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  1. Article ; Online: Counterpoint: stenting for idiopathic intracranial hypertension should be trialed.

    Derdeyn, Colin P / Wall, Michael

    Journal of neurointerventional surgery

    2023  Volume 15, Issue 11, Page(s) 1063–1064

    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Angioplasty and stenting for atherosclerotic cerebrovascular disease

    Derdeyn, Colin P.

    (Neuroimaging clinics of North America ; 17,3)

    2007  

    Author's details guest ed. Colin P. Derdayn
    Series title Neuroimaging clinics of North America ; 17,3
    Collection
    Language English
    Size XIV S., S. 285 - 395 : zahlr. Ill.
    Publisher Elsevier Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015341509
    ISBN 1-4160-4336-5 ; 978-1-4160-4336-2
    Database Catalogue ZB MED Medicine, Health

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    Se 1309 -17,3- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Hemodynamics and oxygen extraction in chronic large artery steno-occlusive disease: Clinical applications for predicting stroke risk.

    Derdeyn, Colin P

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2017  Volume 38, Issue 9, Page(s) 1584–1597

    Abstract: Depending on the adequacy of collateral sources of blood flow, arterial stenosis or occlusion may lead to reduced perfusion pressure and ultimately reduced blood flow in the distal territory supplied by that vessel. There are two well-defined ... ...

    Abstract Depending on the adequacy of collateral sources of blood flow, arterial stenosis or occlusion may lead to reduced perfusion pressure and ultimately reduced blood flow in the distal territory supplied by that vessel. There are two well-defined compensatory mechanisms to reduced pressure or flow - autoregulatory vasodilation and increased oxygen extraction fraction. Other changes, such as metabolic downregulation, are likely. The positive identification of autoregulatory vasodilation and increased oxygen extraction fraction in humans is an established risk factor for future ischemic stroke in some disease states such as atherosclerotic carotid stenosis and occlusion. The mechanisms by which ischemic stroke may occur are not clear, and may include an increased vulnerability to embolic events. The use of hemodynamic assessment to identify patients with occlusive vasculopathy at an increased risk for stroke is very appealing for several different patient populations, such as those with symptomatic intracranial atherosclerotic disease, moyamoya phenomenon, complete internal carotid artery occlusion, and asymptomatic cervical carotid artery stenosis. While there is very good data for stroke risk prediction in some of these groups, no intervention based on these tools has been proven effective yet. In this manuscript, we will review these topics above and identify areas for future research.
    MeSH term(s) Arterial Occlusive Diseases/metabolism ; Arterial Occlusive Diseases/physiopathology ; Cerebrovascular Circulation/physiology ; Hemodynamics/physiology ; Humans ; Oxygen/metabolism ; Stroke/etiology ; Stroke/metabolism ; Stroke/physiopathology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017-09-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X17732884
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  4. Article ; Online: Direct bypass reduces the risk of recurrent hemorrhage in moyamoya syndrome, but effect on functional outcome is less certain.

    Derdeyn, Colin P

    Stroke

    2014  Volume 45, Issue 5, Page(s) 1245–1246

    MeSH term(s) Cerebral Hemorrhage/prevention & control ; Cerebral Revascularization/methods ; Female ; Humans ; Male ; Moyamoya Disease/surgery ; Postoperative Complications/etiology
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.114.004994
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  5. Article ; Online: Comment.

    Derdeyn, Colin P

    Neurosurgery

    2012  Volume 71, Issue 1, Page(s) 99

    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
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  6. Article ; Online: Image level detection of large vessel occlusion on 4D-CTA perfusion data using deep learning in acute stroke.

    Bathla, Girish / Durjoy, Dhruba / Priya, Sarv / Samaniego, Edgar / Derdeyn, Colin P

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2022  Volume 31, Issue 11, Page(s) 106757

    Abstract: Objectives: Automated image-level detection of large vessel occlusions (LVO) could expedite patient triage for mechanical thrombectomy. A few studies have previously attempted LVO detection using artificial intelligence (AI) on CT angiography (CTA) ... ...

    Abstract Objectives: Automated image-level detection of large vessel occlusions (LVO) could expedite patient triage for mechanical thrombectomy. A few studies have previously attempted LVO detection using artificial intelligence (AI) on CT angiography (CTA) images. To our knowledge this is the first study to detect LVO existence and location on raw 4D-CTA/ CT perfusion (CTP) images using neural network (NN) models.
    Materials and methods: Retrospective study using data from a level-I stroke center was performed. A total of 306 (187 with LVO, and 119 without) patients were evaluated. Image pre-processing included co-registration, normalization and skull stripping. Five consecutive time-points for each patient were selected to provide variable contrast density in data. Additional data augmentation included rotation and horizonal image flipping. Our model architecture consisted of two neural networks, first for classification (based on hemispheric asymmetry), followed by second model for exact site of LVO detection. Only cases deemed positive by the classification model were routed to the detection model, thereby reducing false positives and improving specificity. The results were compared with expert annotated LVO detection.
    Results: Using a 80:20 split for training and validation, the combination of both classification and detection model achieved a sensitivity of 86.5%, a specificity of 89.5%, and an accuracy of 87.5%. A 5-fold cross-validation using the entire data achieved a mean sensitivity of 82.7%, a specificity of 89.8%, and an accuracy of 85.5% and a mean AUC of 0.89 (95% CI: 0.85-0.93).
    Conclusion: Our findings suggest that accurate image-level LVO detection is feasible on CTP raw images.
    MeSH term(s) Humans ; Computed Tomography Angiography/methods ; Deep Learning ; Artificial Intelligence ; Retrospective Studies ; Cytidine Triphosphate ; Stroke/diagnostic imaging ; Stroke/therapy ; Tomography, X-Ray Computed/methods ; Perfusion ; Brain Ischemia
    Chemical Substances Cytidine Triphosphate (65-47-4)
    Language English
    Publishing date 2022-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2022.106757
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  7. Article ; Online: Re: Perez et al 'Intracranial thrombectomy using the Solitaire stent: a historical vignette'.

    Derdeyn, Colin P

    Journal of neurointerventional surgery

    2012  Volume 4, Issue 2, Page(s) 153–4; author reply 154

    MeSH term(s) History, 21st Century ; Humans ; Intracranial Aneurysm/history ; Stents/history ; Thrombectomy/history
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Historical Article ; Letter
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2011-010242
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  8. Article ; Online: Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions.

    Al Kasab, Sami / Nguyen, Thanh N / Derdeyn, Colin P / Yaghi, Shadi / Amin-Hanjani, Sepideh / Kicielinski, Kimberly / Zaidat, Osama O / de Havenon, Adam

    Stroke

    2024  Volume 55, Issue 2, Page(s) 355–365

    Abstract: This comprehensive literature review focuses on acute stroke related to intracranial atherosclerotic stenosis (ICAS), with an emphasis on ICAS-large vessel occlusion. ICAS is the leading cause of stroke globally, with high recurrence risk, especially in ... ...

    Abstract This comprehensive literature review focuses on acute stroke related to intracranial atherosclerotic stenosis (ICAS), with an emphasis on ICAS-large vessel occlusion. ICAS is the leading cause of stroke globally, with high recurrence risk, especially in Asian, Black, and Hispanic populations. Various risk factors, including hypertension, diabetes, hyperlipidemia, smoking, and advanced age lead to ICAS, which in turn results in stroke through different mechanisms. Recurrent stroke risk in patients with ICAS with hemodynamic failure is particularly high, even with aggressive medical management. Developments in advanced imaging have improved our understanding of ICAS and ability to identify high-risk patients who could benefit from intervention. Herein, we focus on current management strategies for ICAS-large vessel occlusion discussed, including the use of perfusion imaging, endovascular therapy, and stenting. In addition, we focus on strategies that aim at identifying subjects at higher risk for early recurrent risk who could benefit from early endovascular intervention The review underscores the need for further research to optimize ICAS-large vessel occlusion treatment strategies, a traditionally understudied topic.
    MeSH term(s) Humans ; Constriction, Pathologic/diagnostic imaging ; Constriction, Pathologic/therapy ; Stroke/diagnostic imaging ; Stroke/etiology ; Hypertension ; Cerebral Infarction ; Risk Factors
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.043635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: American Stroke Association Stroke Council Update.

    Derdeyn, Colin P / Broderick, Joseph P / Furie, Karen

    Stroke

    2017  Volume 48, Issue 4, Page(s) e108–e109

    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.117.016049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: STAIR X: Emerging Considerations in Developing and Evaluating New Stroke Therapies.

    Liebeskind, David S / Derdeyn, Colin P / Wechsler, Lawrence R

    Stroke

    2018  Volume 49, Issue 9, Page(s) 2241–2247

    MeSH term(s) Biomarkers ; Cerebral Angiography ; Device Approval ; Education ; Endovascular Procedures ; Guidelines as Topic ; Humans ; Intracranial Hemorrhages ; Precision Medicine ; Randomized Controlled Trials as Topic ; Registries ; Research Design ; Stroke/therapy ; Thrombectomy ; Thrombolytic Therapy ; Treatment Outcome ; United States ; United States Food and Drug Administration
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.021424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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