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  1. Article ; Online: Tamoxifen evolution.

    Howell, A / Howell, S J

    British journal of cancer

    2023  Volume 128, Issue 3, Page(s) 421–425

    MeSH term(s) Humans ; Female ; Tamoxifen/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy
    Chemical Substances Tamoxifen (094ZI81Y45) ; Antineoplastic Agents, Hormonal
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-023-02158-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: S. Cederroth, C. Corlin, J. Lindström, eds. On the Morning of Death

    Signe Howell

    The Copenhagen Journal of Asian Studies, Vol 6, Iss

    Essays on Mortuary Rituals and Eschatological Beliefs

    1991  Volume 1

    Keywords Political institutions and public administration - Asia (Asian studies only) ; JQ1-6651 ; Social sciences and state - Asia (Asian studies only) ; H53
    Language English
    Publishing date 1991-07-01T00:00:00Z
    Publisher CBS Open Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Preoperative hypertension: perioperative implications and management.

    Tait, A / Howell, S J

    BJA education

    2021  Volume 21, Issue 11, Page(s) 426–432

    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2888911-3
    ISSN 2058-5357 ; 2058-5349
    ISSN (online) 2058-5357
    ISSN 2058-5349
    DOI 10.1016/j.bjae.2021.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pathogenic variant detection rate varies considerably in male breast cancer families and sporadic cases: minimal additional contribution beyond

    Evans, D Gareth / Burghel, George J / Howell, Sacha J / Pugh, Sarah / Forde, Claire / Howell, Anthony / Lalloo, Fiona / Woodward, Emma Roisin

    Journal of medical genetics

    2024  

    Abstract: Background: Male breast cancer (MBC) affects around 1 in 1000 men and is known to have a higher underlying component of high and moderate risk gene pathogenic variants (PVs) than female breast cancer, particularly in : Methods: We reviewed germline ... ...

    Abstract Background: Male breast cancer (MBC) affects around 1 in 1000 men and is known to have a higher underlying component of high and moderate risk gene pathogenic variants (PVs) than female breast cancer, particularly in
    Methods: We reviewed germline testing in 204 families including at least one MBC for
    Results: In the 204 families,
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmg-2023-109826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Abdominal aortic aneurysm repair in the United Kingdom: an exemplar for the role of anaesthetists in perioperative medicine.

    Howell, S J

    British journal of anaesthesia

    2017  Volume 119, Issue suppl_1, Page(s) i15–i22

    Abstract: The past two decades have seen an increasing recognition that the delivery of safe surgery with low complication rates and good long-term outcomes is a team endeavour embracing the whole patient care pathway. The key role of the anaesthetist in managing ... ...

    Abstract The past two decades have seen an increasing recognition that the delivery of safe surgery with low complication rates and good long-term outcomes is a team endeavour embracing the whole patient care pathway. The key role of the anaesthetist in managing the patient through the surgical process is widely understood and has driven the emergence of perioperative medicine. In parallel with these developments there has been a sea change in the organisation of the care of patients presenting for elective abdominal aortic aneurysm (AAA) repair. Data from the 2008 report of the VASCUNET vascular registry suggested that the UK had the highest mortality for elective open AAA repair in Europe (7.9%). In response, a national quality improvement programme (AAAQIP) spanning the disciplines of surgery, anaesthesia, radiology and nursing was put in place. This led to significant changes in all aspects of AAA repair including the role of the anaesthetist. Preoperative assessment by an anaesthetist with a vascular practice was mandated and the role of the anaesthetist in the vascular multidisciplinary team meeting (MDT) established. Anaesthetic data were included in the national data collection system for vascular surgery, the National Vascular Registry. These changes paralleled and in some cases led the wider evolution of the role of the anaesthetist in perioperative medicine. The mortality from infrarenal AAA repair in the UK decreased to 2.4% by 2012. This improvement reflects changes in perioperative care supported and in some cases led by anaesthetists.
    MeSH term(s) Anesthesiology/methods ; Anesthetists ; Aortic Aneurysm, Abdominal/surgery ; Endovascular Procedures/methods ; Humans ; Length of Stay ; Perioperative Care/methods ; United Kingdom
    Language English
    Publishing date 2017-11-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1093/bja/aex360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Measuring frailty in the older surgical patient: the case for evidence synthesis.

    Howell, Simon J / Nair, Sherena

    British journal of anaesthesia

    2021  Volume 126, Issue 4, Page(s) 763–767

    MeSH term(s) Aged ; Aged, 80 and over ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Geriatric Assessment/methods ; Humans ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Risk Factors
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Editorial ; Systematic Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Process, structural, and outcome quality indicators to support perioperative opioid stewardship: a rapid review.

    Thomas, C / Ayres, M / Pye, K / Yassin, D / Howell, S J / Alderson, S

    Perioperative medicine (London, England)

    2023  Volume 12, Issue 1, Page(s) 34

    Abstract: Opioids are effective analgesics but can cause harm. Opioid stewardship is key to ensuring that opioids are used effectively and safely. There is no agreed set of quality indicators relating to the use of opioids perioperatively. This work is part of the ...

    Abstract Opioids are effective analgesics but can cause harm. Opioid stewardship is key to ensuring that opioids are used effectively and safely. There is no agreed set of quality indicators relating to the use of opioids perioperatively. This work is part of the Yorkshire Cancer Research Bowel Cancer Quality Improvement programme and aims to develop useful quality indicators for the improvement of care and patient outcomes at all stages of the perioperative journey.A rapid review was performed to identify original research and reviews in which quality indicators for perioperative opioid use are described. A data tool was developed to enable reliable and reproducible extraction of opioid quality indicators.A review of 628 abstracts and 118 full-text publications was undertaken. Opioid quality indicators were identified from 47 full-text publications. In total, 128 structure, process and outcome quality indicators were extracted. Duplicates were merged, with the final extraction of 24 discrete indicators. These indicators are based on five topics: patient education, clinician education, pre-operative optimization, procedure, and patient-specific prescribing and de-prescribing and opioid-related adverse drug events.The quality indicators are presented as a toolkit to contribute to practical opioid stewardship. Process indicators were most commonly identified and contribute most to quality improvement. Fewer quality indicators relating to intraoperative and immediate recovery stages of the patient journey were identified. An expert clinician panel will be convened to agree which of the quality indicators identified will be most valuable in our region for the management of patients undergoing surgery for bowel cancer.
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2683800-X
    ISSN 2047-0525
    ISSN 2047-0525
    DOI 10.1186/s13741-023-00312-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Integrating Measures of Fecal Glucocorticoid Metabolites and Giving-Up Densities to Assess Adrenocortical Activity and Well-Being in Zoo-Housed Three-Banded Armadillos (

    Howell-Stephens, Jennifer / Potratz, Emily J / Brown, Joel S / Bernier, Dave / Santymire, Rachel M

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 12

    Abstract: To monitor adrenocortical activity in zoo-housed species, we propose using physiological and behavioral indicators that are non-invasive and practical to implement. We explore this model in the southern three-banded armadillo ( ...

    Abstract To monitor adrenocortical activity in zoo-housed species, we propose using physiological and behavioral indicators that are non-invasive and practical to implement. We explore this model in the southern three-banded armadillo (
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13121975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Closing the gender gap in gastroenterology leadership.

    Bowker-Howell, Freya J / Kaur, Kamaldeep E / Raju, Suneil A / Sanders, David S

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 4, Page(s) 302

    MeSH term(s) Humans ; Leadership ; Gastroenterology ; Sex Factors ; Gastrointestinal Tract
    Language English
    Publishing date 2023-03-10
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00013-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A pragmatic qualitative study to explore women's and clinicians' experience of access to systemic anti-cancer therapies for the treatment of secondary breast cancer.

    Pearson, Sally Anne / Taylor, Sally / Krishan, Ashma / Marsden, Antonia / Howell, Sacha / Yorke, Janelle

    European journal of oncology nursing : the official journal of European Oncology Nursing Society

    2024  Volume 70, Page(s) 102515

    Abstract: Purpose: An estimated 57,000 women are currently living with secondary (metastatic) breast cancer across the UK. Equitable access to treatment has been associated with improved clinical outcomes, however geographical disparities have been reported which ...

    Abstract Purpose: An estimated 57,000 women are currently living with secondary (metastatic) breast cancer across the UK. Equitable access to treatment has been associated with improved clinical outcomes, however geographical disparities have been reported which remain poorly understood. The purpose of our study was to explore women and clinicians' experience of geographic access to systemic anti-cancer therapies for the treatment of secondary breast cancer.
    Method: The study setting was the integrated cancer system across the northwest region of Greater Manchester UK. A pragmatic qualitative study design was used. Women aged >18 years with a confirmed SBC diagnosis and clinicians responsible for the care and treatment of women with a secondary breast cancer diagnosis were interviewed using semi structured interviews to elicit their experience and perspectives on geographic access to treatment. Data were analysed using thematic analysis to identify emergent themes.
    Results: Eighteen interviews with women and 12 interviews with clinicians were completed. Four meta-themes were identified for geographic access, the influence of the health care system, person centred factors and the impact of Covid-19 on treatment access and receipt.
    Conclusion: Our study was the first of its kind to explore women and clinicians experience of geographic access to systemic anti-cancer therapies for the treatment of secondary breast cancer. Findings provided a greater understanding of distance decay and the influence of the health care system on treatment access. This included the importance and availability of clinical trials as a potential treatment option. This provided important insights and contributed to ongoing debate.
    Language English
    Publishing date 2024-02-02
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2017117-1
    ISSN 1532-2122 ; 1462-3889
    ISSN (online) 1532-2122
    ISSN 1462-3889
    DOI 10.1016/j.ejon.2024.102515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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