC mortality is still high in low-income countries, due to the lack of optimal healthcare infrastructures. In the context of marked inequities in BC management across world regions, international collaborations such as the Global Breast Cancer Initiative and the Global Initiative for Cancer Registry Development work to foster capacity-building in developing countries, tackle the burden of BC and deliver the Sustainable Development Goals by 2030. Summary: Collection of robust, high-quality data from population-based cancer registries is crucial to drive and refine public health interventions. Population-based data are also the litmus paper to evaluate the real-world impact of clinical advances and monitor progress.
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000000991
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Article ; Online: There is no such a thing as a '

Trapani, Dario / Girardi, Fabio / Cinieri, Saverio / Curigliano, Giuseppe

Tumori

2023 Volume 110, Issue 2, Page(s) 82–87

Abstract: Improved strategies of cancer prevention and control have resulted in tangible benefits for patients with cancer. Disparities in outcome have been reported as a result of inequal access to health care. Historically, differences in health outcomes at ... ...

Abstract	Improved strategies of cancer prevention and control have resulted in tangible benefits for patients with cancer. Disparities in outcome have been reported as a result of inequal access to health care. Historically, differences in health outcomes at population level have been reported according to key characteristics, including race, ethnicity and, more recently, ancestry. These population descriptors have been used to display the differences in the outcome and highlight actionable areas of health disparities, through policy and population health interventions. Yet, they have been commonly mis-intended as ultimate determinants of health outcomes, as recapitulating intrinsic biological differences. A plethora of past literature has described "biological" differences in patients belonging to a specific racial, ethnical or ancestral group, with certain cancers - commonly overlooking the social and economic contextures. The attention has ultimately focused on the existence of intrinsic differences and biological reasons, as opposed to social and economic determinants of disparities in the outcome in disadvantaged or excluded communities, thus nurturing double stigma. In our editorial, we evaluate some key roots of racial attitudes in displaying patient outcomes in oncology epidemiological studies, and call to report ultimate determinants of health - that are, primarily social and economic determinants.
MeSH term(s)	Humans ; United States ; Ethnicity ; Delivery of Health Care ; Medical Oncology ; Neoplasms/epidemiology ; Outcome Assessment, Health Care ; Healthcare Disparities
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Editorial
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/03008916231196369
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Article: Histopathological Pattern of Head and Neck Recurrent BCC After Previous Cryotherapy.

Girardi, Fábio Muradás / de Carvalho Neto, Antônio Augusto / Martins, Manoela Domingues

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 4, Page(s) 2993–2997

Abstract: Surgical resection is the gold standard treatment for basal cell carcinomas, although there is literature supporting cryotherapy for low-risk cases. Our aim was to compare the histopathological aspects of recurrent postcryotherapy head and neck cutaneous ...

Abstract	Surgical resection is the gold standard treatment for basal cell carcinomas, although there is literature supporting cryotherapy for low-risk cases. Our aim was to compare the histopathological aspects of recurrent postcryotherapy head and neck cutaneous BCC with de novo tumors, using a case-control study. 51 Recurrent postcryotherapy cases were selected between January 2017 and December 2021 and compared to 132 controls filtered from a consecutive series of de novo head and neck cutaneous BCC operated between January and December 2021. Aggressive variants, multifocality, invasion beyond adipose tissue and higher Clark levels were associated with recurrent cases on multivariate analysis. Previous cryotherapy treatment may have contributed to an increased risk of more aggressive recurrent disease and caution using this treatment modality is advised. Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-03919-7.
Language	English
Publishing date	2023-06-02
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03919-7
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Article ; Online: Reply to "Reporting pediatric brain tumors according to their behavior code can result in biased survival estimates-A European perspective to Girardi et al".

Girardi, Fabio / Coleman, Michel P / Allemani, Claudia

Neuro-oncology

2022 Volume 24, Issue 7, Page(s) 1208–1209

MeSH term(s)	Brain Neoplasms/epidemiology ; Child ; Humans
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Letter ; Comment
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noac077
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Article: Thyroid Carcinoma Pattern Presentation According to Age.

Girardi, Fábio Muradás

International archives of otorhinolaryngology

2016 Volume 21, Issue 1, Page(s) 38–41

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2016-07-12
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0036-1585095
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Article ; Online: Wetting induced instabilities in layered slopes: A Material Point Method analysis

Girardi, Veronica / Yerro, Alba / Simonini, Paolo / Gabrieli, Fabio / Ceccato, Francesca

Engineering Geology. 2023 Feb., v. 313 p.106978-

2023

Abstract: The increase of pore water pressure due to rainfall infiltration or upstream recharge is among the primary triggers of landslides, and soil layering has a significant effect on the hydromechanical behavior of the slope. The failure and post-failure ... ...

Abstract	The increase of pore water pressure due to rainfall infiltration or upstream recharge is among the primary triggers of landslides, and soil layering has a significant effect on the hydromechanical behavior of the slope. The failure and post-failure behavior of heterogeneous layered slopes triggered by these phenomena are investigated in this study. In particular, a low permeability layer is embedded in a reference slope with different inclinations, and the impact of different saturation mechanisms on the post-failure behavior is assessed. To this aim, an unsaturated formulation of the Material Point Method (MPM) is used to reproduce the whole deformation process of a layered slope. The results show different failure and post-failure mechanisms and kinematics for both upstream recharge and rainfall infiltration (i.e., bottom-up and top-down saturation processes, respectively). Bottom-up saturation mechanism triggers deep failure mechanisms that barely evolve during the instability process. On the contrary, top-down saturation mechanism induces an anticipated shallow semi-planar failure limited by the location of the low permeable layer. These failures are characterized by high velocities and by a deepening of the slip surface during the post-failure process. Final displacements in both wetting mechanisms are of the same order of magnitude. The subsequent reactivation movements are observed as a result of the continuous injection of water in the system.
Keywords	deformation ; geology ; kinematics ; permeability ; rain ; soil ; Layering ; Landslides ; Large displacement ; Post-failure ; Safety Assessment ; Material Point Method
Language	English
Dates of publication	2023-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ISSN	0013-7952
DOI	10.1016/j.enggeo.2022.106978
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Thyroid Carcinoma Pattern Presentation According to Age

Fábio Muradás Girardi

International Archives of Otorhinolaryngology, Vol 21, Iss 01, Pp 38-

2017 Volume 41

Abstract: Abstract Introduction Patients with thyroid cancer in different age groups present with different prognosis. Objective The objective of this study is to analyze the clinicopathological pattern of thyroid carcinoma presentation according to age groups. ... ...

Abstract	Abstract Introduction Patients with thyroid cancer in different age groups present with different prognosis. Objective The objective of this study is to analyze the clinicopathological pattern of thyroid carcinoma presentation according to age groups. Methods This is a retrospective study. From 2000 to 2010, 623 patients underwent thyroidectomy for cancer in our institution, with 596 enrolled. Patients were divided into groups of 10 years and then in four age subgroups (≤ 24, 25–44, 45–64, and ≥65 years) for statistical analysis. We compared age, gender, and histopathological characteristics between groups. Results Individuals belonging to the earlier age group presented with a highest prevalence of neuro-vascular invasion, capsular invasion and lymph node metastasis. Together with individuals of advanced age, that group also had larger tumor diameter and higher prevalence of extra-glandular disease. Even when analyzed only cases with well-differentiated carcinoma, younger individuals remain with a highest prevalence of lymph node metastasis, neuro-vascular invasion and larger tumor diameter. Conclusion We observed a distinct pattern of clinicopathological manifestation of thyroid cancer according to age. Individuals belonging to age extremes resemble in several pathological features, and young people usually present with more aggressive disease characteristics.
Keywords	papillary carcinoma ; thyroid neoplasms ; age ; Medicine ; R ; Otorhinolaryngology ; RF1-547
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Thieme Revinter Publicações Ltda.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of AJCC 8 pT staging in cutaneous head and neck squamous cell carcinoma in a nonselected real-world patient sample.

Girardi, Fábio Muradás / Wagner, Vivian P / Martins, Manoela Domingues / Abentroth, Aliende Lengler / Hauth, Luiz Alberto

Head & neck

2022 Volume 45, Issue 2, Page(s) 337–346

Abstract: Objective: Our aim was to evaluate characteristics associated with worse survival and the effectiveness of AJCC 8 in a real-world cohort of HNCSCC from South Brazil.: Methods: A 10-year retrospective cohort study (2011-2020) at a tertiary care center ...

Abstract	Objective: Our aim was to evaluate characteristics associated with worse survival and the effectiveness of AJCC 8 in a real-world cohort of HNCSCC from South Brazil. Methods: A 10-year retrospective cohort study (2011-2020) at a tertiary care center comprising 647 HNCSCC excised from 435 patients. Results: At multivariable analysis, ear/nose/zygomatic or periorbital site, compromised or exiguous margins, and advanced pT stage were independent factors associated to DFS, while age, pN, and loco-regional recurrence were independent factors associated to DSS. Cox-regression multivariable models showed that the pT stage was statistically significant for the DFS, but not DSS. A significant distinction was only observed between T1 and T2. Conclusion: It was only in the lower categories of AJCC 8 (T1 and T2) that we were able to demonstrate the ability to stratify tumors with a significant risk of poor disease-related outcomes.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/pathology ; Carcinoma, Squamous Cell/surgery ; Skin Neoplasms/surgery ; Skin Neoplasms/pathology ; Retrospective Studies ; Neoplasm Staging ; Head and Neck Neoplasms/surgery ; Head and Neck Neoplasms/pathology ; Prognosis
Language	English
Publishing date	2022-11-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27233
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Article: Thyroid Carcinoma Pattern Presentation According to Age

Girardi, Fábio Muradás

International Archives of Otorhinolaryngology

2016 Volume 21, Issue 01, Page(s) 38–41

Abstract: Introduction: Patients with thyroid cancer in different age groups present with different prognosis.: Objective: The objective of this study is to analyze the clinicopathological pattern of thyroid carcinoma presentation according to age groups.: ... ...

Abstract	Introduction: Patients with thyroid cancer in different age groups present with different prognosis. Objective: The objective of this study is to analyze the clinicopathological pattern of thyroid carcinoma presentation according to age groups. Methods: This is a retrospective study. From 2000 to 2010, 623 patients underwent thyroidectomy for cancer in our institution, with 596 enrolled. Patients were divided into groups of 10 years and then in four age subgroups (≤ 24, 25–44, 45–64, and ≥65 years) for statistical analysis. We compared age, gender, and histopathological characteristics between groups. Results: Individuals belonging to the earlier age group presented with a highest prevalence of neuro-vascular invasion, capsular invasion and lymph node metastasis. Together with individuals of advanced age, that group also had larger tumor diameter and higher prevalence of extra-glandular disease. Even when analyzed only cases with well-differentiated carcinoma, younger individuals remain with a highest prevalence of lymph node metastasis, neuro-vascular invasion and larger tumor diameter. Conclusion: We observed a distinct pattern of clinicopathological manifestation of thyroid cancer according to age. Individuals belonging to age extremes resemble in several pathological features, and young people usually present with more aggressive disease characteristics.
Keywords	papillary carcinoma ; thyroid neoplasms ; age
Language	English
Publishing date	2016-07-12
Publisher	Thieme-Revinter Publicações Ltda
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0036-1585095
Database	Thieme publisher's database

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