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  1. Article ; Online: Early Detection of Acute Kidney Injury Can Further Improve the Prognosis of Acute Myocardial Infarction.

    Asanuma, Hiroshi

    JACC. Asia

    2021  Volume 1, Issue 3, Page(s) 382–384

    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Editorial
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2021.08.005
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  2. Article ; Online: Editorial Comment.

    Asanuma, Hiroshi

    The Journal of urology

    2019  Volume 201, Issue 2, Page(s) 385

    MeSH term(s) Abdominal Muscles ; Atrophy ; Gubernaculum ; Humans ; Male ; Orchiopexy ; Testis
    Language English
    Publishing date 2019-01-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/01.JU.0000553003.73595.8e
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  3. Article ; Online: Is Aspirin Loading Before Primary Percutaneous Coronary Intervention for Patients with ST-Elevation Myocardial Infarction Necessary?

    Asanuma, Hiroshi / Kitakaze, Masafumi

    Cardiovascular drugs and therapy

    2022  Volume 36, Issue 6, Page(s) 1243–1245

    MeSH term(s) Humans ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; Aspirin/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/adverse effects ; Treatment Outcome
    Chemical Substances Aspirin (R16CO5Y76E) ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-022-07314-2
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    Zs.B 3057: Show issues Location:
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  4. Article ; Online: Site-Selective Photo-Crosslinking of Stilbene Pairs in a DNA Duplex Mediated by Ruthenium Photocatalyst.

    Kashida, Hiromu / Azuma, Hidenori / Sotome, Hikaru / Miyasaka, Hiroshi / Asanuma, Hiroyuki

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 14, Page(s) e202319516

    Abstract: We herein report a method for site-selective photo-crosslinking of a DNA duplex. A stilbene pair was introduced into a DNA duplex and a ruthenium complex was conjugated with a triplex-forming oligonucleotide. We demonstrated that [2+2] photocycloaddition ...

    Abstract We herein report a method for site-selective photo-crosslinking of a DNA duplex. A stilbene pair was introduced into a DNA duplex and a ruthenium complex was conjugated with a triplex-forming oligonucleotide. We demonstrated that [2+2] photocycloaddition of the stilbene pair occurred upon irradiation with visible light when the ruthenium complex was in close proximity due to triplex formation. No reaction occurred when the ruthenium complex was not in proximity to the stilbene pair. The wavelength of visible light used was of lower energy than the wavelength of UV light necessary for direct excitation of stilbene. Quantum chemical calculation indicated that ruthenium complex catalyzed the photocycloaddition via triplet-triplet energy transfer. Site selectivity of this photo-crosslinking system was evaluated using a DNA duplex bearing two stilbene pairs as a substrate; we showed that the site of crosslinking was precisely regulated by the sequence of the oligonucleotide linked to the ruthenium complex. Since this method does not require orthogonal photoresponsive molecules, it will be useful in construction of complex photoresponsive DNA circuits, nanodevices and biological tools.
    MeSH term(s) Ruthenium/chemistry ; Stilbenes ; DNA/chemistry ; Light ; Oligonucleotides
    Chemical Substances Ruthenium (7UI0TKC3U5) ; Stilbenes ; DNA (9007-49-2) ; Oligonucleotides
    Language English
    Publishing date 2024-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202319516
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  5. Article ; Online: Current clinical perspective of urological oncology in the adolescent and young adult generation.

    Takahashi, Ryohei / Asanuma, Hiroshi / Mizuno, Ryuichi / Oya, Mototsugu

    International journal of clinical oncology

    2022  

    Abstract: Among adolescents and young adults, hematological tumors are the most common malignancies in younger patients; however, solid tumors also increase with advancing age. The pathogenesis of some of these tumors differs from that of tumors which develop in ... ...

    Abstract Among adolescents and young adults, hematological tumors are the most common malignancies in younger patients; however, solid tumors also increase with advancing age. The pathogenesis of some of these tumors differs from that of tumors which develop in children, or middle-aged and older adults, and special care should be taken in their treatment and management. A treatment plan that takes into consideration future fertility is necessary for testicular tumors, and an educational campaign to encourage early detection is also essential. The treatment of adolescents with advanced testicular tumors should resemble therapeutic approaches for young adults and not a pediatric regimen. Adrenal tumors often develop as part of familiar hereditary syndrome. Therefore, taking the personal and family history is very important, and genetic counseling should be also recommended. In renal tumors, the incidence of translocation renal cell carcinomas is higher. Complete resection is the only promising method for long-term prognosis because of no established treatment for translocation renal cell carcinomas with distant metastasis. Bladder tumors are often detected by symptoms of gross hematuria and are found at a relatively early stage. Along with renal tumors, oncological evaluation including cystoscopy is also considered essential for gross hematuria. Wilms tumors and rhabdomyosarcomas could be managed in accordance with pediatric protocols to improve the treatment outcomes. The dedicated cancer survivorship care for adolescents and young adults could be also indispensable to conquer cancer and maintain a better quality of life.
    Language English
    Publishing date 2022-12-17
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-022-02251-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4828: Show issues Location:
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  6. Article ; Online: Ultrasound finding of vaginal bleeding in infants with 21-hydroxylase deficiency.

    Sato, Takeshi / Ishii, Tomohiro / Ichihashi, Yosuke / Asanuma, Hiroshi / Hasegawa, Tomonobu

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e14966

    MeSH term(s) Adrenal Hyperplasia, Congenital/diagnosis ; Adrenal Hyperplasia, Congenital/diagnostic imaging ; Female ; Humans ; Infant ; Uterine Hemorrhage
    Language English
    Publishing date 2022-02-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.14966
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    Zs.A 848: Show issues Location:
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  7. Article ; Online: Electric polarization and crystal orientation of lead zirconate titanate under mechanical stress due to embedding in a metal matrix

    Tetsuro Yanaseko / Hiroshi Sato / Fumio Narita / Hiroshi Asanuma

    SN Applied Sciences, Vol 3, Iss 10, Pp 1-

    2021  Volume 8

    Abstract: Abstract The mechanical characteristics of piezoelectric ceramic fibers can be improved by embedding the fibers in a metal matrix. The compressive stress generated during the embedding process, however, limits the polarization of piezoelectric ceramic ... ...

    Abstract Abstract The mechanical characteristics of piezoelectric ceramic fibers can be improved by embedding the fibers in a metal matrix. The compressive stress generated during the embedding process, however, limits the polarization of piezoelectric ceramic composites. To study and determine the relationship between the mechanical and piezoelectric properties of piezoelectric ceramics, we analyzed the crystallographic orientation of piezoelectric ceramics embedded in an aluminum matrix via electron backscatter diffraction. The orientation of the crystals before and after the polarization of the piezoelectric fibers, in which residual stresses were generated during embedding, was evaluated. Furthermore, the residual stresses were reduced by heat treatment, and the resultant angle of orientation was evaluated before and after polarization. Results showed that, as the residual stresses were relieved, the orientation of the piezoelectric ceramic crystals changed to reveal increased polarization. Our analysis shows that the crystal orientation of piezoelectric ceramics is impacted by the residual compressive stress that arises from embedding the piezoelectric fiber in the aluminum matrix; it also illustrates the hindering effect of residual stress on the polarization of piezoelectric ceramics.
    Keywords Piezoelectric ceramic fiber ; Compressive stress ; Residual stress ; Crystallographic orientation analysis ; Aluminum matrix ; Science ; Q ; Technology ; T
    Subject code 500
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Springer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Effectiveness of dihydrotestosterone ointment on glans penis size increment in a 5-alpha-reductase type 2 deficiency patient.

    Sato, Takeshi / Nakano, Satsuki / Asanuma, Hiroshi / Ishii, Tomohiro / Hasegawa, Tomonobu

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e15079

    MeSH term(s) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/deficiency ; Dihydrotestosterone ; Disorder of Sex Development, 46,XY ; Humans ; Hypospadias ; Male ; Ointments ; Penis ; Steroid Metabolism, Inborn Errors
    Chemical Substances Ointments ; Dihydrotestosterone (08J2K08A3Y) ; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (EC 1.3.99.5)
    Language English
    Publishing date 2022-03-21
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15079
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  9. Article ; Online: Anemia in patients ≥ 75 years with metastatic clear cell renal cell carcinoma: an important poor prognostic factor in the international metastatic renal cell carcinoma database consortium model.

    Mizuno, Ryuichi / Yasumizu, Yota / Tanaka, Nobuyuki / Takeda, Toshikazu / Morita, Shinya / Matsumoto, Kazuhiro / Kosaka, Takeo / Asanuma, Hiroshi / Oya, Mototsugu

    BMC urology

    2024  Volume 24, Issue 1, Page(s) 13

    Abstract: Background: Due to an increase in life expectancy, the incidence of metastatic renal cell carcinoma (mRCC) in patients aged ≥75 years has been increasing. In this study we investigated the characteristics before treatment and the outcomes of systemic ... ...

    Abstract Background: Due to an increase in life expectancy, the incidence of metastatic renal cell carcinoma (mRCC) in patients aged ≥75 years has been increasing. In this study we investigated the characteristics before treatment and the outcomes of systemic therapies for patients aged ≥75 years with mRCC and compared the results with those for patients aged < 75 years in order to determine whether differences in age influenced survival.
    Methods: A total of 206 consecutive Japanese patients with mRCC, including 47 patients aged ≥75 years, who received systemic therapy were included. Clinical data from medical records were retrieved and analyzed retrospectively. Survival analyses were determined using a Kaplan-Meier method, and analyzed with a log-rank test.
    Results: Elderly patients categorized as favorable risk group based on the International Metastatic RCC Database Consortium (IMDC) stratification system were significantly lower. Among IMDC risk factors, the rate of anemia was significantly higher in elderly patients. No statistically significant benefit in progression free survival for first and second line treatment was observed, whereas improvements in overall survival as well as cancer specific survival were seen in patients aged < 75 years.
    Conclusions: For mRCC patients aged ≥75 years, a higher proportion of base line anemia, which resulted in higher rates of IMDC intermediate/poor risk, would be responsible for shorter OS/CSS. Furthermore, mRCC patients aged ≥75 years tend to receive BSC instead of second line active treatment. Overcoming under-treatment in elderly patients might help to prolong survival in mRCC.
    MeSH term(s) Aged ; Humans ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms/pathology ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-024-01403-0
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  10. Article ; Online: Clinical audit of ultrasonography for detecting sialoliths in the submandibular gland in paediatric patients: A comparison to computed tomography and magnetic resonance imaging.

    Hosokawa, Takahiro / Tanami, Yutaka / Sato, Yumiko / Adachi, Nodoka / Asanuma, Hiroshi / Oguma, Eiji

    Australasian journal of ultrasound in medicine

    2023  Volume 27, Issue 1, Page(s) 19–25

    Abstract: Objectives: To compare the performance of ultrasonography with magnetic resonance imaging (MRI) and computed tomography (CT) for detecting submandibular sialoliths.: Methods: Thirteen patients with suspected submandibular sialoliths who underwent ... ...

    Abstract Objectives: To compare the performance of ultrasonography with magnetic resonance imaging (MRI) and computed tomography (CT) for detecting submandibular sialoliths.
    Methods: Thirteen patients with suspected submandibular sialoliths who underwent ultrasonography and CT or MRI were included. Sialoliths were diagnosed using CT (11 cases) or MRI (two cases). The submandibular duct was classified into distal and proximal ducts based on the point around the mylohyoid muscle. Sialoliths located in the proximal duct were difficult to differentiate from those located within the submandibular gland (SMG). Therefore, the location of the sialoliths was classified as follows: within the SMG/proximal duct and within the distal duct. The ultrasound results were compared with CT/MRI results.
    Results: Of the 13 patients included, two had sialoliths in both the SMG/proximal duct and the distal duct, three had sialoliths in the SMG/proximal duct, and five had sialoliths in the distal duct on CT or MRI. In this small cohort, all five sialoliths in the SMG/proximal duct were detected by ultrasoonography; however, of the seven cases with sialoliths located in the distal duct, only three could be detected by ultrasonography.
    Conclusions: The incidence of sialoliths in the distal duct was higher than that in the SMG/proximal duct. Ultrasonography showed a good performance compared with CT/MRI in the SMG/proximal duct but not in the distal duct.
    Language English
    Publishing date 2023-12-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2843953-3
    ISSN 2205-0140 ; 1836-6864
    ISSN (online) 2205-0140
    ISSN 1836-6864
    DOI 10.1002/ajum.12370
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