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Article ; Online: (+)-/(-)-Rutabenzofuran A and (+)-/(-)- Rutabenzofuran B: Two unprecedented pairs of Z/E isomeric benzofuran enantiomers from the aerial part of Ruta graveolens L.

Liu, Yanyang / Peng, Jing / Huang, Ling / Li, Bichen / Ge, Chengyu / Liu, Shao / Jiang, Yueping

2023 Volume 210, Page(s) 113677

Abstract: Two pairs of Z/E isomeric benzofuran enantiomers possessing unprecedented carbon skeletons ... from the water extract of the aerial part of Ruta graveolens L. Their structures were determined by extensive ...

Abstract	Two pairs of Z/E isomeric benzofuran enantiomers possessing unprecedented carbon skeletons featuring ring cleavage and addition reactions in the α-pyrone ring of furocoumarin, named rutabenzofuran A [(+)-1 and (-)-1], and rutabenzofuran B [(+)-2 and (-)-2], respectively, were isolated as minor compounds from the water extract of the aerial part of Ruta graveolens L. Their structures were determined by extensive spectroscopic data analysis. The absolute configurations were assigned by comparing the optical rotation with previous research and the experimental circular dichroism (CD) spectra with the calculated electronic CD (ECD) spectra. (-)-1, (+)-2, and (-)-2 were evaluated for antibacterial, anticoagulant, anticancer, and acetylcholinesterase (AChE) inhibitory activities. No anticancer or anticoagulant activities were observed, yet (-)-2 exhibited weak antibacterial activity against Salmonella enterica subsp. Enterica. At the same time, (-)-1, (+)-2, and (-)-2 displayed weak inhibitory activity on AChE.
MeSH term(s)	Ruta/chemistry ; Acetylcholinesterase ; Plant Components, Aerial/chemistry ; Benzofurans/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7) ; Benzofurans ; Anti-Bacterial Agents
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113677
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Article ; Online: Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.

Cramer, Shira L / Saha, Achinto / Liu, Jinyun / Tadi, Surendar / Tiziani, Stefano / Yan, Wupeng / Triplett, Kendra / Lamb, Candice / Alters, Susan E / Rowlinson, Scott / Zhang, Yan Jessie / Keating, Michael J / Huang, Peng / DiGiovanni, John / Georgiou, George / Stone, Everett

Nature medicine

2016 Volume 23, Issue 1, Page(s) 120–127

Abstract: ... ROS, endogenous L-cysteine (L-Cys) production is insufficient for GSH synthesis. This necessitates ... uptake of L-Cys that is predominantly in its disulfide form, L-cystine (CSSC), via the xCT(-) transporter ... We show that administration of an engineered and pharmacologically optimized human cyst(e)inase enzyme ...

Abstract	Cancer cells experience higher oxidative stress from reactive oxygen species (ROS) than do non-malignant cells because of genetic alterations and abnormal growth; as a result, maintenance of the antioxidant glutathione (GSH) is essential for their survival and proliferation. Under conditions of elevated ROS, endogenous L-cysteine (L-Cys) production is insufficient for GSH synthesis. This necessitates uptake of L-Cys that is predominantly in its disulfide form, L-cystine (CSSC), via the xCT(-) transporter. We show that administration of an engineered and pharmacologically optimized human cyst(e)inase enzyme mediates sustained depletion of the extracellular L-Cys and CSSC pool in mice and non-human primates. Treatment with this enzyme selectively causes cell cycle arrest and death in cancer cells due to depletion of intracellular GSH and ensuing elevated ROS; yet this treatment results in no apparent toxicities in mice even after months of continuous treatment. Cyst(e)inase suppressed the growth of prostate carcinoma allografts, reduced tumor growth in both prostate and breast cancer xenografts and doubled the median survival time of TCL1-Tg:p53
MeSH term(s)	Animals ; Blotting, Western ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cystathionine gamma-Lyase/pharmacology ; Cysteine/drug effects ; Cysteine/metabolism ; Cystine/drug effects ; Cystine/metabolism ; Female ; Glutathione/metabolism ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Macaca fascicularis ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Neoplasm Transplantation ; Oxidative Stress ; Polyethylene Glycols/pharmacology ; Prostatic Neoplasms/metabolism ; Reactive Oxygen Species/metabolism ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Reactive Oxygen Species ; Tumor Suppressor Protein p53 ; Polyethylene Glycols (3WJQ0SDW1A) ; Cystine (48TCX9A1VT) ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; cyst(e)inase protein, human (EC 4.4.1.1) ; Glutathione (GAN16C9B8O) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2016-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/nm.4232
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Article ; Online: (+)-/(−)-Rutabenzofuran a and (+)-/(−)- Rutabenzofuran b: Two unprecedented pairs of Z/E isomeric benzofuran enantiomers from the aerial part of Ruta graveolens L

Liu, Yanyang / Peng, Jing / Huang, Ling / Li, Bichen / Ge, Chengyu / Liu, Shao / Jiang, Yueping

Phytochemistry. 2023 Apr. 12, p.113677-

2023 , Page(s) 113677–

Abstract	Two pairs of Z/E isomeric benzofuran enantiomers possessing unprecedented carbon skeletons featuring ring cleavage and addition reactions in the α-pyrone ring of furocoumarin, named rutabenzofuran A [(+)-1 and (−)-1], and rutabenzofuran B [(+)-2 and (−)-2], respectively, were isolated as minor compounds from the water extract of the aerial part of Ruta graveolens L. Their structures were determined by extensive spectroscopic data analysis. The absolute configurations were assigned by comparing the optical rotation with previous research and the experimental circular dichroism (CD) spectra with the calculated electronic CD (ECD) spectra. (−)-1, (+)-2, and (−)-2 were evaluated for antibacterial, anticoagulant, anticancer, and acetylcholinesterase (AChE) inhibitory activities. No anticancer or anticoagulant activities were observed, yet (−)-2 exhibited weak antibacterial activity against Salmonella enterica subsp. Enterica. At the same time, (−)-1, (+)-2, and (−)-2 displayed weak inhibitory activity on AChE.
Keywords	Ruta graveolens ; acetylcholinesterase ; aerial parts ; antibacterial properties ; anticoagulants ; carbon ; circular dichroism spectroscopy ; enantiomers ; plant biochemistry ; spectral analysis ; Ruta graveolens L. ; Enantiomer ; Z/E isomeric ; Rutabenzofuran a and rutabenzofuran B ; Antibacterial activity ; Acetylcholinesterase inhibitory activity
Language	English
Dates of publication	2023-0412
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113677
Database	NAL-Catalogue (AGRICOLA)

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Article: Supplementation of L-Arginine, L-Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice.

Chen, Yi-Ming / Li, Huashuai / Chiu, Yen-Shuo / Huang, Chi-Chang / Chen, Wen-Chyuan

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 8312647

Abstract: ... comprising L-arginine, L-glutamine, vitamin C, vitamin E, folic acid, and green tea extract (LVFG ...

Abstract	It has been reported that abundant nitric oxide content in endothelial cells can increase exercise performance. The purpose of this study was to evaluate the potential beneficial effects of a combined extract comprising L-arginine, L-glutamine, vitamin C, vitamin E, folic acid, and green tea extract (LVFG) on nitric oxide content to decrease exercise fatigue. Male ICR (Institute of Cancer Research) mice were randomly divided into 4 groups and orally administered LVFG for 4 weeks. The 4-week LVFG supplementation significantly increased serum nitric oxide content in the LVFG-1X and LVFG-2X groups. Antifatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming test, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after an acute swimming exercise. LVFG supplementation dose-dependently improved exercise performance and nitric oxide content, and it dose-dependently decreased serum ammonia and CK activity after exhaustive swimming test. LVFG's antifatigue properties appear to manifest by preserving energy storage (as blood glucose) and increasing nitric oxide content. Taken together, our results show that LVFG could have the potential for alleviating physical fatigue due to its pharmacological effect of increasing serum nitric oxide content.
Language	English
Publishing date	2020-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/8312647
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Article: Search for the rare decay K(L)-->pi(0)e(+)e(-).

Alavi-Harati, A / Alexopoulos, T / Arenton, M / Barbosa, R F / Barker, A R / Barrio, M / Bellantoni, L / Bellavance, A / Blucher, E / Bock, G J / Bown, C / Bright, S / Cheu, E / Coleman, R / Corcoran, M D / Cox, B / Erwin, A R / Escobar, C O / Ford, R /

Glazov, A / Golossanov, A / Gomes, R A / Gouffon, P / Graham, J / Hamm, J / Hanagaki, K / Hsiung, Y B / Huang, H / Jejer, V / Jensen, D A / Kessler, R / Kobrak, H G E / Kotera, K / LaDue, J / Lai, N / Ledovskoy, A / McBride, P L / Monnier, E / Nelson, K S / Nguyen, H / Ping, H / Prasad, V / Qi, X R / Quinn, B / Ramberg, E J / Ray, R E / Ronquest, M / Santos, E / Senyo, K / Shanahan, P / Shields, J / Slater, W / Smith, D E / Solomey, N / Swallow, E C / Taegar, S A / Tesarek, R J / Toale, P A / Tschirhart, R / Velissaris, C / Wah, Y W / Wang, J / White, H B / Whitmore, J / Wilking, M / Winstein, B / Winston, R / Worcester, E T / Yamanaka, T / Zukanovich, R F

Physical review letters

2004 Volume 93, Issue 2, Page(s) 21805

Abstract: The KTeV/E799 experiment at Fermilab has searched for the rare kaon decay K(L)-->pi(0)e(+)e ... result based on the data set taken in 1997 yields the final KTeV result: BR(K(L)-->pi(0)e(+)e(-))<2.8x10 ... 10) at 90% C.L. ...

Abstract	The KTeV/E799 experiment at Fermilab has searched for the rare kaon decay K(L)-->pi(0)e(+)e(-). This mode is expected to have a significant CP violating component. The measurement of its branching ratio could support the standard model or could indicate the existence of new physics. This Letter reports new results from the 1999-2000 data set. One event is observed with an expected background at 0.99+/-0.35 events. We set a limit on the branching ratio of 3.5x10(-10) at the 90% confidence level. Combining with the previous result based on the data set taken in 1997 yields the final KTeV result: BR(K(L)-->pi(0)e(+)e(-))<2.8x10(-10) at 90% C.L.
Language	English
Publishing date	2004-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.93.021805
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Article ; Conference proceedings: Einfluss der Typ-2-Diabetesdauer auf die Wirkung von iGlarLixi gegenüber Insulin glargin 100 E / ml bei einer basalunterstützten oralen Therapie (BOT): Eine Subanalyse der LixiLan-L-Studie

Seufert, J / Blonde, L / Berard, Lori / Saremi, A / Huang, Y / Aroda, V / Raccah, D

Diabetologie und Stoffwechsel

2021 Volume 16, Issue S 01

Event/congress	Diabetes Kongress 2021 - 55. Jahrestagung der DDG, Online-Kongress, 2021-05-12
Language	German
Publishing date	2021-05-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2222993-0
ISSN	1861-9010 ; 1861-9002
ISSN (online)	1861-9010
ISSN	1861-9002
DOI	10.1055/s-0041-1727315
Database	Thieme publisher's database

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Zs.A 6479/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: R.E.N.A.L. Nephrometry Score: A Preoperative Risk Factor Predicting the Fuhrman Grade of Clear-Cell Renal Carcinoma.

Chen, Shao-Hao / Wu, Yu-Peng / Li, Xiao-Dong / Lin, Tian / Guo, Qing-Yong / Chen, Ye-Hui / Huang, Jin-Bei / Wei, Yong / Xue, Xue-Yi / Zheng, Qing-Shui / Xu, Ning

Journal of Cancer

2017 Volume 8, Issue 18, Page(s) 3725–3732

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2017-10-17
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.21189
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Article ; Online: Supplementation of L-Arginine, L-Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice

Yi-Ming Chen / Huashuai Li / Yen-Shuo Chiu / Chi-Chang Huang / Wen-Chyuan Chen

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: ... comprising L-arginine, L-glutamine, vitamin C, vitamin E, folic acid, and green tea extract (LVFG ...

Abstract	It has been reported that abundant nitric oxide content in endothelial cells can increase exercise performance. The purpose of this study was to evaluate the potential beneficial effects of a combined extract comprising L-arginine, L-glutamine, vitamin C, vitamin E, folic acid, and green tea extract (LVFG) on nitric oxide content to decrease exercise fatigue. Male ICR (Institute of Cancer Research) mice were randomly divided into 4 groups and orally administered LVFG for 4 weeks. The 4-week LVFG supplementation significantly increased serum nitric oxide content in the LVFG-1X and LVFG-2X groups. Antifatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming test, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after an acute swimming exercise. LVFG supplementation dose-dependently improved exercise performance and nitric oxide content, and it dose-dependently decreased serum ammonia and CK activity after exhaustive swimming test. LVFG’s antifatigue properties appear to manifest by preserving energy storage (as blood glucose) and increasing nitric oxide content. Taken together, our results show that LVFG could have the potential for alleviating physical fatigue due to its pharmacological effect of increasing serum nitric oxide content.
Keywords	Other systems of medicine ; RZ201-999
Subject code	796
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Metabolic engineering of E. coli for the production of O-succinyl-L-homoserine with high yield

Huang, Jian-Feng / Zhang, Bo / Shen, Zhen-Yang / Liu, Zhi-Qiang / Zheng, Yu-Guo

3 Biotech. 2018 July, v. 8, no. 7

2018

Abstract: ... of the resulting strain E. coli ∆JIB* TrcmetL was dramatically increased to 7.30 g/L. The feedback regulation was ... O-succinyl-L-homoserine (OSH) is a promising platform chemical for the production of C4 chemicals ... of DL-methionine transporter) were deleted in Escherichia coli W3110 to obtain a strain E. coli ∆JI ...

Abstract	O-succinyl-L-homoserine (OSH) is a promising platform chemical for the production of C4 chemicals with huge market potential which can be produced by fermentation from glucose. To construct a strain capable of producing OSH with high yield, the metJ (encodes transcriptional repressor) and metI (encodes a subunit of DL-methionine transporter) were deleted in Escherichia coli W3110 to obtain a strain E. coli ∆JI. Then, overexpression of metL (encodes bifunctional aspartate kinase/homoserine dehydrogenase II) and inactivation of metB (encodes cystathionine γ-synthase) were implemented in one step, and the OSH titer of the resulting strain E. coli ∆JIB* TrcmetL was dramatically increased to 7.30 g/L. The feedback regulation was further relieved by progressively overexpressing metAfbr (encodes homoserine O-succinyltransferase), yjeH (encodes L-methionine exporter), and thrAfbr (encodes bifunctional aspartate kinase/homoserine dehydrogenase I) to increase the metabolic flux from aspartate to OSH. The 100% rationally designed strain E. coli ∆JIB* TrcmetL/pTrc-metAfbr-Trc-thrAfbr-yjeH produced 9.31 g/L OSH from 20 g/L glucose (0.466 g/g glucose) in batch fermentation, which represents the highest OSH yield from glucose reported to date. The culture profiles of the newly constructed strains were recorded to investigate their productive properties. The effects of L-methionine addition on the fermentation process of the optimal strain were also studied. Our results demonstrate that tuning the expression level of metL, inactivation of metB, and attenuation of feedback resistance of the crucial enzymes in the biosynthetic pathway are the key factors that impact the OSH production in E. coli.
Keywords	Escherichia coli ; aspartate kinase ; aspartic acid ; batch fermentation ; biochemical pathways ; cystathionine ; glucose ; homoserine ; markets ; metabolic engineering ; repressor proteins
Language	English
Dates of publication	2018-07
Size	p. 310.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-018-1332-x
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Article ; Online: Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells.

Hsu, Y-C / Chen, M-J / Huang, T-Y

Cell death & disease

2014 Volume 5, Page(s) e1087

Abstract: Cucurbitacin E (CuE) is a natural compound previously shown to have anti-feedant, antioxidant and ...

Abstract	Cucurbitacin E (CuE) is a natural compound previously shown to have anti-feedant, antioxidant and antitumor activities as well as a potent chemo-preventive action against cancer. The present study investigates its anti-proliferative property using MTT assay; CuE demonstrated cytotoxic activity against malignant glioma GBM 8401 cells and induced cell cycle G2/M arrest in these cells. CuE-treated cells accumulated in metaphase (CuE 2.5-10 μM) as determined using MPM-2 by flow cytometry. We attempted to characterize the molecular pathways responsible for cytotoxic effects of CuE in GBM 8401 cells. We studied the genome-wide gene expression profile on microarrays and molecular networks by using pathway analysis tools of bioinformatics. The CuE reduced the expression of 558 genes and elevated the levels of 1354 genes, suggesting an existence of the common pathways involved in induction of G2/M arrest. We identified the RB (GADD45β and GADD45γ) and the p53 (GADD45α) signaling pathways as the common pathways, serving as key molecules that regulate cell cycle. Results indicate that CuE produced G2/M arrest as well as the upregulation of GADD45 γ and binding with CDC2. Both effects increased proportionally with the dose of CuE, suggesting that the CuE-induced mitosis delay is regulated by GADD45γ overexpression. Our findings suggest that, in addition to the known effects on cancer prevention, CuE may have antitumor activity in glioma therapy.
MeSH term(s)	Antimitotic Agents/isolation & purification ; Antimitotic Agents/pharmacology ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; CDC2 Protein Kinase ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Computational Biology ; Cucumis melo/chemistry ; Cyclin B/genetics ; Cyclin B/metabolism ; Cyclin-Dependent Kinases ; Dose-Response Relationship, Drug ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mitosis/drug effects ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Oligonucleotide Array Sequence Analysis ; Phytotherapy ; Plant Stems ; Plants, Medicinal ; Protein Binding ; Signal Transduction/drug effects ; Triterpenes/isolation & purification ; Triterpenes/pharmacology ; Up-Regulation
Chemical Substances	Antimitotic Agents ; Antineoplastic Agents, Phytogenic ; Cyclin B ; GADD45G protein, human ; Intracellular Signaling Peptides and Proteins ; Triterpenes ; CDC2 Protein Kinase (EC 2.7.11.22) ; CDK1 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; cucurbitacin E (V8A45XYI21)
Language	English
Publishing date	2014-02-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/cddis.2014.22
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