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Article: Beat-to-beat alterations of acoustic intensity and frequency at the maximum power of heart sounds are associated with NT-proBNP levels.

Fujiyoshi, Kazuhiro / Yamaoka-Tojo, Minako / Fujiyoshi, Kanako / Komatsu, Takumi / Oikawa, Jun / Kashino, Kunio / Tomoike, Hitonobu / Ako, Junya

Frontiers in cardiovascular medicine

2024 Volume 11, Page(s) 1372543

Abstract: Background: Auscultatory features of heart sounds (HS) in patients with heart failure (HF) have been studied intensively. Recent developments in digital and electrical devices for auscultation provided easy listening chances to recognize peculiar sounds ...

Abstract	Background: Auscultatory features of heart sounds (HS) in patients with heart failure (HF) have been studied intensively. Recent developments in digital and electrical devices for auscultation provided easy listening chances to recognize peculiar sounds related to diastolic HS such as S Methods: Forty consecutive patients aged between 46 and 87 years (mean age, 74 years) with chronic cardiovascular disease (CVD) were enrolled in the present study after providing written informed consent during their visits to the Kitasato University Outpatient Clinic. HS were recorded at the fourth intercostal space along the left sternal border using a highly sensitive digital device. Two consecutive heartbeats were quantified on sound intensity (dB) and audio frequency (Hz) at the peak power of each spectrogram of S Results: The intensities of four components of HS (S Conclusions: Despite significant attenuations of all four components of HS by BMI, beat-to-beat alterations of both intensity and frequency of S
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2024.1372543
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Article ; Online: Non-occlusive mesenteric ischemia during bevacizumab treatment for glioblastoma: a case report.

Oikawa, Nozomu / Kinoshita, Masashi / Yamamura, Minako / Uno, Takehiro / Ichinose, Toshiya / Sabit, Hemragul / Hayashi, Tomoyuki / Inoue, Dai / Harada, Kenichi / Nakada, Mitsutoshi

Acta neurochirurgica

2022 Volume 164, Issue 10, Page(s) 2767–2771

Abstract: Glioblastoma is one of the most aggressive brain tumors in adults. The standard treatment is radiotherapy and chemotherapy based on the Stupp regimen after maximal safe resection. One effective chemotherapeutic drug is bevacizumab, which can prolong ... ...

Abstract	Glioblastoma is one of the most aggressive brain tumors in adults. The standard treatment is radiotherapy and chemotherapy based on the Stupp regimen after maximal safe resection. One effective chemotherapeutic drug is bevacizumab, which can prolong progression-free survival in glioblastoma patients but not overall survival. Adverse events of bevacizumab include hypertension, proteinuria, delayed wound healing, bleeding of the nose and gums, and thromboembolism resulting in gastrointestinal perforation. Herein, we describe an autopsy case of a patient with glioblastoma who died from non-occlusive mesenteric ischemia that was presumably caused by bevacizumab.
MeSH term(s)	Adult ; Angiogenesis Inhibitors/adverse effects ; Bevacizumab/adverse effects ; Brain Neoplasms/surgery ; Glioblastoma/drug therapy ; Humans ; Mesenteric Ischemia/chemically induced ; Mesenteric Ischemia/drug therapy
Chemical Substances	Angiogenesis Inhibitors ; Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2022-07-30
Publishing country	Austria
Document type	Case Reports ; Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-022-05328-1
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Article ; Online: Variation in heart rate range by 24-h Holter monitoring predicts heart failure in patients with atrial fibrillation.

Oikawa, Jun / Fukaya, Hidehira / Ishii, Shunsuke / Nabeta, Takeru / Nakamura, Hironori / Ishizue, Naruya / Kitasato, Lisa / Kishihara, Jun / Yamaoka-Tojo, Minako / Niwano, Shinichi / Ako, Junya

ESC heart failure

2022 Volume 9, Issue 5, Page(s) 3092–3100

Abstract: Aims: The analysis of heart rate (HR) changes, such as the HR variability or HR turbulence, has been reported as a marker of cardiovascular events during sinus rhythm; however, those relationships during atrial fibrillation (AF) remain controversial, ... ...

Abstract	Aims: The analysis of heart rate (HR) changes, such as the HR variability or HR turbulence, has been reported as a marker of cardiovascular events during sinus rhythm; however, those relationships during atrial fibrillation (AF) remain controversial, and those parameters are not commonly used in AF patients. We sought to investigate the relationship between a simple index focused on the HR and heart failure (HF) events in patients with permanent AF. Methods and results: We enrolled 198 patients with permanent AF and evaluated the HR range, defined as the maximum HR minus the minimum HR on 24-h Holter electrocardiogram recordings. The patients were divided into two groups, i.e., the larger (n = 101) and smaller (n = 97) HR range (HRR) groups, determined by the median value. The HF events were defined as hospitalizations for HF or urgent hospital visits due to exacerbations of one's HF status. The observation period of this study was set at 5 years from registration. The median age was 73 (68-77) years, and 29% were female. The median HRR was 84 (63-118) beats per minutes (bpm). During the observational period of 1825 days (median), HF events occurred in 37 (0.047 per patient-year) patients. In a log-rank test, the larger HRR group had more frequent HF events than the smaller HRR group (P = 0.0078). In the adjusted Cox proportional hazards model using the significantly different factors from the univariate analysis (Model 1) and factors and medications associated with HF (Model 2), the larger HRR group had a higher prevalence of HF events than the smaller HRR group for both models [Model 1, adjusted hazard ratio = 3.21, 95% confidence interval (CI) 1.593-6.708, P = 0.0009; Model 2, adjusted hazard ratio = 3.12, 95% CI 1.522-6.685, P = 0.002]. When analysed using the time-dependent Cox proportional hazards model, the HRR was associated with HF with a statistically significant difference in both the univariate and multivariate analyses [hazard ratio = 1.01, 95% CI 1.006-1.020, P = 0.0002; Model 1, adjusted hazard ratio = 1.02, 95% CI 1.011-1.027, P < 0.0001; Model 2, adjusted hazard ratio = 1.01, 95% CI 1.008-1.021, P = 0.0003). There was no significant difference in the chronotropic medications between the two groups. Conclusions: In patients with permanent AF, a larger HRR was associated with HF events.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Heart Rate ; Electrocardiography, Ambulatory ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/complications ; Proportional Hazards Models
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14035
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Article ; Online: MRI of carotid atherosclerosis.

Yuan, Chun / Oikawa, Minako / Miller, Zach / Hatsukami, Thomas

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2008 Volume 15, Issue 2, Page(s) 266–275

MeSH term(s)	Carotid Arteries/pathology ; Carotid Artery Diseases/diagnosis ; Contrast Media ; Ferrosoferric Oxide ; Humans ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods
Chemical Substances	Contrast Media ; superparamagnetic blood pool agent ; Ferrosoferric Oxide (XM0M87F357)
Language	English
Publishing date	2008-03-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1016/j.nuclcard.2008.02.001
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Article ; Online: Successful treatment of Group A β-hemolytic Streptococcus infection-associated juvenile cutaneous polyarteritis nodosa with tonsillectomy.

Yamamoto, Takeshi / Inoue, Yuzaburo / Tomiita, Minako / Oikawa, Makiko / Kambe, Naotomo / Arima, Takayasu / Shimojo, Naoki / Kohno, Yoichi

Modern rheumatology

2015 Volume 25, Issue 6, Page(s) 967–969

Abstract: Cutaneous polyarteritis nodosa (cutaneous PAN) is a form of necrotizing vasculitis of small- and medium-sized arteries, primarily involving the skin. In juvenile cases, cutaneous PAN is known to be frequently associated with Group A β-hemolytic ... ...

Abstract	Cutaneous polyarteritis nodosa (cutaneous PAN) is a form of necrotizing vasculitis of small- and medium-sized arteries, primarily involving the skin. In juvenile cases, cutaneous PAN is known to be frequently associated with Group A β-hemolytic Streptococcus (GAS) infections. We herein describe the first reported juvenile case of GAS-associated recurrent cutaneous PAN successfully improved with tonsillectomy. To avoid the use of steroids and immunosuppressive drugs, especially in juvenile cases, tonsillectomy is a possible treatment for GAS-associated recurrent cutaneous PAN.
MeSH term(s)	Child, Preschool ; Female ; Humans ; Polyarteritis Nodosa/complications ; Polyarteritis Nodosa/surgery ; Streptococcal Infections/complications ; Streptococcal Infections/surgery ; Streptococcus ; Tonsillectomy ; Treatment Outcome
Language	English
Publishing date	2015
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.3109/14397595.2013.844388
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Article: [Report from the 6th Tohoku Chapter Educational Seminar; a case of elevated serum IgA levels complicated with heart failure].

Miyazaki, Mariko / Niinuma, Hiroyuki / Fusazaki, Tetsuya / Satoh, Mamoru / Oikawa, Minako / Noji, Hideyoshi / Osawa, Hiroshi

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2011 Volume 100, Issue 2, Page(s) 513–521

MeSH term(s)	Amyloidosis/complications ; Cardiomyopathies/complications ; Heart Failure/etiology ; Humans ; Immunoglobulin A/blood ; Male ; Middle Aged ; Multiple Myeloma/diagnosis
Chemical Substances	Immunoglobulin A
Language	Japanese
Publishing date	2011-02-22
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.100.513
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Article ; Online: Prediction of high-risk plaque development and plaque progression with the carotid atherosclerosis score.

Xu, Dongxiang / Hippe, Daniel S / Underhill, Hunter R / Oikawa-Wakayama, Minako / Dong, Li / Yamada, Kiyofumi / Yuan, Chun / Hatsukami, Thomas S

JACC. Cardiovascular imaging

2014 Volume 7, Issue 4, Page(s) 366–373

Abstract: Objectives: The goal of this prospective study was to evaluate the carotid atherosclerosis score (CAS) for predicting the development of high-risk plaque features and plaque burden progression.: Background: Previous studies have shown that carotid ... ...

Abstract	Objectives: The goal of this prospective study was to evaluate the carotid atherosclerosis score (CAS) for predicting the development of high-risk plaque features and plaque burden progression. Background: Previous studies have shown that carotid intraplaque hemorrhage (IPH) and a disrupted luminal surface (DLS), as identified by using magnetic resonance imaging, are associated with greater risk for cerebrovascular events. On the basis of data from a large cross-sectional study, a scoring system was developed to determine which plaque features are associated with the presence of IPH and DLS. However, the predictive value of CAS has not been previously tested in a prospective, longitudinal study. Methods: A total of 120 asymptomatic subjects with 50% to 79% carotid stenosis underwent carotid magnetic resonance imaging scans at baseline and 3 years thereafter. Presence of IPH and DLS, wall volume, maximum wall thickness, and maximum percent lipid-rich necrotic core area were measured at both time-points. Baseline CAS values were calculated on the basis of previously published criteria. Results: Of the 73 subjects without IPH or DLS at baseline, 9 (12%) developed 1 or both of these features during follow-up. There was a significant increasing trend between CAS and the development of new DLS (p < 0.001) and with plaque burden progression (p = 0.03) but not with the development of new IPH (p = 0.3). Percent carotid stenosis was not significantly associated with new DLS (p = 0.2), new IPH (p = 0.1), or plaque progression (p = 0.6). Conclusions: CAS was found to have a significant increasing relationship with incident DLS and plaque progression in this prospective study. CAS can potentially provide improved risk stratification beyond luminal stenosis.
MeSH term(s)	Aged ; Aged, 80 and over ; Asymptomatic Diseases ; Carotid Arteries/pathology ; Carotid Stenosis/epidemiology ; Carotid Stenosis/pathology ; Disease Progression ; Female ; Humans ; Incidence ; Longitudinal Studies ; Magnetic Resonance Angiography ; Male ; Middle Aged ; Necrosis ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prospective Studies ; Risk Assessment ; Risk Factors ; Rupture, Spontaneous ; Time Factors ; Washington/epidemiology
Language	English
Publishing date	2014-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2013.09.022
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Article ; Online: Optical coherence tomography as a novel diagnostic tool for distal type chronic thromboembolic pulmonary hypertension.

Tatebe, Shunsuke / Fukumoto, Yoshihiro / Sugimura, Koichiro / Nakano, Makoto / Miyamichi, Saori / Satoh, Kimio / Oikawa, Minako / Shimokawa, Hiroaki

Circulation journal : official journal of the Japanese Circulation Society

2010 Volume 74, Issue 8, Page(s) 1742–1744

MeSH term(s)	Adult ; Aged ; Blood Vessels/pathology ; Diagnosis, Differential ; Female ; Humans ; Hypertension, Pulmonary/classification ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/physiopathology ; Male ; Middle Aged ; Thromboembolism/etiology ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2010-05-22
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.cj-10-0160
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Article ; Online: Carotid magnetic resonance imaging. A window to study atherosclerosis and identify high-risk plaques.

Oikawa, Minako / Ota, Hideki / Takaya, Norihide / Miller, Zach / Hatsukami, Thomas S / Yuan, Chun

Circulation journal : official journal of the Japanese Circulation Society

2009 Volume 73, Issue 10, Page(s) 1765–1773

Abstract: Despite recent advances in the understanding and etiology of cardiovascular disease, it remains the leading cause of morbidity and mortality worldwide. A great deal of research has been dedicated to investigating and identifying plaque instability: the ... ...

Abstract	Despite recent advances in the understanding and etiology of cardiovascular disease, it remains the leading cause of morbidity and mortality worldwide. A great deal of research has been dedicated to investigating and identifying plaque instability: the so-called "vulnerable plaque". A reliable, in vivo, imaging method capable of identifying plaque characteristics associated with high-risk plaque will be immensely useful for evaluating plaque status and predicting future events. With excellent soft-tissue contrast and resolution, magnetic resonance imaging (MRI) has the ability to visualize features of vulnerable plaques, as well as perform longitudinal studies on the etiology, progression, and regression of atherosclerotic plaque. This review will cover the current state-of-the-art and new developments in carotid MRI to characterize atherosclerosis and its use in clinical diagnoses and longitudinal studies to understand mechanisms of lesion progression and regression.
MeSH term(s)	Cardiovascular Diseases/etiology ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnosis ; Carotid Artery Diseases/pathology ; Disease Progression ; Humans ; Magnetic Resonance Angiography ; Predictive Value of Tests ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Rupture ; Time Factors
Language	English
Publishing date	2009-09-15
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.cj-09-0617
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Article ; Online: MRI of cardiac sarcoidosis: basal and subepicardial localization of myocardial lesions and their effect on left ventricular function.

Ichinose, Azusa / Otani, Hiroki / Oikawa, Minako / Takase, Kei / Saito, Haruo / Shimokawa, Hiroaki / Takahashi, Shoki

AJR. American journal of roentgenology

2008 Volume 191, Issue 3, Page(s) 862–869

Abstract: Objective: The objective of our study was to use MRI to analyze the topographic localization of myocardial lesions and their relationship to plasma brain natriuretic peptide (BNP) levels and several cardiac function parameters in patients with cardiac ... ...

Abstract	Objective: The objective of our study was to use MRI to analyze the topographic localization of myocardial lesions and their relationship to plasma brain natriuretic peptide (BNP) levels and several cardiac function parameters in patients with cardiac sarcoidosis. Materials and methods: Delayed contrast-enhanced MRI was performed in 40 patients with sarcoidosis (11 cardiac, 29 extracardiac cases). Using a 29-segment model of the left ventricle (LV), the extent of myocardial hyperenhancement was visually scored (0 = no hyperenhancement, 1 = 1-25%, 2 = 26-50%, 3 = 51-75%, 4 = 76-100% hyperenhancement) and was compared with plasma BNP level and several parameters of cardiac function. Results: Ten of the 11 patients with cardiac sarcoidosis showed myocardial hyperenhancement, whereas none of the 29 patients without cardiac sarcoidosis did. In patients with cardiac sarcoidosis, hyperenhancement was significantly more extensive in basal short axis slices than in apical short axis slices (p < 0.0005). Myocardial hyperenhancement was significantly more frequent in subepicardial layers than in subendocardial layers. The global extent of myocardial hyperenhancement was significantly correlated with plasma BNP levels and the LV end-diastolic volume index and was negatively correlated with the LV ejection fraction. Conclusion: In patients with cardiac sarcoidosis, myocardial lesions detected on delayed contrast-enhanced MRI were predominantly localized in the basal and subepicardial myocardium. The extent of myocardial lesions may be related to LV dysfunction and plasma BNP level in patients with cardiac sarcoidosis.
MeSH term(s)	Cardiomyopathies/blood ; Cardiomyopathies/complications ; Cardiomyopathies/diagnosis ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Reproducibility of Results ; Sarcoidosis/blood ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Sensitivity and Specificity ; Ventricular Dysfunction, Left/blood ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology
Chemical Substances	Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2008-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.07.3089
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