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Article ; Online: Analysis of O-Glycopeptides by Acetone Enrichment and Capillary Electrophoresis-Mass Spectrometry.

Mancera-Arteu, Montserrat / Giménez, Estela / Benavente, Fernando / Barbosa, José / Sanz-Nebot, Victòria

2017 Volume 16, Issue 11, Page(s) 4166–4176

Abstract: ... for the selective purification of O-glycopeptides from enzymatic digests of glycoproteins. Ovalbumin (OVA), human ...

Abstract	Acetone precipitation was evaluated as a rapid, simple, low-cost, and efficient method for the selective purification of O-glycopeptides from enzymatic digests of glycoproteins. Ovalbumin (OVA), human and bovine α
MeSH term(s)	Acetone/chemistry ; Animals ; Apolipoprotein C-III/metabolism ; Cattle ; Chemical Precipitation ; Electrophoresis, Capillary/methods ; Erythropoietin/metabolism ; Glycopeptides/analysis ; Glycopeptides/isolation & purification ; Humans ; Mass Spectrometry/methods ; Orosomucoid/metabolism ; Ovalbumin/metabolism
Chemical Substances	Apolipoprotein C-III ; Glycopeptides ; Orosomucoid ; Erythropoietin (11096-26-7) ; Acetone (1364PS73AF) ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2017-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.7b00524
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Article: Analysis of O-Glycopeptides by Acetone Enrichment and Capillary Electrophoresis-Mass Spectrometry

Mancera-Arteu, Montserrat / Giménez Estela / Benavente Fernando / Barbosa José / Sanz-Nebot Victòria

Journal of Proteome Research. 2017 Nov. 03, v. 16, no. 11

2017

Abstract: ... for the selective purification of O-glycopeptides from enzymatic digests of glycoproteins. Ovalbumin (OVA), human ... of peptides, N-glycopeptides, and O-glycopeptides. After digestion and before capillary electrophoresis ... recoveries of O-glycopeptides. Furthermore, the different behavior of peptides, N- and O-glycopeptides was ...

Abstract	Acetone precipitation was evaluated as a rapid, simple, low-cost, and efficient method for the selective purification of O-glycopeptides from enzymatic digests of glycoproteins. Ovalbumin (OVA), human and bovine α₁-acid glycoprotein (hAGP and bAGP), human apolipoprotein C–III (APO-C3), and recombinant human erythropoietin (rhEPO) were used to obtain enzymatic digests with a broad and varied set of peptides, N-glycopeptides, and O-glycopeptides. After digestion and before capillary electrophoresis mass spectrometry (CE-MS) analysis, the amount of ice-cold acetone added to the digests was optimized to maximize recoveries of O-glycopeptides. Furthermore, the different behavior of peptides, N- and O-glycopeptides was explained by studying with multivariate data analysis methods the influence of several physicochemical parameters and properties related to their composition and structure. Principal component analysis (PCA) and, afterward, partial least-squares discriminant analysis (PLS-DA) were used to identify the most significant variables and their importance to differentiate between peptides, N-glycopeptides and O-glycopeptides, or within these classes. This information was useful to understand precipitation of these compounds after addition of acetone and for the selection of the optimal conditions for purification of specific O-glycopeptide biomarkers. Special attention was paid to O₁₂₆-glycopeptide glycoforms of rhEPO because of their applicability in biopharmaceutical quality control and doping analysis.
Keywords	acetone ; apolipoprotein C-III ; biomarkers ; biopharmaceuticals ; capillary electrophoresis ; cattle ; digestion ; discriminant analysis ; erythropoietin ; humans ; least squares ; mass spectrometry ; ovalbumin ; physicochemical properties ; principal component analysis ; proteome ; quality control
Language	English
Dates of publication	2017-1103
Size	p. 4166-4176.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021%2Facs.jproteome.7b00524
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Recomendaciones para la prevención, la detección y el manejo de la hiperbilirrubinemia en los recién nacidos con 35 o más semanas de edad gestacional.

Sánchez-Redondo Sánchez-Gabriel, María Dolores / Leante Castellanos, José Luis / Benavente Fernández, Isabel / Pérez Muñuzuri, Alejandro / Rite Gracia, Segundo / Ruiz Campillo, Cesar W / Sanz López, Ester / Sánchez Luna, Manuel

Anales de pediatria (Barcelona, Spain : 2003)

2017 Volume 87, Issue 5, Page(s) 294.e1–294.e8

Abstract: Hyperbilirubinaemia is one of the most frequent causes of hospital readmission during the first week of life. Its detection is still a big challenge, mainly due to the early discharge from the hospital that can be associated with a delay of the diagnosis. ...

Title translation	Guidelines for prevention, detection and management of hyperbilirubinaemia in newborns of 35 or more weeks of gestation.
Abstract	Hyperbilirubinaemia is one of the most frequent causes of hospital readmission during the first week of life. Its detection is still a big challenge, mainly due to the early discharge from the hospital that can be associated with a delay of the diagnosis. The identification of those newborns at risk of developing significant hyperbilirubinaemia is one of the main priorities in the public health care system. An approach to the management of newborn jaundice is presented in this article, following the recommendations based on the medical evidence and on the opinion of the Standards Committee of the Spanish Society of Neonatology.
MeSH term(s)	Gestational Age ; Humans ; Hyperbilirubinemia/diagnosis ; Hyperbilirubinemia/prevention & control ; Hyperbilirubinemia/therapy ; Infant, Newborn
Language	Spanish
Publishing date	2017-05-16
Publishing country	Spain
Document type	Journal Article ; Practice Guideline
ISSN	1695-9531
ISSN (online)	1695-9531
DOI	10.1016/j.anpedi.2017.03.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: EL CONTRATO DE KNOW HOW O DE PROVISIÓN DE CONOCIMIENTOS TÉCNICOS

Hesbert Benavente Chorres

Ius et Praxis , Vol 14, Iss 2, Pp 407-

ASPECTOS A SER CONSIDERADOS PARA SU REGULACIÓN NORMATIVA THE AGREEMENT OF KNOW HOW OR OF PROVISION OF TECHNICAL KNOWLEDGES: APPEARANCES TO SER CONSIDERED FOR HIS REGULACIÓN NORMATIVE

2008 Volume 457

Abstract: ... características y naturaleza jurídica del contrato de Know How o de provisión de conocimientos técnicos, entendido ... como: aquel negocio jurídico cuyo objeto es la cesión o transmisión del derecho sobre un conocimiento técnico ...

Abstract	Mediante el presente estudio se analizarán los diferentes conceptos, así como, cláusulas, características y naturaleza jurídica del contrato de Know How o de provisión de conocimientos técnicos, entendido como: aquel negocio jurídico cuyo objeto es la cesión o transmisión del derecho sobre un conocimiento técnico reservado, realizada por su titular a favor de la otra parte, a cambio de una contraprestación; resaltándose tanto la posibilidad de cesión, así como de venta - modalidad discutida en la doctrina - del Know How. Todo ello, con fines de establecer los lineamientos para su positivización en el ordenamiento jurídico, para lo cual, se anexa un proyecto de ley, el cual se estructura con lo desarrollado en la presente investigación. By means of the present study the different concepts will be analyzed, as well as, clauses, characteristics and juridical nature of the contract of Know How or of provision of technical knowledge, understood like: that juridical business which object is the transfer or transmission of the right on a technical knowledge reserved, realized by your holder in favour of another part, in exchange for a consideration; the possibility of transfer being highlighted so much, as well as of sale - modality discussed in the doctrine - of the Know How. All this, with purposes of establishing the limits for your positivización in the Juridical system, for which, there is annexed a project of law, which is constructed by the developed in the present research.
Keywords	Know How ; cesión ; venta ; pautas para su legislación ; transfer ; sale ; rules for your legislation ; Law in general. Comparative and uniform law. Jurisprudence ; K1-7720 ; Law ; K ; DOAJ:Law ; DOAJ:Law and Political Science
Language	Spanish
Publishing date	2008-01-01T00:00:00Z
Publisher	Universidad de Talca
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Reset osmostat o alteración del osmorreceptor.

Benavente Fernández, A / Pérez Ramos, M A / Romero-Jiménez, M J / Barrios Merino, A

Anales de medicina interna (Madrid, Spain : 1984)

2001 Volume 18, Issue 11, Page(s) 606; author reply 607

Title translation	Reset osmostat or altered osmoreceptor.
MeSH term(s)	Humans ; Water-Electrolyte Imbalance/diagnosis
Language	Spanish
Publishing date	2001-11
Publishing country	Spain
Document type	Comment ; Letter
ZDB-ID	639013-4
ISSN	0212-7199
ISSN	0212-7199
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Imaginería o escultura religiosa cusqueña de los siglos XVI, XVII y XVIII

Benavente Velarde, Teófilo

historia del arte cusqueño

2006

Author's details	Teófilo Benavente Velarde
Keywords	Christian saints in art ; Indians of South America ; Sculpture, Peruvian
Language	Spanish
Size	XXI, 222 S, zahlr. Ill
Edition	1. ed
Publisher	Publicación Familia Benavente-Gutiérrez
Publishing place	Cusco
Document type	Book
ISBN	9972333477 ; 9789972333477
Database	Former special subject collection: coastal and deep sea fishing

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Article: Síndrome "Nutcracker" o Cascanueces: demostración mediante TAC Helicoidal con reconstrucción "3D" (VR).

Martínez-Salamanca García, J I / Herranz Amo, F / Gordillo Gutiérrez, I / Díez Cordero, J M / Subirá Ríos, D / Castaño González, I / Moralejo Gárate, M / Cabello Benavente, R / Hernández Fernández, C

Actas urologicas espanolas

2004 Volume 28, Issue 7, Page(s) 549–552

Abstract: The nutcracker's syndrome or phenomenom is defined as the left renal vein compression between the aorta and the superior mesenteric artery. Diagnosis is uncommon, not only due to its low frequency but for the dificulty to be suspected in usual findings ... ...

Title translation	Nutcracker's syndrome: demostration with helicoidal TC with volumetric reconstruction "3D".
Abstract	The nutcracker's syndrome or phenomenom is defined as the left renal vein compression between the aorta and the superior mesenteric artery. Diagnosis is uncommon, not only due to its low frequency but for the dificulty to be suspected in usual findings as lumbar pain or hematuria. We present the case of a patient to whom we were able to show mentioned pathology with the helicoidal TC with volumetric reconstruction "3D" (VR).
MeSH term(s)	Adult ; Constriction, Pathologic/complications ; Constriction, Pathologic/diagnostic imaging ; Female ; Hematuria/diagnostic imaging ; Hematuria/etiology ; Hematuria/therapy ; Humans ; Renal Veins/diagnostic imaging ; Renal Veins/pathology ; Tomography, Spiral Computed ; Treatment Outcome
Language	Spanish
Publishing date	2004-07-21
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	604530-3
ISSN	0210-4806
ISSN	0210-4806
DOI	10.1016/s0210-4806(04)73128-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative characterisation and phytotoxicity assessment of biochar and hydrochar derived from municipal wastewater microalgae biomass.

Sun, Jiacheng / Benavente, Veronica / Jansson, Stina / Mašek, Ondřej

Bioresource technology

2023 Volume 386, Page(s) 129567

Abstract: Microalgae, originating from a tertiary treatment of municipal wastewater, is considered a sustainable feedstock for producing biochar and hydrochar, offering great potential for agricultural use due to nutrient content and carbon storage ability. ... ...

Abstract	Microalgae, originating from a tertiary treatment of municipal wastewater, is considered a sustainable feedstock for producing biochar and hydrochar, offering great potential for agricultural use due to nutrient content and carbon storage ability. However, there are risks related to contamination and these need to be carefully assessed to ensure safe use of material from wastewater microalgae. Therefore, this study compared the properties and phototoxicity of biochar and hydrochar produced via pyrolysis and hydrothermal carbonisation (HTC) of microalgae under different temperatures and residence times. While biochar promoted germination and seedling growth by up to 11.0% and 70.0%, respectively, raw hydrochar showed strong phytotoxicity, due to the high content of volatile matter. Two post-treatments, dichloromethane (DCM) washing and further pyrolysis, proved to be effective methods for mitigating phytotoxicity of hydrochar. Additionally, biochar had 35.8-38.6% fixed carbon, resulting in higher carbon sequestration potential compared to hydrochar.
MeSH term(s)	Wastewater ; Microalgae ; Biomass ; Temperature ; Carbon
Chemical Substances	biochar ; Wastewater ; Carbon (7440-44-0)
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129567
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sensitive Analysis of Recombinant Human Erythropoietin Glycopeptides by On-Line Phenylboronic Acid Solid-Phase Extraction Capillary Electrophoresis Mass Spectrometry.

Mancera-Arteu, Montserrat / Benavente, Fernando / Sanz-Nebot, Victoria / Giménez, Estela

Journal of proteome research

2023 Volume 22, Issue 3, Page(s) 826–836

Abstract: ... The tryptic O ...

Abstract	In this study, several chromatographic sorbents: porous graphitic carbon (PGC), aminopropyl hydrophilic interaction (aminopropyl-HILIC), and phenylboronic acid (PBA) were assessed for the analysis of glycopeptides by on-line solid-phase extraction capillary electrophoresis mass spectrometry (SPE-CE-MS). As the PBA sorbent provided the most promising results, a PBA-SPE-CE-MS method was developed for the selective and sensitive preconcentration of glycopeptides from enzymatic digests of glycoproteins. Recombinant human erythropoietin (rhEPO) was selected as the model glycoprotein and subjected to enzymatic digestion with several proteases. The tryptic O
MeSH term(s)	Humans ; Electrophoresis, Capillary/methods ; Erythropoietin/metabolism ; Glycopeptides/analysis ; Glycoproteins ; Mass Spectrometry/methods ; Recombinant Proteins/analysis ; Solid Phase Extraction/methods
Chemical Substances	benzeneboronic acid (L12H7B02G5) ; Erythropoietin (11096-26-7) ; Glycopeptides ; Glycoproteins ; Recombinant Proteins ; titanium dioxide (15FIX9V2JP) ; EPO protein, human
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.2c00569
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Article: Profilaxis del cáncer superficial de vejiga con Mitomicina C o Interferón: resultados definitivos de un estudio prospectivo.

Ojea Calvo, A / Domínguez Freire, F / Vérez Vivero, M / Alonso Rodrigo, A / Rodríguez Iglesias, B / Benavente Delgado, J / Barros Rodríguez, M / Nogueira March, Y J

Archivos espanoles de urologia

1996 Volume 49, Issue 8, Page(s) 807–812

Abstract: Objectives: Herein we present the final results of a prospective randomized study comparing two prophylactic treatment modalities for superficial bladder tumors: chemotherapy with mitomycin C and immunotherapy with interferon.: Methods: The study ... ...

Title translation	Prevention of superficial bladder cancer with mitomycin C or interferon: final results of a prospective study.
Abstract	Objectives: Herein we present the final results of a prospective randomized study comparing two prophylactic treatment modalities for superficial bladder tumors: chemotherapy with mitomycin C and immunotherapy with interferon. Methods: The study comprised 65 patients. Mitomycin C was utilized in 34 and interferon in 31 patients. Results: The mitomycin C-treated patients had 41% recurrence, 1.7 recurrence/100 patients-month, 17 months mean time to recurrence and 8.8% tumor progression. The patients receiving interferon had 45% recurrence, 2.4 recurrence/100 patients-month, 12 months mean time to recurrence and 22.2% tumor progression rate. No significant differences were observed between the two groups of patients. Treatment was well-tolerated by both groups and the cost:efficacy ratio was higher for the interferon-treated patients. Conclusions: Immunoprophylaxis with interferon is as effective, but costs more than chemoprophylaxis with mitomycin C. Both agents have a moderate effect relative to control of recurrence, time to recurrence and tumor progression.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Humans ; Interferon-alpha/therapeutic use ; Middle Aged ; Mitomycin/therapeutic use ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Prospective Studies ; Recombinant Proteins ; Urinary Bladder Neoplasms/prevention & control
Chemical Substances	Interferon-alpha ; Recombinant Proteins ; interferon alfa-2a (47RRR83SK7) ; Mitomycin (50SG953SK6)
Language	Spanish
Publishing date	1996-10
Publishing country	Spain
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
Database	MEDical Literature Analysis and Retrieval System OnLINE

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