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  1. Article ; Online: Care for laboratory animals during COVID-19 crisis.

    Pullium, Jennifer K

    Nature

    2020  Volume 579, Issue 7800, Page(s) 497

    MeSH term(s) Animals ; Animals, Laboratory ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Workload
    Keywords covid19
    Language English
    Publishing date 2020-03-24
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-00869-w
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  3. Article ; Online: Care for laboratory animals during COVID-19 crisis

    Pullium, Jennifer K.

    Nature

    2020  Volume 579, Issue 7800, Page(s) 497–497

    Keywords Multidisciplinary ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-00869-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Disaster Planning and Research Continuity in Responsible Animal Research.

    Petervary, Nicolette / Pullium, Jennifer K

    ILAR journal

    2019  Volume 60, Issue 1, Page(s) 74–85

    Abstract: Disaster preparedness for research facilities can be a daunting task. The purpose of this review is to introduce basic preparedness concepts and terminology so that facilities may begin to develop customized plans for their specific needs. Regulatory ... ...

    Abstract Disaster preparedness for research facilities can be a daunting task. The purpose of this review is to introduce basic preparedness concepts and terminology so that facilities may begin to develop customized plans for their specific needs. Regulatory requirements are reviewed and an overview of the Incident Command System, National Preparedness System Planning Frameworks, and fundamental terms is provided. Important concepts for successful planning are then explored. Good planning involves fostering a culture of preparedness, resilience, and understanding the interactions and partnerships with other groups that are essential for core functions and incident response. Methods to gain institutional support and set up an advisory committee are examined in detail. Next, the steps to develop and carry out a plan are outlined. Risk assessments using an all hazards approach and tools such as risk indices and risk matrices are explained, and tips to design and test plans, train personnel, and evaluate improvement are discussed. Finally, special challenges unique to animal research facilities are considered along with ways to address them. Examples and information are drawn from a wide variety of organizations both to underscore themes common to all preparedness plans and to introduce new concepts that may be adapted for use in research institutions.
    MeSH term(s) Animal Experimentation/legislation & jurisprudence ; Animal Experimentation/standards ; Animals ; Disaster Planning/legislation & jurisprudence ; Disaster Planning/methods
    Language English
    Publishing date 2019-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2192062-X
    ISSN 1930-6180 ; 1084-2020
    ISSN (online) 1930-6180
    ISSN 1084-2020
    DOI 10.1093/ilar/ily023
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  5. Article ; Online: Emergency planning: Be prepared.

    Pullium, Jennifer K / Roble, Gordon S / Raymond, Mark A

    Nature

    2014  Volume 514, Issue 7523, Page(s) 430

    MeSH term(s) Animals ; Animals, Laboratory ; Cyclonic Storms ; Decision Making ; Disaster Planning/methods ; Disasters/prevention & control ; Humans ; Leadership ; Mice ; New York City ; Psychology, Industrial/methods ; Rescue Work/methods ; Rescue Work/standards ; Risk Assessment ; Stress, Psychological/psychology
    Language English
    Publishing date 2014-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/514430a
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  6. Article ; Online: Chapter 26 Quarantine facilities and operations

    Huerkamp, Michael J. / Pullium, Jennifer K.

    Planning and Designing Research Animal Facilities

    Abstract: Publisher Summary This chapter focuses on quarantine requirements at animal facilities. The well-established quarantine measures for nonhuman primates and those that have re-emerged for rodents are very important. The increased use and exchange of ... ...

    Abstract Publisher Summary This chapter focuses on quarantine requirements at animal facilities. The well-established quarantine measures for nonhuman primates and those that have re-emerged for rodents are very important. The increased use and exchange of genetically engineered mutant mice especially demands rodent quarantine capabilities for the majority of research institutions. Apart from species-specific housing requirements, it is important to consider pathogens to be contained in terms of the route of transmission, and degree of hazard to human and animal health. Animals obtained from commercial vendors, as opposed to other research institutions, may be less likely to harbor undesirable microorganisms, often allowing them to be exempt from a quarantine program. The ideal quarantine facility should be flexible enough to allow the use of multiple species, and take into account the number and frequency of shipments expected. The more shipments and different species involved, the more subdivided the facility should be, through the use of multiple rooms, cubicles, isolators, etc. At a minimum, ABSL2 design criteria should be used to enable the containment of pathogens at the room or cage level, while also preventing agent transmission via contaminated animal waste, fomites, and personnel.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/b978-0-12-369517-8.00026-8
    Database COVID19

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  7. Article ; Online: Quarantine facilities and operations

    Huerkamp, Michael J. / Pullium, Jennifer K.

    Planning and Designing Research Animal Facilities

    Abstract: This chapter focuses on quarantine requirements at animal facilities. The well-established quarantine measures for nonhuman primates and those that have re-emerged for rodents are very important. The increased use and exchange of genetically engineered ... ...

    Abstract This chapter focuses on quarantine requirements at animal facilities. The well-established quarantine measures for nonhuman primates and those that have re-emerged for rodents are very important. The increased use and exchange of genetically engineered mutant mice especially demands rodent quarantine capabilities for the majority of research institutions. Apart from species-specific housing requirements, it is important to consider pathogens to be contained in terms of the route of transmission, and degree of hazard to human and animal health. Animals obtained from commercial vendors, as opposed to other research institutions, may be less likely to harbor undesirable microorganisms, often allowing them to be exempt from a quarantine program. The ideal quarantine facility should be flexible enough to allow the use of multiple species, and take into account the number and frequency of shipments expected. The more shipments and different species involved, the more subdivided the facility should be, through the use of multiple rooms, cubicles, isolators, etc. At a minimum, ABSL2 design criteria should be used to enable the containment of pathogens at the room or cage level, while also preventing agent transmission via contaminated animal waste, fomites, and personnel.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/b978-0-12-369517-8.00026-8
    Database COVID19

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  8. Article ; Online: Pregnancy following homologous prepubertal ovarian transplantation in the dog.

    Pullium, Jennifer K / Milner, Ross / Tuma, Gary A

    Journal of experimental & clinical assisted reproduction

    2008  Volume 5, Issue 1, Page(s) 1

    Abstract: In several canine models of hereditary human disease the homozygote dogs die prior to puberty, or have substantially reduced fertility. To create a clinically healthy animal that can be bred, but can also transmit the gene of interest, a model of ... ...

    Abstract In several canine models of hereditary human disease the homozygote dogs die prior to puberty, or have substantially reduced fertility. To create a clinically healthy animal that can be bred, but can also transmit the gene of interest, a model of homologous ovarian transplantation in prepubertal dogs was developed. Six dog leukocyte antigen (DLA) identical littermates underwent transplantation of ovarian cortical strips (n = 2) or the entire ovary (n = 4). Immunosuppression was maintained with cyclosporine and MMF in the immediate post-operative period and cyclosporine alone thereafter. All 6 dogs entered puberty and normal semiannual estrus cycles as demonstrated by both physical changes and increasing serum progesterone. Four dogs were bred to a proven stud male, and one became pregnant. Three viable fetuses with observable heart-beats were detected on ultrasound examination. Although the dog eventually aborted the litter, this work represents the first pregnancy achieved following a prepubertal ovarian transplant in the dog.
    Language English
    Publishing date 2008-04-22
    Publishing country Ireland
    Document type Journal Article
    ISSN 1743-1050
    ISSN (online) 1743-1050
    DOI 10.1186/1743-1050-5-1
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  9. Article: Rodent vendor apparent source of mouse parvovirus in sentinel mice.

    Pullium, Jennifer K / Benjamin, Kimberly A / Huerkamp, Michael J

    Contemporary topics in laboratory animal science

    2004  Volume 43, Issue 4, Page(s) 8–11

    Abstract: Mouse parvovirus (MPV) has been increasingly prevalent in laboratory animal facilities, and the source of infection often can be difficult to determine. After 4 years of sporadic MPV detected in our sentinel mice and continual failure to identify index ... ...

    Abstract Mouse parvovirus (MPV) has been increasingly prevalent in laboratory animal facilities, and the source of infection often can be difficult to determine. After 4 years of sporadic MPV detected in our sentinel mice and continual failure to identify index cases in colony mice, we developed a regimen to house newly arrived vendor mice in large sterile cages with a high stocking density. Some of these mice were retained in isolation after the remaining mice were deployed as sentinels. After detecting MPV seropositive sentinel mice 4 weeks after introduction to the mouse colonies in one facility, the remaining naïve mice that had been previously housed with those sentinels also tested positive for MPV, despite never having been exposed to colony mice. These results suggest that commercially bred mice intended for use as sentinels may, in fact, arrive at animal facilities already infected with MPV. Depending upon numerous factors, including the health surveillance methods used, it is possible that a low prevalence of MPV may exist undetected at rodent vendors.
    MeSH term(s) Animals ; Animals, Outbred Strains ; Contract Services ; Disease Outbreaks ; Female ; Mice ; Parvoviridae Infections/epidemiology ; Parvoviridae Infections/veterinary ; Parvovirus/isolation & purification ; Rodent Diseases/epidemiology ; Rodent Diseases/virology ; Sentinel Surveillance/veterinary ; Specific Pathogen-Free Organisms
    Language English
    Publishing date 2004-07
    Publishing country United States
    Document type Journal Article
    ISSN 1060-0558
    ISSN 1060-0558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Fecal corticosterone levels in RCAN1 mutant mice.

    Rakowski-Anderson, Tammy / Wong, Helen / Rothermel, Beverly / Cain, Peter / Lavilla, Carmencita / Pullium, Jennifer K / Hoeffer, Charles

    Comparative medicine

    2012  Volume 62, Issue 2, Page(s) 87–94

    Abstract: Regulator of calcineurin 1 (RCAN1) is related to the expression of human neurologic disorders such as Down syndrome, Alzheimer disease, and chromosome 21q deletion syndrome. We showed here that RCAN1-knockout mice exhibit reduced innate anxiety as ... ...

    Abstract Regulator of calcineurin 1 (RCAN1) is related to the expression of human neurologic disorders such as Down syndrome, Alzheimer disease, and chromosome 21q deletion syndrome. We showed here that RCAN1-knockout mice exhibit reduced innate anxiety as indicated by the elevated-plus maze. To examine whether glucocorticoids contribute to this phenotype, we measured fecal corticosterone in male wildtype and RCAN1-knockout mice and in male and female transgenic mice with neuronal overexpression of RCAN1 (Tg-RCAN1(TG)). We found no difference in fecal corticosterone levels of RCAN1-knockout mice and their wildtype littermates. As expected, we found differences between sexes in fecal corticosterone levels. In addition, we found higher levels of excreted corticosterone in Tg-RCAN1(TG) female mice as compared with female wildtype mice. Our data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice.
    MeSH term(s) Animals ; Anxiety/genetics ; Anxiety/metabolism ; Anxiety/psychology ; Behavior, Animal ; Calcium-Binding Proteins ; Circadian Rhythm ; Corticosterone/metabolism ; Feces/chemistry ; Female ; Genotype ; Intracellular Signaling Peptides and Proteins/deficiency ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Motor Activity ; Muscle Proteins/deficiency ; Muscle Proteins/genetics ; Mutation ; Phenotype ; Photoperiod ; Sex Factors ; Time Factors
    Chemical Substances Calcium-Binding Proteins ; DSCR1 protein, mouse ; Intracellular Signaling Peptides and Proteins ; Muscle Proteins ; Corticosterone (W980KJ009P)
    Language English
    Publishing date 2012-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006425-1
    ISSN 1532-0820 ; 0023-6764
    ISSN 1532-0820 ; 0023-6764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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