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  1. Article ; Online: A Birds-Eye View: An Interview with Nick Leschly.

    Wilson, James M

    Human gene therapy. Clinical development

    2019  Volume 30, Issue 1, Page(s) 5–6

    MeSH term(s) Drug Industry/trends ; Genetic Therapy/trends ; Humans ; Patients
    Language English
    Publishing date 2019-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2768506-8
    ISSN 2324-8645 ; 2324-8637
    ISSN (online) 2324-8645
    ISSN 2324-8637
    DOI 10.1089/humc.2019.29044.int
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Nick-free formation of reciprocal heteroduplexes: a simple solution to the topological problem.

    Wilson, J H

    Proceedings of the National Academy of Sciences of the United States of America

    1979  Volume 76, Issue 8, Page(s) 3641–3645

    Abstract: ... formation of fully coiled heteroduplexes. This paper describes a simple, nick-free solution to the winding ...

    Abstract Because the individual strands of DNA are intertwined, formation of heteroduplex structures between duplexes--as in presumed recombination intermediates--presents a topological puzzle, known as the winding problem. Previous approaches to this problem have assumed that single-strand breaks are required to permit formation of fully coiled heteroduplexes. This paper describes a simple, nick-free solution to the winding problem that satisfies all topological constraints. Homologous duplexes associated by their minor-groove surfaces can switch strand pairing to form reciprocal heteroduplexes that coil together into a compact, four-stranded helix throughout the region of pairing. Model building shows that this fused heteroduplex structure is plausible, being composed entirely of right-handed primary helices with Watson-Crick base pairing throughout. Its simplicity of formation, structural symmetry, and high degree of specificity are suggestive of a natural mechanism for alignment by base pairing between intact homologous duplexes. Implications for genetic recombination are discussed.
    MeSH term(s) Base Sequence ; DNA ; Hydrogen Bonding ; Models, Molecular ; Models, Structural ; Nucleic Acid Conformation ; Recombination, Genetic
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 1979-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.76.8.3641
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  3. Article ; Online: Assumptions, uncertainty, and catastrophic/existential risk: National risk assessments need improved methods and stakeholder engagement.

    Boyd, Matt / Wilson, Nick

    Risk analysis : an official publication of the Society for Risk Analysis

    2023  Volume 43, Issue 12, Page(s) 2486–2502

    Abstract: Two key shortcomings of national risk assessments (NRAs) are: (1) lack of justification and transparency around important foundational assumptions of the process, (2) omission of almost all the largest scale risks. Using a demonstration set of risks, we ... ...

    Abstract Two key shortcomings of national risk assessments (NRAs) are: (1) lack of justification and transparency around important foundational assumptions of the process, (2) omission of almost all the largest scale risks. Using a demonstration set of risks, we illustrate how NRA process assumptions around time horizon, discount rate, scenario choice, and decision rule impact on risk characterization and therefore any subsequent ranking. We then identify a neglected set of large-scale risks that are seldom included in NRAs, namely global catastrophic risks and existential threats to humanity. Under a highly conservative approach that considers only simple probability and impact metrics, the use of significant discount rates, and harms only to those currently alive at the time, we find these risks have likely salience far greater than their omission from national risk registers might suggest. We highlight the substantial uncertainty inherent in NRAs and argue that this is reason for more engagement with stakeholders and experts. Widespread engagement with an informed public and experts would legitimize key assumptions, encourage critique of knowledge, and ease shortcomings of NRAs. We advocate for a deliberative public tool that can support informed two-way communication between stakeholders and governments. We outline the first component of such a tool for communication and exploration of risks and assumptions. The most important factors for an "all hazards" approach to NRA are ensuring license for key assumptions and that all the salient risks are included before proceeding to ranking of risks and considering resource allocation and value.
    Language English
    Publishing date 2023-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 778660-8
    ISSN 1539-6924 ; 0272-4332
    ISSN (online) 1539-6924
    ISSN 0272-4332
    DOI 10.1111/risa.14123
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  4. Article ; Online: Consumption of Seafood Near Fukushima Nuclear Power Plant.

    Reyes, Anatalia / Cairns, Nick / Sarmiento, Jomel / Wilson, Cassidy

    Radiologic technology

    2023  Volume 95, Issue 2, Page(s) 143–144

    MeSH term(s) Fukushima Nuclear Accident ; Nuclear Power Plants ; Radiation Monitoring ; Seafood
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 414079-5
    ISSN 1943-5657 ; 0033-8397
    ISSN (online) 1943-5657
    ISSN 0033-8397
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  5. Article ; Online: Incidental imaging findings from head to toe: challenges and management: introductory editorial.

    Given-Wilson, Rosalind / Screaton, Nick / Taylor, Stuart A

    The British journal of radiology

    2023  Volume 96, Issue 1142, Page(s) 20239002

    MeSH term(s) Humans ; Tomography, X-Ray Computed ; Toes/diagnostic imaging ; Incidental Findings
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20239002
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  6. Article ; Online: Mitigating imported fuel dependency in agricultural production: Case study of an island nation's vulnerability to global catastrophic risks.

    Boyd, Matt / Ragnarsson, Sam / Terry, Simon / Payne, Ben / Wilson, Nick

    Risk analysis : an official publication of the Society for Risk Analysis

    2024  

    Abstract: A major global catastrophe would likely disrupt trade in liquid fuels. Countries dependent on imported oil products might struggle to sustain industrial agriculture. Island nations importing 100% of refined fuels are particularly vulnerable. Our case ... ...

    Abstract A major global catastrophe would likely disrupt trade in liquid fuels. Countries dependent on imported oil products might struggle to sustain industrial agriculture. Island nations importing 100% of refined fuels are particularly vulnerable. Our case study aimed to estimate the agricultural land area and biofuel volumes needed to feed the population of New Zealand in the absence of trade. Results showed that stored diesel would quickly be exhausted with ordinary use (weeks) and even with strict rationing (months). To preserve fuel, we found that farming wheat (requiring as little as 5.4 million liters [L] of diesel per annum) was more fuel-efficient than potatoes (12.3) or dairy (38.7) to feed the national population under a climate-as-usual scenario. In a nuclear winter scenario, with reduced agricultural yields, proportionately greater diesel is needed. The wheat would require 24% of current grain-cropped land, and the canola crop used as feedstock for the required biofuel would occupy a further 1%-7%. Investment in canola biodiesel or renewable diesel refineries could ensure supply for the bare minimum agricultural liquid fuel needs. Were subsequent analysis to favor this option as part of a fuels resilience response and as a tradeoff for routine food use, expansion in refining and canola cropping before a catastrophe could be encouraged through market mechanisms, direct government investment, or a combination of these. Logistics of biofuel refining scale-up, post-catastrophe, should also be analyzed. Further, biodiesel produced in normal times would help the nation meet its emissions reduction targets. Other countries should conduct similar analyses.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 778660-8
    ISSN 1539-6924 ; 0272-4332
    ISSN (online) 1539-6924
    ISSN 0272-4332
    DOI 10.1111/risa.14297
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  7. Article ; Online: Island refuges for surviving nuclear winter and other abrupt sunlight-reducing catastrophes.

    Boyd, Matt / Wilson, Nick

    Risk analysis : an official publication of the Society for Risk Analysis

    2022  Volume 43, Issue 9, Page(s) 1824–1842

    Abstract: Some island nations in the Southern Hemisphere might survive a severe sun-reducing catastrophe such as nuclear winter and be well placed to help reboot-collapsed human civilization. Such islands must be resilient to the cascading effects abrupt sunlight ... ...

    Abstract Some island nations in the Southern Hemisphere might survive a severe sun-reducing catastrophe such as nuclear winter and be well placed to help reboot-collapsed human civilization. Such islands must be resilient to the cascading effects abrupt sunlight reduction scenarios (ASRS) would impose beyond the impacts on agricultural systems. We aimed to identify island nations whose societies are most likely to survive nuclear winter or other ASRS. We also aimed to conduct a case study of one island nation to consider how it might enhance its resilience and therefore its chance of aiding a global reboot of complex technological society. We performed a threshold analysis on food self-sufficiency under severe nuclear winter conditions to identify islands. We then profiled each island across global macroindices representing resilience factors reported in the literature. We undertook a case study of the island nation of New Zealand. The island nations of Australia, New Zealand, Iceland, the Solomon Islands, and Vanuatu appear most resilient to ASRS. However, our case-study island nation of New Zealand is threatened in scenarios of no/low trade, has precarious aspects of its energy supply, and shortcomings in manufacturing of essential components. Therefore, inadequate preparations and critical failures in these systems could see rapid societal breakdown. Despite some islands' favorable baseline conditions and apparent food security even in a severe ASRS, cascading impacts through other socioecological systems threaten complex functioning. We identified specific resilience measures, many with cobenefits, which may protect island nodes of sustained complexity in ASRS.
    MeSH term(s) Humans ; Sunlight ; New Zealand ; Seasons ; Australia ; Iceland
    Language English
    Publishing date 2022-12-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 778660-8
    ISSN 1539-6924 ; 0272-4332
    ISSN (online) 1539-6924
    ISSN 0272-4332
    DOI 10.1111/risa.14072
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  8. Article ; Online: Multifractality in stride-to-stride variations reveals that walking involves more movement tuning and adjusting than running.

    Wilson, Taylor J / Mangalam, Madhur / Stergiou, Nick / Likens, Aaron D

    Frontiers in network physiology

    2023  Volume 3, Page(s) 1294545

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2674-0109
    ISSN (online) 2674-0109
    DOI 10.3389/fnetp.2023.1294545
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  9. Article ; Online: COVID-19 and other pandemics require a coherent response strategy.

    Baker, Michael G / Durrheim, David / Hsu, Li Yang / Wilson, Nick

    Lancet (London, England)

    2023  Volume 401, Issue 10373, Page(s) 265–266

    MeSH term(s) Humans ; COVID-19 ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)02489-8
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  10. Article ; Online: Failures with COVID-19 at the international level must not be repeated in an era facing global catastrophic biological risks.

    Boyd, Matt / Wilson, Nick

    Australian and New Zealand journal of public health

    2021  Volume 45, Issue 2, Page(s) 184

    MeSH term(s) COVID-19 ; Global Burden of Disease ; Global Health ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Letter
    ZDB-ID 1323548-5
    ISSN 1753-6405 ; 1326-0200
    ISSN (online) 1753-6405
    ISSN 1326-0200
    DOI 10.1111/1753-6405.13082
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