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  1. Article ; Online: A Biotinylated cpFIT-PNA Platform for the Facile Detection of Drug Resistance to Artemisinin in

    Tepper, Odelia / Appella, Daniel H / Zheng, Hongchao / Dzikowski, Ron / Yavin, Eylon

    ACS sensors

    2024  Volume 9, Issue 3, Page(s) 1458–1464

    Abstract: The evolution of drug resistance to many antimalarial drugs in the lethal strain of malaria ( ...

    Abstract The evolution of drug resistance to many antimalarial drugs in the lethal strain of malaria (
    MeSH term(s) Humans ; Plasmodium falciparum/genetics ; Peptide Nucleic Acids ; Streptavidin ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Protozoan Proteins/pharmacology ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; Malaria, Falciparum/drug therapy ; Drug Resistance/genetics ; RNA
    Chemical Substances Peptide Nucleic Acids ; Streptavidin (9013-20-1) ; Protozoan Proteins ; artemisinin (9RMU91N5K2) ; Artemisinins ; RNA (63231-63-0)
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c02553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Cyclopentane FIT-PNAs: bright RNA sensors.

    Tepper, Odelia / Zheng, Hongchao / Appella, Daniel H / Yavin, Eylon

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 77, Page(s) 11593

    Abstract: Correction for 'Cyclopentane FIT-PNAs: bright RNA sensors' by Odelia ... ...

    Abstract Correction for 'Cyclopentane FIT-PNAs: bright RNA sensors' by Odelia Tepper
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc90303f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intrathecal Saline Infusion as an Effective Temporizing Measure in the Management of Spontaneous Intracranial Hypotension.

    Muram, Sandeep / Yavin, Daniel / DuPlessis, Stephan

    World neurosurgery

    2019  Volume 125, Page(s) 37–41

    Abstract: Background: Spontaneous intracranial hypotension (SIH) is a rare condition for which no optimal treatment guidelines have been determined. The most common presentation is orthostatic headaches, but patients can present with a variety of symptoms.: ... ...

    Abstract Background: Spontaneous intracranial hypotension (SIH) is a rare condition for which no optimal treatment guidelines have been determined. The most common presentation is orthostatic headaches, but patients can present with a variety of symptoms.
    Case description: We present a case of a 34-year-old man who developed progressive orthostatic headaches and bilateral subdural collections. His symptoms along with imaging of his brain and spine were consistent with SIH. Unfortunately, his symptoms continued to progress, and his level of consciousness became affected. The patient did not respond to either conservative management or epidural blood patching. As the result of his worsening condition, a lumbar drain was inserted for the intrathecal infusion of normal saline to prevent tonsillar herniation. Once the infusion was started, his level of consciousness improved. It was discovered that his cerebrospinal fluid leak was due to an osteophyte within his thoracic spine, which was eroding the dura. He underwent a costo-transversectomy with the removal of the osteophyte and repair of the dural defect. The patient had some improvement after this procedure, but he remained more somnolent than expected. On subsequent imaging, it was found that his subdural collections had increased slightly in size and it was decided to drain them. Both collections were released under high pressure, and he went on to make an excellent recovery.
    Conclusions: This case demonstrates that an intrathecal saline infusion can be used as an effective temporizing measure in patients with critical symptoms of SIH and it also alerts clinicians that low-pressure subdural collections can progress to subdural collections under high pressure.
    MeSH term(s) Adult ; Cerebrospinal Fluid Leak/diagnostic imaging ; Cerebrospinal Fluid Leak/therapy ; Disease Management ; Humans ; Injections, Spinal ; Intracranial Hypotension/diagnostic imaging ; Intracranial Hypotension/therapy ; Male ; Saline Solution/administration & dosage ; Treatment Outcome
    Chemical Substances Saline Solution
    Language English
    Publishing date 2019-02-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.01.127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cyclopentane FIT-PNAs: bright RNA sensors.

    Tepper, Odelia / Zheng, Hongchao / Appella, Daniel H / Yavin, Eylon

    Chemical communications (Cambridge, England)

    2020  Volume 57, Issue 4, Page(s) 540–543

    Abstract: Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine ... ...

    Abstract Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine-pyrimidine single nucleotide variants (SNVs).
    MeSH term(s) Benzothiazoles/chemistry ; Cyclopentanes/chemistry ; Fluorescent Dyes/chemistry ; Limit of Detection ; Nucleic Acid Hybridization ; Peptide Nucleic Acids/chemistry ; Peptide Nucleic Acids/genetics ; Quinolines/chemistry ; RNA/analysis ; RNA/genetics ; Spectrometry, Fluorescence
    Chemical Substances Benzothiazoles ; Cyclopentanes ; Fluorescent Dyes ; Peptide Nucleic Acids ; Quinolines ; thiazole orange (107091-89-4) ; RNA (63231-63-0)
    Language English
    Publishing date 2020-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc07400d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increasing Lesion Dimensions of Bipolar Ablation by Modulating the Surface Area of the Return Electrode.

    Younis, Arwa / Yavin, Hagai D / Higuchi, Koji / Zilberman, Israel / Sroubek, Jakub / Tchou, Patrick / Bubar, Zachary P / Barkagan, Michael / Leshem, Eran / Shapira-Daniels, Ayelet / Kanj, Mohamad / Cantillon, Daniel J / Hussein, Ayman A / Tarakji, Khaldoun G / Saliba, Walid I / Koruth, Jacob S / Anter, Elad

    JACC. Clinical electrophysiology

    2022  Volume 8, Issue 4, Page(s) 498–510

    Abstract: Objectives: This study sought to examine the effect of the return electrode's surface area on bipolar RFA lesion size.: Background: Bipolar radiofrequency ablation (RFA) is typically performed between 2 3.5-mm tip catheters serving as active and ... ...

    Abstract Objectives: This study sought to examine the effect of the return electrode's surface area on bipolar RFA lesion size.
    Background: Bipolar radiofrequency ablation (RFA) is typically performed between 2 3.5-mm tip catheters serving as active and return electrodes. We hypothesized that increasing the surface area of the return electrode would increase lesion dimensions by reducing the circuit impedance, thus increasing the current into a larger tissue volume enclosed between the electrodes.
    Methods: In step 1, ex vivo bipolar RFA was performed between 3.5-mm and custom-made return electrodes with increasing surface areas (20, 80, 180 mm
    Results: In step 1, increasing the surface area of the return electrode resulted in lower circuit impedance (R = -0.65; P < 0.001), higher current (R = +0.80; P < 0.001), and larger lesion volume (R = +0.88; P < 0.001). In step 2, an 8-mm return electrode parallel to tissue produced larger and deeper lesions compared with a 3.5-mm return electrode (P = 0.014 and P = 0.02). Similarly, in step 3, compared with a 3.5-mm, bipolar RFA with an 8-mm return electrode produced larger (volume: 1,525 ± 871 mm
    Conclusions: Bipolar RFA using an 8-mm return electrode positioned parallel to the tissue produces larger lesions in comparison with a 3.5-mm return electrode.
    MeSH term(s) Catheter Ablation/methods ; Electrodes ; Equipment Design ; Heart Ventricles/surgery ; Humans
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2022.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of High-Power Short-Duration Radiofrequency Ablation on Esophageal Temperature Dynamic.

    Yavin, Hagai D / Bubar, Zachary P / Higuchi, Koji / Sroubek, Jakub / Kanj, Mohamed / Cantillon, Daniel / Saliba, Walid I / Tarakji, Khaldoun G / Hussein, Ayman A / Wazni, Oussama / Anter, Elad

    Circulation. Arrhythmia and electrophysiology

    2021  Volume 14, Issue 11, Page(s) e010205

    Abstract: Background: High-power short-duration (HP-SD) radiofrequency ablation (RFA) has been proposed as a method for producing rapid and effective lesions for pulmonary vein isolation. The underlying hypothesis assumes an increased resistive heating phase and ... ...

    Abstract Background: High-power short-duration (HP-SD) radiofrequency ablation (RFA) has been proposed as a method for producing rapid and effective lesions for pulmonary vein isolation. The underlying hypothesis assumes an increased resistive heating phase and decreased conductive heating phase, potentially reducing the risk for esophageal thermal injury. The objective of this study was to compare the esophageal temperature dynamic profile between HP-SD and moderate-power moderate-duration (MP-MD) RFA ablation strategies.
    Methods: In patients undergoing pulmonary vein isolation, RFA juxtaposed to the esophagus was delivered in an alternate sequence of HP-SD (50 W, 8-10 s) and MP-MD (25 W, 15-20 s) between adjacent applications (distance, ≤4 mm). Esophageal temperature was recorded using a multisensor probe (CIRCA S-CATH). Temperature data included magnitude of temperature rise, maximal temperature, time to maximal temperature, and time return to baseline. In swine, a similar experimental design compared the effect of HP-SD and MP-MD on patterns of esophageal injury.
    Results: In 20 patients (68.9±5.8 years old; 60% persistent atrial fibrillation), 55 paired HP-SD and MP-MD applications were analyzed. The esophageal temperature dynamic profile was similar between HP-SD and MP-MD ablation strategies. Specifically, the magnitude of temperature rise (2.1 °C [1.4-3] versus 2.0 °C [1.5-3];
    Conclusions: Esophageal temperature dynamics are similar between HP-SD and MP-MD RFA strategies and result in comparable esophageal tissue injury. Therefore, when using a HP-SD RFA strategy, the shorter application duration should not prompt shorter intervals between applications.
    MeSH term(s) Aged ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Body Temperature/physiology ; Catheter Ablation/methods ; Esophagus/physiopathology ; Female ; Follow-Up Studies ; Heart Conduction System/physiology ; Humans ; Male ; Pulmonary Veins/surgery ; Retrospective Studies ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.121.010205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fractures After Removal of Spinal Instrumentation: Revisiting the Stress-Shielding Effect of Instrumentation in Spine Fusion.

    Teles, Alisson R / Yavin, Daniel / Zafeiris, Christos P / Thomas, Kenneth C / Lewkonia, Peter / Nicholls, Fred H / Swamy, Ganesh / Jacobs, W Bradley

    World neurosurgery

    2018  Volume 116, Page(s) e1137–e1143

    Abstract: Background: Many practicing spine surgeons believe that instrumentation can be removed during revision surgery in successful posterolateral or anterior spinal fusions, confirmed by computed tomography and intraoperative exploration. The stress-shielding ...

    Abstract Background: Many practicing spine surgeons believe that instrumentation can be removed during revision surgery in successful posterolateral or anterior spinal fusions, confirmed by computed tomography and intraoperative exploration. The stress-shielding effect of spinal instrumentation was well described in the late 1980s and 1990s but has not received recent attention. Despite the paucity of recent literature, concepts underlying the biology and biomechanics of the spinal fusion mass remain particularly salient given the increasing incidence of revision spinal fusion surgery. The aim of this study was to highlight a potential complication of instrumentation removal owing to stress shielding of instrumentation on the spinal column and fusion mass.
    Methods: A retrospective review was performed, and a small case series was described.
    Results: In 3 cases, despite apparent solid fusion demonstrated on preoperative computed tomography and confirmed by intraoperative exploration, new fractures developed after removal of instrumentation. In these cases, fracture occurred at the transition zone between the newly rigid instrumented area and previous fusion. This highlights the relative weakness of the fusion and may be explained by the stress-shielding effect of instrumentation within the fusion mass.
    Conclusions: Spinal instrumentation revision requires careful consideration, and routine implant removal should not be performed. The presence of a solid fusion on computed tomography and/or at intraoperative exploration may not justify implant removal in these cases. In cases of extension of a fusion, use of a bridging connection to the new implants should be considered. The cases presented demonstrate the consequences of the stress-shielding effect of implants on the spine and fusion mass.
    MeSH term(s) Aged ; Female ; Fractures, Bone/surgery ; Humans ; Lumbar Vertebrae/surgery ; Middle Aged ; Prostheses and Implants ; Reoperation/methods ; Retrospective Studies ; Spinal Diseases/surgery ; Spinal Fusion/methods ; Spine/surgery
    Language English
    Publishing date 2018-06-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2018.05.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Intrathecal Morphine Following Lumbar Fusion: A Randomized, Placebo-Controlled Trial.

    Dhaliwal, Perry / Yavin, Daniel / Whittaker, Tara / Hawboldt, Geoffrey S / Jewett, Gordon A E / Casha, Steven / du Plessis, Stephan

    Neurosurgery

    2018  Volume 85, Issue 2, Page(s) 189–198

    Abstract: Background: Despite the potential for faster postoperative recovery and the ease of direct intraoperative injection, intrathecal morphine is rarely provided in lumbar spine surgery.: Objective: To evaluate the safety and efficacy of intrathecal ... ...

    Abstract Background: Despite the potential for faster postoperative recovery and the ease of direct intraoperative injection, intrathecal morphine is rarely provided in lumbar spine surgery.
    Objective: To evaluate the safety and efficacy of intrathecal morphine following lumbar fusion.
    Methods: We randomly assigned 150 patients undergoing elective instrumented lumbar fusion to receive a single intrathecal injection of morphine (0.2 mg) or placebo (normal saline) immediately prior to wound closure. The primary outcome was pain on the visual-analogue scale during the first 24 h after surgery. Secondary outcomes included respiratory depression, treatment-related side effects, postoperative opioid requirements, and length of hospital stay. An intention-to-treat, repeated-measures analysis was used to estimate outcomes according to treatment in the primary analysis.
    Results: The baseline characteristics of the 2 groups were similar. Intrathecal morphine reduced pain both at rest (32% area under the curves [AUCs] difference, P < .01) and with movement (22% AUCs difference, P < .02) during the initial 24 h after surgery. The risk of respiratory depression was not increased by intrathecal morphine (hazard ratio, 0.86; 95% confidence interval, 0.44 to 1.68; P = .66). Although postoperative opioid requirements were reduced with intrathecal morphine (P < .03), lengths of hospital stay were similar (P = .32). Other than a trend towards increased intermittent catheterization among patients assigned to intrathecal morphine (P = .09), treatment-related side effects did not significantly differ. The early benefits of intrathecal morphine on postoperative pain were no longer apparent after 48 h.
    Conclusion: A single intrathecal injection of 0.2 mg of morphine safely reduces postoperative pain following lumbar fusion.
    MeSH term(s) Adult ; Aged ; Analgesics, Opioid/administration & dosage ; Double-Blind Method ; Female ; Humans ; Injections, Spinal ; Male ; Middle Aged ; Morphine/administration & dosage ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Spinal Fusion/adverse effects ; Treatment Outcome
    Chemical Substances Analgesics, Opioid ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2018-09-28
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyy384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction: Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance.

    Isaacs, Albert M / Riva-Cambrin, Jay / Yavin, Daniel / Hockley, Aaron / Pringsheim, Tamara M / Jette, Nathalie / Lethebe, Brendan Cord / Lowerison, Mark / Dronyk, Jarred / Hamilton, Mark G

    PloS one

    2019  Volume 14, Issue 1, Page(s) e0210851

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0204926.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0204926.].
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0210851
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  10. Article: Oblique Intrathecal Injection in Lumbar Spine Surgery: A Technical Note.

    Jewett, Gordon A E / Yavin, Daniel / Dhaliwal, Perry / Whittaker, Tara / Krupa, JoyAnne / Du Plessis, Stephan

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2017  Volume 44, Issue 5, Page(s) 514–517

    Abstract: Objectives: Intrathecal morphine (ITM) is an efficacious method of providing postoperative analgesia and reducing pain associated complications. Despite adoption in many surgical fields, ITM has yet to become a standard of care in lumbar spine surgery. ... ...

    Abstract Objectives: Intrathecal morphine (ITM) is an efficacious method of providing postoperative analgesia and reducing pain associated complications. Despite adoption in many surgical fields, ITM has yet to become a standard of care in lumbar spine surgery. Spine surgeons' reticence to make use of the technique may in part be attributed to concerns of precipitating a cerebrospinal fluid (CSF) leak.
    Methods: Herein we describe a method for oblique intrathecal injection during lumbar spine surgery to minimize risk of CSF leak. The dural sac is penetrated obliquely at a 30° angle to offset dural and arachnoid puncture sites. Oblique injection in instances of limited dural exposure is made possible by introducing a 60° bend to a standard 30-gauge needle.
    Results: The technique was applied for injection of ITM or placebo in 104 cases of lumbar surgery in the setting of a randomized controlled trial. Injection was not performed in two cases (2/104, 1.9%) following preinjection dural tear. In the remaining 102 cases no instances of postoperative CSF leakage attributable to oblique intrathecal injection occurred. Three cases (3/102, 2.9%) of transient CSF leakage were observed immediately following intrathecal injection with no associated sequelae or requirement for postsurgical intervention. In two cases, the observed leak was repaired by sealing with fibrin glue, whereas in a single case the leak was self-limited requiring no intervention.
    Conclusions: Oblique dural puncture was not associated with increased incidence of postoperative CSF leakage. This safe and reliable method of delivery of ITM should therefore be routinely considered in lumbar spine surgery.
    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2017.45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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