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  1. Article ; Online: Caring for Patients with Advanced Stage Cancer at the Time of COVID-19.

    Brunello, Antonella / Zagonel, Vittorina

    The oncologist

    2020  Volume 25, Issue 7, Page(s) e1131

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Influenza, Human ; Neoplasms ; Pandemics ; Patient Care ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2020-0230
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    Zs.A 4845: Show issues Location:
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  2. Article ; Online: Italian oncologists and vaccinations against infectious diseases: Results of a survey of the Italian Association of Medical Oncology.

    Lasagna, Angioletta / Brunello, Antonella / Silvestris, Nicola / Pedrazzoli, Paolo / Di Maio, Massimo / Cinieri, Saverio

    Tumori

    2023  Volume 110, Issue 1, Page(s) 60–68

    Abstract: Background: Patients with cancer present a higher risk of vaccine-preventable diseases. Recommended vaccinations are the most cost-effective measure to reduce the risk of transmission and related complications. Nevertheless, vaccination rates are ... ...

    Abstract Background: Patients with cancer present a higher risk of vaccine-preventable diseases. Recommended vaccinations are the most cost-effective measure to reduce the risk of transmission and related complications. Nevertheless, vaccination rates are inadequate. Oncologists have a central role in tailored vaccine communication to their patients. We present the results of a survey conducted by AIOM in 2022, focusing on the perception of the problem by oncologists.
    Materials and methods: An anonymous 31-item online questionnaire was shared on 15 September 2022 on the AIOM website. The objectives of this survey were to examine the perception of Italian oncologists on vaccine-preventable diseases and the main available vaccines, their attitude towards recommending vaccines and the COVID-19 pandemic impact on their habits regarding vaccine-preventable diseases.
    Results: Between September 2022 and January 2023, 114 medical oncologists (5% of the members) completed the anonymous questionnaire. At the first oncological visit, only 30% of respondents usually propose a vaccination schedule to all their patient, 41% do not usually discuss vaccinations at the first visit and 29% recommend vaccines exclusively to specific categories of patients. For 56% of respondents, patients are more aware of the benefits of vaccines, whereas 36% reported that patients are worried of receiving too many vaccines.
    Conclusion: This is the first survey conducted among Italian oncologists to better understand the perception and attitudes towards the vaccination. It highlights the urgent issues of educating and training oncologists in vaccine-preventable diseases and vaccine awareness and the need to build (or implement) a network of multidisciplinary collaborations.
    MeSH term(s) Humans ; Pandemics ; Vaccine-Preventable Diseases/chemically induced ; Vaccination ; Vaccines/adverse effects ; Surveys and Questionnaires ; Communicable Diseases/chemically induced ; Medical Oncology ; Oncologists ; Italy
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    DOI 10.1177/03008916231191547
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  3. Article ; Online: What do cancer patients experience of the simultaneous care clinic? Results of a cross-sectional study on patient care satisfaction.

    Galiano, Antonella / Feltrin, Alessandra / Pambuku, Ardi / Lo Mauro, Leda / De Toni, Chiara / Murgioni, Sabina / Soldà, Caterina / Maruzzo, Marco / Bergamo, Francesca / Brunello, Antonella / Zagonel, Vittorina

    Cancer medicine

    2024  Volume 13, Issue 3, Page(s) e7000

    Abstract: Background: Veneto Institute of Oncology has activated a simultaneous care outpatient clinic (SCOC) in which cancer patients with advanced-stage cancer are evaluated by oncologist and palliative care specialists. This cross-sectional study investigated ... ...

    Abstract Background: Veneto Institute of Oncology has activated a simultaneous care outpatient clinic (SCOC) in which cancer patients with advanced-stage cancer are evaluated by oncologist and palliative care specialists. This cross-sectional study investigated patients' perceptions of the quality of this service.
    Materials and methods: An ad-hoc self-administered questionnaire, developed by SCOC team, was used to assess the satisfaction of patients admitted at SCOC consultation. The questionnaire, in addition to the socio-demographic questions, contains eight questions with the Likert scale: time dedicated, feel listened to, feel understood, feel free to speak openly and to express doubts and concerns, feeling about information and indication received, level of empathy of health care and quality of the relationship, level of professional/quality of performance and utility of consultation, and one open-ended question. The questionnaire has been proposed to all 174 consecutively admitted patients at SCOC.
    Results: One hundred and sixty-two patients filled in the questionnaire: 66.7% were male, median age was 71 years, 88.3% had metastatic disease. The time dedicated to SCOC consultation was judged more than adequate (55%) or adequate (35%) by 90% of subjects. Patients completely satisfied about being listened to were 92.5%, with 80.9% being completely satisfied with understanding of their issues and 92% with the freedom to speak and express doubts. Usefulness of the SCOC was rated as excellent by 40% and good by 54.4% of patients. No statistically significant differences were observed in the responses to the questions by gender, age (< or ≥70 years old) and type of tumor.
    Conclusion: Our study shows high levels of satisfactions after SCOC consultation in advanced cancer subjects. Patients' feedback confirmed that SCOC model was effective in helping them during their treatment journey and decision at the end of life. This study encouraged us to enhance our practice of SCOC consultation.
    Implications for practice: A joint evaluation of patients living with cancer by oncologist and palliative care team (SCOC-embedded model), has shown to enhance patients' experience/satisfaction with care-such as listening, understanding, receiving information, symptom control, and decision about future, independently of age, gender, and kind of tumor.
    MeSH term(s) Humans ; Male ; Aged ; Female ; Patient Satisfaction ; Cross-Sectional Studies ; Palliative Care/methods ; Neoplasms/therapy ; Ambulatory Care Facilities ; Carrier Proteins ; Membrane Proteins
    Chemical Substances SCOC protein, human ; Carrier Proteins ; Membrane Proteins
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.7000
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  5. Article: Management and Outcomes of Older Patients (Age ≥ 70 Years) with Advanced Soft Tissue Sarcoma and Role of Geriatric Assessment and Oncological Multidimensional Prognostic Index (Onco-MPI) in a Real-World Setting.

    Chiusole, Benedetta / Tortorelli, Ilaria / Galiano, Antonella / Murtas, Fabio / Ahcene-Djaballah, Selma / Tierno, Giuseppina / Bergo, Eleonora / Banzato, Alberto / Gatti, Maura / Di Maggio, Antonio / Sergi, Giuseppe / Rastrelli, Marco / Sbaraglia, Marta / Zagonel, Vittorina / Brunello, Antonella

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041043
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  6. Article ; Online: Caring for Patients with Advanced Stage Cancer at the Time of COVID ‐19

    Brunello, Antonella / Zagonel, Vittorina

    The Oncologist

    2020  Volume 25, Issue 7

    Keywords Cancer Research ; Oncology ; covid19
    Language English
    Publisher Alphamed Press
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1409038-7
    ISSN 1083-7159
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2020-0230
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  7. Article ; Online: Caring for Patients with Advanced Stage Cancer at the Time of COVID ‐19

    Brunello, Antonella / Zagonel, Vittorina

    The Oncologist

    2020  Volume 25, Issue 7

    Keywords Cancer Research ; Oncology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1409038-7
    ISSN 1083-7159
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2020-0230
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  8. Article ; Online: Case report: The lesson from opioid withdrawal symptoms mimicking paraganglioma recurrence during opioid deprescribing in cancer pain.

    Ruggiero, Elena / Pambuku, Ardi / Caccese, Mario / Lombardi, Giuseppe / Gallio, Ivan / Brunello, Antonella / Ceccato, Filippo / Formaglio, Fabio

    Frontiers in pain research (Lausanne, Switzerland)

    2023  Volume 4, Page(s) 1256809

    Abstract: Pain is one of the predominant and troublesome symptoms that burden cancer patients during their whole disease trajectory: adequate pain management is a fundamental component of cancer care. Opioid are the cornerstone of cancer pain relief therapy and ... ...

    Abstract Pain is one of the predominant and troublesome symptoms that burden cancer patients during their whole disease trajectory: adequate pain management is a fundamental component of cancer care. Opioid are the cornerstone of cancer pain relief therapy and their skillful management must be owned by physicians approaching cancer pain patients. In light of the increased survival of cancer patients due to advances in therapy, deprescription should be considered as a part of the opioid prescribing regime, from therapy initiation, dose titration, and changing or adding drugs, to switching or ceasing. In clinical practice, opioid tapering after pain remission could be challenging due to withdrawal symptoms' onset. Animal models and observations in patients with opioid addiction suggested that somatic and motivational symptoms accompanying opioid withdrawal are secondary to the activation of stress-related process (mainly cortisol and catecholamines mediated). In this narrative review, we highlight how the lack of validated guidelines and tools for cancer patients can lead to a lower diagnostic awareness of opioid-related disorders, increasing the risk of developing withdrawal symptoms. We also described an experience-based approach to opioid withdrawal, starting from a case-report of a symptomatic patient with a history of metastatic pheochromocytoma-paraganglioma.
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2673-561X
    ISSN (online) 2673-561X
    DOI 10.3389/fpain.2023.1256809
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  9. Article ; Online: Sex Differences in Soft Tissue Sarcoma: Incidence, Clinicopathological Profile, Survival, and Costs.

    Buja, Alessandra / Rugge, Massimo / Tropea, Saveria / Cozzolino, Claudia / Formaro, Carlo Maria / Grotto, Giulia / Zorzi, Manuel / Vecchiato, Antonella / Del Fiore, Paolo / Brunello, Antonella / Sbaraglia, Marta / Ferroni, Eliana / Rossi, Carlo Riccardo / Dei Tos, Angelo Paolo / Mocellin, Simone

    Journal of women's health (2002)

    2023  Volume 32, Issue 11, Page(s) 1257–1264

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Humans ; Male ; Female ; Incidence ; Retrospective Studies ; Sex Characteristics ; Sarcoma/epidemiology ; Soft Tissue Neoplasms/epidemiology
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2023.0019
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    Zs.A 3584: Show issues Location:
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  10. Article ; Online: The black swan: a case of central nervous system graft-versus-host disease.

    Butera, Sara / Tavarozzi, Rita / Brunello, Lucia / Rivela, Paolo / Sofia, Antonella / Viero, Lorenzo / Salvio, Michela / Ladetto, Marco / Zallio, Francesco

    Journal of basic and clinical physiology and pharmacology

    2023  Volume 34, Issue 6, Page(s) 805–809

    Abstract: Objectives: Graft-versus-host disease (GVHD) of central nervous system is an atypical and rare manifestation of chronic GVHD, presenting with a heterogeneous spectrum of signs and symptoms. Diagnosis of neurological manifestations of GVHD can be highly ... ...

    Abstract Objectives: Graft-versus-host disease (GVHD) of central nervous system is an atypical and rare manifestation of chronic GVHD, presenting with a heterogeneous spectrum of signs and symptoms. Diagnosis of neurological manifestations of GVHD can be highly challenging and remain associated with dismal prognosis, significant morbidity, and reduced quality of life.
    Case presentation: In this report, we describe a 39-year-old woman developing neurological signs and symptoms 8 months after allogeneic HSCT magnetic resonance imaging showed multifocal hyperintense lesions involving the periventricular region and frontal subcortical white matter. There was no laboratory evidence of infective or malignant etiology, and the case was diagnosed as CNS-GVHD. The patient was treated with intravenous methylprednisolone pulse therapy and the clinical conditions gradually improved. After few months, patient symptoms progressed despite the addition of high-dose intravenous immunoglobulin, tacrolimus, and a new course of high dose steroids. To engage targeted therapy, the patient underwent brain biopsy that revealed a loss of myelin fibers, perivascular and diffuse infiltration of T cells, and macrophages associated with reactive gliosis, representing a demyelinating disease. We intensified treatment with cyclophosphamide and subsequently introduced ibrutinib as salvage strategy. Despite a magnetic resonance imaging showing great regression of the demyelinating lesions, patient's conditions deteriorated and she died 16 months after HSCT.
    Conclusions: CNS-GVHD is a rare complication of HSCT that is difficult to diagnose. Based on our experience, brain biopsy may represent a useful diagnostic tool when the clinical features of neurological symptoms are ambiguous or in patients without evidence of preceding chronic GVHD.
    MeSH term(s) Female ; Humans ; Adult ; Hematopoietic Stem Cell Transplantation/adverse effects ; Quality of Life ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/etiology ; Central Nervous System/pathology ; Tacrolimus/therapeutic use ; Bronchiolitis Obliterans Syndrome
    Chemical Substances Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2023-10-17
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1071737-7
    ISSN 2191-0286 ; 0792-6855 ; 0334-1534
    ISSN (online) 2191-0286
    ISSN 0792-6855 ; 0334-1534
    DOI 10.1515/jbcpp-2023-0194
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    Zs.A 3207: Show issues Location:
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