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  1. Article ; Online: The Truth about SARS-CoV-2 Cycle Threshold Values Is Rarely Pure and Never Simple.

    Rhoads, Daniel D / Pinsky, Benjamin A

    Clinical chemistry

    2021  Volume 68, Issue 1, Page(s) 16–18

    MeSH term(s) COVID-19/diagnosis ; Humans ; RNA, Viral ; Real-Time Polymerase Chain Reaction ; SARS-CoV-2/isolation & purification ; Viral Load
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvab146
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    Ud II Zs.171: Show issues Location:
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  2. Article: Evaluation of an automated system for the quantitation of human Herpesvirus-6 DNA from clinical specimens.

    Mah, Jordan / Huang, ChunHong / Sahoo, Malaya K / Pinsky, Benjamin A

    Practical laboratory medicine

    2023  Volume 36, Page(s) e00329

    Abstract: Background: Quantitation of human herpesvirus-6 (HHV-6) DNA in clinical specimens is important for the diagnosis and management of HHV-6-associated infection and reactivation in immunocompromised patients, particularly transplant recipients.: Methods!# ...

    Abstract Background: Quantitation of human herpesvirus-6 (HHV-6) DNA in clinical specimens is important for the diagnosis and management of HHV-6-associated infection and reactivation in immunocompromised patients, particularly transplant recipients.
    Methods: The analytical performance of the Altona RealStar ASR HHV-6 qPCR on the semi-automated AltoStar AM16 system was assessed using HHV-6 reference material in plasma and cerebral spinal fluid (CSF). Qualitative and quantitative agreement was determined using 123 clinical EDTA plasma specimens tested using a laboratory-developed HHV-6 qPCR.
    Results: The 95% Lower Limit of Detection was 20 IU/mL [95% confidence interval (CI): 10 to 29] in plasma and 78 IU/mL (95% CI: 55 to 146) in CSF. The assay was linear from 7.0 to 2.0 log
    Conclusions: The RealStar ASR HHV-6 qPCR on the AltoStar AM16 provides accurate quantitation for clinical monitoring of HHV-6 in immunocompromised hosts.
    Language English
    Publishing date 2023-08-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834973-8
    ISSN 2352-5517
    ISSN 2352-5517
    DOI 10.1016/j.plabm.2023.e00329
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  3. Article ; Online: Evaluation of a Semiautomated System for the Quantitation of Human Adenovirus DNA from Clinical Samples.

    Mah, Jordan / Huang, Chun Hong / Sahoo, Malaya K / Pinsky, Benjamin A

    Microbiology spectrum

    2023  , Page(s) e0501022

    Abstract: Human adenoviruses (HAdVs) cause severe disease in immunocompromised patients. Quantitation of HAdV DNA in peripheral blood is used to assess the risk of disseminated disease and to monitor response to therapy. The lower limit of detection, precision, ... ...

    Abstract Human adenoviruses (HAdVs) cause severe disease in immunocompromised patients. Quantitation of HAdV DNA in peripheral blood is used to assess the risk of disseminated disease and to monitor response to therapy. The lower limit of detection, precision, and linearity of the semiautomated AltoStar adenovirus quantitative PCR (qPCR) was evaluated using reference HAdV-E4 in EDTA plasma and respiratory virus matrix. Qualitative and quantitative agreement was determined using 122 clinical EDTA plasma specimens previously tested using a laboratory-developed HAdV qPCR. The 95% lower limit of detection (LLOD) was 33 IU/mL (95% confidence interval [CI], 10 to 56) for EDTA plasma and 188 IU/mL (95% CI, 145 to 304) for respiratory swab matrix. In both matrices, the AltoStar HAdV qPCR was linear from 7.0 to 2.0 log
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.05010-22
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  4. Article ; Online: Assessment of an automated Cytomegalovirus nucleic acid amplification test using clinical plasma, bronchoalveolar lavage, and tissue specimens.

    Huang, ChunHong / Solis, Daniel / Sahoo, Malaya K / Pinsky, Benjamin A

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2023  Volume 168, Page(s) 105582

    Abstract: Background: Cytomegalovirus (CMV) causes significant morbidity and mortality in immunocompromised patients, particularly transplant recipients. Quantitation of CMV DNA in peripheral blood is used to monitor prophylactic and pre-emptive approaches to ... ...

    Abstract Background: Cytomegalovirus (CMV) causes significant morbidity and mortality in immunocompromised patients, particularly transplant recipients. Quantitation of CMV DNA in peripheral blood is used to monitor prophylactic and pre-emptive approaches to prevent CMV disease, whereas CMV DNA testing of non-plasma specimens may aid in the diagnosis of end-organ disease.
    Methods: The analytical performance of the FDA-approved Aptima CMV Quant Assay was evaluated using reference CMV (SeraCare) diluted in defibrinated human plasma, as well as negative bronchoalveolar lavage fluid and tissue. Agreement was determined using 100 clinical acid-citrate-dextrose (ACD) plasma specimens, 77 bronchoalveolar lavage (BAL) fluids, and 101 tissues previously tested using artus CMV qPCR.
    Results: Aptima CMV lower limit of detection (LLOD) was 169 IU/mL for ACD plasma, 100 IU/mL for BAL, and 50 IU/mL for tissue. Positive percent agreement (PPA) was 100.0% (50/50; 95% CI: 92.9% - 100.0%) and negative percent agreement (NPA) was 94.0% (47/50; 95% CI: 83.5% - 98.8%) for ACD plasma. Bland-Altman analysis revealed a bias of 0.20 log
    Conclusions: The Aptima CMV Quant Assay demonstrates high analytical sensitivity and good overall agreement using clinical plasma and tissue specimens.
    MeSH term(s) Humans ; Cytomegalovirus/genetics ; Bronchoalveolar Lavage ; Cytomegalovirus Infections/diagnosis ; Bronchoalveolar Lavage Fluid ; Nucleic Acid Amplification Techniques ; Viral Load ; DNA ; DNA, Viral/genetics
    Chemical Substances DNA (9007-49-2) ; DNA, Viral
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2023.105582
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    Zs.A 3790: Show issues Location:
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  5. Article ; Online: Carving Out a Niche for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Plasma RNA Testing.

    Pinsky, Benjamin A / Hogan, Catherine A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 3, Page(s) e803–e804

    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; Intensive Care Units ; RNA, Viral/genetics ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1412
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  6. Article ; Online: Postpandemic Effects of COVID-19 Shelter-in-Place Orders on the Gastrointestinal Pathogen Landscape.

    Bulterys, Philip L / Leung, Nicole Y / Saleem, Atif / Budvytiene, Indre / Pinsky, Benjamin A / Banaei, Niaz

    Journal of clinical microbiology

    2023  Volume 61, Issue 8, Page(s) e0038523

    MeSH term(s) Humans ; COVID-19 ; Emergency Shelter ; SARS-CoV-2 ; Quarantine
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Letter
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00385-23
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  8. Article ; Online: Reply to Muller and Chaudhury.

    Hogan, Catherine A / Pinsky, Benjamin A / Banaei, Niaz

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 10, Page(s) 2775–2776

    MeSH term(s) Cell-Free Nucleic Acids ; Communicable Diseases ; High-Throughput Nucleotide Sequencing ; Humans ; Plasma ; Retrospective Studies
    Chemical Substances Cell-Free Nucleic Acids
    Language English
    Publishing date 2020-03-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa220
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Carving Out a Niche for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Plasma RNA Testing

    Pinsky, Benjamin A / Hogan, Catherine A

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1412
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2.

    Hogan, Catherine A / Sahoo, Malaya K / Pinsky, Benjamin A

    JAMA

    2020  Volume 323, Issue 19, Page(s) 1967–1969

    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; California/epidemiology ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/statistics & numerical data ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; DNA-Directed RNA Polymerases/genetics ; Disease Transmission, Infectious ; Humans ; Mass Screening ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances DNA-Directed RNA Polymerases (EC 2.7.7.6)
    Keywords covid19
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.5445
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