Article ; Online: Interaction of tau with HNRNPA2B1 and N
2021 Volume 81, Issue 20, Page(s) 4209–4227.e12
Abstract: ... connecting oTau with N ...
Abstract | The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau (oTau) are unknown. We have used Cry2-based optogenetics to induce tau oligomers (oTau-c). Optical induction of oTau-c elicits tau phosphorylation, aggregation, and a translational stress response that includes stress granules and reduced protein synthesis. Proteomic analysis identifies HNRNPA2B1 as a principle target of oTau-c. The association of HNRNPA2B1 with endogenous oTau was verified in neurons, animal models, and human Alzheimer brain tissues. Mechanistic studies demonstrate that HNRNPA2B1 functions as a linker, connecting oTau with N |
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MeSH term(s) | Adenosine/analogs & derivatives ; Adenosine/metabolism ; Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Case-Control Studies ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Disease Models, Animal ; Disease Progression ; Female ; HEK293 Cells ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/metabolism ; Humans ; Male ; Methylation ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Protein Aggregates ; Protein Aggregation, Pathological ; RNA/genetics ; RNA/metabolism ; RNA Processing, Post-Transcriptional ; Severity of Illness Index ; tau Proteins/genetics ; tau Proteins/metabolism ; Mice |
Chemical Substances | Heterogeneous-Nuclear Ribonucleoprotein Group A-B ; MAPT protein, human ; Protein Aggregates ; hnRNP A2 ; tau Proteins ; RNA (63231-63-0) ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567) |
Language | English |
Publishing date | 2021-08-27 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Video-Audio Media |
ZDB-ID | 1415236-8 |
ISSN | 1097-4164 ; 1097-2765 |
ISSN (online) | 1097-4164 |
ISSN | 1097-2765 |
DOI | 10.1016/j.molcel.2021.07.038 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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