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  1. Article: Elaeagnus umbellata

    Park, Seok-Man / Jung, Cheol-Jong / Lee, Dae-Geon / Yu, Yeong-Eun / Ku, Tae-Hun / Hong, Mu-Seok / Lim, Tae-Kyung / Paeng, Kwong-Il / Cho, Hyun-Ki / Cho, Il-Je / Ku, Sae-Kwang

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Photoaging refers to the accumulation of skin damage which includes wrinkle formation, loss of elasticity, and epidermal thickening due to repeated ultraviolet (UV) irradiation. The present study investigated the protective effects ... ...

    Abstract Photoaging refers to the accumulation of skin damage which includes wrinkle formation, loss of elasticity, and epidermal thickening due to repeated ultraviolet (UV) irradiation. The present study investigated the protective effects of
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13020195
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  2. Article ; Online: Disease Course of Korean African Swine Fever Virus in Domestic Pigs Exposed Intraorally, Intranasally, Intramuscularly, and by Direct Contact with Infected Pigs.

    Cho, Ki-Hyun / Hong, Seong-Keun / Kim, Da-Young / Sohn, Hyun-Joo / Yoo, Dae-Sung / Kang, Hae-Eun / Kim, Yeon-Hee

    Viruses

    2024  Volume 16, Issue 3

    Abstract: African swine fever (ASF) is a fatal contagious disease affecting swine. The first Korean ASF virus (ASFV) isolate (Korea/Pig/Paju1/2019) was used to compare the disease course of ASFV in pigs inoculated via the four routes. In the challenge experiment, ... ...

    Abstract African swine fever (ASF) is a fatal contagious disease affecting swine. The first Korean ASF virus (ASFV) isolate (Korea/Pig/Paju1/2019) was used to compare the disease course of ASFV in pigs inoculated via the four routes. In the challenge experiment, domestic pigs were infected via the intraoral (IO) and intranasal (IN) routes with a 10
    MeSH term(s) Swine ; Animals ; African Swine Fever Virus ; Sus scrofa ; African Swine Fever ; Virulence ; Republic of Korea
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Data-driven risk assessment of the incursion of African swine fever virus

    Yoo, Dae-Sung / Cho, Ki-Hyun / Hong, Seong-Keun / Kang, Hae-Eun / Park, Jee-Yong

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 994749

    Abstract: Since 2018, Asian countries have been affected by the African swine fever (ASF) virus, with major socioeconomic consequences. Moreover, the number of people traveling in Asian countries has been increasing, leading to an inevitable increase in the risk ... ...

    Abstract Since 2018, Asian countries have been affected by the African swine fever (ASF) virus, with major socioeconomic consequences. Moreover, the number of people traveling in Asian countries has been increasing, leading to an inevitable increase in the risk of ASF spread through livestock products carried by travelers. China and South Korea have close geo-economic ties and numerous international travelers. After the ASF outbreak in China in 2018, many illegally imported pig products (IIPPs) that were confiscated from travelers from China at the port of entry in South Korea tested positive for ASF. The detection of ASF virus (ASFV)-positive IIPPs highlights the need to further assess the risk of incursion by travelers and review the existing prevention strategies. Here, we investigated the temporal relationship between ASF outbreaks in China and the detection of ASFV-positive IIPPs in randomly confiscated samples from all ports of entry, such as flights and ships to South Korea, from 2018 to 2019 using a cross-correlation analysis. Based on the significantly correlated temporal lags between the bivariate time-series data, a risk assessment model, using the Bayesian framework, was built to estimate the distribution of the parameters for the risk assessment model and the monthly probability of ASF being introduced
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.994749
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  4. Article ; Online: Redundant role of OsCNGC4 and OsCNGC5 encoding cyclic nucleotide-gated channels in rice pollen germination and tube growth.

    Kim, Eun Young / Kim, Myung-Hee / Yun, Sang Dae / Lee, Su-Kyoung / Kim, Eui-Jung / Kim, Ji-Hyun / Oh, Sung-Aeong / Kim, Yu-Jin / Jung, Ki-Hong / Park, Soon Ki

    Plant physiology and biochemistry : PPB

    2024  Volume 208, Page(s) 108522

    Abstract: In staple crops, such as rice (Oryza sativa L.), pollen plays a crucial role in seed production. However, the molecular mechanisms underlying rice pollen germination and tube growth remain underexplored. Notably, we recently uncovered the redundant ... ...

    Abstract In staple crops, such as rice (Oryza sativa L.), pollen plays a crucial role in seed production. However, the molecular mechanisms underlying rice pollen germination and tube growth remain underexplored. Notably, we recently uncovered the redundant expression and mutual interaction of two rice genes encoding cyclic nucleotide-gated channels (CNGCs), OsCNGC4 and OsCNGC5, in mature pollen. Building on these findings, the current study focused on clarifying the functional roles of these two genes in pollen germination and tube growth. To overcome functional redundancy, we produced gene-edited rice plants with mutations in both genes using the CRISPR-Cas9 system. The resulting homozygous OsCNGC4 and OsCNGC5 gene-edited mutants (oscngc4/5) exhibited significantly lower pollen germination rates than the wild type (WT), along with severely reduced fertility. Transcriptome analysis of the double oscngc4/5 mutant revealed downregulation of genes related to receptor kinases, transporters, and cell wall metabolism. To identify the direct regulators of OsCNGC4, which form a heterodimer with OsCNGC5, we screened a yeast two-hybrid library containing rice cDNAs from mature anthers. Subsequently, we identified two calmodulin isoforms (CaM1-1 and CaM1-2), NETWORKED 2 A (NET2A), and proline-rich extension-like receptor kinase 13 (PERK13) proteins as interactors of OsCNGC4, suggesting its roles in regulating Ca
    MeSH term(s) Oryza/physiology ; Cyclic Nucleotide-Gated Cation Channels/genetics ; Germination/genetics ; Pollen/metabolism ; Pollen Tube/genetics ; Calmodulin/genetics ; Calmodulin/metabolism ; Phosphotransferases ; Nucleotides, Cyclic/metabolism
    Chemical Substances Cyclic Nucleotide-Gated Cation Channels ; Calmodulin ; Phosphotransferases (EC 2.7.-) ; Nucleotides, Cyclic
    Language English
    Publishing date 2024-03-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2024.108522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2696: Show issues
    Z 2005/727: Show issues

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  5. Article ; Online: Anti-Inflammatory Effects of Alphitolic Acid Isolated from

    Park, Su Jin / Lee, Jin Seok / Nam, Yu Ran / Lee, Ji Min / Ki, Dae-Won / Yun, Bong-Sik / Choi, Seong Woo / Van, Nhung Thi Hong / Nam, Joo Hyun / Kim, Hyun Jong / Kim, Woo Kyung

    International journal of molecular sciences

    2023  Volume 24, Issue 24

    Abstract: Agrimonia ... ...

    Abstract Agrimonia pilosa
    MeSH term(s) Humans ; Agrimonia ; T-Lymphocytes ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Anti-Inflammatory Agents/pharmacology
    Chemical Substances alphitolic acid ; Plant Extracts ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Safety Evaluation and Population Pharmacokinetics of Camostat Mesylate and Its Major Metabolites Using a Phase I Study.

    Kim, Gwanyoung / Moon, Hyun-Ki / Kim, Taeheon / Yun, So-Hye / Yun, Hwi-Yeol / Hong, Jang Hee / Kim, Dae-Duk

    Pharmaceutics

    2023  Volume 15, Issue 9

    Abstract: Camostat mesylate is expected to be promising as a treatment option for COVID-19, in addition to other indications for which it is currently used. Furthermore, in vitro experiments have confirmed the potential of camostat and its metabolites to be ... ...

    Abstract Camostat mesylate is expected to be promising as a treatment option for COVID-19, in addition to other indications for which it is currently used. Furthermore, in vitro experiments have confirmed the potential of camostat and its metabolites to be effective against COVID-19. Therefore, clinical trials were conducted to evaluate the safety and pharmacokinetic characteristics of camostat after single-dose administration. Additionally, we aim to predict the pharmacokinetics of repeated dosing through modeling and simulation based on clinical trials. Clinical trials were conducted on healthy Korean adults, and an analysis was carried out of the metabolites of camostat, GBPA, and GBA. Pharmacokinetic modeling and simulation were performed using Monolix. There were no safety issues (AEs, physical examinations, clinical laboratory tests, vital sign measurements, and ECG) during the clinical trial. The pharmacokinetic characteristics at various doses were identified. It was confirmed that AUC
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15092357
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  7. Article ; Online: Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023.

    Cho, Ki-Hyun / Yoo, Dae-Sung / Hong, Seong-Keun / Kim, Da-Young / Jang, Min-Kyung / Kang, Hae-Eun / Kim, Yeon-Hee

    Viruses

    2023  Volume 15, Issue 7

    Abstract: Fifteen pig farms were affected by African swine fever (ASF) in South Korea during the outbreaks between 2022 and April 2023. The ASF virus (ASFV) genome was directly extracted from the blood and tissue samples of 15 ASFV-positive pig farms to analyze ... ...

    Abstract Fifteen pig farms were affected by African swine fever (ASF) in South Korea during the outbreaks between 2022 and April 2023. The ASF virus (ASFV) genome was directly extracted from the blood and tissue samples of 15 ASFV-positive pig farms to analyze the genetic characteristics. Phylogenetic analysis revealed that the 15 strains belonged to p72 genotype II and CD2v serogroup 8, which were the central variable region (CVR) I variants of the
    MeSH term(s) Swine ; Animals ; African Swine Fever Virus ; African Swine Fever ; Farms ; Phylogeny ; Genetic Profile ; Genotype ; Disease Outbreaks ; Republic of Korea/epidemiology ; DNA, Intergenic ; Sus scrofa ; Sequence Analysis, DNA
    Chemical Substances DNA, Intergenic
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Smart Pack: Online Autonomous Object-Packing System Using RGB-D Sensor Data.

    Hong, Young-Dae / Kim, Young-Joo / Lee, Ki-Baek

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 16

    Abstract: This paper proposes a novel online object-packing system which can measure the dimensions of every incoming object and calculate its desired position in a given container. Existing object-packing systems have the limitations of requiring the exact ... ...

    Abstract This paper proposes a novel online object-packing system which can measure the dimensions of every incoming object and calculate its desired position in a given container. Existing object-packing systems have the limitations of requiring the exact information of objects in advance or assuming them as boxes. Thus, this paper is mainly focused on the following two points: (1) Real-time calculation of the dimensions and orientation of an object; (2) Online optimization of the object's position in a container. The dimensions and orientation of the object are obtained using an RGB-D sensor when the object is picked by a manipulator and moved over a certain position. The optimal position of the object is calculated by recognizing the container's available space using another RGB-D sensor and minimizing the cost function that is formulated by the available space information and the optimization criteria inspired by the way people place things. The experimental results show that the proposed system successfully places the incoming various shaped objects in their proper positions.
    Language English
    Publishing date 2020-08-09
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20164448
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  9. Article ; Online: Pathophysiological Roles of Transient Receptor Potential (Trp) Channels and Zinc Toxicity in Brain Disease.

    Hong, Dae Ki / Kho, A Ra / Lee, Song Hee / Kang, Beom Seok / Park, Min Kyu / Choi, Bo Young / Suh, Sang Won

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Maintaining the correct ionic gradient from extracellular to intracellular space via several membrane-bound transporters is critical for maintaining overall cellular homeostasis. One of these transporters is the transient receptor potential (TRP) channel ...

    Abstract Maintaining the correct ionic gradient from extracellular to intracellular space via several membrane-bound transporters is critical for maintaining overall cellular homeostasis. One of these transporters is the transient receptor potential (TRP) channel family that consists of six putative transmembrane segments systemically expressed in mammalian tissues. Upon the activation of TRP channels by brain disease, several cations are translocated through TRP channels. Brain disease, especially ischemic stroke, epilepsy, and traumatic brain injury, triggers the dysregulation of ionic gradients and promotes the excessive release of neuro-transmitters and zinc. The divalent metal cation zinc is highly distributed in the brain and is specifically located in the pre-synaptic vesicles as free ions, usually existing in cytoplasm bound with metallothionein. Although adequate zinc is essential for regulating diverse physiological functions, the brain-disease-induced excessive release and translocation of zinc causes cell damage, including oxidative stress, apoptotic cascades, and disturbances in energy metabolism. Therefore, the regulation of zinc homeostasis following brain disease is critical for the prevention of brain damage. In this review, we summarize recent experimental research findings regarding how TRP channels (mainly TRPC and TRPM) and zinc are regulated in animal brain-disease models of global cerebral ischemia, epilepsy, and traumatic brain injury. The blockade of zinc translocation via the inhibition of TRPC and TRPM channels using known channel antagonists, was shown to be neuroprotective in brain disease. The regulation of both zinc and TRP channels may serve as targets for treating and preventing neuronal death.
    MeSH term(s) Animals ; Transient Receptor Potential Channels/metabolism ; Brain/metabolism ; Brain Ischemia/metabolism ; Brain Injuries, Traumatic/metabolism ; Zinc/metabolism ; Mammals/metabolism
    Chemical Substances Transient Receptor Potential Channels ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076665
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  10. Article: Engineered Mesenchymal Stem Cells Over-Expressing BDNF Protect the Brain from Traumatic Brain Injury-Induced Neuronal Death, Neurological Deficits, and Cognitive Impairments.

    Choi, Bo Young / Hong, Dae Ki / Kang, Beom Seok / Lee, Si Hyun / Choi, Seunghyuk / Kim, Hyo-Jin / Lee, Soon Min / Suh, Sang Won

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 3

    Abstract: Traumatic brain injury (TBI) causes transitory or permanent neurological and cognitive impairments, which can intensify over time due to secondary neuronal death. However, no therapy currently exists that can effectively treat brain injury following TBI. ...

    Abstract Traumatic brain injury (TBI) causes transitory or permanent neurological and cognitive impairments, which can intensify over time due to secondary neuronal death. However, no therapy currently exists that can effectively treat brain injury following TBI. Here, we evaluate the therapeutic potential of irradiated engineered human mesenchymal stem cells over-expressing brain-derived neurotrophic factor (BDNF), which we denote by BDNF-eMSCs, in protecting the brain against neuronal death, neurological deficits, and cognitive impairment in TBI rats. BDNF-eMSCs were administered directly into the left lateral ventricle of the brain in rats that received TBI damage. A single administration of BDNF-eMSCs reduced TBI-induced neuronal death and glial activation in the hippocampus, while repeated administration of BDNF-eMSCs reduced not only glial activation and delayed neuronal loss but also enhanced hippocampal neurogenesis in TBI rats. In addition, BDNF-eMSCs reduced the lesion area in the damaged brain of the rats. Behaviorally, BDNF-eMSC treatment improved the neurological and cognitive functions of the TBI rats. The results presented in this study demonstrate that BDNF-eMSCs can attenuate TBI-induced brain damage through the suppression of neuronal death and increased neurogenesis, thus enhancing functional recovery after TBI, indicating the significant therapeutic potential of BDNF-eMSCs in the treatment of TBI.
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16030436
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